scholarly journals Effectiveness of the Arthrofon in the treatment of dogs with knee osteoarthritis

2019 ◽  
Vol 2019 (4) ◽  
pp. 30-36
Author(s):  
Сергей Позябин ◽  
Sergey Pozyabin ◽  
Михаил Качалин ◽  
Mihail Kachalin
Keyword(s):  
Synovial Fluid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Normal Values ◽  
Cruciate Ligament ◽  
Postoperative Treatment ◽  
Cranial Cruciate Ligament ◽  
X Ray ◽  
Complex Therapy ◽  
Degenerative Processes

The article describes the results of using the drug Arthrofon in complex postoperative treatment of rupture of the cranial cruciate ligament of the knee in dogs. The studies were conducted on two groups selected by the method of analogues. Based on the results of orthopedic examination, radiography and cytological studies of the synovial fluid of the knee joint, it was found that the use of the drug Arthrofon prevents the development of degenerative processes in the knee joint in the first 45 days after surgery. Animals on the background of the use of Arthrofon in complex therapy did not have X-ray signs of progression of osteoarthritis, and the synovial fluid recovered to normal values for this species.

scholarly journals Circulating IL-10 is compromised in patients predisposed to developing and in patients with severe knee osteoarthritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tyler Barker ◽  
Victoria E. Rogers ◽  
Vanessa T. Henriksen ◽  
Roy H. Trawick ◽  
Nathan G. Momberger ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Cruciate Ligament ◽  
Ligamentous Injury ◽  
Radiographic Evidence ◽  
X Ray ◽  
Tnf Α ◽  
Total Knee ◽  
Anterior Cruciate ◽  
Anterior Cruciate Ligament Surgery ◽  
Necrosis Factor

AbstractThe purpose of this investigation was to identify if serum interleukin (IL)-10 and tumor necrosis factor (TNF)-α concentrations and their ratio (IL-10/TNF-α) are altered in subjects predisposed to developing knee osteoarthritis following ligamentous injury and in those with severe knee osteoarthritis. Serum IL-10 and TNF-α concentrations were measured in four groups of subjects (n = 218): (1) reportedly-healthy and non-injured control subjects (CON; n = 92), (2) subjects scheduled to undergo anterior cruciate ligament surgery (ACL; n = 42), (3) non-surgical subjects with knee osteoarthritis (OA; n = 60), and (4) subjects with knee osteoarthritis scheduled to undergo total knee arthroplasty (TKA; n = 24). X-ray images were used to grade the severity of knee osteoarthritis. Serum IL-10 and the serum IL-10/TNF-α ratio were significantly lower while serum TNF-α was not significantly perturbed with severe compared to moderate knee osteoarthritis (i.e., Kellgren-Lawrence grade 4 vs. 3, respectively). Serum IL-10 was significantly lower in the absence of serum TNF-α alterations in the ACL group. We conclude that serum IL-10 concentrations are compromised in subjects predisposed to developing knee osteoarthritis following ligamentous trauma and in subjects with radiographic evidence of severe knee osteoarthritis.

scholarly journals Evaluation of serum MMP-2 and MMP-3, synovial fluid IL-8, MCP-1, and KC concentrations as biomarkers of stifle osteoarthritis associated with naturally occurring cranial cruciate ligament rupture in dogs

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242614
Author(s):  
Sarah Malek ◽  
Hsin-Yi Weng ◽  
Shannon A. Martinson ◽  
Mark C. Rochat ◽  
Romain Béraud ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Linear Regression ◽  
Cruciate Ligament ◽  
Discriminative Ability ◽  
Cranial Cruciate Ligament ◽  
Discriminative Performance ◽  
Naturally Occurring ◽  
Veterinary Pathologist ◽  
Concentration Changes ◽  
And Control

The purpose of this study was to evaluate matrix metalloproteinases (MMP) -2 and MMP-3 in serum, and keratinocyte-derived chemoattractant (KC), interleukin 8 (IL-8) and monocyte chemoattractant 1 (MCP-1) in synovial fluid (SF) as stifle osteoarthritis (OA) biomarkers in dogs. Dogs with naturally occurring cranial cruciate ligament (CrCL) rupture (OA group) and healthy controls were recruited. Stifles with CrCL deficiency were surgically stabilized. Serum, SF, and synovial biopsy samples were collected from the OA group preoperatively, whereas samples were collected once from control dogs. A blinded veterinary pathologist graded synovial biopsies. Serum and SF analyses were performed using xMAP technology. General linear regression was used for statistical comparisons of serum biomarkers, and mixed linear regression for SF biomarkers and temporal concentration changes. The overall discriminative ability was quantified using area under curve (AUC). Spearman’s correlation coefficient was used to assess correlations between synovial histology grades and the biomarkers. Samples from 62 dogs in the OA group and 50 controls were included. The MMP-2 and MMP-3 concentrations between the OA and control groups were not significantly different, and both with an AUC indicating a poor discriminative ability. All three SF biomarker concentrations were significantly different between the OA group and controls (P <0.05). The MCP-1 was the only biomarker showing an acceptable discriminative performance with an AUC of 0.91 (95% confidence interval: 0.83–0.98). The sum of the inflammatory infiltrate score was significantly correlated with all three SF biomarkers (P <0.01). Summed synovial stroma, and all scores combined were significantly correlated with IL-8 and MCP-1 concentrations (P <0.003), and the summed synoviocyte scores were significantly correlated with MCP-1 concentrations (P <0.001). Correlations between MCP-1 concentrations and synovial histopathologic grading and its discriminative ability suggest its potential as a synovitis biomarker in canine stifle OA associated with CrCL rupture.

scholarly journals Effects of exercise therapy on knee joint function and synovial fluid cytokine levels in patients with knee osteoarthritis

2012 ◽  
Vol 7 (1) ◽  
pp. 183-186 ◽  
Author(s):  
SHAO-LAN ZHANG ◽  
HONG-QI LIU ◽  
XIAO-ZU XU ◽  
JUAN ZHI ◽  
JIAO-JIAO GENG ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Exercise Therapy ◽  
Joint Function ◽  
Cytokine Levels

Rheological Study of Synovial Fluid Obtained from Dogs: Healthy, Pathological, and Post-Surgery, after Spontaneous Rupture of Cranial Cruciate Ligament

2009 ◽  
Vol 38 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Thomas B. Goudoulas ◽  
Eleftherios G. Kastrinakis ◽  
Stavros G. Nychas ◽  
Lysimachos G. Papazoglou ◽  
George M. Kazakos ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Spontaneous Rupture ◽  
Cruciate Ligament ◽  
Cranial Cruciate Ligament ◽  
Rheological Study ◽  
Post Surgery

scholarly journals Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mikel Sánchez ◽  
Diego Delgado ◽  
Pello Sánchez ◽  
Emma Muiños-López ◽  
Bruno Paiva ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Fluid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Subchondral Bone ◽  
Platelet Rich Plasma ◽  
Joint Function ◽  
Novel Approach ◽  
New Strategy

The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovial membrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma. We explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously. We assessed the clinical outcomes through osteoarthritis outcome score (KOOS) and the inflammatory response by quantifying mesenchymal stem cells in synovial fluid. There was a significant pain reduction in the KOOS from baseline(61.55±14.11)to week 24(74.60±19.19), after treatment(p=0.008), in the secondary outcomes (symptoms,p=0.004; ADL,p=0.022; sport/rec.,p=0.017; QOL,p=0.012), as well as VAS score (p<0.001) and Lequesne Index(p=0.008). The presence of mesenchymal stem cells in synovial fluid and colony-forming cells one week after treatment decreased substantially from7.98±8.21 MSC/μL to4.04±5.36 MSC/μL(p=0.019)and from601.75±312.30to139.19±123.61  (p=0.012), respectively. Intra-articular injections combined with intraosseous infiltrations of platelet rich plasma reduce pain and mesenchymal stem cells in synovial fluid, besides significantly improving knee joint function in patients with severe knee osteoarthritis. This trial is registered on EudraCT with the number2013-003982-32.

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