scholarly journals Effects of exercise therapy on knee joint function and synovial fluid cytokine levels in patients with knee osteoarthritis

2012 ◽  
Vol 7 (1) ◽  
pp. 183-186 ◽  
Author(s):  
SHAO-LAN ZHANG ◽  
HONG-QI LIU ◽  
XIAO-ZU XU ◽  
JUAN ZHI ◽  
JIAO-JIAO GENG ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Exercise Therapy ◽  
Joint Function ◽  
Cytokine Levels

scholarly journals Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mikel Sánchez ◽  
Diego Delgado ◽  
Pello Sánchez ◽  
Emma Muiños-López ◽  
Bruno Paiva ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Fluid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Subchondral Bone ◽  
Platelet Rich Plasma ◽  
Joint Function ◽  
Novel Approach ◽  
New Strategy

The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovial membrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma. We explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously. We assessed the clinical outcomes through osteoarthritis outcome score (KOOS) and the inflammatory response by quantifying mesenchymal stem cells in synovial fluid. There was a significant pain reduction in the KOOS from baseline(61.55±14.11)to week 24(74.60±19.19), after treatment(p=0.008), in the secondary outcomes (symptoms,p=0.004; ADL,p=0.022; sport/rec.,p=0.017; QOL,p=0.012), as well as VAS score (p<0.001) and Lequesne Index(p=0.008). The presence of mesenchymal stem cells in synovial fluid and colony-forming cells one week after treatment decreased substantially from7.98±8.21 MSC/μL to4.04±5.36 MSC/μL(p=0.019)and from601.75±312.30to139.19±123.61  (p=0.012), respectively. Intra-articular injections combined with intraosseous infiltrations of platelet rich plasma reduce pain and mesenchymal stem cells in synovial fluid, besides significantly improving knee joint function in patients with severe knee osteoarthritis. This trial is registered on EudraCT with the number2013-003982-32.

scholarly journals Research Progress on Acupuncture Treatment of Knee Osteoarthritis

2021 ◽  
Vol 9 (4) ◽  
pp. 106-110
Author(s):  
Zhang Yueyu ◽  
Song Aiqun ◽  
Peng Ying
Keyword(s):  
Acupuncture Therapy ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Joint Pain ◽  
Acupuncture Treatment ◽  
Treatment Plan ◽  
Joint Inflammation ◽  
Research Progress ◽  
Osteoarthritis Of The Knee ◽  
Joint Function

Osteoarthritis of the knee is a common clinical degenerative disease, which occurs in middle-aged and elderly people. Acupuncture therapy has a significant effect in the treatment of knee osteoarthritis, and is gradually accepted by more and more patients. Observing the treatment of knee osteoarthritis by different acupuncture and moxibustion therapies, we can find that acupuncture treatment of knee osteoarthritis has the advantages of relieving knee joint pain, improving knee joint function, absorbing knee joint inflammation, and promoting the recovery of damaged soft tissue. The treatment of osteoarthritis provides a more effective treatment plan.

Sodium Hyaluronate Combined with Jintiange on Knee Joint Function After Arthroscopy for Knee Osteoarthritis

2021 ◽  
Vol 11 (12) ◽  
pp. 2507-2511
Author(s):  
Qi’ning Yang ◽  
Xiaofei Li ◽  
Tianbao Wang ◽  
Siqi Gao ◽  
Pengfei Cai ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Interleukin 1 ◽  
Sodium Hyaluronate ◽  
Effective Rate ◽  
Joint Function ◽  
Necrosis Factor

Objective: To explore the effects of sodium hyaluronate combined with Jintiange on knee joint function after arthroscopic debridement. Methods: Totally 122 knee osteoarthritis patients underwent arthroscopic debridement were randomized into control and experimental groups. The interleukin-1β, interleukin-6 and tumor necrosis factor-α serum levels were tested via Elisa before and after treatment. The Lysholm knee joint function score, effective rate of treatment, interleukin-1β, interleukin-6 and tumor necrosis factor-α expression, visual analogue scale of pain, incidence of adverse reactions and patient satisfaction were compared. Results: Compared with the control group, the effective rate of treatment and the score of Lysholm knee joint function in the other were higher (both P <0.001), and the serum interleukin-1β, interleukin-6, tumor necrosis factor-α expression and visual analogue scale score were lower (all P <0.001). The incidence of adverse reactions revealed no marked difference (P >0.05), but the satisfaction scores of the experimental group were higher (P <0.01). Conclusion: sodium hyaluronate combined with Jintiange is helpful for knee joint function recovery after arthroscopic knee osteoarthritis, which effectively decreases the level of inflammatory factors and increase patients’ satisfaction.

scholarly journals Application Effect of Different Concentrations of Platelet-Rich Plasma Combined with Quadriceps Training on Cartilage Repair of Knee Osteoarthritis

2022 ◽  
Vol 2022 ◽  
pp. 1-8
Author(s):  
Zutong Wu ◽  
Jianwen Yin ◽  
Yajia Yue ◽  
Yiqun Zhang
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Cartilage Repair ◽  
Platelet Rich Plasma ◽  
Cartilage Thickness ◽  
Knee Function ◽  
Inflammatory Factor ◽  
High Concentration ◽  
Joint Function

We investigated the application effect of different concentrations of platelet-rich plasma (PRP) combined with quadriceps training on cartilage repair of knee osteoarthritis. Data of 37 patients with knee osteoarthritis (KOA) treated in our hospital (November 2019–February 2021) were retrospectively analyzed and the patients were divided into low concentration group (LCG) (n = 12), medium concentration group (MCG) (n = 12), and high concentration group (HCG) (n = 13) according to the order of admission. All patients received quadriceps training. Three groups above received knee injection of PRP, and the platelet concentrations were 1000–1400 × 109/L, 1400–1800 × 109/L, and 1800–2100 × 109/L, respectively. Articular cartilage thickness of the medial and lateral femur, knee joint function scores, inflammatory factor levels, and matrix metalloproteinases (MMPs) levels were compared. After treatment, compared with the MCG and HCG, articular cartilage thickness of the medial and lateral femur of the diseased side in the LCG was obviously lower ( P < 0.05 ). At 2 months after treatment (T3), compared with the HCG, articular cartilage thickness of the medial and lateral femur of the diseased side in the MCG was obviously higher ( P < 0.05 ), without remarkable difference in articular cartilage thickness of the medial and lateral femur of the healthy side among three groups ( P > 0.05 ). After treatment, compared with the LCG, knee joint function scores of the MCG and HCG were obviously better ( P < 0.001 ). Compared with the HCG, the knee function score at T3 in the MCG was obviously better ( P < 0.001 ). After treatment, compared with the LCG, inflammatory factor levels and levels of MMPs in the MCG and HCG were obviously lower ( P < 0.05 ). Compared with the HCG, inflammatory factor levels and levels of MMPs at T3 in the MCG were obviously lower ( P < 0.05 ). PRP combined with quadriceps training can accelerate cartilage repair of patients with KOA and reduce inflammatory factor levels and levels of MMPs, but the treatment effect of PRP depends on platelet concentration, with the best range of 1400–1800 × 109/L. Too high or too low platelet concentrations will affect recovery of knee function.

scholarly journals Effectiveness of the Arthrofon in the treatment of dogs with knee osteoarthritis

2019 ◽  
Vol 2019 (4) ◽  
pp. 30-36
Author(s):  
Сергей Позябин ◽  
Sergey Pozyabin ◽  
Михаил Качалин ◽  
Mihail Kachalin
Keyword(s):  
Synovial Fluid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Normal Values ◽  
Cruciate Ligament ◽  
Postoperative Treatment ◽  
Cranial Cruciate Ligament ◽  
X Ray ◽  
Complex Therapy ◽  
Degenerative Processes

The article describes the results of using the drug Arthrofon in complex postoperative treatment of rupture of the cranial cruciate ligament of the knee in dogs. The studies were conducted on two groups selected by the method of analogues. Based on the results of orthopedic examination, radiography and cytological studies of the synovial fluid of the knee joint, it was found that the use of the drug Arthrofon prevents the development of degenerative processes in the knee joint in the first 45 days after surgery. Animals on the background of the use of Arthrofon in complex therapy did not have X-ray signs of progression of osteoarthritis, and the synovial fluid recovered to normal values for this species.

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