scholarly journals Role of Endothelial Dysfunction in Cardiovascular Disease: Potential Therapeutic Target

2021 ◽  
Vol 13 (20) ◽  
pp. 170-173
Author(s):  
Korzh Oleksii
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Dysfunction ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals Toll-like Receptors Signaling Pathways as a Potential Therapeutic Target in Cardiovascular Disease

2018 ◽  
Vol 24 (17) ◽  
pp. 1887-1898 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Maryam Ghandehari ◽  
Motahareh Heydari-majd ◽  
Sima Seifi ◽  
Ramin Mardani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Immune System ◽  
Signaling Pathways ◽  
Cardiac Remodeling ◽  
Therapeutic Target ◽  
Good Evidence ◽  
Toll Like Receptors ◽  
Potential Therapeutic Target

Cardiovascular Disease (CVD) is one of the most important causes of morbidity and mortality, and associated with an important economic burden globally. Over the last decade, the prevalence of CVD has been rising globally, and is now associated with millions of death annually in both developed and developing countries. There is good evidence that the immune system is involved in the pathophysiology of CVD. Toll-like receptors (TLRs) and their down-stream signaling pathways play an important role in the immune system. Recent studies have suggested that the TLRs are involved in atherogenesis, including stroke, myocardial infarction, ischemiareperfusion injury, cardiac remodeling and development of Heart Failure (HF). In this review we have summarized the recent studies investigating the role of TLRs in CVD and the potential for using TLRs signaling pathways as a therapeutic target in CVD.

scholarly journals Role of Endothelial Dysfunction in Cardiovascular Disease: A Review

2000 ◽  
Vol 5 (2) ◽  
pp. 59-66
Author(s):  
Amudha Kadirvelu ◽  
Chee Kok Han ◽  
Tan Kim Heung ◽  
Anna Maria Choy ◽  
Mustafa Mohd Rais ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Dysfunction

scholarly journals The Role of Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target

2021 ◽  
Vol 11 ◽  
Author(s):  
Manqiu Ding ◽  
Yongqiang Chen ◽  
Yue Lang ◽  
Li Cui
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Cell Survival ◽  
Cancer Cells ◽  
Prion Protein ◽  
Therapeutic Target ◽  
Cancer Biology ◽  
Cellular Prion Protein ◽  
Potential Therapeutic Target

Prion protein has two isoforms including cellular prion protein (PrPC) and scrapie prion protein (PrPSc). PrPSc is the pathological aggregated form of prion protein and it plays an important role in neurodegenerative diseases. PrPC is a glycosylphosphatidylinositol (GPI)-anchored protein that can attach to a membrane. Its expression begins at embryogenesis and reaches the highest level in adulthood. PrPC is expressed in the neurons of the nervous system as well as other peripheral organs. Studies in recent years have disclosed the involvement of PrPC in various aspects of cancer biology. In this review, we provide an overview of the current understanding of the roles of PrPC in proliferation, cell survival, invasion/metastasis, and stem cells of cancer cells, as well as its role as a potential therapeutic target.

scholarly journals SHP2 promotes NETosis through ERK5 pathway and mediates the development of psoriasis

2021 ◽  
Author(s):  
Yang Sun ◽  
Yan Ding ◽  
Jiao Qu ◽  
Chenyang Zhang ◽  
Yuyu Zhu ◽  
...  
Keyword(s):  
Immune Cells ◽  
Experimental Verification ◽  
Inflammatory Disease ◽  
Therapeutic Target ◽  
Tyrosine Phosphatase ◽  
Skin Lesions ◽  
Chronic Inflammatory Disease ◽  
Potential Therapeutic Target ◽  
Single Cell Rna Sequencing

Psoriasis is a chronic inflammatory disease which infiltrated a large number of neutrophils among skin lesions. Here, we investigated the contribution of tyrosine phosphatase SHP2 in neutrophils, as well as its pathogenesis in psoriasis. We combined single-cell RNA sequencing with experimental verification to declare that SHP2 in neutrophils could promote the NETs formation through the ERK5 pathway, and resulted in the infiltration of inflammatory immune cells, which leads to psoriasis. Our study provides evidence for the role of SHP2 in NETosis in the progression of psoriasis, and SHP2 may be a potential therapeutic target for the treatment of psoriasis.

scholarly journals The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Iyad Khamaysi ◽  
Preeti Singh ◽  
Susan Nasser ◽  
Hoda Awad ◽  
Yehuda Chowers ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

Role of spinal neurons in the maintenance of elevated sympathetic activity: a novel therapeutic target?

2020 ◽  
Vol 319 (3) ◽  
pp. R282-R287
Author(s):  
Maycon I. O. Milanez ◽  
Erika E. Nishi ◽  
Cássia T. Bergamaschi ◽  
Ruy R. Campos
Keyword(s):  
Cardiovascular Diseases ◽  
Therapeutic Target ◽  
Sympathetic Activity ◽  
Spinal Neurons ◽  
Potential Therapeutic Target ◽  
Present Evidence ◽  
Extensive Range ◽  
Vasomotor Activity ◽  
The Brain

The control of sympathetic vasomotor activity involves a complex network within the brain and spinal circuits. An extensive range of studies has indicated that sympathoexcitation is a common feature in several cardiovascular diseases and that strategies to reduce sympathetic vasomotor overactivity in such conditions can be beneficial. In the present mini-review, we present evidence supporting the spinal cord as a potential therapeutic target to mitigate sympathetic vasomotor overactivity in cardiovascular diseases, focusing mainly on the actions of spinal angiotensin II on the control of sympathetic preganglionic neuronal activity.

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