scholarly journals Eccentric and concentric resistance exercise induced changes on insulin sensitivity and inflammation

2010 ◽  
Author(s):  
Tom Elder
2019 ◽  
Vol 127 (3) ◽  
pp. 858-866 ◽  
Author(s):  
Alex J. Wadley ◽  
Gary Keane ◽  
Tom Cullen ◽  
Lynsey James ◽  
Jordan Vautrinot ◽  
...  

Redox enzymes modulate intracellular redox balance and are secreted in response to cellular oxidative stress, potentially modulating systemic inflammation. Both aerobic and resistance exercise are known to cause acute systemic oxidative stress and inflammation; however, how redox enzyme concentrations alter in extracellular fluids following bouts of either type of exercise is unknown. Recreationally active men ( n = 26, mean ± SD: age 28 ± 8 yr) took part in either: 1) two separate energy-matched cycling bouts: one of moderate intensity (MOD) and a bout of high intensity interval exercise (HIIE) or 2) an eccentric-based resistance exercise protocol (RES). Alterations in plasma (study 1) and serum (study 2) peroxiredoxin (PRDX)-2, PRDX-4, superoxide dismutase-3 (SOD3), thioredoxin (TRX-1), TRX-reductase and interleukin (IL)-6 were assessed before and at various timepoints after exercise. There was a significant increase in SOD3 (+1.5 ng/mL) and PRDX-4 (+5.9 ng/mL) concentration following HIIE only, peaking at 30- and 60-min post-exercise respectively. TRX-R decreased immediately and 60 min following HIIE (−7.3 ng/mL) and MOD (−8.6 ng/mL), respectively. In non-resistance trained men, no significant changes in redox enzyme concentrations were observed up to 48 h following RES, despite significant muscle damage. IL-6 concentration increased in response to all trials, however there was no significant relationship between absolute or exercise-induced changes in redox enzyme concentrations. These results collectively suggest that HIIE, but not MOD or RES increase the extracellular concentration of PRDX-4 and SOD3. Exercise-induced changes in redox enzyme concentrations do not appear to directly relate to systemic changes in IL-6 concentration. NEW & NOTEWORTHY Two studies were conducted to characterize changes in redox enzyme concentrations after single bouts of exercise to investigate the emerging association between extracellular redox enzymes and inflammation. We provide evidence that SOD3 and PRDX-4 concentration increased following high-intensity aerobic but not eccentric-based resistance exercise. Changes were not associated with IL-6. The results provide a platform to investigate the utility of SOD3 and PRDX-4 as biomarkers of oxidative stress following exercise.


2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Lia R Servidio ◽  
Sally A. Roberts ◽  
Mary L. Laycock ◽  
M. Brennan Harris

2007 ◽  
Vol 32 (6) ◽  
pp. 1198-1205 ◽  
Author(s):  
Stuart M. Phillips

Progressive resistance training promotes strength gains in both the young and the aged. Importantly, gains in strength in aged persons are, with the appropriate duration, intensity, and progression, not simply due to neuromuscular mechanisms, but also encompass muscle fibre hypertrophy. Critically, the resistance exercise-induced changes in aged skeletal muscle are associated with numerous health benefits, the most obvious of which are the gains in strength and, with the correct training program, power; as a result, functional independence is improved and the risk for falls is apparently reduced. Aside from the well-documented effects of resistance training on strength and power, a body of research is now beginning to emerge that shows resistance exercise also promotes metabolic health. This is crucial information, since it effectively highlights an underappreciated aspect of resistance exercise. Specifically, resistance exercise not only promotes strength gains, but also reduces risk for diabetes and cardiovascular disease. The benefits of resistance exercise do not end at metabolic health, however, and “spill over” into many other realms. In fact, resistance exercise programs have been shown to reduce participants’ use of the health care system. Viewed collectively, the multiple benefits of resistance exercise represent an attractive option for our aging population to enhance and maintain their health from a number of perspectives that are not achievable through pharmacological intervention or with solely aerobic-based exercise.


2002 ◽  
Vol 102 (2) ◽  
pp. 223-231 ◽  
Author(s):  
Jason M.R. GILL ◽  
Sara L. HERD ◽  
Natassa V. TSETSONIS ◽  
Adrianne E. HARDMAN

Moderate exercise improves insulin sensitivity and reduces triacylglycerol (triglyceride; TG) concentrations. We hypothesized that changes in insulin sensitivity are an important determinant of exercise-induced changes in postprandial TG concentrations. Altogether, 38 men and 43 women, all of whom were normotriglyceridaemic and normoglycaemic, each underwent two oral fat tolerance tests with different pre-conditions: control (no exercise) and prior exercise (90min of exercise at 60% of maximal O2 uptake the day before). Venous blood samples were obtained in the fasting state and for 6h after a high-fat mixed meal. In the control trial there were significant correlations between log fasting TG concentration and log fasting insulin concentration (r = 0.42, P < 0.0005) and between log postprandial TG response (area under the curve) and log postprandial insulin response (r = 0.48, P < 0.0005). Prior exercise reduced the fasting TG concentration by 18.2±2.2% (mean±S.E.M.) (P < 0.0005), the postprandial TG response by 21.5±1.9% (P < 0.0005), the fasting insulin concentration by 3.8±3.1% (P < 0.01) and the postprandial insulin response by 11.9±2.5% (P < 0.0005). However, there was no relationship between the exercise-induced changes in log fasting TG and log fasting insulin (r = 0.08, P = 0.50), nor between the exercise-induced changes in log postprandial TG response and log postprandial insulin response (r = 0.04, P = 0.70). These data suggest that the reductions in fasting and postprandial TG levels elicited by a session of moderate-intensity exercise are not mediated by an increase in insulin sensitivity.


2020 ◽  
Vol 52 (7S) ◽  
pp. 456-457
Author(s):  
Everson A. Nunes ◽  
Josie Jakubowski ◽  
Filipe J. Teixeira ◽  
Victoria Vescio ◽  
Robert W. Morton ◽  
...  

2012 ◽  
Vol 37 (3) ◽  
pp. 551-554 ◽  
Author(s):  
Nicholas A. Burd ◽  
Cameron J. Mitchell ◽  
Tyler A. Churchward-Venne ◽  
Stuart M. Phillips

It is often recommended that heavier training intensities (∼70%–80% of maximal strength) be lifted to maximize muscle growth. However, we have reported that intensities as low as 30% of maximum strength, when lifted to volitional fatigue, are equally effective at stimulating muscle protein synthesis rates during resistance exercise recovery. This paper discusses the idea that high-intensity contractions are not the exclusive driver of resistance exercise-induced changes in muscle protein synthesis rates.


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