Comparative Effects of Valine-5 Angiotensin II Amide and Pitressin on Renal Excretory Function in Diabetes Insipidus.

1962 ◽  
Vol 109 (1) ◽  
pp. 105-110 ◽  
Author(s):  
F. Del Greco
Keyword(s):  
Angiotensin Ii ◽  
Diabetes Insipidus ◽  
Excretory Function ◽  
Renal Excretory Function

Acute Effects of Acetazolamide (Diamox) on Plasma and Urinary Electrolytes of Dogs With Special Reference to Calcium

1957 ◽  
Vol 191 (2) ◽  
pp. 388-392 ◽  
Author(s):  
Smith Freeman ◽  
Anne B. Jacobsen
Keyword(s):  
Carbon Dioxide ◽  
Plasma Concentration ◽  
Chloride Concentration ◽  
Total Plasma ◽  
Acute Effects ◽  
Plasma Phosphate ◽  
Sodium Potassium ◽  
Excretory Function ◽  
Acute Increase ◽  
Renal Excretory Function

Administration of Diamox by ingestion or injection to adult fasting female dogs consistently produced an acute increase of approximately 1 mg % in the plasma concentration of calcium. At the same time there was an increase in the plasma phosphate and chloride concentration and a decrease in total plasma content of carbon dioxide of Diamox-infused dogs. Diamox did not affect the plasma concentration of calcium, chloride or bicarbonate if renal excretory function was abolished prior to its administration. Infusion of Diamox produced a prompt rise in the urinary excretion of sodium, potassium, calcium, phosphate, citrate, chloride and water in fasting female dogs. The effect of Diamox on the fasting concentration of calcium rendered unsatisfactory the interpretation of data concerned with a study of its effect on the disappearance of injected calcium. However, intravenous injection of small amounts of sodium carbonate was found to produce a definite delay in the rate of disappearance of injected calcium.

Abstract 067: Mechanism of Action of 8-Aminoguanine on Renal Excretory Function

Hypertension ◽  
2018 ◽  
Vol 72 (Suppl_1) ◽  
Author(s):  
Edwin K Jackson ◽  
Zaichuan Mi ◽  
Thomas R Kleyman ◽  
Dongmei Cheng
Keyword(s):  
Mechanism Of Action ◽  
Excretory Function ◽  
Renal Excretory Function

Aortic blood flow subtraction: an alternative method for measuring total renal blood flow in conscious dogs

2002 ◽  
Vol 282 (5) ◽  
pp. R1528-R1535 ◽  
Author(s):  
N. C. F. Sandgaard ◽  
J. L. Andersen ◽  
N.-H. Holstein-Rathlou ◽  
P. Bie
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Renal Blood Flow ◽  
Aortic Blood Flow ◽  
Excretory Function ◽  
Endothelin 1 ◽  
Arterial Blood ◽  
Aortic Blood ◽  
Bilateral Carotid ◽  
Total Renal Blood Flow

We have measured total renal blood flow (TRBF) as the difference between signals from ultrasound flow probes implanted around the aorta above and below the renal arteries. The repeatability of the method was investigated by repeated, continuous infusions of angiotensin II and endothelin-1 seven times over 8 wk in the same dog. Angiotensin II decreased TRBF (350 ± 16 to 299 ± 15 ml/min), an effect completely blocked by candesartan (TRBF 377 ± 17 ml/min). Subsequent endothelin-1 infusion reduced TRBF to 268 ± 20 ml/min. Bilateral carotid occlusion (8 sessions in 3 dogs) increased arterial blood pressure by 49% and decreased TRBF by 12%, providing an increase in renal vascular resistance of 69%. Dynamic analysis showed autoregulation of renal blood flow in the frequency range <0.06–0.07 Hz, with a peak in the transfer function at 0.03 Hz. It is concluded that continuous measurement of TRBF by aortic blood flow subtraction is a practical and reliable method that allows direct comparison of excretory function and renal blood flow from two kidneys. The method also allows direct comparison between TRBF and flow in the caudal aorta.

Renal hemodynamics in rats with myocardial infarction: selective antagonism of angiotensin receptor subtypes

1996 ◽  
Vol 271 (6) ◽  
pp. H2306-H2312 ◽  
Author(s):  
P. F. Mento ◽  
M. E. Maita ◽  
B. M. Wilkes
Keyword(s):  
Myocardial Infarction ◽  
Angiotensin Ii ◽  
Peripheral Resistance ◽  
Renal Hemodynamics ◽  
Coronary Artery Ligation ◽  
Receptor Subtypes ◽  
At2 Receptor ◽  
Angiotensin Ii Receptor ◽  
Artery Ligation ◽  
Excretory Function

Rats with congestive heart failure demonstrate striking intrarenal vasoconstriction that contributes to reduced renal excretory function. The importance of specific angiotensin II receptor subtypes (AT1, AT2) for mediating changes in renal hemodynamics was studied in anesthetized rats 1 mo after myocardial infarction (MI) created by coronary artery ligation. AT1 antagonism with losartan alone decreased mean arterial pressure (MAP), total peripheral resistance (TPR), and renal resistance (RR) in control and MI rats to a similar extent without affecting renal blood flow (RBF) or RBF as a percentage of cardiac output (%RBF/CO). In contrast, AT2 antagonism with PD-123319 alone significantly reduced MAP and RR in MI rats without affecting these parameters in control rats. TPR and %RBF/CO were not changed significantly in either group. In contrast, combined AT1- and AT2-receptor inhibition lowered TPR and RR and increased RBF and %RBF/CO, thus the effects of renin or ACE inhibition were mimicked in MI rats. We conclude that angiotensin II acts at both AT1 and AT2 receptor sites in rats with reduced cardiac mass to modulate renal hemodynamics.

scholarly journals STUDIES ON EXPERIMENTAL HYPERTENSION

1941 ◽  
Vol 73 (3) ◽  
pp. 439-451 ◽  
Author(s):  
Harry Goldblatt ◽  
Harry Weinstein ◽  
Joseph R. Kahn
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Arterial Occlusion ◽  
Experimental Hypertension ◽  
Excretory Function ◽  
Main Renal Artery ◽  
Significant Impairment ◽  
Temporary Occlusion ◽  
Renal Origin ◽  
Renal Excretory Function

By means of a silver chain attached to a silver ring around the main renal artery, intermittent renal arterial occlusion, up to 30 minutes daily, was practiced for as long as 5 months in unilaterally nephrectomized dogs. This did not result in the development of persistently elevated blood pressure. Persistent moderate constriction of the renal artery of such animals by a silver clamp, after intermittent temporary occlusion had failed to affect the blood pressure, produced the usual rise of blood pressure, without accompanying significant impairment of renal excretory function. When the renal artery accidentally became persistently constricted to a great degree, or actually occluded, or if occlusion was deliberately produced by continuous pulling of the chain, hypertension and renal insufficiency (the malignant phase) quickly developed. The results do not lend support to the view that brief daily periods of renal ischemia from intrarenal vasospasm, or from any other cause, can produce persistent hypertension of renal origin.

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