Hydrogels as Controlled Drug Delivery System: A Brief Review of Properties Classification and Synthesis

Hyrogels are cariers of novel drug delievry system and these polymeric network have ability to hold large amount of water but they do not dissolve in water .These polymeric network may be crosslinked either through chemical or physical crosslinking method. Without changing their three dimensional structure hydrogels undergo the swelling mechanism Hydrogels are used as drug delivery carriers because of their distinctive properties. They have three dimensional configurations and have water soluble cross linked network of polymers .Hydrogels have porous structure and by changing the cross linker concentration we can modify their affinity for water. Because of their unique properties these are used for various medical purposes like cellular immobilization , tissue engineering ,diagnostics and regenerative medicines.

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Hydrogel as a Novel Drug Delivery System: Recent Advancements and Patents

Current Nanoscience ◽

10.2174/1573413716999200626211915 ◽

2020 ◽

Vol 16 ◽

Author(s):

Ruchi Singh ◽

Surya Goel ◽

Pankaj Kumar Sharma ◽

Abhinav Agarwal

Keyword(s):

Drug Delivery ◽

Three Dimensional ◽

Dimensional Structure ◽

Tissue Engineering Scaffolds ◽

Hydrophilic Drugs ◽

Pharmaceutical Industries ◽

Intensive Work ◽

Novel Drug ◽

Work Done ◽

The Impact

Background: A semisolid gel-like preparation constitutes with the cross-linked polymers may easily swell in the presence of water and incorporate the amount of drug substance known as ‘Hydrogel.’ Objective: To prepare the review on the hydrogels, leading ennoblements, classification, mechanism, recent patents, and evaluation parameters. Methods: This review accrued by taking the help of online and offline journals, books, and other sources. This field includes new developments in the field of inventions in the novel drug delivery of hydrogels. Results: The impact of the formulation of hydrogels is attracting the focus of the researchers expeditiously because of their nature, three-dimensional structure, compatibility with the other excipients was found enormously useful in the biomedical applications and pharmaceutical industries, less time consuming, better sustained and prolonged the effect. Currently, hydrogels growing expeditiously for the intensive work done by the use of natural, synthetic, and semi-synthetic polymers for the transformation of hydrophobic and hydrophilic drugs into hydrogels as compared to develop the conventional gels. Conclusion: The journey of hydrogel goes through with the numerous inventions research papers, reports, publications, and many other sources. The development arouses with the hydrogels in the use of wound dressing, making diapers, contact lens, etc. Now a day it’s pivotally growing in the field of tissue engineering scaffolds, preparation of hydrophobic drugs into hydrogels which is a critical challenge in prompt conditions.

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Recent Advances in Novasome Formulation Technology

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2014.7.2.1 ◽

2014 ◽

Vol 7 (2) ◽

pp. 2407-2411

Author(s):

J M Shah ◽

N.H Shah ◽

Hadiya P D

Keyword(s):

Drug Delivery ◽

Effective Means ◽

Entrapment Efficiency ◽

Bilayer Membrane ◽

Water Soluble ◽

Delivery Methods ◽

Liposomal Drug ◽

Pharmaceutical Technology ◽

Insoluble Drugs ◽

Novel Drug

Pharmaceutical technology has developed various newer modes of novel drug delivery aspects. Modifications in the previously existing drug delivery methods have led to various newly innovated technologies serving as a safe and effective means of improvement over the existing ones. Novasome technology is one of the new innovations of liposomes which have solved many of the problems related to liposomal drug delivery system. It offers a seven bilayer membrane which has the ability to incorporate both water soluble and insoluble drugs. It has an excellent entrapment efficiency which provides better medication. Formulation of novasomes is achieved in a high shear device. Due to its numerous advantages, novasomes have been used extensively in various fields like cosmetics, chemical, personal care, foods, pharmaceuticals and agrochemicals.

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An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

Current Drug Metabolism ◽

10.2174/1389200221666210105121532 ◽

2021 ◽

Vol 21 ◽

Author(s):

Madhukar Garg ◽

Anju Goyal ◽

Sapna Kumari

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Lipid Bilayers ◽

Delivery System ◽

Liquid Crystalline ◽

Three Dimensional ◽

Biologically Active ◽

Potential Applications ◽

Health Related ◽

Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

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Novel Drug Delivery Device Using Silicone: Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.51.15 ◽

2003 ◽

Vol 51 (1) ◽

pp. 15-19 ◽

Cited By ~ 19

Author(s):

Masako Kajihara ◽

Toshihiko Sugie ◽

Hiroo Maeda ◽

Akihiko Sano ◽

Keiji Fujioka ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Water Soluble ◽

Delivery Device ◽

Drug Delivery Device ◽

Water Soluble Drugs ◽

Insoluble Drugs ◽

Novel Drug

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Mirena® (Levonorgestrel intrauterine system): A successful novel drug delivery option in contraception

Advanced Drug Delivery Reviews ◽

10.1016/j.addr.2009.04.022 ◽

2009 ◽

Vol 61 (10) ◽

pp. 808-812 ◽

Cited By ~ 22

Author(s):

Susan Rose ◽

Angela Chaudhari ◽

C. Matthew Peterson

Keyword(s):

Drug Delivery ◽

System A ◽

Novel Drug

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Crystallization and preliminary X-ray diffraction analysis of a single variable domain of the immunoglobulin superfamily in amphioxus,Amphi-IgSF-V

Acta Crystallographica Section F Structural Biology Communications ◽

10.1107/s2053230x14012746 ◽

2014 ◽

Vol 70 (8) ◽

pp. 1072-1075 ◽

Cited By ~ 1

Author(s):

Bo Jiang ◽

Yanjie Liu ◽

Rong Chen ◽

Zhenbao Wang ◽

Mansoor Tariq ◽

...

Keyword(s):

Immune System ◽

Structural Information ◽

Three Dimensional ◽

Dimensional Structure ◽

Immunoglobulin Superfamily ◽

X Ray Diffraction ◽

X Ray ◽

Cell Parameters ◽

System A ◽

Human Immunoglobulins

Amphioxus is regarded as an essential animal model for the study of immune evolution. Discovery of new molecules with the immunoglobulin superfamily (IgSF) variable (V) domain in amphioxus would help in studying the evolution of IgSF V molecules in the immune system. A protein was found which just contains only one IgSF V domain in amphioxus, termedAmphi-IgSF-V; it has over 30% sequence identity to the V domains of human immunoglobulins and mammalian T-cell receptors. In order to clarify the three-dimensional structure of this new molecule in amphioxus,Amphi-IgSF-V was expressed, purified and crystallized, and diffraction data were collected to a resolution of 1.95 Å. The crystal belonged to space groupP3221, with unit-cell parametersa=b= 53.9,c= 135.5 Å. The Matthews coefficient and solvent content were calculated to be 2.58 Å3 Da−1and 52.38%, respectively. The results will provide structural information to study the evolution of IgSF V molecules in the immune system.

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Microfluidic Synthesis of Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery

MRS Advances ◽

10.1557/adv.2016.446 ◽

2016 ◽

Vol 1 (29) ◽

pp. 2155-2160

Author(s):

Eri A. Takami ◽

Folarin Erogbogbo

Keyword(s):

Drug Delivery ◽

Low Cost ◽

Three Dimensional ◽

Hybrid Nanoparticles ◽

Dimensional Structure ◽

Force Microscopy ◽

Polymer Hybrid ◽

Medical Issues ◽

Transmission Electron ◽

Size And Morphology

ABSTRACTLipid-polymer hybrid nanoparticles (LPHN) have great potential as drug delivery devices for treatment of serious medical issues such as cardiovascular disease, tuberculosis, and cancer. Nanoprecipitation is a commonly used method to synthesize LPHN in a low cost manner. However, this multi-step process proves to be difficult in consistently producing uniformly sized nanoparticles. Here we developed a microfluidic device that utilizes a three-channel pathway and mixer channel to synthesize uniformly sized LPHN in a controlled manner. Dynamic light scattering results of the microfluidic synthesized nanoparticles show decrease in diameter size from 140 nm to 40 nm as the Reynolds number of the channel inflow increases. Transmission electron microscopy confirms the size and morphology of the nanoparticles. Three dimensional structure of the LPHN were observed using atomic force microscopy. The production of higher quality nanoparticles using our microfluidics device can expedite the research and development process of drug delivering lipid polymer nanoparticles.

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