Characterization of cardiovascular risk factors and Framingham score in an HIV-1 population

With the advent of high-potency antiretroviral treatment introduced in 1996, HIV infection ceased to be an acute and deadly disease to become chronic and controllable. However, the early aging of this population, which according to some authors and cohorts, is 10 years less than in the "normal" population, has been studied. Although the realities of these patients comorbidities are well known, the definition of time, when and how or with what to treat still seems to be a matter of debate. The aim of this study is to evaluate the incidence and prevalence according to the state of the art for the non-HIV population of cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus) and apply the adjusted Framingham Risk Score by recording analytical and clinical factors in an HIV-1 population with more than 50 years of age, followed in the Infectious Diseases Service for more than 6 months.

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Carotid intima–media thickness and cardiovascular risk factors in healthy volunteers

The Ultrasound Journal ◽

10.1186/s13089-021-00218-6 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Birgit-Christiane Zyriax ◽

Kira Dransfeld ◽

Eberhard Windler

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Risk Prediction ◽

Framingham Risk Score ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Continuous Variables ◽

Framingham Risk ◽

Low Cardiovascular Risk

Abstract Background Assessment of cardiovascular risk by scores lacks sensitivity and leaves the majority of future cardiovascular patients unidentified particularly individuals at low cardiovascular risk. The present analysis investigates into the correlation of carotid intima–media thickness (CIMT) and cardiovascular risk factors and derived scores as to the potential of improved cardiovascular risk prediction by combining the two. Methods The Stress, Atherosclerosis and ECG Study (STRATEGY) is a cross-sectional study of selectively healthy 107 women and 106 men without diagnosed and treated cardiovascular risk factors evenly distributed between 30 and 70 years. CIMT was determined by evaluating B-mode ultrasonograms offline according to a standardized protocol. The unpaired t-test was used to compare normal-distributed continuous variables, the Chi-squared test for normal-distributed categorical variables and the Mann–Whitney U test for non-normal distributed continuous variables. The association between risk prediction scores and CIMT was calculated by the Spearman rank correlation coefficient. Pearson correlation coefficient was used for the correlation between cardiovascular risk factors and CIMT. A multiple linear regression analysis was executed for the association of cardiovascular risk factors and CIMT. Results Age, systolic blood pressure, fasting glucose, total, LDL- and non-HDL-cholesterol and waist circumference were significantly associated with CIMT (each P ≤ 0.03). The Framingham Risk Score, the Prospective Cardiovascular Münster Study Score and the European Society of Cardiology Score correlated significantly but only moderately with CIMT. The Framingham Risk Score considering BMI correlated most strongly and predicted 27% of the CIMT variance in men and 20% in women. Conclusion In individuals without overt cardiovascular risk factors and thus at low cardiovascular risk, CIMT and cardiovascular risk factors correlated only partially suggesting that combining CIMT and conventional risk factors or common derived scores may improve risk prediction in individuals at low cardiovascular risk. The clinical benefit as to cardiovascular events of such combined risk prediction needs to be explored in large prospective cohorts of still healthy low-risk volunteers. DRKS ID DRKS00015209 07/02/2019 retrospectively registered https://www.drks.de/drks_web/navigate.do?navigationId=resultsExt

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Prevalence of Emerging Cardiovascular Risk Factors in Younger Individuals with a Family History of Premature Coronary Heart Disease and Low Framingham Risk Score

Clinical Cardiology ◽

10.1002/clc.20355 ◽

2008 ◽

Vol 31 (11) ◽

pp. 542-545 ◽

Cited By ~ 15

Author(s):

Vivek Sailam ◽

Dean G. Karalis ◽

Ashish Agarwal ◽

Firas Alani ◽

Susan Galardi ◽

...

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Heart Disease ◽

Cardiovascular Risk ◽

Family History ◽

Cardiovascular Risk Factors ◽

Framingham Risk Score ◽

Premature Coronary Heart Disease ◽

Framingham Risk ◽

History Of

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AB0636 A comparison study of prevalence of traditional cardiovascular risk factors and framingham risk score in systemic sclerosis patients and matched controls

10.1136/annrheumdis-2017-eular.4528 ◽

2017 ◽

Author(s):

J Sousa-Neves ◽

M Cerqueira ◽

D Santos-Faria ◽

J Leite Silva ◽

C Afonso ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Systemic Sclerosis ◽

Cardiovascular Risk Factors ◽

Risk Score ◽

Framingham Risk Score ◽

Comparison Study ◽

Framingham Risk

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Increased risk of Roma for 10-year development of CVDs based on Framingham Risk Score calculation

European Journal of Public Health ◽

10.1093/eurpub/ckz187.067 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

P Piko ◽

S Fiatal ◽

Z Kosa ◽

J Sandor ◽

R Adany

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

General Population ◽

Systolic Blood Pressure ◽

Cardiovascular Risk Factors ◽

Risk Score ◽

Framingham Risk Score ◽

Roma Population ◽

Framingham Risk

Abstract Background Increased mortality and short life expectancy of Roma are well known epidemiological findings which can be partially explained by the high prevalence of cardiovascular risk factors among them. This study assesses the prevalence of the cardiovascular disease (CVD) risk factors (age, sex, systolic blood pressure, smoking and diabetes status, elevated total and reduced high density lipoprotein cholesterol level (HDL-C)) and the estimation of 10-year risk of development of CVD (CVD in general, coronary heart disease (CHD), myocardial infarction (MI) and stroke) and that of death from CHD and CVD based on the Framingham Risk Score (FRS) in case of the Hungarian general (HG) and Roma (HR) populations. Methods A complex health survey incl. questionnaire based interview, physical examination and laboratory test was carried out in 2018 on the HG and HR populations. The prevalence of different cardiovascular risk factors was defined and FRS was computed and compared between the HG (n = 378) and HR (n = 386) populations. Results The prevalence of diabetes was significantly higher among Roma females compared to females of general population (17.8% vs. 7.7%; p = 0.001) while the average systolic blood pressure level was less elevated among Roma males (127.9 mmHg vs. 129.4 mmHg; p = 0.020). The prevalence of smoking (males: 63.1% vs. 33.7%; females: 67.6% vs. 31%; p < 0.001) and reduced HDL-C level (males: 40% vs. 25.9%, p = 0.014; females: 55.5% vs. 35.1%, p < 0.001) were significantly higher in both sexes among Roma. The 10-year estimated risk for development of CHD, MI and CVD and the death from CHD was significantly (P < 0.05) higher in both sexes among Roma compared to the general population while the average risk scores for stroke and death from CVD were significantly higher only among Roma men. Conclusions Our results show that both sexes in the Roma population have a significantly higher risk for 10-year development of CVD compared to the Hungarian general population. Key messages The Roma population have a significantly higher risk for 10-year development of cardiovascular diseases and death from them based on the Framingham Risk Score. The targeted cardiovascular interventions should be focus on reduce smoking and provide information on the recognition and treatment of diabetes and lipid disorders among Roma.

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