scholarly journals Therapeutic Efficacy of Ficus Glomerata Leaves in Alloxan Monohydrate Induced Type-1 Diabetes in Albino Rats

2021 ◽  
Vol 5 (4) ◽  
pp. 01-02
Author(s):  
Sanjeev Kumar ◽  
N.K. Prasad ◽  
Kumari Shachi
Keyword(s):  
Blood Glucose ◽  
Insulin Treatment ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Insulin Production ◽  
Glucose Lowering ◽  
Glucose Lowering Effect ◽  
Alloxan Monohydrate ◽  
Ficus Glomerata

Present study was aimed to evaluate the anti-diabetic efficacy of Ficus glomerata in Alloxan monohydrate induced albino rats. Oral administration of fresh Ficus glomerataleaves (2 - 4 g/day) for 60 days shows significant blood glucose lowering effect in experimental alloxan induced diabetic rats. These diabetic rats blood glucose level became normal when fed with Ficus glomerata leaves. It is amply revealed that fresh Ficus glomerata indica leaves possessed anti-diabetic properties. The results suggest that statistically significant anti-diabetic potential in alloxan monohydrate induced diabetic rats. The Ficus glomerata leaves to be almost similar effect like insulin treatment in alloxan monohydrate administered animal model. From the present investigation it appeared that Ficus glomerata leaves might have some ingredients to increase the output of insulin by binding to the receptors of the Beta cells of the Langerhans located in the pancreas. Once they bind to the Sulphonyl urea receptors, the K+ -ATP channels are probably closed and therefore the membrane is depolarized and insulin production is stimulated.

scholarly journals ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC EFFECTS OF THE ETHANOL EXTRACT OF THE LEAVES AND STEM OF CISSUS GRACILLIS (GULL ET PERR) (VITACEAE)

2021 ◽  
pp. 54-56
Author(s):  
OLUSAYO A SHORINWA ◽  
GORDON EI EMENU
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Phytochemical Screening ◽  
Glucose Levels ◽  
Diabetic Control Group ◽  
Alloxan Monohydrate

Objectives: This study investigated the antidiabetic and antihyperlipidemic potential of the ethanol extract of the leaves and stem of Cissus gracillis on alloxan monohydrate-induced diabetic albino rats. Methods: Preliminary phytochemical screening and acute toxicity were carried out. Animals were assigned into seven groups of five rats each. Groups A and B were administered 10 mg/kg each of glibenclamide and atorvastatin respectively, C, D, and E were given 125, 250 and 500 mg/kg of ethanol extract of C. gracillis, respectively, daily for 21 days through oral gavage, group F was diabetic but untreated (diabetic control group), while group G was non-diabetic and untreated which served as the control group. Results: Phytochemical screening revealed the presence of steroids/triterpenoids and carbohydrates. LD50 was above 5000 mg/kg. The extract at 500 mg/kg showed a statistically significant (p<0.05) decrease in blood glucose level when compared with the glibenclamide group on day 21. However, gradual non- significant reduction in blood glucose levels were observed in the extract treated groups on the 7th, 14th, and 21st days of treatment. The administration of ethanol extract of C. gracillis to alloxan-induced diabetic rats produced a decrease in total cholesterol, triglycerides, and low-density lipoproteins comparable to glibenclamide and atorvastatin. Conclusion: The ethanol extract of the leaves and stem of C. gracillis possess a mildly significant antidiabetic and antihyperlipidemic activity.

scholarly journals ANTIDIABETIC ACTIVITY OF BACOLEPIS NERVOSA (WIGHT AND ARN.) DECNE. EX MOQ. EXTRACT ON ALLOXAN INDUCED DIABETIC RATS

2016 ◽  
Vol 8 (11) ◽  
pp. 320
Author(s):  
Arockia Jenecius Alphonse A. ◽  
Mohan V. R. ◽  
Doss A.
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Serum Enzymes ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Ethanol Extracts ◽  
Wistar Albino Rats ◽  
Alloxan Monohydrate ◽  
Lipid Parameters

Objective: The aim of this study was to investigate the effect of ethanol extracts of stem and leaf of Bacolepis nervosa as antihyperglycemic, anti-hyperlipidemic and antioxidant activity in alloxan-induced diabetic rats. Methods: Diabetes was induced in wistar albino rats by administration of alloxan monohydrate (150 mg/kg). The ethanol extract of B. nervosa leaf and stem at a dose of 150 and 300 mg/kg body weight was administrated at a single dose per day to diabetes-induced rats for a period of 14 d. The effect of ethanol extract of B. nervosa leaf and stem on blood glucose, insulin, urea, creatinine, HbA1C, serum protein, albumin, globulin, serum enzymes, serum lipid profiles, lipid peroxidase (LPO) and antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were measured in the diabetic rats.Results: The ethanol extract of B. nervosa stem and leaf elicited significant reduction in blood glucose (p<0.001), serum enzymes (SGPT, SGOT, ALP) (p<0.01), lipid parameters (TC, TG, VLDL-LDL, PL) (p<0.01) except HDL-C and significantly increased insulin (p<0.01), HDL-C (p<0.05),, GPx, GSH, SOD and CAT (p<0.05) at the dose of 300 mg/kg when compared with the diabetic-induced control.Conclusion: From the above results, it is concluded that ethanol extracts of B. nervosa leaf and stem possesses significant antihyperglycemic, antihyperlipidemic and antioxidant effect in alloxan induced diabetic rats.

scholarly journals Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

2016 ◽  
Vol 33 (4) ◽  
pp. 259-272 ◽  
Author(s):  
Rotimi Olusanya Arise ◽  
Oluwaseun Ruth Aburo ◽  
Samuel Tobi Farohunbi ◽  
Adenike Adebola Adewale
Keyword(s):  
Lipid Peroxidation ◽  
Blood Glucose ◽  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
The Body ◽  
Albino Rats ◽  
Reference Drug ◽  
Glucose Lowering

Abstract This study was undertaken to determine the antidiabetic and antioxidant effects of oral administration of ethanolic extract of Moringa oleiferaflower on stretozotocin-induced diabetic rats at 100, 200, and 300 mg/kg b.w. Thirty (30) male experimental albino rats were grouped randomly into six groups: groups A, B, and F are the control, diabetic control and reference drug groups, while C-E received 100, 200, and 300mg/kg b.w of the extract, respectively. Blood samples and organs were collected to assay for blood glucose level and antioxidant enzymes. Levels of blood glucose, serum lipids and lipid peroxidation as well as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) activities were significantly reduced (p<0.05) in STZ-induced diabetic rats orally administered ethanolic extract of M. oleifera flower. However, the body weight; catalase and superoxide dismutase activities were significantly increased (p < 0.05) when compared with the controls. M. oleifera flower ethanolic extract administered orally therefore exhibited improved lipid metabolism, glucose-lowering potential and is hence beneficial in preventing diabetic complications as a result of lipid peroxidation and oxidative systems in streptozotocin-induced diabetic rats. It could thus be employed therapeutically in managing diabetes mellitus.

scholarly journals Blood Sugar Lowering Potentials of Aqueous and Ethanol Extracts of the Mixture of Rinds of Citrullus vulgaris Schrad (Watermelon) and Chrysophyllum albidum G. (Udara) Fruits on Alloxan-Induced Diabetic Wistar Rats

2020 ◽  
pp. 86-90
Author(s):  
Owo, Gogo James ◽  
Beresford, Simon Jnr
Keyword(s):  
Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Glucose Lowering ◽  
Citrullus Vulgaris ◽  
Group 2 ◽  
Ethanol Extracts ◽  
Wistar Albino Rats

Citrullus vulgaris Schrad, commonly known as “watermelon” and Chrysophyllum albidum G., commonly called ‘‘Udara’’ are two important plants known to possess high antioxidant and therapeutic properties especially antidiabetic properties. The present study is aimed at investigating the blood glucose lowering potentials of both the aqueous and ethanolic extracts of the mixture of rinds of C. vulgaris Schrad and C. albidum in normal and alloxan-induced-diabetic rats. Aqueous and ethanol rinds extracts of the mixture were administered in wistar albino rats of weight range of 150-200g to determine their blood glucose lowering activity. The oral administration of aqueous mixed rinds extracts at dose of 1500 mg/kg body weight (Group 4) for 9 days led to a highly significant blood glucose reduction at P<0.05 when compared to the diabetic control (Group 2) and the ethanol mixed rinds extracts at the same dose (Group 6). There was a significant reduction in blood glucose (P<0.05) by other group dose extracts (Groups 3,5 and 6) compared to diabetic control. Hence, aqueous mixed rinds extracts of Citrullus vulgaris Schrad and C. albidum might be recommended as a potential hypoglycemic drug in the treatment of diabetes mellitus.

scholarly journals Intracellular Signalling Pathways Associated with the Glucose-Lowering Effect of St36 Electroacupuncture in Streptozotocin-Induced Diabetic Rats

2015 ◽  
Vol 33 (5) ◽  
pp. 395-399 ◽  
Author(s):  
Chung-Yuh Tzeng ◽  
Yu-Chen Lee ◽  
Tin-Yun Ho ◽  
Ying-I Chen ◽  
Tai-Hao Hsu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cell Adhesion Molecules ◽  
Diabetic Rats ◽  
Intracellular Signalling ◽  
Signalling Pathways ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Intracellular Signalling Pathways ◽  
Glucose Lowering Effect

Background and Aim Previous animal studies have reported a glucose-lowering effect of electroacupuncture (EA) and suggested that the mechanisms are closely related to intracellular signalling pathways. The aim of this study was to screen for potential intracellular signalling pathways that are upregulated by EA at ST36 bilaterally in rats with diabetes mellitus (DM) using microarray analysis. Methods Streptozotocin (STZ)-induced diabetic rats were randomly assigned to experimental (EA, n=8) or control (non-EA, n=8) groups. Plasma glucose levels were measured at baseline and after 30 and 60 min, and microarray analysis was performed on samples of gastrocnemius muscle. Results Relative to baseline values, EA significantly reduced plasma levels of glucose at 30 and 60 min. The microarray pathway analysis showed that cell adhesion molecules and type 1 DM gene sets were both upregulated in EA versus non-EA groups (p<0.05). Conclusions Cell adhesion molecules might be related to the glucose-lowering effect induced by EA in rats with STZ-induced type 1 diabetes. Further research will be required to examine the involvement of related intracellular signalling pathways.

scholarly journals Ethyl Acetate Fraction of Total Phenols from Zanthoxylum zanthoxyloides Leaves Treated Alloxan-Induced Diabetic Albino Rats

2021 ◽  
pp. 19-30
Author(s):  
C. O. Ekwemba ◽  
N. Nwachukwu ◽  
C. O. Ibegbulem
Keyword(s):  
Blood Glucose ◽  
Ethyl Acetate ◽  
Histopathological Examination ◽  
Ethyl Acetate Fraction ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Total Phenols ◽  
Zanthoxylum Zanthoxyloides ◽  
Alloxan Monohydrate ◽  
Phenol Extract

Aims: Ethyl acetate fraction of total phenols from Zanthoxylum zanthoxyloides leaves was evaluated for its effects in alloxan-induced diabetic male albino rats. Methodology: Diabetes was induced in rats by administrating alloxan monohydrate at a dose of 130 mg/kg body weight. The ethyl acetate fraction was administered to rats at 100, 200 and 400 mg/kg b.w. daily for 15 days. Blood glucose, lipid profile and pancreatic histopathology were monitored using standard methods. Results: Results indicated that two weeks after treatment with Z. zanthoxyloides, significant (p<0.05) reductions in hyperglycemic blood glucose, total cholesterol and low-density lipoproteins (LDL) were recorded; with lowest values recorded in the group treated with the highest concentration of the extract. Histopathological examination of pancreatic tissues supported the protective effect of Z. zanthoxyloides phenol extract against diabetic damage. Conclusion: In conclusion, total phenols of Z. zanthoxyloides exerted antidiabetic effects in alloxan-induced diabetic rats and protected pancreatic tissues from diabetic damage.

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