scholarly journals The Impact of Tick-Borne Diseases on the Bone

2021 ◽  
Vol 9 (3) ◽  
pp. 663
Author(s):  
Imran Farooq ◽  
Tara J. Moriarty
Keyword(s):  
Bone Marrow ◽  
Lyme Disease ◽  
Bone Loss ◽  
Human Body ◽  
Virus Disease ◽  
Hemorrhagic Fever ◽  
Research Literature ◽  
Tick Borne Encephalitis ◽  
Bone Marrow Function ◽  
The Impact

Tick-borne infectious diseases can affect many tissues and organs including bone, one of the most multifunctional structures in the human body. There is a scarcity of data regarding the impact of tick-borne pathogens on bone. The aim of this review was to survey existing research literature on this topic. The search was performed using PubMed and Google Scholar search engines. From our search, we were able to find evidence of eight tick-borne diseases (Anaplasmosis, Ehrlichiosis, Babesiosis, Lyme disease, Bourbon virus disease, Colorado tick fever disease, Tick-borne encephalitis, and Crimean–Congo hemorrhagic fever) affecting the bone. Pathological bone effects most commonly associated with tick-borne infections were disruption of bone marrow function and bone loss. Most research to date on the effects of tick-borne pathogen infections on bone has been quite preliminary. Further investigation of this topic is warranted.

scholarly journals The Impact of Intervention to Routine Surveillance of Natural Focal Diseases During the Outbreak of COVID-19 in Jiangsu Province, China

2020 ◽  
Author(s):  
Jianli Hu ◽  
Xiaoqing Cheng ◽  
Li Luo ◽  
Zeyu Zhao ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Lower Limit ◽  
Urban Areas ◽  
Virus Disease ◽  
Hemorrhagic Fever ◽  
Nonparametric Tests ◽  
Jiangsu Province ◽  
Control Effect ◽  
Rural And Urban Areas ◽  
Rural And Urban ◽  
The Impact

Abstract Background: With the strength intervention of China, the outbreak of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) had a great control effect. The measures may influence the development and progression of others infectious diseases.Method: The data of daily coronavirus virus disease 2019 (COVID-19) confirmed cases from January 3, 2020 to April 30, 2020 and natural focal disease cases from January, 2005 to April, 2020 were collected from Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Provincial CDC). We describe and compare the data of natural focal diseases from January to April, 2020 with the same months from 2015 to 2019 in the four aspects: trend of incidence, regional, age and sex distribution. Nonparametric tests were used to analyzed to the difference between the duration from onset of illness to date of diagnosis of natural focal diseases and the same period of the previous year. Results: The incidence of malaria in February (0.9 per 10,000,000 people), March (0.3 per 10,000,000 people) and April (0.1 per 10,000,000 people) 2020 less than the lower limit for range of February (1.6-4.5 per 10,000,000 people), March (0.8-3.3 per 10,000,000 people) and April (1.0-2.9 per 10,000,000 people) from 2015 to 2019 respectively. The incidence of brucellosis in February was 0.9 (per 10,000,000 people), less than the lower limit for the range from 2015 to 2019 (1.6-4.5 per 10,000,000 people). The incidence of hemorrhagic fever (HF) in March was 1.0 (per 10,000,000 people), less than the lower limit for the range from 2015 to 2019 (1.4-2.6 per 10,000,000 people). However, the incidence of Severe Fever with Thrombocytopenia Syndrome (SEFT) in March was 0.3 (per 10,000,000 people), higher than the upper limit for the range from 2015 to 2019 (0.0-0.1 per 10,000,000 people). Furthermore, we respectively observed the incidence with various degree of reduction in male, 20-60 years old and both rural and urban areas. Conclusions: In Jiangsu province, the incidence of natural focal diseases decreased during the outbreak of COVID-19 in 2020, especially malaria, HF and SEFT. The impact of interventions were felt most by male individuals within the age group of 20-50 years. The interventions for COVID-19 may control the epidemics of natural focal diseases.

Transport and Chronic Injuries Caused by Improper Use of Cell Phones：Evidences from 41 Studies (Preprint)

2020 ◽  
Author(s):  
Xinxi Cao ◽  
Yangyang Cheng ◽  
Chenjie Xu ◽  
Yabing Hou ◽  
Hongxi Yang ◽  
...  
Keyword(s):  
Human Body ◽  
Cell Phone ◽  
Injury Risk ◽  
Negative Impact ◽  
Mental Disease ◽  
Cell Phones ◽  
Cell Phone Use ◽  
Improper Use ◽  
Chronic Injuries ◽  
The Impact

BACKGROUND Cell phone use brought convenience to people, but using phones for a long period of time or in the wrong way and with a wrong posture might cause damage to the human body. OBJECTIVE To assess the impact of improper cell phone use on transport and chronic injuries. METHODS Studies were systematically searched in PubMed, EMBASE, Cochrane, and Web of Science up to April 4, 2019 and relevant reviews were searched to identify additional studies. A random-effects model was used to estimate the overall pooled estimates. RESULTS Cell phone users were at a higher risk for transport injuries (RR: 1.37, 95%CI: 1.221.55), long-term use of cell phones increased the transport injury risk to non-use or short-term use (RR: 2.10, 95% CI: 1.632.70). Neoplasm risk caused by cell phone use was 1.07 times that of non-use (95% CI: 1.011.14); Compared with non-use, cell phone use had a higher risk of eye disease, with a risk of 2.03 (95% CI: 1.273.23), the risk of mental disease was 1.26 (95% CI: 1.171.35), the risk of neurological disorder was 1.16 (95% CI: 1.021.32), and a pooled risk of other chronic injuries was 1.20 (95% CI: 0.981.59). CONCLUSIONS Cell phone use at inappropriate situations has a negative impact on the human body. Therefore, it is necessary to use cell phones correctly and reasonably.

Drug Use in Prison: Patterns, Processes, and Implications for Treatment

1993 ◽  
Vol 23 (1) ◽  
pp. 119-129 ◽  
Author(s):  
James A. Inciardi ◽  
Dorothy Lockwood ◽  
Judith A. Quintan
Keyword(s):  
Drug Use ◽  
Drug Testing ◽  
Research Literature ◽  
Prison Violence ◽  
Patterns Of Use ◽  
Correctional Settings ◽  
Correctional System ◽  
The Impact

Although there seems to be a consensus that “drugs are in every prison,” and that “prison drug use is widespread,” little is really known about the prevalence and patterns of drug use in prison. What appears in the academic and research literature is at best anecdotal, suggesting only that drug use and trafficking exist in correctional settings, and that the control of drugs by inmates is in part related to prison violence. Similarly, press reports descriptive of drug use in prison typically focus on trafficking networks and the complicity of prison personnel, rather than on prevalence and patterns of use. Within this context, this article addresses the nature of drug use in prison, based on systematic interviewing and drug testing in the Delaware correctional system. Some conclusions and implications are offered relative to the impact of prison drug use on corrections-based therapeutic initiatives.

scholarly journals How Do the Timing and Duration of Courses Affect Participation in Adult Learning and Education? A Panel Analysis

2021 ◽  
pp. 074171362110190
Author(s):  
Fabian Rüter ◽  
Andreas Martin
Keyword(s):  
Adult Education ◽  
Adult Learning ◽  
Fixed Effects ◽  
Research Literature ◽  
Temporal Organization ◽  
Educational Institutions ◽  
Positive Effects ◽  
Matching Process ◽  
Education Participation ◽  
The Impact

Participation in adult learning and education requires the availability of, and accessibility to, learning opportunities provided by educational institutions. One fundamental element is time. Adult learning and education participation can only be realized by successfully matching individual time-availabilities with the temporal organization of provided courses. To address this required matching process, this study contributes to research literature as one of the first studies that investigates the impact of timing and course duration on participation counts (longitudinally). For this, we use organizational data from public adult education centers ( Volkshochschulen—VHS; the main adult education providers in Germany) from 2007 to 2017. Methodologically, random- and fixed-effects models are applied. We find significant positive effects on participation counts between increasing program breadth in terms of temporal formats and increasing average course duration.

scholarly journals Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells

2021 ◽  
Vol 22 (2) ◽  
pp. 772
Author(s):  
Javier Conde ◽  
Marlene Schwarzfischer ◽  
Egle Katkeviciute ◽  
Janine Häfliger ◽  
Anna Niechcial ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Titanium Dioxide ◽  
Genetic Risk ◽  
Intestinal Inflammation ◽  
Sodium Sulphate ◽  
Food Additive ◽  
Wild Type ◽  
Dextran Sodium Sulphate ◽  
Risk Gene ◽  
The Impact

Environmental and genetic factors have been demonstrated to contribute to the development of inflammatory bowel disease (IBD). Recent studies suggested that the food additive; titanium dioxide (TiO2) might play a causative role in the disease. Therefore, in the present study we aimed to explore the interaction between the food additive TiO2 and the well-characterized IBD risk gene protein tyrosine phosphatase non-receptor type 2 (Ptpn2) and their role in the development of intestinal inflammation. Dextran sodium sulphate (DSS)-induced acute colitis was performed in mice lacking the expression of Ptpn2 in myeloid cells (Ptpn2LysMCre) or their wild type littermates (Ptpn2fl/fl) and exposed to the microparticle TiO2. The impact of Ptpn2 on TiO2 signalling pathways and TiO2-induced IL-1β and IL-10 levels were studied using bone marrow-derived macrophages (BMDMs). Ptpn2LysMCre exposed to TiO2 exhibited more severe intestinal inflammation than their wild type counterparts. This effect was likely due to the impact of TiO2 on the differentiation of intestinal macrophages, suppressing the number of anti-inflammatory macrophages in Ptpn2 deficient mice. Moreover, we also found that TiO2 was able to induce the secretion of IL-1β via mitogen-activated proteins kinases (MAPKs) and to repress the expression of IL-10 in bone marrow-derived macrophages via MAPK-independent pathways. This is the first evidence of the cooperation between the genetic risk factor Ptpn2 and the environmental factor TiO2 in the regulation of intestinal inflammation. The results presented here suggest that the ingestion of certain industrial compounds should be taken into account, especially in individuals with increased genetic risk

scholarly journals Neuropsychiatric, cognitive and sexual impairment in mastocytosis patients

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Fatma Jendoubi ◽  
Maella Severino-Freire ◽  
Mathilde Negretto ◽  
Christophe Arbus ◽  
Carle Paul ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rating Scale ◽  
Negative Impact ◽  
Diagnostic Delay ◽  
Professional Lives ◽  
Cutaneous Lesions ◽  
Kit Mutation ◽  
Sexual Symptoms ◽  
Organ Systems ◽  
The Impact

Abstract Background Mastocytosis is a rare disease characterised by the accumulation and/or proliferation of abnormal mast cells (MCs) in one or several organs. It may present with a number of different symptoms that involve various organ systems. The current study aims to assess the prevalence of MC mediator-related symptoms in a cohort of mastocytosis patients with a specific focus on neurological, psychiatric, cognitive and sexual symptoms. We also assessed the impact of the disease on patients’ professional lives. Patients were administered a validated multidimensional questionnaire to collect information on patients’ perception of the severity of their symptoms. From the questionnaires we extracted the neurological, cognitive, psychiatric and sexual symptoms and the impact of the disease on patients’ professional lives as well as their grading. The affective status was assessed using the 17-item version of the Hamilton Depression Rating Scale. Results We included 139 patients. Mastocytosis was classified as systemic in 113 patients and cutaneous in 26 patients. The prevalence of MC mediator-related systemic symptoms was as follows: cutaneous (71%), gastro-intestinal (48%), cardio-vascular (36%), musculoskeletal (26.6%), fatigue (24%), urinary (14.4%) and respiratory (10%). Headaches and vertigo were noted in respectively 55% and 32% of patients. Irritability, episodes of memory loss and difficulty concentrating were reported in 54%, 52% and 40% of cases, respectively. Sexual impairment was noted in 24% of patients. No associations were found between neuropsychiatric/cognitive impairment and age, gender, diagnostic delay, disease form, the presence of cutaneous lesions, the level of serum and bone marrow tryptase and the presence of KIT mutation in bone marrow and/or skin. Depression was noted in 49% of patients. One in four patients reported a negative impact of the disease on their professional lives. Conclusion This current study provides some insights regarding symptoms related to mastocytosis and their impact on patients’ professional lives.

scholarly journals Threshold Dynamics in a Model for Zika Virus Disease with Seasonality

2021 ◽  
Vol 83 (4) ◽  
Author(s):  
Mahmoud A. Ibrahim ◽  
Attila Dénes
Keyword(s):  
Zika Virus ◽  
Reproduction Number ◽  
Virus Disease ◽  
Threshold Dynamics ◽  
Global Dynamics ◽  
Threshold Parameter ◽  
Globally Asymptotically Stable ◽  
Linear Integral ◽  
The Impact ◽  
Disease Free

AbstractWe present a compartmental population model for the spread of Zika virus disease including sexual and vectorial transmission as well as asymptomatic carriers. We apply a non-autonomous model with time-dependent mosquito birth, death and biting rates to integrate the impact of the periodicity of weather on the spread of Zika. We define the basic reproduction number $${\mathscr {R}}_{0}$$ R 0 as the spectral radius of a linear integral operator and show that the global dynamics is determined by this threshold parameter: If $${\mathscr {R}}_0 < 1,$$ R 0 < 1 , then the disease-free periodic solution is globally asymptotically stable, while if $${\mathscr {R}}_0 > 1,$$ R 0 > 1 , then the disease persists. We show numerical examples to study what kind of parameter changes might lead to a periodic recurrence of Zika.

The Impact of Age and Gender on Hematopoietic Stem Cells and Immune Contexture of the Bone Marrow Microenvironment

2020 ◽  
pp. 1-6
Author(s):  
Rebar N. Mohammed
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Hematopoietic Stem Cells ◽  
Immune Cells ◽  
Absolute Number ◽  
Cell Number ◽  
Hematopoietic Stem ◽  
The Absolute ◽  
And Gender ◽  
The Impact

Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. Thirty-six healthy donors, attending the HSCT center to donate their bone marrow, were categorized according to their age into child (0–12 years), adolescence (13–18 years), and adult (19–59 years) groups, and gender into male and female groups. Then, the absolute number of HSCs and mature immune cells in their harvested bone marrow was investigated. Here, we report that the absolute cell number can vary considerably based on the age of the healthy donor, and the number of both HSCs and immune cells declines with advancing age. The gender of the donor (male or female) did not have any impact on the number of the HSCs and immune cells in the bone marrow. In conclusion, since the number of HSCs plays a pivotal role in the clinical outcome of allogeneic HSC transplantations, identifying a younger donor regardless the gender is critical.

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