scholarly journals Metformin Efficiency in Genital Endometriosis Management

Doctor Ru ◽  
2021 ◽  
Vol 20 (6) ◽  
pp. 62-67
Author(s):  
M.I. Yarmolinskaya ◽  
◽  
M.S. Florova ◽  
Keyword(s):  
Pain Syndrome ◽  
Study Objective ◽  
Group 4 ◽  
Metformin Monotherapy ◽  
Study Results ◽  
Before And After ◽  
Therapy Option ◽  
Group 3 ◽  
Group 2 ◽  
Selection Of

Study Objective: To assess clinical efficiency of combination therapy with Metformin and Metformin monotherapy in the management of endometriosis genitalis externa (EGE). Study Design: perspective randomised singe-arm study in parallel groups. Materials and Methods. 146 patients with pain syndrome associated with endometreosis were treated with one therapy option for 6 months: Dienogest 2mg/d (group 1, n = 32); Dienogest 2mg/d + Metformin 1,500mg/d (group 2, n = 61); Dienogest 2mg/d + Metformin 750mg/d (group 3, n = 29); Metformin 1,500 mg/d (group 4, n = 24). The intensity and prevalence of dysmenorrhea, dyspareunea, chronic pelvis pain (CPP) before and after treatment were evaluated. Study Results. In group 2, pain syndrome became less intensive in 85.2% of EGE patients. Dysmenorrhea reduction was statistically more frequent (p = 0.031), CPP was less intensive (p = 0.027), as compared to the standard Dienogest therapy. 75.9% of group 3 patients and 66.7% of group 4 patients had less intensive pain syndrome. There were no statistically significant differences in therapy results between group 3 and group 4 and Dienogest monotherapy. Conclusion. Combination of Dienogest (2mg/day) and Metformin (1,500mg/d) allows boosting the efficiency of therapy of endometreosis-associated pain syndrome. Personification of pathogen-specific EGE management with individualised selection of a drug combination and Metformin dose is a promising option. Keywords: endometreosis, pain syndrome, Dienogest, Metformin

scholarly journals The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1337
Author(s):  
Joseph Yusin ◽  
Vivian Wang ◽  
Susanne M. Henning ◽  
Jieping Yang ◽  
Chi-Hong Tseng ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Spray ◽  
Placebo Tablet ◽  
Group 4 ◽  
Cytokine Levels ◽  
Before And After ◽  
Group 3 ◽  
Nasal Steroid ◽  
Group 2 ◽  
Broccoli Sprout

Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (p ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 (p = 0.03), 15 (p = 0.057) and 30 (p = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures.

Evaluation of the preventive care effectiveness in the adults with odontogenic infection given social and hygienic risk factors

2021 ◽  
Vol 21 (3) ◽  
pp. 175-181
Author(s):  
S. B. Ulitovskiy ◽  
O. V. Kalinina ◽  
A. V. Shevcov ◽  
E. S. Soloveva ◽  
N. K. Fok
Keyword(s):  
Preventive Care ◽  
Oral Hygiene ◽  
Adult Population ◽  
Oral Care ◽  
Odontogenic Infection ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Selection Of ◽  
Group 1

Relevance. Odontogenic infection is one of the most important problems of dental science. The variety of anti-inflammatory oral hygiene products determines the need for targeted selection of preventive toothpastes and rinses, balms, foams, elixirs, as well as monitoring and training the algorithm of hygienic measures for a patient with an odontogenic infection. The aim of the study was to study the hygienic status of the adult population for the selection of individual oral hygiene products for odontogenic infection, taking into account social and hygienic factors.Materials and methods. The study examined the prevalence of odontogenic infection in the adult population to determine the need for professional care and dental education. The study involved 198 people without somatic pathology, who were allocated into four groups according to the performed oral care and taking into account the dental status and the intensity of oral microbiota formation in the adult population. The patients were followed-up every week for one month. The study examined the simplified oral hygiene index by GreenVermillion (OHI-S), PMA index and Mühlemann and Son sulcus bleeding index, which allowed calculating the effectiveness of oral care products.Results. The preventive care effectiveness evaluation showed an increase in the cleansing effect in the adult population over the entire study period. The anti-inflammatory effectiveness analysis demonstrated positive changes: by the end of the study, the PMA index was 51.52 ± 3.40% in group 1; it increased by a factor of 3 and amounted to 44.17 ± 2.77% in group 2; 56.51 ± 4.61% – in group 3, 48.95 ± 3.60% – in group 4. The Mühlemann and Son sulcus bleeding index demonstrated the changes in the periodontal tissue condition and amounted to 52.78 ± 3.62% in group 1, 44.11 ± 3.54% in group 2, 54.97 ± 3.98% in group 3, 47.78 ± 2.73% in group 4.Conclusions. The development of oral health promotion measures determines the significance of oral care products for the prevention of odontogenic infection in the adult population, which plays a crucial role in the individual program planning for the main dental disease prevention.

scholarly journals Atopic Biomarker Changes after Exposure to Porphyromonas gingivalis Lipopolysaccharide: A Small Experimental Study in Wistar Rat

2021 ◽  
Author(s):  
Sindy Cornelia Nelwan ◽  
Ricardo Adrian Nugraha ◽  
Anang Endaryanto ◽  
Asti Meizarini ◽  
Udijanto Tedjosasongko ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Wistar Rat ◽  
Periodontal Pathogen ◽  
Rapid Decline ◽  
Group 4 ◽  
Area Of Interest ◽  
Before And After ◽  
Porphyromonas Gingivalis Lipopolysaccharide ◽  
Group 3 ◽  
Group 2

BackgroundIgE and IgG4 are implicated in atopic development and clinically utilized as major biomarkers. Atopic responses following certain pathogens such as Porphyromonas gingivalis is currently an area of interest for further research.PurposeThe aim of this study is to measure the level of IgE, IgG4, and IgG4/IgE ratio periodically after exposure of periodontal pathogen Porphyromonas gingivalis (Pg) lipopolysaccharide (LPS).MethodsWe used 16 wistar rats (Rattus norvegicus) randomly subdivided into 4 groups, group 1 were injected by placebo, group 2 by LPS Pg 0.3 μg/mL,group 3 by LPS Pg 1 μg/mL, and group 4 by LPS Pg 3 μg/mL. Sera from both groups were taken from retro-orbital plexus before and after exposure.ResultsLevel of IgE and IgG4 increased significantly following exposure of LPS Pg at day-4 and day-11. Greater increase of IgE rather than IgG4 contributes to rapid decline of IgG4/IgE ratio, detected in the peripheral blood at day-4 and day-11.ConclusionModulation of atopic responses following exposure to LPS Pg is reflected by decrease in IgG4/IgE ratio that accompanies an increase of IgE.Clinical significancePorphyromonas gingivalis, a keystone pathogen during periodontal disease, may have a tendency to disrupt atopic biomarkers.

scholarly journals Effect of Three Wavelengths of Diode Laser on the Efficacy of Bleaching of Stained Teeth

2020 ◽  
Author(s):  
Reza Saeedi ◽  
Ladan Ranjbar Omrani ◽  
Mahdi Abbasi ◽  
Nasim Chiniforush ◽  
Mojgan Kargar
Keyword(s):  
Diode Laser ◽  
Tooth Bleaching ◽  
Color Parameters ◽  
Group 4 ◽  
Before And After ◽  
Group 3 ◽  
Group 2 ◽  
Laser Bleaching ◽  
Group 1

Objectives: Light irradiation and heat have been used to accelerate the process of tooth bleaching. This study aimed to assess the efficacy of conventional bleaching compared to laser-bleaching using three different wavelengths of diode lasers. Materials and Methods: In this in-vitro experimental study, 40 extracted human central incisors were immersed in a coloring solution made of tea, coffee, and cola for 21 days. The L*, a*, and b* color parameters were measured before and after the immersion using spectrophotometry. The teeth were then randomly divided into four groups (n=10) as follows: group 1: 810-nm diode laser + Biolase Laser White 20, group 2: 940-nm diode laser + Biolase Laser White 20, group 3: 980-nm diode laser + Biolase Laser White 20, and group 4: conventional bleaching with Opalescence Boost without laser irradiation. One-way analysis of variance (ANOVA) was used to assess the effect of laser type and bleaching technique on color parameters. Results: The 940-nm (∆E=28.5896) and 810-nm laser groups (∆E=21.2382) showed the highest and the lowest bleaching efficacy, respectively; however, the groups were not significantly different in terms of bleaching efficacy (P>0.05). Conclusion: Laser-bleaching with 810-, 940- and 980-nm wavelengths of diode laser has an efficacy similar to that of conventional bleaching but in a shorter period. No difference was noted between different laser wavelengths in terms of bleaching efficacy.

scholarly journals Atopic biomarker changes after exposure to Porphyromonas gingivalis lipopolysaccharide: a small experimental study in Wistar rats

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 371
Author(s):  
Sindy Cornelia Nelwan ◽  
Ricardo Adrian Nugraha ◽  
Anang Endaryanto ◽  
Asti Meizarini ◽  
Udijanto Tedjosasongko ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Wistar Rats ◽  
Periodontal Pathogen ◽  
Rapid Decline ◽  
Group 4 ◽  
Area Of Interest ◽  
Before And After ◽  
Porphyromonas Gingivalis Lipopolysaccharide ◽  
Group 3 ◽  
Group 2

Background: IgE and IgG4 are implicated in atopic development and clinically utilized as major biomarkers. Atopic responses following certain pathogens, such as Porphyromonas gingivalis (Pg), are currently an area of interest for further research. The aim of this study is to measure the level of IgE, IgG4, and IgG4/IgE ratio periodically after exposure of periodontal pathogen Pg lipopolysaccharide (LPS). Methods: We used 16 Wistar rats (Rattus norvegicus) randomly subdivided into four groups: Group 1,  injected with placebo; Group 2, injected with LPS Pg 0.3 µg/mL; Group 3, injected with LPS Pg 1 µg/mL; and Group 4, injected with LPS Pg 3 µg/mL. Sera from all groups were taken from retro-orbital plexus before and after exposure. Results: Levels of IgE and IgG4 increased significantly following exposure of LPS Pg at day-4 and day-11. Greater increase of IgE rather than IgG4 contributed to rapid decline of IgG4/IgE ratio, detected in the peripheral blood at day-4 and day-11. Conclusion: Modulation of atopic responses following exposure to LPS Pg is reflected by a decrease in IgG4/IgE ratio that accompanies an increase of IgE. Therefore, Pg, a keystone pathogen during periodontal disease, may have a tendency to disrupt atopic biomarkers.

scholarly journals Saliva Contamination Effect on Shear Bond Strength of Self-etching Primer with Different Debond Times

2007 ◽  
Vol 77 (5) ◽  
pp. 901-906 ◽  
Author(s):  
Tamer Turk ◽  
Selma Elekdag-Turk ◽  
Devrim Isci ◽  
Fethiye Cakmak ◽  
Nurhat Ozkalayci
Keyword(s):  
Control Group ◽  
Group 4 ◽  
Contamination Effect ◽  
Significant Difference ◽  
Before And After ◽  
Group 3 ◽  
Bond Strengths ◽  
Group 2 ◽  
Saliva Contamination ◽  
Group 1

Abstract Objective: To evaluate shear bond strengths (SBSs) of a self-etching primer (SEP) following saliva contamination at different stages of bonding at debond times of 5, 15, and 30 minutes and 24 hours. Materials and Methods: Two-hundred forty human premolars were divided into four groups: group 1, uncontaminated; group 2, saliva contamination after priming; group 3, saliva contamination before priming; and group 4, saliva contamination before and after priming. Four subgroups according to debond times of 5, 15, 30 minutes and 24 hours were composed. Metal brackets were bonded with an SEP (Transbond Plus) and light-cure adhesives paste (Transbond XT). SBS values and the adhesive remnants were determined. Results: The highest SBS was obtained at a debond time of 24 hours for the control group. This was significantly different from the other groups. SBSs at 5, 15, and 30 minutes showed no significant difference from each other in the control group (P > .05). Lowest SBSs were obtained at a debond time of 5 minutes for groups 1, 2, 3, and 4 (8.38, 7.10, 7.06, and 6.26 MPa, respectively) and were not significantly different from each other (P > .05). SBSs at 24 hours were not significantly different from each other for groups 2, 3, and 4 (P > .05). Significant differences were found in the adhesive remnant (P < .001). Conclusions: SEP (Transbond Plus) may produce clinically acceptable bracket bonding after 5, 15, and 30 minutes from time of placement on the teeth, even with light and heavy saliva contamination.

scholarly journals Therapeutic effects of Salvadora persica (Miswak) on patients with mild to moderate gingivitis.

2020 ◽  
Vol 3 (2) ◽  
pp. 119-125
Author(s):  
Kawa Dizaye ◽  
Zainab Othman
Keyword(s):  
Plaque Index ◽  
Therapeutic Effects ◽  
Gingival Index ◽  
Salvadora Persica ◽  
Cross Sectional ◽  
Group 4 ◽  
Before And After ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Background and Objectives: Miswak is the public name of Salvadora persica, which is beneficial for dental treatments and can thus be used to treat gingivitis. This study compares the therapeutic effects of miswak (S. persica), toothbrush, S. persica mouthwash, and chlorhexidine mouthwash on patients with mild to moderate gingivitis by estimating gingival index and (debris) plaque index. Patients and Methods: The study is a selective sampling, cross-sectional, clinical comparative study of 50 systemically healthy patients in Erbil city. The patients were divided randomly into five groups, with each group having 10 patients. Group 1 used S. persica chewing stick only; group 2 used toothbrush only; group 3 used both S. persica and toothbrush, group 4 used S. persica mouthwash and toothbrush; while group 5 used chlorhexidine mouthwash and tooth-brush. The patients’ mouths were examined, recording clinical indices before and after four weeks from the administration of treatments. Results: There is significant improvement observed between groups 3 and 1 and groups 3 and 2 regarding gingival index. Moreover, there is significant improvement in debris (plaque) index between groups 2 and 3 and groups 2 and 1. Conclusion: The gingival index indicates that using S. persica and toothbrush together is better than using S. persica or toothbrush alone. Meanwhile, the debris index shows that using S. persica alone or using it with toothbrush is more effective than using toothbrush alone. Keywords: Salvadora persica, gingivitis, gingival index, debris index.

scholarly journals SURFACE ROUGHNESS OF LITHIUM DISILICATE PRESS CERAMICS AFTER DIFFERENT TYPES OF POLISHING

2021 ◽  
Vol 2 ◽  
pp. 174-177
Author(s):  
Elena Vasileva ◽  
Angelina Vlahova ◽  
Ilian Hristov ◽  
Svetlin Alexandrov ◽  
Zlatina Tomova
Keyword(s):  
Lithium Disilicate ◽  
Ceramic Surface ◽  
Group 4 ◽  
Diamond Bur ◽  
Atomic Force ◽  
Glazed Ceramic ◽  
Before And After ◽  
Group 3 ◽  
Group 2 ◽  
Diamond Paste

INTRODUCTION: The smoothness of a ceramic’s surface is very important of its esthetic and prophylactic qualities. AIM: The purpose of this investigation is to study the possibilities of polishing lithium disilicate ceramics after making a correction on the glazed ceramic surface. MATERIALS AND METHODS: The subject of the study were 20 test samples made of lithium disilicate press ceramics. They were divided into 4 groups according to the method of processing and polishing. Group 1 was treated with a red diamond bur and polishing set; Group 2 was treated with a green diamond bur and polishing set; Group 3 was treated with a red diamond bur, polishing set and diamond paste; Group 4 was treated with a diamond bur with green coding, polishing set and diamond paste. The samples were examined with an atomic force microscope to observe the change in surface relief. The reference point for comparison was the surface of the glazed ceramic. RESULTS: After polishing with diamond paste, the surface became smoother compared to the treatment of the surface with a polishing kit alone. CONCLUSION: Regardless of the polishing protocol used, there was a difference in the topography of the ceramic surface before and after treatment.

scholarly journals Fluoride releasing and Uptake Capacities of Esthetic Restorations

2013 ◽  
Vol 14 (5) ◽  
pp. 887-891 ◽  
Author(s):  
Rajesh Shetty ◽  
M Gururaj ◽  
Shwetha Shetty ◽  
CN Vijay Kumar
Keyword(s):  
Weekly Interval ◽  
Fluoride Ion ◽  
Fluoride Release ◽  
Burst Effect ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Selection Of

ABSTRACT Background and objectives The purpose of this study was to evaluate and compare in vitro the fluoride release and uptake from 5 different esthetic restorative materials. Materials and methods Materials tested were conventional GIC — Fuji 7, GC (group1), resin modified GIC — Vitremer, 3M ESPE (group 2), polyacid modified composite — Dyract, Dentsply (group 3), fluoride releasing composite — Tetric ceram, Ivoclar Vivadent (group 4), Giomer-Beautifil, Shofu (group 5). Fluoride release was estimated at 6th, 24th, 48th hour and weekly interval for 5 weeks. For fluoride recharge, each specimen was exposed to 2 ml of 1.23% APF gel for 4 minutes and fluoride release measured at 1st, 2nd, 3rd day and 7th day. The fluoride release and recharge was measured using fluoride ion specific electrode. Results ANOVA and Tukey HSD test were used for statistical analysis. During tested period all materials showed statistically different capability to release and uptake fluoride. Groups 1 and 2 results were comparable in fluoride release. Similarly groups 3 and 5. Groups 1 and 2 vs 3, 4, 5 were statistically very highly significant. Only conventional GIC showed initial ‘burst effect’. Interpretation and conclusion Materials tested showed potential for fluoride release and recharge. Different esthetic materials had variable fluoride release hence selection of materials should be guided by specific clinical situations. How to cite this article Gururaj M, Shetty R, Nayak M, Shetty S, Kumar CNV. Fluoride releasing and Uptake Capacities of Esthetic Restorations. J Contemp Dent Pract 2013;14(5): 887-891.

scholarly journals Zenlens scleral lenses for visual rehabilitation of patients with irregular cornea: a usage experience

2018 ◽  
Vol 11 (4) ◽  
pp. 68-74 ◽  
Author(s):  
O. O. Alyaeva ◽  
O. I. Ryabenko ◽  
E. M. Tananakina ◽  
I. S. Yushkova
Keyword(s):  
Visual Acuity ◽  
Social Significance ◽  
Visual Rehabilitation ◽  
Group 4 ◽  
Average Improvement ◽  
Uncorrected Visual Acuity ◽  
Before And After ◽  
Ring Segment ◽  
Group 3 ◽  
Group 2

Scleral lenses improve visual acuity in patients with irregular corneal astigmatism, which is especially important when other methods of correction are ineffective.Purpose: to assess the efficiency of Zenlens scleral lenses in patients with irregular cornea.Material and methods. A total of 120 patients (164 eyes) were examined, including 86 males and 34 females, aged from 13 to 63 years (mean age 35 ± 12 years). The patients were divided into 4 groups. Group 1 consisted of patients with keratoconus, group 2 — postpenetrating keratoplasty, group 3 — keratoconus after cross-linking and/or corneal ring segment implantation, while group 4 consisted of patients with other diseases. The efficiency criteria included visual acuity before and after scleral lens fitting and wearing time (hours per day). To determine social significance of scleral lens wearing, we selected 30 patients (46 eyes) with average best-corrected visual acuity (BCVA) before fitting 0.21 ± 0.08 (0.1–0.3).Results. Average uncorrected visual acuity before fitting did not exceed 0.2 and average visual acuity after fitting was 0.8 ± 0.15. Average improvement in visual acuity after fitting compared to uncorrected visual acuity was at least six lines in all groups and average improvement of visual acuity was approximately three lines compared to BCVA before fitting. 74.4 % and 19.5 % of patients demonstrated long-term (> 10 hours per day) and partial (8–10 hours per day) wear, respectively. Short-term wear (< 8 hours per day) was noted in 6.1 % of patients. Visual acuity of  patients with low BCVA (mean 0.21 ± 0.08) increased by 0.57 (271.4 %).Conclusion. Scleral lenses can be successfully used for visual acuity improvement and social rehabilitation of patients with irregular cornea when other methods of correction are ineffective. 

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