Acute Effects of Acetazolamide (Diamox) on Plasma and Urinary Electrolytes of Dogs With Special Reference to Calcium

1957 ◽  
Vol 191 (2) ◽  
pp. 388-392 ◽  
Author(s):  
Smith Freeman ◽  
Anne B. Jacobsen
Keyword(s):  
Carbon Dioxide ◽  
Plasma Concentration ◽  
Chloride Concentration ◽  
Total Plasma ◽  
Acute Effects ◽  
Plasma Phosphate ◽  
Sodium Potassium ◽  
Excretory Function ◽  
Acute Increase ◽  
Renal Excretory Function

Administration of Diamox by ingestion or injection to adult fasting female dogs consistently produced an acute increase of approximately 1 mg % in the plasma concentration of calcium. At the same time there was an increase in the plasma phosphate and chloride concentration and a decrease in total plasma content of carbon dioxide of Diamox-infused dogs. Diamox did not affect the plasma concentration of calcium, chloride or bicarbonate if renal excretory function was abolished prior to its administration. Infusion of Diamox produced a prompt rise in the urinary excretion of sodium, potassium, calcium, phosphate, citrate, chloride and water in fasting female dogs. The effect of Diamox on the fasting concentration of calcium rendered unsatisfactory the interpretation of data concerned with a study of its effect on the disappearance of injected calcium. However, intravenous injection of small amounts of sodium carbonate was found to produce a definite delay in the rate of disappearance of injected calcium.

scholarly journals ANALYSIS OF INFLUENCE OF RUTIN AND GRAVITY ACTION ON THE RENAL EXCRETORY FUNCTION

2016 ◽  
Vol 1 (4) ◽  
pp. 47-50
Author(s):  
E N Zaitceva ◽  
A V Dubishchev ◽  
V A Kurkin
Keyword(s):  
Tubular Reabsorption ◽  
Diuretic Activity ◽  
Sodium Potassium ◽  
Water Load ◽  
Excretory Function ◽  
Series Of Experiments ◽  
Complex Influence ◽  
Renal Excretory Function ◽  
Tubular Component ◽  
Stimulation Of

Aim - to analyze the effect of rutin on the renal excretory function in the conditions of normogravity and hypergravity. Materials and methods. 9 series of experiments were conducted, including 4 series with the use of a centrifuge of ultra-short radius. The effect of rutin in the dose of 10 mg/kg on the renal excretory function was studied in normal conditions and in combination with the gravity action 3g. All the animals received 3% water load intragastrically and were placed into exchange cages for 24 hours. We obtained urine samples and determined the amount and the concentration of sodium, potassium and creatinine. Results. It was found that under normal conditions rutin, administered intragastrically in a dose of 10 mg/kg, promotes significant increase in diuresis and saluresis solely due to the inhibition of tubular reabsorption. Rutin in a dose of 10 mg/kg in combination with the gravity action enhances its original diuretic activity by complex influence on tubular and glomerular kidney structures. Rutin alone and rutin in combination with hypergravity stimulates the excretory function of the kidneys similarly to hydrochlorothiazide, but has a shorter latent period. Conclusion. The use of rutin combined with the gravity action contributes to the stimulation of the renal excretory function not only due to the tubular component, but also due to the glomerular one.

THE RELATIONSHIP OF THE SODIUM, POTASSIUM, AND CHLORIDE CONCENTRATION OF THE FEEDING TO THE WEIGHT GAIN OF PREMATURE INFANTS

PEDIATRICS ◽  
1962 ◽  
Vol 30 (6) ◽  
pp. 909-916
Author(s):  
Herbert I. Goldman ◽  
Samuel Karelitz ◽  
Hedda Acs ◽  
Eli Seifter
Keyword(s):  
Weight Gain ◽  
Sodium Chloride ◽  
Human Milk ◽  
Premature Infants ◽  
Chloride Concentration ◽  
The Other ◽  
Milk Formula ◽  
Sodium Potassium ◽  
Relationship Of ◽  
The Relationship

One hundred four healthy premature infants, of birth weight 1,000 to 1,800 gm, were fed one of five feedings: (1) human milk; (2) human milk plus 13 meq/l of sodium chloride; (3) human milk plus 13 meq/l of sodium chloride and 18 meq/l of potassium chloride; (4) a half-skimmed cows milk formula; and (5) a partially-skimmed vegetable oil, cows milk formula. The infants fed any of the three human milk formulas gained weight at a slower rate than the infants fed either of the two cows milk formulas. Infants whose diets were changed from unmodified human milk to the half-skimmed cows milk gained large amounts of weight, and at times were visibly edematous. Infants whose diets were changed from the human milks with added sodium chloride, to the half-skimmed cows milk, gained lesser amounts of weight and did not become edematous. The infants fed the two cows milk diets gained similar amounts of weight, although one diet provided 6.5 gm/kg/day, the other 3.1 gm/kg/day of protein.

Cardiovascular and renal effects of hypoxia in conscious carotid body-denervated rats

1993 ◽  
Vol 74 (6) ◽  
pp. 2795-2800 ◽  
Author(s):  
R. Behm ◽  
H. Mewes ◽  
W. H. DeMuinck Keizer ◽  
T. Unger ◽  
R. Rettig
Keyword(s):  
Carotid Body ◽  
Normobaric Hypoxia ◽  
Sodium Potassium ◽  
Water Excretion ◽  
Excretory Function ◽  
Arterial Blood ◽  
Peripheral Arterial ◽  
Renal Responses ◽  
Arterial Po2 ◽  
Sodium And Potassium

The contribution of peripheral arterial chemoreceptors to cardiovascular and renal responses to acute hypocapnic hypoxia is currently not well understood. We compared the effects of normobaric hypoxia on mean arterial blood pressure (MABP), heart rate, glomerular filtration rate (GFR), renal blood flow (RBF), and renal volume and electrolyte excretion in conscious unilaterally nephrectomized carotid body-denervated (n = 10) and sham-operated (n = 10) control rats. Thirty minutes of normobaric hypoxia (12.5% O2) resulted in significant reductions in arterial PO2 and PCO2 as well as decreases in MABP, GFR, RBF, and renal sodium, potassium, and water excretion. These effects occurred more rapidly and/or were significantly more pronounced in carotid body-denervated than in sham-operated rats. These data indicate that moderate acute hypocapnic hypoxia has profound effects on systemic and renal hemodynamics as well as on renal excretory function in conscious rats. We conclude that stimulation of the peripheral arterial chemoreceptors can partially offset the hypoxia-induced decreases in MABP, RBF, GFR, urine flow, and urinary sodium and potassium excretion, thereby helping to maintain cardiovascular as well as fluid and electrolyte homeostasis.

Abstract 067: Mechanism of Action of 8-Aminoguanine on Renal Excretory Function

Hypertension ◽  
2018 ◽  
Vol 72 (Suppl_1) ◽  
Author(s):  
Edwin K Jackson ◽  
Zaichuan Mi ◽  
Thomas R Kleyman ◽  
Dongmei Cheng
Keyword(s):  
Mechanism Of Action ◽  
Excretory Function ◽  
Renal Excretory Function

Bound sodium in artery wall

1960 ◽  
Vol 199 (5) ◽  
pp. 783-787 ◽  
Author(s):  
Verle E. Headings ◽  
Paul A. Rondell ◽  
David F. Bohr
Keyword(s):  
Carotid Artery ◽  
Potassium Concentration ◽  
Chloride Concentration ◽  
Chloride Content ◽  
Krebs Solution ◽  
Artery Wall ◽  
Sodium Potassium ◽  
Inulin Space ◽  
Excess Sodium ◽  
Total Sodium

Analyses were made of total sodium, potassium and chloride content and of inulin space in dog carotid artery. The Ki/Ko gradient was found to be 125/4. Sodium space calculated from these analyses is larger than total hydration, thus precluding calculation of the Nai/No gradient. It is postulated that the excess sodium is associated with the mucopolysaccharides present in the interstitial spaces of the artery wall media. This associated sodium is readily replaced during 3-minute incubation of the artery wall media in Krebs' solution in which either the hydrogen or the potassium concentration is increased. It appears improbable that the majority of the excess sodium can be attributed to a Donna equilibrium since chloride concentration in the incubated tissue is much greater than that calculated to be required for this equilibrium.

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