scholarly journals Pertussis Outbreak Analysis in Republic of Moldova

2017 ◽  
Vol 16 (3) ◽  
pp. 96-100 ◽  
Author(s):  
V. . Bukova ◽  
A. . Melnik ◽  
L. . Tsurcan ◽  
A. . Cheban ◽  
V. . Gutsu

There are analyzed the incidence of whooping cough for the period of 1993 - 2016 in Republic of Moldova in this article. 210 from 280 cases of pertussis reported in 2016 and. Specific IgM antibodies of 174 patients were investigated. The epidemic process of pertussis is cyclical, with a period of 3 - 4 years, with a higher incidence in urban areas and in children up to two years, with a tendency to increase the proportion among the patients of school-age children and adults. The decrease in vaccination coverage from 95.4% in 2008 to 89.7% in 2015 led to an increased incidence. From total number of cases, 68.1% were children aged from 0 to 6 years old. The age structure of registered cases in 2016 included: 22.4% under one year old; 44.3% between 1 - 2 years, 27.1% school age children between 7 -17 years and 4.8% adults. A later uptake of medical care was registered, with an average of 10.5 days after onset of the disease, but in age group of children under one year it was 9.6 days. The bases of the diagnosis of whooping cough in 10.7% of cases were clinical data, in 16.2% were clinical - epidemiological data and in 73.1% were laboratory data. Specific IgM antibodies were detected in 77.0 ± 6.4% of patients. Among patients under one year old, 14.9% were under the age of vaccination, 34.0% received from 1 to 3 doses of vaccine, 19.1% are not vaccinated by false contraindications and 27.6% due to refusal. Among patients from the age group of 3-6 years, 56.0% received 3 - 4 doses of vaccine, 18.0% were not vaccinated because of false contraindications and 40.0% due to the failure of the vaccination. From children patients who received a full course of vaccination against pertussis, 25.0% had been vaccinated 1 - 2 years ago and other 25.0% became ill after three or four years after immunization.

Author(s):  
Santiago Vernucci ◽  
Yesica Aydmune ◽  
María Laura Andrés ◽  
Débora Inés Burin ◽  
Lorena Canet‐Juric

2020 ◽  
Vol 19 (2) ◽  
pp. 58-63
Author(s):  
A. P. Cherdantsev ◽  
E. V. Prutskova ◽  
M. P. Kostinov

The review provides information about the current features of the spread of whooping cough among children and adolescents. It is shown that there is a shift in morbidity to an older age group of the population, which is facilitated by changes in the properties of the pathogen and the widespread use of drugs based on cell-free technology as primary vaccination. Information is given about the possibility of preventing morbidity among schoolchildren and adults by introducing additional revaccinating doses against whooping cough with special drugs in the vaccination calendars. Information is given on effective protection of newborns against this infection by immunization of pregnant women. In our country, there is an opportunity to expand pertussis immunoprophylaxis among children of preschool-school age and adults within regional programs and individual vaccination with acellular pertussis-diphtheria-tetanus vaccines, which has a high profile of safety and immunological effectiveness.


PEDIATRICS ◽  
1972 ◽  
Vol 50 (3) ◽  
pp. 412-419
Author(s):  
K. Fishler ◽  
G. N. Donnell ◽  
W. R. Bergren ◽  
R. Koch

This study deals with the developmental and intellectual status of 45 treated galactosemia patients, 23 females and 22 males, followed longitudinally for up to 23 years. Intellectual achievement, visual-perceptual ability, and EEG findings are analyzed. The intellectual status of the parents and unaffected siblings of the galactosemia patients are also considered. The findings indicate that the preschool age group of children show the best developmental progress by the psychometric tests used, those of school age level scoring lower, but still within the low normal range. Adult patients demonstrate better intellectual achievement than the school age children, possibly due to a compensatory process. The greatest incidence of visual-perceptual difficulties was found in the school-age group, and remedial educational programs were necessary for some of these children. In each group, emotional-social characteristics were observed which may reflect the continuing nature of dietary restriction. The overall findings indicate that early treatment results in a more favorable outcome than does a delay in initiation of dietary restriction.


2007 ◽  
Vol 125 (5) ◽  
pp. 281-285 ◽  
Author(s):  
Maria Regina Cavariani Silvares ◽  
Kunie Iabuki Rabello Coelho ◽  
Ivete Dalben ◽  
Joel Carlos Lastória ◽  
Luciana Patrícia Fernandes Abbade

CONTEXT AND OBJECTIVE: Chronic urticaria-angioedema is a common, multiple-cause complaint. The aim was to investigate the sociodemographic and clinical characteristics, causal and aggravating factors and evolution of urticaria-angioedema. DESIGN AND SETTING: This was a descriptive prospective study carried out at the Dermatology outpatient clinic of Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp). METHODS: A total of 125 patients with chronic urticaria-angioedema were evaluated to obtain sociodemographic data, anamnesis, dermatological and general clinical data and laboratory data, emphasizing causal and aggravating factors and complaint evolution. RESULTS: Chronic urticaria-angioedema occurred mainly in females (mean age: 35 years), but also in men (mean age: 32 years). White color and living in urban areas also predominated. There was no preferential time for symptoms to appear, and nighttime was the most commonly reported time for clinical worsening. Around half of the patients had urticaria associated with angioedema. There were no associated factors in most of the cases, and stress was the most commonly reported aggravating factor. The cause was ascertained in 37.6% of our cases. The mean duration of follow-up was 11.7 months. Around 60% of the patients evolved with the problem under control, 32% improved, 9% had no change in dermatological condition and only one patient worsened. CONCLUSIONS: Chronic urticaria-angioedema was more common among middle-aged women. It is a long-term disease, and its cause was explained in about one-third of the patients. Half of the patients presented disease control after treatment lasting an average of approximately one year.


1995 ◽  
Vol 28 (4) ◽  
pp. 339-343 ◽  
Author(s):  
Solange Artimos de Oliveira ◽  
Walquíria Nascimento Soares ◽  
Marcos Olivier Dalston ◽  
Maria Teresa G.N. de Almeida ◽  
Antonio José L. Costa

From March 1991 to April 1992, 250 measles suspected cases were studied in the Municipality of Niterói, State of Rio de Janeiro. The median age found was 11 years and 76.0% of the cases were in school age children. Exposure histories were present in 149 patients and schools were the most frequent sites of transmission (45.0%). Vaccination status was known for 127 studied cases and 76.4% of them had received measles vaccine before their first birthday. One or more complications were reported for 68 cases aitd in 8.9% of the studied cases hospitalization was required. Frequency of complications varied according to each age group studied and were more commonly encountered among children < 1 year of age (55.6%). The history of previous vaccination did not diminish the number of complications of the cases studied. The results of this work show changes in age distribution of measles leading to sizeable outbreaks among teenagers and young adults.


2017 ◽  
Vol 15 (11-12) ◽  
pp. 303
Author(s):  
Jo Kian Tjay ◽  
Robencius Saragih ◽  
Sahat Halim ◽  
Tjut Irawati ◽  
P. Harnopidjati ◽  
...  

Data of child tuberculosis, clinical visits and those who were treated in the three hospitals, visits to the 6 public health centers (Puskesmas) and figures of BCG immunization in the North Sumatra Province were presented.Although the tuberculin index in children in Medan (1965) was lower than that in Java (BCG Mass Campaign, 1954 - 1964), primary tuberculosis patients treated in the General Hospital (RSUPP) constituted 1.14% of the total patients admitted to the hospital in 1963 - 1972, whereas in the ”PNP IX” hospital it was 0.84%. From a survey of families (1962 - 1969) it revealed that infection in the families was ± 50%. While 76.1% of the meningitis patients were under the age of 4 years. From a survey of 6 public health centers we found through a Pilot Project that 1.02% patients had a positive sputum. The above mentioned figures gave the indication that BCG immunization had to be performed in children under the age of 4 years. However, the figures of the BCG campaign (1970 - 1973) at the above mentioned Pilot Project revealed that coverage in the under 5 - years - old age was 20.5%, whereas in the 5 - 14 years age group it was 49.2%.In practice the realization of massal BCG immunization was certainly the simplest with school age children who were already grouped and registered; nevertheless, partly of them hai already got infected and had been released from tuberculous meningitis complication. BCG immunization as mentioned above (probably it was also given mother areas in Indonesia) did obviously not reach its right target.


1997 ◽  
Vol 28 (2) ◽  
pp. 164-176 ◽  
Author(s):  
Deborah J. Brisk ◽  
E. Charles Healey ◽  
Karen A. Hux

The purpose of this survey was to obtain updated information on school-based speech-language pathologists’ training, confidence, attitudes, and perceptions associated with treating school-age children who stutter. A second goal was to investigate the impact of impending specialization training in fluency on service delivery to children who stutter. A total of 278 out of 500 (56%) randomly selected school clinicians certified by the American Speech-Language-Hearing Association (ASHA) responded to the survey. The results showed a general improvement over previous reports in clinicians’ training, confidence, and attitudes concerning providing assessment and intervention services to school-age children who stutter. However, clinicians who received their degrees in the mid-to-late 1970s were less positive regarding their preparation to evaluate and treat preschool children who stutter than those clinicians who received their degrees within the last 10 years. The results also showed that respondents have fewer successes with adolescents who stutter than with any other student age group. Although a large majority of respondents would consult and request assistance from a "fluency specialist" if one were available, only 40% reported that specialists in fluency were needed in the schools. The results suggest that university training programs need to continue offering clinical experiences with school-age children who stutter and courses devoted exclusively to fluency disorders in order to develop clinicians who feel confident evaluating and treating fluency disorders.


BMJ ◽  
2014 ◽  
pp. g3668 ◽  
Author(s):  
Kay Wang ◽  
Norman K Fry ◽  
Helen Campbell ◽  
Gayatri Amirthalingam ◽  
Timothy G Harrison ◽  
...  

Objective To estimate the prevalence and clinical severity of whooping cough (pertussis) in school age children presenting with persistent cough in primary care since the introduction and implementation of the preschool pertussis booster vaccination. Design Prospective cohort study (November 2010 to December 2012). Setting General practices in Thames Valley, UK. Participants 279 children aged 5 to 15 years who presented in primary care with a persistent cough of two to eight weeks’ duration. Exclusion criteria were cough likely to be caused by a serious underlying medical condition, known immunodeficiency or immunocompromise, participation in another clinical research study, and preschool pertussis booster vaccination received less than one year previously. Main outcome measures Evidence of recent pertussis infection based on an oral fluid anti-pertussis toxin IgG titre of at least 70 arbitrary units. Cough frequency was measured in six children with laboratory confirmed pertussis. Results 56 (20%, 95% confidence interval 16% to 25%) children had evidence of recent pertussis infection, including 39 (18%, 13% to 24%) of 215 children who had been fully vaccinated. The risk of pertussis was more than three times higher (21/53; 40%, 26% to 54%) in children who had received the preschool pertussis booster vaccination seven years or more previously than in those who had received it less than seven years previously (20/171; 12%, 7% to 17%). The risk of pertussis was similar between children who received five and three component preschool pertussis booster vaccines (risk ratio for five component vaccine 1.14, 0.64 to 2.03). Four of six children in whom cough frequency was measured coughed more than 400 times in 24 hours. Conclusions Pertussis can still be found in a fifth of school age children who present in primary care with persistent cough and can cause clinically significant cough in fully vaccinated children. These findings will help to inform consideration of the need for an adolescent pertussis booster vaccination in the United Kingdom. Study registration UK Clinical Research Network portfolio ID 8361.


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