scholarly journals Solid-supported Synthesis of 3, 4-dihydrobenzo [2, 3-d] pyrimidines

1970 ◽  
Vol 11 ◽  
pp. 153-158 ◽  
Author(s):  
AD Mishra
Keyword(s):  
Key Words ◽  
Science And Technology ◽  
Environmentally Benign ◽  
Bacterial Strains ◽  
Pyrimidine Derivatives ◽  
Solid Supports ◽  
Substituted 1

Different 3,4-dihydrobenzo[2,3-d] pyrimidine derivatives were synthesized by the condensation of substituted 1, 3- cyclohexadienes and formamide, using inorganic solid supports under microwaves. Simple and commonly available compounds were used as starting materials in the reactions. The compounds were tested against different fungal and bacterial strains and found considerably effective. Key words: inorganic solid supports; microwave; benzopyrimidines; environmentally benign; antimicrobial DOI: 10.3126/njst.v11i0.4138Nepal Journal of Science and Technology 11 (2010) 153-158

scholarly journals Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed El Fal ◽  
Youssef Ramli ◽  
Abdelfettah Zerzouf ◽  
Ahmed Talbaoui ◽  
Youssef Bakri ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Dipolar Cycloaddition ◽  
Bacterial Strains ◽  
Pyrimidine Derivatives ◽  
H Nmr ◽  
Biological Interest ◽  
Mic Value

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR,13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains:Staphylococcus aureus,Enterococcus faecalis,Escherichia coli, andPseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL againstStaphylococcus aureusandStreptococcus fasciens.

scholarly journals Microbial Load on Paper/Polymer Currency and Coins

1970 ◽  
Vol 9 ◽  
pp. 105-109 ◽  
Author(s):  
Tista Prasai ◽  
Kayo Devi Yami ◽  
Dev Raj Joshi
Keyword(s):  
Key Words ◽  
Heterotrophic Bacteria ◽  
Science And Technology ◽  
Microbial Load ◽  
Disease Spread ◽  
Coliform Bacteria ◽  
Aerobic Bacteria ◽  
Contamination Level

Currency notes and coins serve as an agency of transmission of microorganisms since they are passed freely from hand to hand as a medium of exchange. A research, with an objective to explore the microbial load on Nepalese paper/ polymer currency notes and coins, was carried out at the Environment Laboratory of Nepal Academy of Science and Technology, Khumaltar from November 2006 to May 2007. All together 63 samples of paper/polymer notes and coins from different professionals of different places at Kathmandu were collected and analyzed for the presence of microorganisms. Among the total tested paper/ polymer and coin samples, 98.4% were found to have heterotrophic aerobic bacteria, 87.3% were contaminated with coliform bacteria and 79.4% showed presence of Staphylococci. Contamination level was found in increasing order of coins> polymer notes>paper notes. The presence of high microbial load on currency notes and coins indicate the potentials of such currencies for possible disease spread in the human communities. Key words: currency notes; coins; heterotrophic bacteria; Coliform bacteria; Staphylococci DOI: 10.3126/njst.v9i0.3173 Nepal Journal of Science and Technology 9 (2008) 105-109

scholarly journals ESTÁGIO SUPERVISIONADO E A TENDÊNCIA À RAZÃO INSTRUMENTAL

Revista Labor ◽  
2017 ◽  
Vol 1 (17) ◽  
pp. 110
Author(s):  
Elenilce Gomes de Oliveira ◽  
Carlos Augusto De Oliveira Azevedo Filho
Keyword(s):  
Key Words ◽  
Social Relations ◽  
Science And Technology ◽  
Historical Materialism ◽  
Instrumental Reason ◽  
Max Horkheimer ◽  
Federal Institute ◽  
Education Science ◽  
Important Milestone

Resumo  Destaca a tendência à razão instrumental, com base em Theodor W. Adorno e Max Horkheimer, cuja crítica a essa racionalidade constitui marco importante para a compreensão dos obstáculos à emancipação e à liberdade humana. A metodologia tem suporte na acepção do materialismo histórico-dialético, de modo a evidenciar elementos atinentes às relações histórico-sociais. Dessa maneira, põe em ressalto peculiaridades relativas à manifestação desta racionalidade no âmbito do Estágio Supervisionado, componente curricular da Licenciatura em Teatro, no Instituto Federal de Educação, Ciência e Tecnologia do Ceará.   Palavras-chave: Racionalidade. Adorno. Horkheimer. Formação. Estágio Supervised internship and tendency to instrumental reason Abstract  The present paper highlights the tendency to instrumental reason as developed by Theodor W. Adorno and Max Horkheimer, whose criticism to this rationality constitutes an important milestone for understanding the obstacles to human emancipation and freedom. The methodology is based on the dialectical and historical materialism, in order to point elements related to historical-social relations. In this way, it emphasizes peculiarities related to the manifestation of this rationality within the scope of Supervised Internship as one of the curricular components of the Teaching License in Theater at the Federal Institute of Education, Science and Technology of Ceará. Key-words: Rationality. Adorno. Horhheimer. Formation. Supervised Internship.

scholarly journals Modernisasi Kurikulum Pendidikan Islam (Studi Atas Pemikiran Azyumardi Azra)

2018 ◽  
Vol 16 (2) ◽  
pp. 169-186
Author(s):  
Imam Nur Hukum
Keyword(s):  
Key Words ◽  
Rapid Development ◽  
Science And Technology ◽  
Islamic Education ◽  
Global Competition

Abstract: Modernization is an effort to change in order to aligned with contemporary demands and needs. The curriculum of Islamic education is important to be modernized so that the curriculum is contextual so as to give an answer to the demands and needs of the students according to era. One of the underlying need for the modernization of Islamic education is characterized curriculum of Islamic education is still a “traditionalist” (despite the fact that not all of them), with one feature of the persistence of the dichotomization of science (materials) of Islamic education, or tend to concerned with the general materials beyond religious materials. Azyumardi Azra, as a prominent reform of Islamic education in Indonesia, declared that the rapid development of science and technology demands Islamic education to be responsive and up to date, so that Muslims continue to survive and compete with advanced nations. For Azyumardi, “making stepchild” science and technology is an attitude that will bring a decline, backwardness, and underdevelopment in the global competition which is getting tougher. Therefore according to Azyumardi, the integration of science (general and religious) in Islamic education is the thing that should be done as a solution to promote Islamic education so as able to compete and beat the forefront. Key words: Modernization, Curriculum, Islamic Education

scholarly journals SIMBIOSIS MUTUALISME PERPUSTAKAAN DENGAN MEDIA CETAK SEBAGAI UPAYA MEMBUDAYAKAN MEMBACA DAN MENULIS BAGI MASYARAKAT

2019 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Muhammad Rohmadi
Keyword(s):  
Key Words ◽  
Print Media ◽  
Science And Technology ◽  
Reading And Writing ◽  
Knowledge Resource ◽  
The Arts ◽  
Symbiotic Mutualism ◽  
The Media

<p>Library and print media as a medium for the dissemination of information and knowledge resource centers. Both the media must have the positive integration of mutual benefi t. It is a form of strengthening the various models of information disseminated directly and indirectly. Various models of literacy and knowledge appeared in the print media and it is presented in the library. Therefore, it is necessary to unify the vision synergistic effort between the library and print media so that it can occur symbiotic mutualism between the library and the print media in a variety of contexts of science and technology and the arts.</p><p>Key words: symbiotic mutualism, libraries, print media, reading, and writing.</p>

Ripensare la "Sociologia urbana". Parte seconda: da bisogno di coerenza a ipotesi di imprevedibilitŕ

2009 ◽  
pp. 7-41
Author(s):  
Paolo Guidicini
Keyword(s):  
Key Words ◽  
Empirical Research ◽  
Urban Sociology ◽  
Science And Technology ◽  
Safety Technology

- I come back to the debate which was begun in the "first part". Now, I focus on the concept of "structure" as a basic moment in the empirical research on the territory (in particular, the concept of perceived structure will be considered). After that, I will stress the connection between science and technology, and the importance to insert them in an Urban Sociology debate (Heidegger and the concept of Ge-Steel). Then, I will conclude putting into evidence the difficulty in territory fruition.Key words: social morphology, structured territorial context, safety/technology, ontology of decline.

scholarly journals Bacteria and actinomycetes growing on floppy and compact discs under ambient conditions

1970 ◽  
Vol 37 (1) ◽  
pp. 7-14
Author(s):  
Mahbubar Rahman Khan ◽  
Mihir Lal Saha ◽  
Sanjida Binte Zuha
Keyword(s):  
Key Words ◽  
Microbial Growth ◽  
Compact Disc ◽  
Bacterial Isolates ◽  
Ambient Conditions ◽  
Bacterial Strains ◽  
Bacillus Lentus ◽  
Floppy Disc

Floppy and compact discs gradually loose their quality. On closer examination deteriorated discs showed diverse microbial growth on their surfaces. Among the associated organisms 15 actinomycetes and 12 bacterial isolates were selected for detailed studies. The selected actinomycetes were Streptomyces diastaticus, S. rimosus, S. cyaneus, S. olivaceoviridis, S. halstedii, S. fulvissimus, S. albidoflavus, S. exfoliates and S. griseoflavus and the bacterial strains were Bacillus lentus, B. circulans, B. badius, B. laterosporus, B. larvae and B. thuringiensis. In addition, Micrococcus sedentarius was also isolated. Utilization of crushed disc materials was observed during this study, which was indicative of deterioration of floppy and compact discs.   Key words: Compact disc, Floppy disc, Microorganisms, Recalcitrant doi:10.3329/bjb.v37i1.1557 Bangladesh J. Bot. 37(1): 7-14, 2008 (June)

scholarly journals H2O2:HCl Catalyzed Synthesis of 5-(3-Substituted-Thiophene) Pyrimidine Derivatives and Evaluation for Their Pharmacological Effects

2021 ◽  
Author(s):  
Sukanya S H ◽  
Talavara Venkatesh ◽  
Adithya Rao S J ◽  
Shivakumara N
Keyword(s):  
In Silico ◽  
Condensation Reaction ◽  
Cancer Cell Line ◽  
Assay Method ◽  
Pharmacological Effects ◽  
Bacterial Strains ◽  
Zone Of Inhibition ◽  
Pyrimidine Derivatives ◽  
Ct Dna

Abstract A series of 5-(3-substituted-thiophene) pyrimidine derivatives (3a-d) were synthesized via Knoevenagel condensation reaction in aqueous ethanol using H2O2:HCl as a green halogenating catalyst and evaluated for their pharmacological effects. The structures of the targets were confirmed by analytical and spectroscopic methods. From antibacterial activity result reveals that, all the four compounds showed appreciable activity with varied zone of inhibition, in that the compounds 3b & 3d exhibited most effective zone of inhibition against bacterial strains E. coli & S. aureus respectively. In-vitro cytotoxicity was carried by MTT assay method against MCF-7 (Breast cancer) cell line and results of all the four compounds showed excellent selectivity, in that compound 3a exhibited excellent cytotoxicity with minimum cell viability range of 23.68 to 44.16 %. The interaction of compounds with CT-DNA was determined by using UV-absorption spectroscopy and results were confirmed that, all the synthesized compounds interacted strongly with CT-DNA through electrostatic or groove binding. In-silico ADME-toxicology results indicated that, all the targets are non-toxic, good oral bioavailability and druglikeness score indicated that they are suitable as drug-leads. From In-silico molecular docking results showed compound 3b was bound with GlcN-6-P and P38 MAPk with least binding energy of -7.9 and -6.4 kcal/mol respectively.

scholarly journals An expeditious synthesis of 3, 4-dihydro-benzo[2,3-d]pyrimidines using inorganic solid supports

2004 ◽  
Vol 69 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Mazaahir Kidwai ◽  
Alkal Mishra
Keyword(s):  
Bacterial Strains ◽  
Solid Supports

Aseries of novel 5-substituted-8-cyano-4,6,7-triphenyl-3,4-dihydrobenzo [2,3-d]pyrimidines were synthesized by the condensation of 6-substituted-2-amino 1-benzoyl-3-cyano-5-hydroxy-4,5-diphenyl-1,3-cyclohexadiene and formamide using inorganic solid supports under microwaves. Some of the compounds were found to be effective against some fungal and bacterial strains.

Application of Microwave Irradiation, Solid Supports and Catalysts in Environmentally Benign Heterocyclic Chemistry

ChemInform ◽  
2005 ◽  
Vol 36 (25) ◽  
Author(s):  
Jose Ramon Carrillo ◽  
Angel Diaz-Ortiz ◽  
Antonio De La Hoz ◽  
Andres Moreno ◽  
Maria Victoria Gomez ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Environmentally Benign ◽  
Heterocyclic Chemistry ◽  
Solid Supports
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