scholarly journals CIRCADIAN RHYTHM AND INDICATORS OF SYSTEMIC INFLAMMATION IN PATIENTS WITH PSORIASIS AND CONCOMITANT ALIMENTARY OBESITY

2021 ◽  
Vol 25 (1-2) ◽  
pp. 7-11
Author(s):  
Ya.O. Yemchenko ◽  
K.Ye. Ishcheikin ◽  
I.P. Kaidashev
Keyword(s):  
Circadian Rhythm ◽  
Systemic Inflammation ◽  
Negative Correlation ◽  
Social Activity ◽  
Working Capacity ◽  
Social Significance ◽  
Alimentary Obesity ◽  
Depth Study

Psoriasis is one of the most common dermatoses, affecting from 2% to 4% of the world's population, according to the statistics from WHO. The recent increase in the incidence of comorbid psoriasis and obesity leads to severe, atypical, disabling, and treatment-resistant forms of dermatosis, which significantly impair the quality of life of patients, reduce the efficiency and social activity of patients, thus acquiring not only a medical but also a social significance. There is a theoretical justification for a possible role of circadian rhythm disorders, manifested by changes in eating behavior, reduced sleep duration, and individual chronotype of patients in the development of obesity, chronic low-intensity inflammation, and some chronic autoimmune diseases such as psoriasis. However, this issue remains understudied and insufficiently substantiated. Therefore, the aim of our research was to identify the correlation between the circadian rhythm in terms of changes in the chronotype of human working capacity and indicators of systemic inflammation in patients with extensive psoriasis and concomitant alimentary obesity. The results of correlation analysis showed a high negative correlation between the working capacity chronotype in patients and the level of IL-33, as well as a medium negative correlation between the working capacity chronotype in patients and the level of IL-6 and CRP. Therefore, changes in the circadian rhythm to the evening type of human working capacity chronotype may increase the level of systemic inflammation in patients with extensive vulgar psoriasis and concomitant alimentary obesity. Thus, further in-depth study of the relationship between systemic inflammation and circadian rhythm changes in patients with extensive vulgar psoriasis and concomitant alimentary obesity is promising and essential for the development of scientifically substantiated principles for early prevention and timely correction of these comorbidities.

scholarly journals relationship between circadian rhythm and severity of psoriasis and obesity

2021 ◽  
Vol 27 (1-2) ◽  
pp. 22-29
Author(s):  
Ya.O. Yemchenko ◽  
◽  
K.Ye. Ischeikin ◽  
I.P. Kaidashev ◽  
O.V. Bezeha ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Weight Gain ◽  
Negative Correlation ◽  
Negative Impact ◽  
Working Capacity ◽  
High Negative Correlation ◽  
Disease Impact ◽  
Very High

The research aim is to identify the correlation between circadian rhythm in terms of changes in the chronotype of human working capacity and severity of psoriasis progression, obesity, and the disease impact on the quality of patients' life. Materials and Methods. The research focuses on the determination of the PASI, BMI, DIAG indexes and a patient's chronotype of working capacity. Results and Discussion. The results of the correlation analysis showed a very high negative correlation between chronotype of patients' working capacity and BMI. They also demonstrated a high negative correlation between PASI and DIAG indicators and chronotype of patients' working capacity. Conclusions. The circadian rhythm changes to the evening chronotype of human working capacity contribute to psoriasis worsening, weight gain, and negative impact of the disease on the quality of patients' life.

scholarly journals THE ROLE OF PPAR IN THE PATHOGENESIS OF PSORIASIS AND OBESITY

2019 ◽  
Vol 19 (2) ◽  
pp. 224-229
Author(s):  
Ya. Yemchenko
Keyword(s):  
Skin Diseases ◽  
Social Activity ◽  
Future Research ◽  
Social Significance ◽  
Inflammatory Reactions ◽  
Multifactorial Diseases ◽  
The Social ◽  
Excessive Body Weight ◽  
Depth Study

Psoriasis is one of the most common chronic recurrent multifactorial diseases of the skin with a predominance of genetic predisposition. The disease is characterized by hyperproliferation of epidermal cells, impairment of the keratinisation against the background of inflammatory reactions in the dermal layer, the nails, joints and scalp involvement. According to the results of clinical and epidemiological research, about 3-4% of the population of our planet has psoriasis, regardless of sex, age and ethnic group, while the share of this pathology in the overall structure of skin diseases reaches from 1% - to 40%, according to some reports. However, despite the wide prevalence of psoriasis and a huge number of works on this issue, there is still no shared view on the pathogenesis of this dermatosis. The data presented by many clinical studies show that there has been a recent increase in cases of comorbidity of psoriasis and obesity, leading to severe, atypical, disabling and resistant to the treatment forms of dermatosis. All this considerably impairs the quality of life of patients with psoriasis, reduces their working capacity and social activity that lays emphasis on not only the medical but also the social significance of the problem. Immunological disorders and genetic defects have been proven as the causes of psoriasis and abdominal obesity. The distinctive feature of the pathogenesis in the patients having comorbidity of psoriasis and obesity, in contrast to the patients without excessive body weight, is a statistically significant increase in hyperleptinomia and in systemic cytokine proinflammatory potential. Therefore, the vision for the future research is in-depth study of the pathogenesis of comorbid disease in patients with psoriasis that will contribute to reveal new targets for the treatment of this dermatosis.

scholarly journals OBESITY AND CIRCADIAN RHYTHM DISORDERS IN PATIENTS WITH PSORIASIS

2021 ◽  
Vol 21 (1) ◽  
pp. 160-165
Author(s):  
Ya.A. Yemchenko ◽  
K.Ye. Ishcheikin ◽  
I.P. Kaidashev
Keyword(s):  
Circadian Rhythm ◽  
Social Activity ◽  
Eating Behaviour ◽  
Stressful Situation ◽  
Adaptive Mechanisms ◽  
The Social ◽  
Depth Study ◽  
The Relationship ◽  
Further Development

Psoriasis is one of the most common dermatoses, which according to WHO world statistics affects from 2% to 4% of the world's population. The problem of psoriasis is quite relevant as it is associated with an increase in morbidity, chronic recurrence, an increase in the number of severe and disabling forms of dermatosis. Despite a large number of scientific studies, the aetiology and pathogenesis of this chronic dermatosis is still remaining unclear. Among the factors contributing to the development of psoriasis, psychosomatic disorders have been considered to play a significant role. Disruption of protective and adaptive mechanisms leads to structural and functional disorders at all levels, including the neuroendocrine and immune systems and this is regarded as the pathogenetic basis of psoriasis. Many individuals develop a hyperphagic way of responding to a stressful situation that is manifested by depression, anxiety, chronic stress, sleep disorders and changes in eating behaviour that in turn lead to weight gain and further development of obesity with a number of metabolic disorders and to changes in the circadian rhythm. The recent increase in comorbid psoriasis and obesity leading to severe, atypical, disabling, and treatment-resistant forms of dermatosis significantly impairs the quality of life of patients, reduces the efficiency and social activity of patients with psoriasis, therefore psoriasis is regarded as the social problem as well. Thus, further in-depth study of the relationship and pathogenesis of the comorbidity between psoriasis, obesity and circadian rhythm changes is promising and essential for the development of scientifically sound principles of early prevention and timely correction of comorbidities.

scholarly journals THIOZOLIDINEDIONES IN THE TREATMENT OF PATIENTS WITH EXTENSIVE PSORIASIS AND CONCOMITANT ALIMENTARY OBESITY

2020 ◽  
Vol 20 (4) ◽  
pp. 30-34
Author(s):  
Ya.O. Yemchenko ◽  
K.Ye. Ishcheikin ◽  
I.P. Kaidashev
Keyword(s):  
Systemic Inflammation ◽  
Molecular Mechanisms ◽  
Current Data ◽  
The Body ◽  
Internal Organs ◽  
Single View ◽  
Multifactorial Diseases ◽  
Alimentary Obesity ◽  
Inflammatory Processes

Psoriasis is one of the most common chronic recurrent systemic autoimmune multifactorial diseases, affected the skin, joints, internal organs and systems of the body. Despite the significant prevalence of psoriasis and a large number of studies devoted this problem there is still no single view on the pathogenesis of this dermatosis. To clear up the pathogenesis of psoriasis, it seems to be reasonable to focus on the common comorbidities or multimorbidities, which may occur in the course of psoriasis, as this issue is still insufficiently studied. Recent reports have proven the evidences of indisputable link between psoriasis and obesity. The scientific literature extensively covers the issues of identical pathogenetic mechanisms of inflammatory processes in psoriasis and obesity. Given the current data on the role of systemic inflammation underlying the development of both psoriasis and obesity, the study of molecular mechanisms of its development and in particularly the role of proinflammatory nuclear transcription factors, thiazolidinediones have been found out as pathogenetically justified medicine of choice for the therapy of these diseases. In this study, we determined the effectiveness of using 30 mg of pioglitazone daily for 6 months in the course of treatment for patients with extensive psoriasis vulgaris of moderate severity, who were also diagnosed as having concomitant grade І-ІІ alimentary obesity that was supported by clinical and immunological findings evidenced of systemic inflammation. Analyzing the results obtained, we have found out the prolonged therapy with pioglitazone leads to a decrease in systemic inflammation and contributes to a milder recurrent course of psoriasis.

scholarly journals Institutional quality dataset

2013 ◽  
Vol 10 (1) ◽  
pp. 135-161 ◽  
Author(s):  
ALJAŽ KUNČIČ
Keyword(s):  
Institutional Environment ◽  
Social Activity ◽  
Institutional Quality ◽  
Classification Systems ◽  
Usual Practice ◽  
Homogeneous Groups ◽  
Underlying Basis ◽  
Quality Ranking

AbstractIn this paper, we emphasize the role of institutions as the underlying basis for economic and social activity. We describe and compare different institutional classification systems, which is rarely done in the literature, and show how to empirically operationalize institutional concepts. More than 30 established institutional indicators can be clustered into three homogeneous groups of formal institutions: legal, political and economic, which capture to a large extent the complete formal institutional environment of a country. We compute the latent quality of legal, political and economic institutions for every country in the world and for every year. On this basis, we propose a legal, political and economic World Institutional Quality Ranking, through which we can follow whether a country is improving or worsening its relative institutional environment. The calculated latent institutional quality measures can be especially useful in further panel data applications and add to the usual practice of using simply one or another index of institutional quality to capture the institutional environment. We make the Institutional Quality Dataset, covering up to 197 countries and territories from 1990 to 2010, freely available online.

scholarly journals Intellectual competitions for schoolchildren: Main tasks and social significance

2020 ◽  
Vol 20 (1) ◽  
pp. 73-88
Author(s):  
D. E. Slizovskiy ◽  
M. G. Ivanova ◽  
E. V. Martynenko
Keyword(s):  
Higher Education ◽  
Social Activity ◽  
Historical Period ◽  
Life Strategies ◽  
Access To Education ◽  
Social Significance ◽  
Additional Information ◽  
Research Activities ◽  
The Social

Every historical period forms a special generation with its own values and norms. Children and youth become the main driving force in the development of the higher education, but this system in Russia is going through a difficult period due to the problems unresolved after the 1990s: the quality, accessibility and effectiveness of the higher education, inequalities in the access to education, etc. Therefore, intellectual competitions can be considered not only a positive manifestation of the social activity of schoolchildren, but also a means to support talented youth and ensure the interconnection of secondary and higher education systems. The article considers social aspects of the intellectual competitions for schoolchildren which aim at the development of social practices related to research activities and teaching at school. The authors focus on the research and practice-oriented interests of schoolchildren within the intellectual competitions in social studies: priorities, values and life strategies of schoolchildren when choosing the sphere of their interests. The authors analyzed the written projects of schoolchildren, presentations of these projects, responses to experts’ questions, reactions to questions not directly related to the topic of the presented project, further participation in the section, and some additional information. As a result, the authors made conclusions not only about the content of the priorities, values and life strategies of schoolchildren, but also about the procedure and conditions necessary for assessing the quality of work and the creative potential of participants of intellectual competitions.

scholarly journals PSYCHOLOGICAL STUDIES OF THE MOTIVATIONAL-SEMANTIC SPHERE IN PATIENTS WITH DIABETES MELLITUS

2018 ◽  
pp. 6-9
Author(s):  
I. Burovska
Keyword(s):  
Diabetes Mellitus ◽  
Detailed Examination ◽  
Social Significance ◽  
Way Of Life ◽  
Leading Role ◽  
Patients With Diabetes ◽  
Psychological Features ◽  
Psychological Studies

The article is devoted to the study of the motivational and semantic sphere for patients with diabetes mellitus. Description of the patients’ main directions of the psychological features are distinguished. This study aims to explorer the formation of a hierarchical system of values, attitudes, experiences and motives of this category of patients. Different approaches in the study of this problem were noted, which point to the great possibilities of prevention in the process of rehabilitation in a given subject. The leading role of psychosocial factors of impairment of their mental adaptation and quality of life in patients with diabetes mellitus is determined. Conducting theoretical analysis of modern psychological studies of the motivational and semantic sphere in patients with diabetes makes it possible to identify and analyze the main directions of rehabilitation of this category of persons, to outline the main motivational components of the disease and their relationship with the semantic sphere of each particular person. The peculiarities of the motivational and semantic sphere of persons with diabetes mellitus are described. The relationship between the motivational and intellectual sphere of personality and its influence on the formation of motives are considered. The importance of life-building and the desire to adapt to a particular way of life, to increase its qualitative characteristics and social significance, to take into account the psychological characteristics of patients, are outlined. A detailed examination of the two structural components of this study (which is one of the key tasks of this topic) allows us to more closely combine them into a single entity that forms the life-orienting purposes of patients with diabetes, and draws attention to the dynamics of motivational processes that occur in individuals during the period the course of the disease and the possibility of correction of these processes. The prospects of further researches which consist in formation and modeling of holistic construct of motivational – semantic sphere in patients with diabetes mellitus are outlined.

scholarly journals The role of nurses' professional values during the COVID-19 crisis

2021 ◽  
pp. 096973302110342
Author(s):  
David González-Pando ◽  
Covadonga González-Nuevo ◽  
Ana González-Menéndez ◽  
Fernando Alonso-Pérez ◽  
Marcelino Cuesta
Keyword(s):  
Quality Of Life ◽  
Perceived Stress ◽  
Negative Correlation ◽  
Compassion Satisfaction ◽  
Professional Values ◽  
Professional Quality Of Life ◽  
Cross Sectional ◽  
Professional Quality

Background: The COVID-19 pandemic has produced high stress in nurses, affecting their professional quality of life. Different variables affect psychological stress response and professional quality of life. In this context, the role of professional values represents an interesting object of research. Objectives: To analyze the relationship between professional values, perceived stress, and professional quality of life among nurses during the COVID-19 crisis. Research design, participants, and research context: Descriptive cross-sectional study. Participants were 439 registered nurses from the public health system. Perceived stress, professional quality of life, and professional values were evaluated by using measuring instruments adapted and validated in the geographic context of research. Data were collected online in December 2020 during the second wave of the COVID-19 pandemic in Spain. Ethical considerations: This study was approved by the Ethics Committee on Clinical Research of the Principality of Asturias. Findings: Within professional values, ethics obtained higher scores showing the primacy of ethical values among nurses. Moderate correlations between ethics, mastery, expertise, and compassion satisfaction were found. Frontline nurses informed high perceived stress. The correlations between professional values and compassion satisfaction were higher in non-frontline nurses. A moderate negative correlation between perceived stress and compassion satisfaction was found in both groups, which implies that the higher the stress, the lower the satisfaction in the helping relationship. Conclusion: Professional values positively influence compassion satisfaction during the COVID-19 pandemic. Compassion satisfaction presents a negative correlation with fatigue compassion and burnout in frontline and non-frontline nurses. Given the functionality of values both to guide clinical practice professionally and ethically, and prevent dissatisfaction with one’s professional quality of life by reinforcing compassion satisfaction, it is necessary to reinforce them with an intensive and cross-sectional learning during the university training.

scholarly journals Family Psychosocial Problem and Role of Psychoeducation in the Improvement of the Quality of Life of the Ex Mental Patient

2017 ◽  
Vol 2 (2) ◽  
pp. 19-25
Author(s):  
Husmiati Yusuf
Keyword(s):  
Quality Of Life ◽  
Social Activity ◽  
Family Members ◽  
Psychosocial Problems ◽  
Mental Patient ◽  
Mental Illnesses ◽  
Mental Patients ◽  
Shame And Guilt

Family plays an important role in maintaining and treating a psychotic mental patient in society. Treatment and family support are believed to accelerate the recovery of ex-psychotic mental patients. However, families often face psychosocial problems either directly or indirectly because they have family members who are psychotic. Psychosocial problems include anxiety, stress, loss of hope, loss of sense, shame and guilt. Families are also experiencing financial problems, disruptions in social activity, and physical health damage. Therefore psychoeducation for families with family members who have psychotic mental illnesses is considered very important to improve the quality of life of former mental patients.

Neuroimmune mechanisms of pruritus in atopic dermatitis

2022 ◽  
pp. 12-16
Author(s):  
Y. A. Kandrashkina ◽  
E. A. Orlova ◽  
A. A. Pribytkov
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Disease ◽  
Neurogenic Inflammation ◽  
New Methods ◽  
Neuroimmune Interactions ◽  
High Prevalence ◽  
Depth Study

Atopic dermatitis is a chronic hereditary recurrent skin disease. One of the most pronounced symptoms of this dermatosis is itchy skin. Pruritus accompanies atopic dermatitis in more than 80% of cases. This review presents modern data on the mechanisms of pruritus formation in atopic dermatitis. The issues of etiological factors, neuroimmune interactions, peculiarities of skin dysfunction, as well as the role of stress are considered. The relevance of studying the topic is due to the high prevalence of atopic dermatitis among the population, a decrease in the quality of life and the lack of effective therapy. Analysis of the literature indicates the need for a comprehensive assessment of the pathogenetic mechanisms of the development of pruritus in atopic dermatitis. A more in-depth study of the mechanisms of neurogenic inflammation in atopic dermatitis will contribute to the development of new methods of diagnosis and treatment.

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