Wireless parathyroid detection device using autofluorescence and smart glasses: A preliminary study

2021 ◽  
pp. 1-9
Author(s):  
Chang Hwan Ryu ◽  
Jungirl Seok ◽  
Yu Lim Choi ◽  
Seok-ki Kim ◽  
Yuh-Seog Jung ◽  
...  
Keyword(s):  
Prospective Study ◽  
Large Scale ◽  
Video Recording ◽  
Controlled Study ◽  
Autofluorescence Imaging ◽  
Agreement Rate ◽  
Smart Glasses ◽  
Practical Effect ◽  
Preliminary Study ◽  
Positive Agreement

BACKGROUND: Autofluorescence imaging technology has been utilized for preserving or identifying parathyroid glands (PTGs) during thyroid surgery. We developed a wireless PTGs detection device linked with smart glasses that allows for real-time video recording and screen switching according to the light source. OBJECTIVE: This study aimed to confirm the feasibility of the device and whether it would help preserve the PTG during the surgery. METHODS: This prospective study was conducted in 30 patients with 66 PTGs. The device’s agreement with the physician’s judgment was evaluated, and we determined how many PTGs were preserved from thyroidectomy. RESULTS: The positive agreement rate for PTGs detection between the surgeon and device was 70.9%. Inadvertent parathyroidectomy was identified in surgical specimens of 6 patients (20%). No PTG was removed when it was confirmed by the device (0/39). Of the 27 glands not detected by the device, there was inadvertent removal of 6 PTGs. CONCLUSIONS: PTGs can be preserved successfully when the detection of them by the device is consistent with the surgeon’s discretion. A large-scale controlled study is necessary to demonstrate the practical effect of this device on hypoparathyroidism after thyroidectomy.

scholarly journals Effect of teriparatide in fracture healing of intertrochanteric fracture: a prospective study

2018 ◽  
Vol 4 (6) ◽  
pp. 918
Author(s):  
Sanjeev K. Singhal ◽  
Naresh Aggarwal ◽  
Ajay Sharma
Keyword(s):  
Prospective Study ◽  
Fracture Healing ◽  
Large Scale ◽  
Intertrochanteric Fracture ◽  
Calcium Supplementation ◽  
Geriatric Trauma ◽  
Controlled Study ◽  
Control Group ◽  
Intertrochanteric Fractures ◽  
Early Return

<p class="abstract"><strong>Background:</strong> Intertrochanteric fracture is a relatively common and serious medical issue in geriatric trauma result in serious health problems and decrease health related quality of life. Faster time-to-union is important for early return to daily activities and reduction of complications. Teriparatide has been shown to accelerate fracture-healing. The purpose of the present prospective, randomized, controlled study was to evaluate the effect of teriparatide on the course of intertrochanteric fracture-healing.</p><p class="abstract"><strong>Methods:</strong> Forty patients of intertrochanteric fractures who underwent surgical intervention between June 2016 and May 2017 were enrolled in this prospective study and followed for minimum of six months. Group A included patients who received only calcium supplementation; patients in Group B received teriparatide along with calcium supplementation postoperatively.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean time to fracture healing was between 8-12 weeks for the treatment group, compared with 12-16 weeks for the control group. There was also significant effectiveness with regards to Parker and Palmer mobility score at 6 months.</p><p class="abstract"><strong>Conclusions:</strong> Postoperative use of teriparatide for 6 months appears to be an effective adjunct therapy in the treatment of patients with intertrochanteric fractures. However, because of the limited power of the study a large-scale cohort study is still required for determining the efficacy of teriparatide.</p>

scholarly journals Attendance, activation and health profiles of participants, a prospective study on a regional cardiometabolic disease self-management program in Laval, Canada

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Magali Girard ◽  
Janusz Kaczorowski ◽  
Marie-Thérèse Lussier ◽  
Vivianne Martin
Keyword(s):  
Primary Care ◽  
Waist Circumference ◽  
Prospective Study ◽  
Cardiovascular Health ◽  
Descriptive Analysis ◽  
Management Program ◽  
Self Management ◽  
Controlled Study ◽  
Cardiometabolic Disease ◽  
A Prospective Study

Abstract Background Chronic diseases are responsible for over 70% of all deaths globally. While some self-management programs have been shown to be efficacious in preventing or altering trajectories for some chronic conditions, scaling-up and sustaining such programs beyond tightly-controlled study conditions remain a major challenge. CISSS-Laval partnered with the Cardiovascular Health Awareness Program team to co-develop Cible-santé/prévention and evaluate the first cohort of participants enrolled in the program, in order to better understand the program’s implementation and scope. The objective of the current study was to describe the profile of attendees and the level of engagement of participants in a new, region-wide cardiometabolic disease self-management program offered in Laval, Canada. Methods This was a prospective study with no comparison group. Potential participants were identified and referred to the program from April to December 2015 by their primary care health professional practicing in one of the city’s interdisciplinary primary care clinics. They had their blood pressure, waist circumference and body mass index measured by trained volunteers, and completed a questionnaire on health habits, level of activation and the risk of developing prediabetes and type 2 diabetes over the next 10 years. Results A descriptive analysis of the first cohort of 141 Cible-Santé/prévention participants showed very low attendance. Furthermore, only 1 in 10 of enrolled participants completed the full program. The program typically attracted adults with some risk factors associated with their conditions (high waist circumference, obesity), but with an already high level of knowledge, skills and confidence to participate in self-management activities. Conclusion This study provides a portrait of new participants to a self-management cardiometabolic disease program, which highlights the potential of supporting patients ready to make changes but also exposes the difficulty of attracting a larger number and diversity of participants and in encouraging completion of the program.

scholarly journals Impact of a Smart-Ring-Based Feedback System on the Quality of Chest Compressions in Adult Cardiac Arrest: A Randomized Preliminary Study

2021 ◽  
Vol 18 (10) ◽  
pp. 5408
Author(s):  
Chiwon Ahn ◽  
Seungjae Lee ◽  
Jongshill Lee ◽  
Jaehoon Oh ◽  
Yeongtak Song ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Feedback System ◽  
Controlled Study ◽  
Feedback Group ◽  
Compression Depth ◽  
System Usability Scale ◽  
The Mean ◽  
Preliminary Study ◽  
The Ideal

This study aimed to assess the effectiveness of a novel chest compression (CC) smart-ring-based feedback system in a manikin simulation. In this randomized, crossover, controlled study, we evaluated the effect of smart-ring CC feedback on cardiopulmonary resuscitation (CPR). The learnability and usability of the tool were evaluated with the System Usability Scale (SUS). Participants were divided into two groups and each performed CCs with and without feedback 2 weeks apart, using different orders. The primary outcome was compression depth; the proportion of accurate-depth (5–6 cm) CCs, CC rate, and the proportion of complete CCs (≤1 cm of residual leaning) were assessed additionally. The feedback group and the non-feedback group showed significant differences in compression depth (52.1 (46.3–54.8) vs. 47.1 (40.5–49.9) mm, p = 0.021). The proportion of accurate-depth CCs was significantly higher in the interventional than in the control condition (88.7 (30.0–99.1) vs. 22.6 (0.0–58.5%), p = 0.033). The mean SUS score was 83.9 ± 8.7 points. The acceptability ranges were ‘acceptable’, and the adjective rating was ‘excellent’. CCs with smart-ring feedback could help achieve the ideal range of depth during CPR. The smart-ring may be a valuable source of CPR feedback.

Wideband Absorbance in Ears with Retraction Pockets and Cholesteatomas: A Preliminary Study

2021 ◽  
Author(s):  
Sreedevi Aithal ◽  
Venkatesh Aithal ◽  
Joseph Kei ◽  
Shane Anderson
Keyword(s):  
Prospective Study ◽  
Roc Curve ◽  
Operating Characteristic ◽  
Peak Pressure ◽  
Clinical Sample ◽  
Ambient Pressure ◽  
Control Group ◽  
Retraction Pockets ◽  
Preliminary Study ◽  
The Difference

Abstract Objectives The objective of this study was to describe wideband absorbance (WBA) findings in patients with cholesteatomas and retraction pockets (RPs). Design In this prospective study, tympanometry, audiometry, and wideband tympanometry (WBT) were performed on 27 ears with an RP (eight with epitympanic RP and 19 ears with mesotympanic RP), 39 ears with a cholesteatoma (23 ears with epitympanic and 16 ears with mesotympanic cholesteatomas [MCs]), and 49 healthy ears serving as controls. Results Mean WBA at ambient pressure (WBAamb) of both experimental groups was reduced significantly between 0.8 and 5 kHz relative to the control group. The difference between mean WBAamb and mean WBA at tympanometric peak pressure (WBATPP) was greater for the RP (0.12–0.16 between 0.5 and 1.5 kHz) than for the cholesteatoma group (0.03–0.11 between 0.6 and 3 kHz). Mean WBAamb of both epitympanic RP (ERP) and epitympanic cholesteatoma (EC) subgroups was significantly lower than that of the control group. Mean WBATPP of the ERP subgroup attained normal levels as per the control group, while mean WBATPP of EC subgroup was significantly lower than that of the control group at 0.8 to 1.5 kHz and 4 to 5 kHz. In contrast, both mesotympanic RP and MC subgroups demonstrated similar mean WBAamb and WBATPP values. No significant differences in WBAamb and WBATPP results between the RP and cholesteatomas groups were observed. Receiver operating characteristic (ROC) analyses indicated that the area under the ROC curve for distinguishing between the RP and cholesteatomas groups ranged from 0.44 to 0.60, indicating low accuracy in separating the two groups. Conclusion While it is not possible to distinguish between the RP and cholesteatomas groups based on the WBAamb and WBATPP results, it is potentially feasible to differentiate between the EC and ERP conditions. Further study using a large clinical sample is recommended to determine the sensitivity and specificity of the WBA test to identify the EC and ERP conditions.

scholarly journals Effects of Human Presence and Voice on the Behaviour of Shelter Dogs and Cats: A Preliminary Study

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 406
Author(s):  
Adele Tuozzi ◽  
Christine Arhant ◽  
Kristina Anderle ◽  
Jessica Backes ◽  
Catherine Cords ◽  
...  
Keyword(s):  
Animal Welfare ◽  
Video Recording ◽  
Auditory Stimulation ◽  
Vertical Dimension ◽  
Physical Contact ◽  
Gaze Direction ◽  
Human Presence ◽  
Reading Condition ◽  
Shelter Dogs ◽  
Preliminary Study

Reading books to shelter animals combining auditory enrichment with human presence is increasingly used although its effects on animal welfare have not yet been investigated. This study compared the behaviour of single-housed shelter dogs and cats during a prerecorded reading condition in the absence or presence of an unfamiliar human (without direct physical contact). Fourteen dogs and twenty-one cats were observed in their enclosure in the two conditions in a counterbalanced order. Behaviours such as scratching the door, gaze direction and location in relation to the audio source/human were analysed from video recording for 10 min per condition. Dogs spent more time in their bed (p < 0.047) and looking at the auditory source (p < 0.004) when a human was present. Cats showed door scratching and rubbing when a human was present (p < 0.043), whereas they tended to spend more time in the vertical dimension (p = 0.051), where the hiding boxes were located, during auditory stimulation without a human present. These results show that the presence of a human induces greater interest compared to just audio stimulation in shelter dogs and cats but may induce frustration likely due to not being able to physically interact in some animals.

scholarly journals Large Scale, Multicenter, Prospective Study of Apatinib in Advanced Gastric Cancer: A Real-World Study from China [Corrigendum]

2020 ◽  
Vol Volume 12 ◽  
pp. 8409-8410
Author(s):  
Wanren Peng ◽  
Fenglin Zhang ◽  
Zishu Wang ◽  
Dongliang Li ◽  
Yifu He ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prospective Study ◽  
Advanced Gastric Cancer ◽  
Real World ◽  
Large Scale ◽  
Multicenter Prospective Study

scholarly journals A novel dynamic network imaging analysis method reveals aging-related fragmentation of cortical networks in mouse

2019 ◽  
Author(s):  
Daniel A Llano ◽  
Chihua Ma ◽  
Umberto Di Fabrizio ◽  
Aynaz Taheri ◽  
Kevin A. Stebbings ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Large Scale ◽  
Brain Slices ◽  
Dynamic Network ◽  
Analytical Tool ◽  
Aging Brain ◽  
Autofluorescence Imaging ◽  
Imaging Data ◽  
Cortical Networks ◽  
Network Metrics

AbstractNetwork analysis of large-scale neuroimaging data has proven to be a particularly challenging computational problem. In this study, we adapt a novel analytical tool, known as the community dynamic inference method (CommDy), which was inspired by social network theory, for the study of brain imaging data from an aging mouse model. CommDy has been successfully used in other domains in biology; this report represents its first use in neuroscience. We used CommDy to investigate aging-related changes in network parameters in the auditory and motor cortices using flavoprotein autofluorescence imaging in brain slices and in vivo. Analysis of spontaneous activations in the auditory cortex of slices taken from young and aged animals demonstrated that cortical networks in aged brains were highly fragmented compared to networks observed in young animals. Specifically, the degree of connectivity of each activated node in the aged brains was significantly lower than those seen in the young brain, and multivariate analyses of all derived network metrics showed distinct clusters of these metrics in young vs. aged brains. CommDy network metrics were then used to build a random-forests classifier based on NMDA-receptor blockade data, which successfully recapitulated the aging findings, suggesting that the excitatory synaptic substructure of the auditory cortex may be altered during aging. A similar aging-related decline in network connectivity was also observed in spontaneous activity obtained from the awake motor cortex, suggesting that the findings in the auditory cortex are reflections of general mechanisms that occur during aging. Therefore, CommDy therefore provides a new dynamic network analytical tool to study the brain and provides links between network-level and synaptic-level dysfunction in the aging brain.

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