Effects of arterial geometry on aneurysm growth: three-dimensional computational fluid dynamics study

2004 ◽  
Vol 101 (4) ◽  
pp. 676-681 ◽  
Author(s):  
Yiemeng Hoi ◽  
Hui Meng ◽  
Scott H. Woodward ◽  
Bernard R. Bendok ◽  
Ricardo A. Hanel ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Three Dimensional ◽  
Impact Zone ◽  
Content Type ◽  
Aneurysm Neck ◽  
Distal Side ◽  
Aneurysm Growth ◽  
Fine Print ◽  
Saccular Aneurysms

Object. Few researchers have quantified the role of arterial geometry in the pathogenesis of saccular cerebral aneurysms. The authors investigated the effects of parent artery geometry on aneurysm hemodynamics and assessed the implications relative to aneurysm growth and treatment effectiveness. Methods. The hemodynamics of three-dimensional saccular aneurysms arising from the lateral wall of arteries with varying arterial curves (starting with a straight vessel model) and neck sizes were studied using a computational fluid dynamics analysis. The effects of these geometric parameters on hemodynamic parameters, including flow velocity, aneurysm wall shear stress (WSS), and area of elevated WSS during the cardiac cycle (time-dependent impact zone), were quantified. Unlike simulations involving aneurysms located on straight arteries, blood flow inertia (centrifugal effects) rather than viscous diffusion was the predominant force driving blood into aneurysm sacs on curved arteries. As the degree of arterial curvature increased, flow impingement on the distal side of the neck intensified, leading to elevations in the WSS and enlargement of the impact zone at the distal side of the aneurysm neck. Conclusions. Based on these simulations the authors postulate that lateral saccular aneurysms located on more curved arteries are subjected to higher hemodynamic stresses. Saccular aneurysms with wider necks have larger impact zones. The large impact zone at the distal side of the aneurysm neck correlates well with other findings, implicating this zone as the most likely site of aneurysm growth or regrowth of treated lesions. To protect against high hemodynamic stresses, protection of the distal side of the aneurysm neck from flow impingement is critical.

Three-dimensional volume rendering for magnetic resonance angiography in the screening and preoperative workup of intracranial aneurysms

1996 ◽  
Vol 85 (6) ◽  
pp. 1050-1055 ◽  
Author(s):  
Philippe P. Maeder ◽  
Reto A. Meuli ◽  
Nicolas de Tribolet
Keyword(s):  
Magnetic Resonance ◽  
Volume Rendering ◽  
Intracranial Aneurysms ◽  
Mr Angiography ◽  
Three Dimensional ◽  
Time Of Flight ◽  
Conventional Angiography ◽  
Content Type ◽  
Aneurysm Neck ◽  
Fine Print

✓ This study was undertaken to evaluate the capacity of three-dimensional (3-D) time-of-flight (TOF) magnetic resonance (MR) angiography with VoxelView (VV) 3-D volume rendering to detect and characterize intracranial aneurysms and to compare this rendering technique with that of maximum intensity projection (MIP). Forty patients with a total of 53 intracranial aneurysms (10 giant and subgiant, 43 saccular) were consecutively admitted to University Hospital, Lausanne, Switzerland, and investigated with 3-D TOF MR angiography. Source images of the 43 saccular aneurysms were processed with both MIP and VV. The aneurysm detection rate of the two techniques and their ability to characterize features of an aneurysm, such as its neck and its relation to the parent vessel, were compared. Intraarterial digital subtraction angiography was used as the gold standard to which these techniques could be compared and evaluated. Four aneurysms, less than 3 mm in size, were missed using MIP compared to three missed using VV. The representation of aneurysmal morphology using VV was superior to that found using conventional angiography in nine cases, equal in 16 cases, and inferior in seven cases. The representation of the aneurysm neck using VV was superior to MIP in 21 cases, equal in 17 cases, and inferior in one case; it was superior to that shown using conventional angiography in 10 cases, equal in 18 cases, and inferior in four cases. Time-of-flight MR angiography in conjunction with both MIP and VV 3-D reconstruction was able to visualize all aneurysms that were larger than 3 mm. Compared to MIP, VV provides a better definition of the aneurysm neck and the morphology of saccular aneurysms, making VV valuable for use in a preoperative diagnostic workup.

Application of computational fluid dynamics to predict hydrodynamic downpull on high head gates

2017 ◽  
Vol 34 (4) ◽  
pp. 1191-1203 ◽  
Author(s):  
Mete Koken ◽  
Ismail Aydin ◽  
Akis Sahin
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Numerical Models ◽  
Separation Bubble ◽  
Three Dimensional ◽  
Experimental Models ◽  
Experimental Results ◽  
Content Type ◽  
Wide Range ◽  
High Head

Purpose High head gates are commonly used in hydropower plants for flow regulation and emergence closure. Hydrodynamic downpull can be a critical parameter in design of the lifting mechanism. The purpose of this paper is to show that a simplified two-dimensional (2D) computational fluid dynamics solution can be used in the prediction of the downpull force on the gate lip by comparison of computed results to experimentally measured data. Design/methodology/approach In this study, ANSYS FLUENT CFD software was used to obtain 2D numerical solution for the flow field around a generic gate model located in a power intake structure which was previously used in an experimental study. Description of the flow domain, computational grid resolution, requirements on setting appropriate boundary conditions and methodology in describing downpull coefficient are discussed. Total number of 245 simulations for variable gate lip geometry and gate openings were run. The downpull coefficient evaluated from the computed pressure field as function of gate opening and lip angle are compared with the experimental results. Findings The computed downpull coefficient agrees well with the previous experimental results, except one gate with small lip angle where a separation bubble forms along the lip, which is responsible from this deviation. It is observed that three-dimensional (3D) effects are confined to the large gate openings where downpull is minimum or even reversed. Research limitations/implications In large gate openings, three dimensionality of the flow around gate slots plays an important role and departure from 2D solutions become more pronounced. In that case, one might need to perform a 3D solution instead. Practical implications This paper presents a very fast and accurate way to predict downpull force on high head gates in the absence of experimental data. Originality/value An extensive amount of simulations are run within the scope of this study. It is shown that knowing its limitations, 2D numerical models can be used to calculate downpull for a wide range of gate openings without the need of expensive experimental models.

Limitations of three-dimensional reconstructed computerized tomography angiography after clip placement for intracranial aneurysms

2005 ◽  
Vol 103 (4) ◽  
pp. 656-661 ◽  
Author(s):  
Yoshiko Sagara ◽  
Hiro Kiyosue ◽  
Yuzo Hori ◽  
Michifumi Sainoo ◽  
Hirofumi Nagatomi ◽  
...  
Keyword(s):  
Ct Angiography ◽  
Computerized Tomography ◽  
Intracranial Aneurysms ◽  
Three Dimensional ◽  
Parent Artery ◽  
3D Ct ◽  
Metal Artifacts ◽  
Content Type ◽  
Aneurysm Neck ◽  
Fine Print

Object. The authors compared the usefulness of three-dimensional (3D) reconstructed computerized tomography (CT) angiography with 3D digital subtraction (DS) angiography in assessing intracranial aneurysms after clip placement. A retrospective review of clinical cases was performed. Methods. Between May 2001 and May 2003, 17 patients with a total of 20 intracranial aneurysms underwent 3D CT and 3D DS angiography following clip placement. The authors assessed the presence or absence of residual aneurysm necks and stenoocclusive changes in the parent artery and the neighboring artery. The efficacy of CT angiographic visualization was also evaluated. In 12 of the 20 aneurysms, both 3D modalities similarly demonstrated the residual aneurysm neck and stenoocclusive changes in the parent artery and neighboring artery. Three-dimensional CT angiography failed to demonstrate three of the aneurysms, and the studies were not considered suitable for evaluation because of the presence of metallic artifacts. In the remaining five studies, the 3D CT angiograms did not effectively demonstrate the neighboring and parent arteries. The detectability of residual aneurysm necks was correlated with the clip material and with the number of clips applied. Conclusions. Three-dimensional DS angiography is still necessary in cases involving multiple clips or with cobalt alloy clips because the clips appear as metal artifacts on 3D CT angiography.

Stereotactic radiosurgery versus stereotactic radiotherapy for patients with vestibular schwannoma: a Leksell Gamma Knife Society 2000 debate

2000 ◽  
Vol 93 (supplement_3) ◽  
pp. 90-92 ◽  
Author(s):  
Mark E. Linskey
Keyword(s):  
Gamma Knife ◽  
Stereotactic Radiotherapy ◽  
Three Dimensional ◽  
Late Recurrence ◽  
Vestibular Schwannomas ◽  
Tumor Control ◽  
Complication Rates ◽  
Content Type ◽  
Single Fraction ◽  
Fine Print

✓ By definition, the term “radiosurgery” refers to the delivery of a therapeutic radiation dose in a single fraction, not simply the use of stereotaxy. Multiple-fraction delivery is better termed “stereotactic radiotherapy.” There are compelling radiobiological principles supporting the biological superiority of single-fraction radiation for achieving an optimal therapeutic response for the slowly proliferating, late-responding, tissue of a schwannoma. It is axiomatic that complication avoidance requires precise three-dimensional conformality between treatment and tumor volumes. This degree of conformality can only be achieved through complex multiisocenter planning. Alternative radiosurgery devices are generally limited to delivering one to four isocenters in a single treatment session. Although they can reproduce dose plans similar in conformality to early gamma knife dose plans by using a similar number of isocenters, they cannot reproduce the conformality of modern gamma knife plans based on magnetic resonance image—targeted localization and five to 30 isocenters. A disturbing trend is developing in which institutions without nongamma knife radiosurgery (GKS) centers are championing and/or shifting to hypofractionated stereotactic radiotherapy for vestibular schwannomas. This trend appears to be driven by a desire to reduce complication rates to compete with modern GKS results by using complex multiisocenter planning. Aggressive advertising and marketing from some of these centers even paradoxically suggests biological superiority of hypofractionation approaches over single-dose radiosurgery for vestibular schwannomas. At the same time these centers continue to use the term radiosurgery to describe their hypofractionated radiotherapy approach in an apparent effort to benefit from a GKS “halo effect.” It must be reemphasized that as neurosurgeons our primary duty is to achieve permanent tumor control for our patients and not to eliminate complications at the expense of potential late recurrence. The answer to minimizing complications while maintaining maximum tumor control is improved conformality of radiosurgery dose planning and not resorting to homeopathic radiosurgery doses or hypofractionation radiotherapy schemes.

scholarly journals Morphological and Hemodynamic Changes during Cerebral Aneurysm Growth

2021 ◽  
Vol 11 (4) ◽  
pp. 520
Author(s):  
Emily R. Nordahl ◽  
Susheil Uthamaraj ◽  
Kendall D. Dennis ◽  
Alena Sejkorová ◽  
Aleš Hejčl ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Kinetic Energy ◽  
Swirling Flow ◽  
Morphological Changes ◽  
Cerebral Aneurysms ◽  
Patient Specific ◽  
Aneurysm Wall ◽  
Aneurysm Growth ◽  
Computational Fluid Dynamics Cfd

Computational fluid dynamics (CFD) has grown as a tool to help understand the hemodynamic properties related to the rupture of cerebral aneurysms. Few of these studies deal specifically with aneurysm growth and most only use a single time instance within the aneurysm growth history. The present retrospective study investigated four patient-specific aneurysms, once at initial diagnosis and then at follow-up, to analyze hemodynamic and morphological changes. Aneurysm geometries were segmented via the medical image processing software Mimics. The geometries were meshed and a computational fluid dynamics (CFD) analysis was performed using ANSYS. Results showed that major geometry bulk growth occurred in areas of low wall shear stress (WSS). Wall shape remodeling near neck impingement regions occurred in areas with large gradients of WSS and oscillatory shear index. This study found that growth occurred in areas where low WSS was accompanied by high velocity gradients between the aneurysm wall and large swirling flow structures. A new finding was that all cases showed an increase in kinetic energy from the first time point to the second, and this change in kinetic energy seems correlated to the change in aneurysm volume.

Biomechanical characteristics of C1–2 cable fixations

1996 ◽  
Vol 85 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Curtis A. Dickman ◽  
Neil R. Crawford ◽  
Christopher G. Paramore
Keyword(s):  
Cyclic Loading ◽  
Translational Motion ◽  
Biomechanical Testing ◽  
Three Dimensional ◽  
Constrained Motion ◽  
Content Type ◽  
Physiological Range ◽  
Fixation Techniques ◽  
Cable Fixation ◽  
Fine Print

✓ The biomechanical characteristics of four different methods of C1–2 cable fixation were studied to assess the effectiveness of each technique in restoring atlantoaxial stability. Biomechanical testing was performed on the upper cervical spines of four human cadaveric specimens. Physiological range loading was applied to the atlantoaxial specimens and three-dimensional motion was analyzed with stereophotogrammetry. The load–deformation relationships and kinematics were measured, including the stiffness, the angular ranges of motion, the linear ranges of motion, and the axes of rotation. Specimens were nondestructively tested in the intact state, after surgical destabilization, and after each of four different methods of cable fixation. Cable fixation techniques included the interspinous technique, the Brooks technique, and two variants of the Gallie technique. All specimens were tested immediately after fixation and again after the specimen was fatigued with 6000 cycles of physiological range torsional loading. All four cable fixation methods were moderately flexible immediately; the different cable fixations allowed between 5° and 40° of rotational motion and between 0.6 and 7 mm of translational motion to occur at C1–2. The Brooks and interspinous methods controlled C1–2 motion significantly better than both of the Gallie techniques. The motion allowed by one of the Gallie techniques did not differ significantly from the motion of the unfixed destabilized specimens. All cable fixation techniques loosened after cyclic loading and demonstrated significant increases in C1–2 rotational and translational motions. The bone grafts shifted during cyclic loading, which reduced the effectiveness of the fixation. The locations of the axes of rotation, which were unconstrained and mobile in the destabilized specimens, became altered with cable fixation. The C1–2 cables constrained motion by shifting the axes of rotation so that C-1 rotated around the fixed cable and graft site. After the specimen was fatigued, the axes of rotation became more widely dispersed but were usually still localized near the cable and graft site. Adequate healing requires satisfactory control of C1–2 motion. Therefore, some adjunctive fixation is advocated to supplement the control of motion after C1–2 cable fixation (that is, a cervical collar, a halo brace, or rigid internal fixation with transarticular screws).

scholarly journals Computational Analysis to Factor Wind into the Design of an Architectural Environment

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Hassam Nasarullah Chaudhry ◽  
John Kaiser Calautit ◽  
Ben Richard Hughes
Keyword(s):  
Fluid Dynamics ◽  
Power Generation ◽  
Computational Fluid Dynamics ◽  
Three Dimensional ◽  
Numerical Data ◽  
Navier Stokes ◽  
Windward Side ◽  
Average Value ◽  
Continuity Equations ◽  
Prevailing Wind Direction

The effect of wind distribution on the architectural domain of the Bahrain Trade Centre was numerically analysed using computational fluid dynamics (CFD). Using the numerical data, the power generation potential of the building-integrated wind turbines was determined in response to the prevailing wind direction. The three-dimensional Reynolds-averaged Navier-Stokes (RANS) equations along with the momentum and continuity equations were solved for obtaining the velocity and pressure field. Simulating a reference wind speed of 6 m/s, the findings from the study quantified an estimate power generation of 6.4 kW indicating a capacity factor of 2.9% for the benchmark model. At the windward side of the building, it was observed that the layers of turbulence intensified in inverse proportion to the height of the building with an average value of 0.45 J/kg. The air velocity was found to gradually increase in direct proportion to the elevation with the turbine located at higher altitude receiving maximum exposure to incoming wind. This work highlighted the potential of using advanced computational fluid dynamics in order to factor wind into the design of any architectural environment.

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