scholarly journals Diagnostic and prognostic value of cystatin C as an early marker of renal dysfunction in patients with cardiovascular pathology

2018 ◽  
pp. 17-23
Author(s):  
N. V. Kuzminova ◽  
A. V. Ivankova ◽  
V. P. Ivanov ◽  
S. E. Lozinsky
Keyword(s):  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Renal Dysfunction ◽  
Functional State ◽  
Cystatin C ◽  
Prognostic Value ◽  
Routine Clinical Practice ◽  
Cardiovascular Pathology ◽  
Diagnostic And Prognostic Value

Disorders of the kidneys often occur in cardiovascular diseases. They are connected with the heart by complex hemodynamic and neuroendocrine bonds. The structure, functions, and possibilities of using an endogenous indicator of the functional state of the kidney - cystatin C are discussed in the article. Available data allow the use of cystatin C as a predictor of renal dysfunction in patients with cardiovascular pathology and arterial hypertension, in particular. However, the widespread use of cystatin C in routine clinical practice requires further study and improvement.

scholarly journals Diagnostic and prognostic value of cystatin C as an early marker of renal dysfunction in patients with cardiovascular pathology

2018 ◽  
pp. 17-23
Author(s):  
N. V. Kuzminova ◽  
A. V. Ivankova ◽  
V. P. Ivanov ◽  
S. E. Lozinsky
Keyword(s):  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Renal Dysfunction ◽  
Functional State ◽  
Cystatin C ◽  
Prognostic Value ◽  
Routine Clinical Practice ◽  
Cardiovascular Pathology ◽  
Diagnostic And Prognostic Value

Disorders of the kidneys often occur in cardiovascular diseases. They are connected with the heart by complex hemodynamic and neuroendocrine bonds. The structure, functions, and possibilities of using an endogenous indicator of the functional state of the kidney - cystatin C are discussed in the article. Available data allow the use of cystatin C as a predictor of renal dysfunction in patients with cardiovascular pathology and arterial hypertension, in particular. However, the widespread use of cystatin C in routine clinical practice requires further study and improvement.

Uromodulin and kidneys

2020 ◽  
Vol 24 (1) ◽  
pp. 22-38
Author(s):  
M. Khasun ◽  
S. A. Orlova ◽  
I. G. Kayukov ◽  
O. V. Galkina ◽  
O. N. Beresneva ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cardiovascular Diseases ◽  
Kidney Disease ◽  
Epithelial Cells ◽  
Arterial Hypertension ◽  
Prognostic Value ◽  
Autosomal Dominant ◽  
Loop Of Henle ◽  
Blood Concentrations ◽  
Cardiovascular Pathology

Uromodulin (UMO) is a multifunctional glycoprotein expressed in the epithelial cells of the thick ascending part of the loop of Henle. Currently a lot of data about mechanisms of biosynthesis, apical and basolateral transport of UMO, changes in urine and blood concentrations in different kidney compartments damage, roles of UMO in protecting kidneys from infections, maintaining mineral homeostasis, development of arterial hypertension and the participation of this glycoprotein in other physiological and pathological processes has been accumulated. The article discusses the clinical significance of UMO in the development and progression of chronic kidney disease, prognostic value of UMO urine and blood concentrations in terms of the risk of cardiovascular diseases and probability of acute kidney damage in patients with cardiovascular pathology. Briefly highlights issues of UMO gene mutation and development of autosomal dominant tubulointerstitial kidney disease.

The significance of serum γ-glutamyltransferase in cardiovascular diseases

2004 ◽  
Vol 42 (10) ◽  
Author(s):  
Alfonso Pompella ◽  
Michele Emdin ◽  
Claudio Passino ◽  
Aldo Paolicchi
Keyword(s):  
Myocardial Infarction ◽  
Reactive Oxygen Species ◽  
Clinical Practice ◽  
Liver Disease ◽  
Cardiovascular Diseases ◽  
Laboratory Test ◽  
Prognostic Value ◽  
Cerebral Arteries ◽  
Atherosclerotic Plaques ◽  
Oxygen Species

AbstractSince early after the introduction of serum γ-glutamyltransferase (GGT) in clinical practice as a reliable and widely employed laboratory test, epidemiological and prospective studies have repeatedly shown that this activity possesses a prognostic value for morbidity and mortality. The association is independent of possibly concomitant conditions of liver disease, and notably, a significant independent correlation of serum GGT exists with the occurrence of cardiovascular diseases (myocardial infarction, stroke). Experimental work has documented that active GGT is present in atherosclerotic plaques of coronary as well as in cerebral arteries. These findings, and the recently recognized functions of GGT in the generation of reactive oxygen species, indicate that serum GGT represents a true marker of cardiovascular diseases and underlying atherosclerosis. Further insights into potential therapeutic interest will probably be derived from studies investigating the origin of GGT activity in plaque tissue.

scholarly journals The ST2 diagnostic value in selection of patients for heart transplantation and post-transplant period

2019 ◽  
Vol 40 (1) ◽  
pp. 4-11
Author(s):  
A. S. Nikonenko ◽  
O. O. Tanska
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Chronic Heart Failure ◽  
Heart Transplantation ◽  
Prognostic Value ◽  
Clinical Manifestations ◽  
Mechanical Damage ◽  
Risk Of Death ◽  
Diagnostic And Prognostic Value

Purpose of the study. Study ST2 diagnostic marker in the development and severity of heart failure, evaluation of transplant status and the risk of developing a rejection crisis, as well as the risk of death in patients with cardiovascular disease.Material and methods. There were 41 patients under observation. The cases were conventionally divided into two groups: the first group of patients with chronic heart failure (n = 28), and the control group who performed orthotopic transplantation of the heart (n = 13).Results and discussion. These results suggest that ST2 is a real marker of chronic heart failure or a good predictor of mortality in decompensated patients. Changes in ST2 levels in patients after orthotopic cardiac transplantation may be potentially useful in detecting acute cellular rejection, as well as in controlling rejection therapy. The article is devoted to the analysis of the prognostic role of the ST2 biomarker in the pre and post-transplantation period. ST2 is one of the most promising diagnostic markers for the development and severity of heart failure, as well as the risk of death in patients with cardiovascular disease. ST2 is expressed in cardiomyocytes in response to pathological processes and various mechanical damage in the heart, which allows to diagnose cardiovascular diseases even before clinical manifestations. It is likely that ST2 level measurement of heart transplantation may have a diagnostic and prognostic value when evaluating the graft state and the risk of developing rejection.Conclusions. ST2 is one of the most promising diagnostic markers of development and severity of heart failure, as well as the risk of death in patients with cardiovascular disease. ST2 is expressed in cardiomyocytes in response to pathological processes and various mechanical damage in the heart, which allows to diagnose cardiovascular diseases even before clinical manifestations. Measuring the level of ST2 for heart transplantation may have a diagnostic and prognostic value in evaluating the condition of the graft and the risk of developing rejection. Keywords:heart failure, ST2, heart transplantation, rejection crisis.

scholarly journals The role of metabolic disorders in the progression of renal dysfunction in patients with metabolic syndrome and arterial hypertension

2019 ◽  
pp. 170-175
Author(s):  
E. I. Polozova ◽  
N. N. Sorokina ◽  
E. V. Puzanova ◽  
A. A. Seskina
Keyword(s):  
Metabolic Syndrome ◽  
Glomerular Filtration Rate ◽  
Arterial Hypertension ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
Filtration Rate ◽  
Metabolic Disorders ◽  
Functional Changes ◽  
Group I

The clinical study enrolled 120 patients, who were hospitalized to the Therapeutic Department of Republican Clinical Hospital No.  5 of Saransk. The patients were divided into 2 groups: Group I (n = 60) included patients with metabolic syndrome; Group II (n = 60)  included patients with arterial hypertension. The paper presents data on the assessment of the functional state of kidneys in the  analysed groups, defines the role of metabolic disorders in the progression of renal dysfunction in patients with metabolic syndrome  and arterial hypertension. It is noted that more pronounced functional changes in the kidneys (microalbuminuria, increased cystatin  C levels, decreased glomerular filtration rate) are detected in patients with arterial hypertension and metabolic syndrome, as compared with patients without metabolic disorders. Cystatin C and microalbuminuria have been shown to be one of the earliest markers of kidney damage in hypertension, especially in combination with metabolic disorders. Cystatin C and microalbuminuria level is  significantly higher in patients with arterial hypertension and metabolic syndrome, as compared with patients with arterial hypertension, who have no metabolic disorders. Significant correlations were found between cystatin C, microalbuminuria levels and lipid  and carbohydrate metabolism in patients with arterial hypertension in combination with metabolic disorders. 

Prognostic value of in-hospital change in cystatin C in patients with acutely decompensated heart failure and renal dysfunction

2015 ◽  
Vol 182 ◽  
pp. 74-76 ◽  
Author(s):  
Pinelopi Rafouli-Stergiou ◽  
John Parissis ◽  
Dimitrios Farmakis ◽  
Vassiliki Bistola ◽  
Maria Nikolaou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
Prognostic Value ◽  
Decompensated Heart Failure ◽  
Acutely Decompensated Heart Failure

Diagnostic and prognostic value of cystatin C in acute heart failure

2017 ◽  
Vol 50 (18) ◽  
pp. 1007-1013 ◽  
Author(s):  
Tobias Breidthardt ◽  
Zaid Sabti ◽  
Ronny Ziller ◽  
Frank Rassouli ◽  
Raphael Twerenbold ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Cystatin C ◽  
Prognostic Value ◽  
Diagnostic And Prognostic Value

scholarly journals Correction to: Renal dysfunction reduces the diagnostic and prognostic value of serum CC16 for acute respiratory distress syndrome in intensive care patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jinle Lin ◽  
Wuyuan Tao ◽  
Jian Wei ◽  
Jian Wu ◽  
Wenwu Zhang ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Intensive Care ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Renal Dysfunction ◽  
Prognostic Value ◽  
Distress Syndrome ◽  
Intensive Care Patients ◽  
Diagnostic And Prognostic Value

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Russian innovations in the treatment of arterial hypertension in clinical practice — a real way to achieve success

2020 ◽  
Vol 96 (7) ◽  
pp. 503-507
Author(s):  
N. Yu. Borovkova
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Fixed Combination ◽  
Wide Range ◽  
Rational Combination ◽  
Pharmaceutical Plant

The review is devoted to introducing a wide range of internists to the new fixed combination of ramipril and indapamide (Concealar-D24), created by Russian scientists. This is the first original domestic development for the treatment of arterial hypertension, which is successfully produced by the first Russian resident of the special economic zone, the pharmaceutical plant «VERTEX» in St. Petersburg. The advantage of Concealar-D24 is a rational combination of two drugs that have not only antihypertensive and organoprotective effects, but also a large convincing base of research on their impact on the prognosis of life in patients with cardiovascular diseases: arterial hypertension, coronary heart disease, heart failure.

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