Clinical case of recurrent vomiting in a child: diagnostic search from functional gastrointestinal disorders to piloid astrocytoma

2021 ◽  
Vol 19 (1) ◽  
pp. 78-81
Author(s):  
E. N. Voronina ◽  
◽  
D. V. Pechkurov ◽  
A. A. Tyazheva ◽  
E. V. Kozarez ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Nutritional Status ◽  
Clinical Case ◽  
Anxiety Symptom ◽  
Functional Gastrointestinal Disorders ◽  
Integrated Approach ◽  
Gastrointestinal Disorders ◽  
Wide Range ◽  
High Prevalence ◽  
Recurrent Vomiting

The urgency of the problem of recurrent vomiting in children is due not only to the high prevalence of this syndrome, but also to a wide range of reasons for its development. The article presents a clinical case of observation of a child with recurrent vomiting syndrome. It shows the dynamics of the disease, the importance of identifying such «anxiety symptom» as the nutritional status violation. In this case, the cause of vomiting of central genesis was not immediately taken into account, although differential diagnosis presupposes an integrated approach, and doctors' oncological alertness should be constantly preserved even in pediatrics.

Calprotectin (S100 A8/A9) and TNF-alpha in differential diagnosis of chronic abdominal pain in children

2017 ◽  
Vol 53 (1) ◽  
pp. 5-10
Author(s):  
Stanisław Pieczarkowski ◽  
Kinga Kowalska-Duplaga ◽  
Andrzej Wędrychowicz ◽  
Krzysztof Fyderek ◽  
Przemko Kwinta ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Functional Gastrointestinal Disorders ◽  
Fecal Calprotectin ◽  
Chronic Abdominal Pain ◽  
Tnf Alpha ◽  
Gastrointestinal Disorders ◽  
Control Group ◽  
Healthy Children ◽  
Inflammatory Bowel

<i>Introduction:</i> Chronic abdominal pain in children is a very frequent and sometimes challenging diagnostic issue. Differential diagnosis in that cases is difficult and often connected with numerous, time-consuming, expensive, and frequently stressful diagnostic studies. The aim of the study was to establish whether fecal calprotectin concentration (FCC) and TNF-alpha may be useful in children with chronic abdominal pain to differentiate between inflammatory bowel disease (IBD), other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders. Methods. The study included patients (median age 13 years), who were assigned to functional gastrointestinal disorders group (n=33); inflammatory gastrointestinal disorders other than IBD (n=71), children with IBD (n=37) and 22 healthy children served as a control group. The concertation of FCC and TNF-alpha in stool samples was measured using ELISA. <i>Results:</i> In healthy children and in children with functional disorders FCCs were below 100 μg/g. In patients with IBD FCCs and TNF-alpha were markedly elevated as compare to children with functional gastrointestinal disorders, however using ROC discrimination of IBD patients was significantly better using FCC than TNF-alpha. <i>Conclusion:</i> FCC is better test for differentiation between IBD, other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders as compare to TNF-alpha concentration in stool. FCC as screening test in patients with chronic abdominal pain should allow to diminish unnecessary diagnostic in cases of functional gastrointestinal disorders.

scholarly journals Approaches to the Modulation of Abdominal Pain

1999 ◽  
Vol 13 (suppl a) ◽  
pp. 66A-70A ◽  
Author(s):  
Emeran A Mayer ◽  
Tony Lembo ◽  
Lin Chang
Keyword(s):  
Disease Model ◽  
Functional Gastrointestinal Disorders ◽  
Great Majority ◽  
Gastrointestinal Disorders ◽  
Dorsal Horn Neurons ◽  
Afferent Nerves ◽  
Calcitonin Gene ◽  
High Prevalence ◽  
The Central Nervous System ◽  
Neurokinin 1

Despite their high prevalence and significant economic impact on the health care system, functional gastrointestinal disorders have evaded successful therapy. Conventional medical therapies are based on inadequate disease models, and the great majority of published treatment trials are flawed in their design, permitting no conclusions to be drawn about the true efficacy of any particular treatment. During the past several years, a new, comprehensive disease model based on alterations in brain-gut interactions has rapidly evolved. Even though the precise mechanisms and sites underlying these alterations remain incompletely understood, plausible targets for the development of effective pharmacological treatments are receptors on peripheral terminals of visceral afferent nerves (opioids and serotonin), ion channels and receptors on dorsal horn neurons within the spinal cord (opioids, glutamate, calcitonin gene-related peptide and neurokinin-1), and supraspinal targets in the brainstem within the limbic system and in the prefrontal cortex (serotonin, catecholamines, dopamine and acetylcholine). Regardless of the primary pathophysiology underlying functional gastrointestinal disorders (ie, central versus peripheral), different pharmacological strategies targeted at different sites in the periphery or within the central nervous system may become effective therapies in the future.

Tu1798 High Prevalence of Joint Hypermobility Syndrome in Patients With Functional Gastrointestinal Disorders

2016 ◽  
Vol 150 (4) ◽  
pp. S950
Author(s):  
Valeria Schindler ◽  
Jonas Zeitz ◽  
Arndt F. van Maren ◽  
Michael Scharl ◽  
Michael Fried ◽  
...  
Keyword(s):  
Functional Gastrointestinal Disorders ◽  
Joint Hypermobility ◽  
Gastrointestinal Disorders ◽  
Hypermobility Syndrome ◽  
Joint Hypermobility Syndrome ◽  
High Prevalence

scholarly journals Poorly Differentiated Chordoma: Case Review

2020 ◽  
Vol 3 (4) ◽  
pp. 86-93
Author(s):  
N. V. Kochergina ◽  
I. V. Boulytcheva ◽  
S. N. Prokhorov ◽  
A. B. Bludov ◽  
A. V. Fеdorova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Research Methods ◽  
Female Patient ◽  
Clinical Case ◽  
Immunohistochemical Study ◽  
Case Review ◽  
Immunohistochemical Examination ◽  
Imaging Methods ◽  
Wide Range ◽  
Poorly Differentiated

Purpose: Demonstrate a clinical case of poorly differentiated chordoma, confirmed using a wide range of research methods.Material and methods: A 63-year-old female patient with poorly differentiated chordoma who underwent immunohistochemical examination, MRI, CT and scintigraphy.Results: An immunohistochemical study confirmed the morphological affiliation of the tumor, supplemented by the data of imaging methods.Conclusion: The poorly differentiated type of chordoma has a specific immunohistochemical picture, however, differential diagnosis based on imaging methods is currently a difficult task.

scholarly journals Functional gastrointestinal disorders: a review of the main provisions of the Rome IV consensus

2019 ◽  
Vol 4 (2) ◽  
pp. 9-15
Author(s):  
Osadchuk AM ◽  
Davydkin IL ◽  
Gritsenko TA ◽  
Kurtov IV
Keyword(s):  
Differential Diagnosis ◽  
Functional Gastrointestinal Disorders ◽  
Abdominal Distention ◽  
Gastrointestinal Disorders ◽  
Abdominal Bloating ◽  
Social Importance ◽  
Rome Iv

Objectives - the review presents the analysis of the main changes in Rome IV. The subsequent Rome IV consensus focused on the etiology, pathogenesis, diagnosis and differential diagnosis of the functional gastrointestinal disorders. It updated some definitions of the functional gastrointestinal disorders; opioid-induced constipation was set as a separate disorder; functional abdominal distention was considered specific for functional abdominal bloating as both disorders are often combined and do not replace each other. The functional gastrointestinal disorders still remain of the high medico-social importance as they are endemic, refractory and cause long-term disability.

An integrated approach to the pathogenetic therapy of constipation

2021 ◽  
pp. 31-35
Author(s):  
Sergey Gennadievich Burkov
Keyword(s):  
Mineral Water ◽  
Functional Gastrointestinal Disorders ◽  
Integrated Approach ◽  
Gastrointestinal Disorders ◽  
Intestinal Pathology ◽  
Pathogenetic Therapy ◽  
Physiological Abnormalities ◽  
Normal Defecation ◽  
Defecation Disorders ◽  
Mucous Barrier

The data on the causes of defecation disorders, mechanisms of normal defecation, and pathogenetic aspects of constipation are presented. Functional gastrointestinal disorders are considered as a common pathology of the gastrointestinal tract, which is based on combined morphological and physiological abnormalities associated with visceral hypersensitivity, disorders of gastrointestinal motility, protective mucous barrier, immune function and the composition of the intestinal microbiota. The article discusses the possibility of using the drinking medicinal mineral water Zajecicka Horka (Zayechitskaya bitter) for intestinal pathology and other functional gastrointestinal disorders.

Functional gastrointestinal disorders: focus on the differential diagnosis of heartburn

Pharmateca ◽  
2020 ◽  
Vol 2_2020 ◽  
pp. 24-30
Author(s):  
Yu.P. Uspensky Uspensky ◽  
A.A. Gnutov Gnutov ◽  
N.V. Baryshnikov Baryshnikov ◽  
O.S. Mirzoev Mirzoev ◽  
◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders

scholarly journals Irritable bowel syndrome: towards an integrated approach

1999 ◽  
Vol 4 (1) ◽  
pp. 45-46 ◽  
Author(s):  
Anita D Stuart ◽  
H Gertie Pretorius ◽  
Lynette Van der Merwe
Keyword(s):  
North Carolina ◽  
Irritable Bowel Syndrome ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Symptoms ◽  
Integrated Approach ◽  
Gastrointestinal Disorders ◽  
University Of North Carolina ◽  
Irritable Bowel ◽  
The Impact

Functional Gastrointestinal Disorders are defined as chronic or recurrent gastrointestinal symptoms characterized by abdominal pain, constipation and/or diarrhoea (Tally, 1994; University of North Carolina, 1998). These disorders are of concern because of their high incidence, associated morbidity, expense and the impact of these disorders on people's quality of life. Drossman (1993, in University of North Carolina (UNC), 1998) found that of 5 400 U.S. households, 69% of people met the criteria for at least one of the functional gastrointestinal disorders which represents a 59% increase in the incidence of functional gastrointestinal disorders since 1983 (Drossman, in UNC, 1998; Drossman, 1983). In particular, Irritable Bowel Syndrome (IBS) sufferers account for 2,4 - 3,5 million visits to doctors annually. Furthermore, IBS sufferers spend $40 million annually on treatment for their condition. They also tend to have 3 to 4 times more disability days than other workers, which illustrates the debilitating effect of this disorder (Drossman, in UNC, 1998). It is therefore necessary that the etiology of IBS be researched, as well as the course and management of this debilitating disease. The studies presented in this series aimed to improve the understanding of the multiple agents that influence the development and course of IBS.

scholarly journals Clinical case of Scheuermann-Mau disease – reminiscence of a century-long history

2021 ◽  
Vol 5 ◽  
pp. 111-116
Author(s):  
P.A. Shesternya ◽  
◽  
O.D. Gritsenko ◽  
A.A. Masterova ◽  
A.O. Vasileva ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Adult Patient ◽  
Clinical Case ◽  
Diagnosis And Treatment ◽  
Newly Diagnosed ◽  
Wide Range

Modern strategy for management of spondyloarthritis (SpA) is aimed at the earliest possible diagnosis and treatment of diseases. Emergence of nonradiographic SpA in clinical practice necessitates differential diagnosis of this condition from a wide range of diseases including juvenile spondylodysplasia. The article presents a clinical case of newly-diagnosed Scheuermann-Mau disease in an adult patient

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