scholarly journals Epidemiology of tick-borne encephalitis in Poland (2010-2019) and the impact of the COVID-19 pandemic on the notified incidence of the disease

2021 ◽  
Keyword(s):  
Tick Borne Encephalitis ◽  
The Impact

scholarly journals The Impact of Tick-Borne Diseases on the Bone

2021 ◽  
Vol 9 (3) ◽  
pp. 663
Author(s):  
Imran Farooq ◽  
Tara J. Moriarty
Keyword(s):  
Bone Marrow ◽  
Lyme Disease ◽  
Bone Loss ◽  
Human Body ◽  
Virus Disease ◽  
Hemorrhagic Fever ◽  
Research Literature ◽  
Tick Borne Encephalitis ◽  
Bone Marrow Function ◽  
The Impact

Tick-borne infectious diseases can affect many tissues and organs including bone, one of the most multifunctional structures in the human body. There is a scarcity of data regarding the impact of tick-borne pathogens on bone. The aim of this review was to survey existing research literature on this topic. The search was performed using PubMed and Google Scholar search engines. From our search, we were able to find evidence of eight tick-borne diseases (Anaplasmosis, Ehrlichiosis, Babesiosis, Lyme disease, Bourbon virus disease, Colorado tick fever disease, Tick-borne encephalitis, and Crimean–Congo hemorrhagic fever) affecting the bone. Pathological bone effects most commonly associated with tick-borne infections were disruption of bone marrow function and bone loss. Most research to date on the effects of tick-borne pathogen infections on bone has been quite preliminary. Further investigation of this topic is warranted.

scholarly journals THE IMPACT OF GLOBAL CLIMATE CHANGE ON THE INCIDENCE OF TICK-BORNE ENCEPHALITIS IN THE EUROPEAN PART OF THE RUSSIAN ARCTIC

2019 ◽  
Vol 8 (4) ◽  
pp. 551
Author(s):  
N. K. Tokarevich ◽  
A. A. Tronin ◽  
B. R. Gnativ ◽  
R. V. Buzinov ◽  
O. V. Sokolova ◽  
...  
Keyword(s):  
Climate Change ◽  
Global Climate Change ◽  
Global Climate ◽  
European Part ◽  
Russian Arctic ◽  
Tick Borne Encephalitis ◽  
The Impact

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scholarly journals The impact of climate change on the expansion ofIxodes persulcatushabitat and the incidence of tick-borne encephalitis in the north of European Russia

2011 ◽  
Vol 4 (1) ◽  
pp. 8448 ◽  
Author(s):  
Nikolay K. Tokarevich ◽  
Andrey A. Tronin ◽  
Olga V. Blinova ◽  
Roman V. Buzinov ◽  
Vitaliy P. Boltenkov ◽  
...  
Keyword(s):  
Climate Change ◽  
European Russia ◽  
Impact Of Climate Change ◽  
The North ◽  
Tick Borne Encephalitis ◽  
The Impact

scholarly journals LONG-TERM MONITORING OF TICK-BORNE VIRAL ENCEPHALITIS AND TICK-BORNE BORRELIOSIS IN THE KOMI REPUBLIC

2019 ◽  
Author(s):  
B. Gnativ ◽  
N. K. Tokarevich
Keyword(s):  
Borrelia Burgdorferi ◽  
Incidence Rate ◽  
Komi Republic ◽  
Tick Bite ◽  
Anthropogenic Factors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tick Bites ◽  
Tick Borne Encephalitis ◽  
The Impact

Our study was aimed at analyzing data combining objective is epidemiological, zoological and entomological research intended to determine the environmental and epidemiological patterns of tick-borne encephalitis (TBE) and Lyme borreliosis (LB) foci, as well as the role of anthropogenic factors in epidemic manifestations to improve anti-epidemic activities.Long-term data on the abundance of ticks flagged from vegetation in various districts of the Komi Republic (RK) have been analyzed. The prevalence of tick-borne encephalitis virus (TBEV) and Borrelia burgdorferi (agent of LB) in ticks picked from vegetation, humans and domestic animals in various districts of the RK was measured by using enzyme-linked immunosorbent assay and polymerase chain reaction (PCR-ELISA). In addition, the data on 1994 – 2017 tick-bite incidence in RK in, 1970 – 2017 TBE incidence, and 1997 – 2017 LB incidence were also examined and correlated with the impact of forest transformation on the TBE incidence.The rise of tick population in the southern districts of RK and its northward expansion were noted. It is also shown that the RK territory, where tick bites are registered, expanded significantly.Mean annual tick-bite incidence rate in 2006 – 2017 vs. 1994 – 2005 timeframe was increased by 4-fold.RK regions where deforestation took place, the tick-bite incidence was increased, and the local TBE incidence elevated distinctly.In recent years, there was a rise in TBEV prevalence in ticks, collected either from vegetation or from humans and animals.In 2006 – 2017 and 1970 – 1981, mean annual TBE incidence rate increased by a 11- and 36-fold as compared to that one registered in 1982 – 1993. In recent years, the most severe focal TBE forms began to be recorded. In 1996 – 2017, the TBE mortality rate was 2.3%.The main features of LB epidemiology mimic those found in TBEV. In particular, the prevalence of Borrelia burgdorferi in ticks flagged from vegetation increased from 9.5% to 34.7% in 2010 vs. 2017, respectively. A sharp rise in LB incidence rate and profound northward shift for bacterial range, where this infection started to be registered only in recent years, were noted. Both TBE and LB demonstrated marked occupation-related pattern.The need in conducting task-oriented prophylaxis of tick-borne infections is necessitated by taking into account geographic specifics. The RK northern regions should be considered as potentially endemic, where tick bites in human population has recently begun to be reported.

scholarly journals Attenuation of Tick-Borne Encephalitis Virus by Structure-Based Site-Specific Mutagenesis of a Putative Flavivirus Receptor Binding Site

2000 ◽  
Vol 74 (20) ◽  
pp. 9601-9609 ◽  
Author(s):  
Christian W. Mandl ◽  
Steven L. Allison ◽  
Heidemarie Holzmann ◽  
Tamara Meixner ◽  
Franz X. Heinz
Keyword(s):  
Amino Acid ◽  
Receptor Binding ◽  
Biological Effects ◽  
Site Directed Mutagenesis ◽  
Single Amino Acid ◽  
Dimensional Structure ◽  
Virus Protein ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
The Impact

ABSTRACT The impact of a specific region of the envelope protein E of tick-borne encephalitis (TBE) virus on the biology of this virus was investigated by a site-directed mutagenesis approach. The four amino acid residues that were analyzed in detail (E308 to E311) are located on the upper-lateral surface of domain III according to the X-ray structure of the TBE virus protein E and are part of an area that is considered to be a potential receptor binding determinant of flaviviruses. Mutants containing single amino acid substitutions, as well as combinations of mutations, were constructed and analyzed for their virulence in mice, growth properties in cultured cells, and genetic stability. The most significant attenuation in mice was achieved by mutagenesis of threonine 310. Combining this mutation with deletion mutations in the 3′-noncoding region yielded mutants that were highly attenuated. The biological effects of mutation Thr 310 to Lys, however, could be reversed to a large degree by a mutation at a neighboring position (Lys 311 to Glu) that arose spontaneously during infection of a mouse. Mutagenesis of the other positions provided evidence for the functional importance of residue 308 (Asp) and its charge interaction with residue 311 (Lys), whereas residue 309 could be altered or even deleted without any notable consequences. Deletion of residue 309 was accompanied by a spontaneous second-site mutation (Phe to Tyr) at position 332, which in the three-dimensional structure of protein E is spatially close to residue 309. The information obtained in this study is relevant for the development of specific attenuated flavivirus strains that may serve as future live vaccines.

scholarly journals Ticking on Pandora’s box: a prospective case-control study into ‘other’ tick-borne diseases

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
D. Hoornstra ◽  
M. G. Harms ◽  
S. A. Gauw ◽  
A. Wagemakers ◽  
T. Azagi ◽  
...  
Keyword(s):  
Disease Burden ◽  
Case Control Study ◽  
Case Control ◽  
Tick Bite ◽  
Spotted Fever Group ◽  
Borrelia Miyamotoi ◽  
Tick Borne Encephalitis ◽  
The Impact ◽  
Control Study ◽  
Prospective Case Control Study

Abstract Background Tick-borne pathogens other than Borrelia burgdorferi sensu lato – the causative agent of Lyme borreliosis – are common in Ixodes ricinus ticks. How often these pathogens cause human disease is unknown. In addition, diagnostic tools to identify such diseases are lacking or reserved to research laboratories. To elucidate their prevalence and disease burden, the study ‘Ticking on Pandora’s Box’ has been initiated, a collaborative effort between Amsterdam University Medical Center and the National Institute for Public Health and the Environment. Methods The study investigates how often the tick-borne pathogens Anaplasma phagocytophilum, Babesia species, Borrelia miyamotoi, Neoehrlichia mikurensis, spotted fever group Rickettsia species and/or tick-borne encephalitis virus cause an acute febrile illness after tick-bite. We aim to determine the impact and severity of these tick-borne diseases in the Netherlands by measuring their prevalence and describing their clinical picture and course of disease. The study is designed as a prospective case-control study. We aim to include 150 cases – individuals clinically suspected of a tick-borne disease – and 3 matched healthy control groups of 200 persons each. The controls consist respectively of a group of individuals with either a tick-bite without complaints, the general population and of healthy blood donors. During a one-year follow-up we will acquire blood, urine and skin biopsy samples and ticks at baseline, 4 and 12 weeks. Additionally, participants answer modified versions of validated questionnaires to assess self-reported symptoms, among which the SF-36, on a 3 monthly basis. Discussion This article describes the background and design of the study protocol of ‘Ticking on Pandora’s Box’. With our study we hope to provide insight into the prevalence, clinical presentation and disease burden of the tick-borne diseases anaplasmosis, babesiosis, B. miyamotoi disease, neoehrlichiosis, rickettsiosis and tick-borne encephalitis and to assist in test development as well as provide recommendations for national guidelines. Trial registration NL9258 (retrospectively registered at Netherlands Trial Register, trialregister.nl in in February 2021).

scholarly journals Perspectives for the Treatment of Infections withFlaviviridae

2000 ◽  
Vol 13 (1) ◽  
pp. 67-82 ◽  
Author(s):  
Pieter Leyssen ◽  
Erik De Clercq ◽  
Johan Neyts
Keyword(s):  
Cell Uptake ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Ongoing Research ◽  
Disease Spectrum ◽  
Viral Proteases ◽  
Tick Borne Encephalitis ◽  
Recent Developments ◽  
Prevention Of Infections ◽  
The Impact

SUMMARY The family Flaviviridae contains three genera: Hepacivirus, Flavivirus, and Pestivirus. Worldwide, more than 170 million people are chronically infected with Hepatitis C virus and are at risk of developing cirrhosis and/or liver cancer. In addition, infections with arthropod-borne flaviviruses (such as dengue fever, Japanese encephalitis, tick-borne encephalitis, St. Louis encephalitis, Murray Valley encephalitis, West Nile, and yellow fever viruses) are emerging throughout the world. The pestiviruses have a serious impact on livestock. Unfortunately, no specific antiviral therapy is available for the treatment or the prevention of infections with members of the Flaviviridae. Ongoing research has identified possible targets for inhibition, including binding of the virus to the cell, uptake of the virus into the cell, the internal ribosome entry site of hepaciviruses and pestiviruses, the capping mechanism of flaviviruses, the viral proteases, the viral RNA-dependent RNA polymerase, and the viral helicase. In light of recent developments, the prevalence of infections caused by these viruses, the disease spectrum, and the impact of infections, different strategies that could be pursued to specifically inhibit viral targets and animal models that are available to study the pathogenesis and antiviral strategies are reviewed.

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