A CLINICO -PATHOLOGICAL STUDY OF NEOPLASTIC AND NON-NEOPLASTIC OVARIAN LESIONS.

Background: Ovarian lesions constitute a complex group with varied clinical behaviour and pathology. The ovaries constitute the internal reproductive organs their lesions can present in childhood to postmenopausal age group Clinical, radiological and gross examination alone cannot distinguish benign from malignant lesions; hence, histopathological examination is needed for their diagnosis and management. Objectives: A Clinico -pathological analysis of non-neoplastic and neoplastic ovarian lesions. Materials and methods: This descriptive study of one year comprised of 80 ovarian lesions diagnosed in the Department of Pathology, Bhagat Phool Singh Government medical college Sonipat. After thorough gross examination, representative bits were routinely processed and stained with H & E. Tumours were classified as per WHO classification. Results: Out of 80 ovarian lesions received, non-neoplastic lesions constituted 39% (31/80). Benign lesions constituted 45% (36/80) whereas borderline and malignant lesions constituted 5% (4/80) and 11.25% (9/80) respectively. Among non-neoplastic lesions, follicular cysts (67.7%) constituted the majority followed by corpus luteal cysts and endometriotic cysts. Among neoplastic lesions majority of the tumours were of surface epithelial type (69.38%) followed by germ cell tumours (18.36%). Bilateral lesions were seen in 17 (26.98%) patients while unilateral lesions were seen in 46 (73.01%) patients. Patients age varied from 16 to 75 years. For non-neoplastic lesions, patient age varied from 16 to 61 years. For neoplastic lesions patient age ranged from 18-75 years with age range of 18-75 years for benign tumours and 26-66 years for malignant tumours. Abnormal uterine bleeding was the commonest clinical presentation of non-neoplastic lesions. Benign and malignant tumours were most commonly associated with pain abdomen. Conclusion: Ovarian lesions comprise of variety of non-neoplastic and neoplastic lesions. By knowing clinical data, gross features, we can narrow our differential diagnosis and reach to the final diagnosis. So, early diagnosis and treatment definitely reduce the mortality from ovarian tumours. Keywords: Non-neoplastic, Benign, Malignant, Ovary, Lesions, Cysts, Tumours.

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A histopathological review of nephrectomy specimens with an emphasis on pathological assessment of prognostic indicators in malignant lesions

Biomedicine ◽

10.51248/.v40i4.327 ◽

2021 ◽

Vol 40 (4) ◽

pp. 492-501

Author(s):

Shubha P. Bhat ◽

Krishna Prasad H.V. ◽

Rajeev T.P. ◽

Kishan Prasad H.L. ◽

Teerthanath Srinivas ◽

...

Keyword(s):

Histopathological Examination ◽

Malignant Tumour ◽

Prognostic Indicators ◽

Wilms Tumour ◽

Malignant Tumours ◽

Neoplastic Lesions ◽

Kidney Lesion ◽

Microscopic Features ◽

Malignant Lesions ◽

Pathological Assessment

Introduction and Aim: Various non-neoplastic and neoplastic lesions occur in the kidney. Pathological assessment of gross and microscopic features in nephrectomy specimens is essential for diagnosis and predicts the prognosis in malignant tumours. Materials and Methods: Case records of 46 nephrectomy specimens received between two-year periods were retrieved. Detailed gross and histopathological and immunohistochemical features were studied, and malignant tumours were analysed using CAP protocol. Results: Out of 46 nephrectomy specimens, 17 were non-neoplastic and 29 neoplastic. Males constituted 32 cases and females 14 cases. The commonest non-neoplastic kidney lesion was chronic pyelonephritis with hydronephrosis (29%). The mixed epithelial and stromal tumour was the frequently encountered benign tumour (50%). Renal cell carcinoma was the most common malignant tumour in adults (70%) and Wilms tumour in children (4%). Conclusion: Histopathological examination of nephrectomy specimens helps in diagnosing, staging, and planning the management.

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Nasomaxillary swellings: our experience at tertiary care hospital

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20210680 ◽

2021 ◽

Vol 7 (3) ◽

pp. 469

Author(s):

Mukesh Rawat ◽

Archana Lall ◽

Kavita Sachdeva

Keyword(s):

Tertiary Care Hospital ◽

Histopathological Examination ◽

Tertiary Care ◽

Final Diagnosis ◽

Inverted Papilloma ◽

Nasal Endoscopy ◽

Common Symptom ◽

Fungal Sinusitis ◽

Care Hospital ◽

Malignant Lesions

Background: A wide spectrum of lesions may present as nasomaxillary swellings ranges from benign to malignant lesions including fungal sinusitis and fibro vascular lesions example: JNA (Juvenile nasopharyngeal angiofibroma) and Inverted papilloma. Many Pathologies ranging from benign to malignant tumors may mimic a simple Nasomaxillary mass. It is diagnostic challenge to determine pathology behind it. A detailed clinical evaluation with nasal endoscopy and relevant pre-operative investigations including radiological imaging and histopathological examination is essential to reach up to final diagnosis. The aim of the study was to do clinicopathological evaluation of patients presenting with nasomaxillary swelling and correlation of clinical, radiological and Histopathological findings.Methods: This was a prospective observational study on 50 nasomaxillary swelling patients who are presented in the Department of ENT and Head and Neck Surgery of N.S.C.B. MCH Jabalpur, a tertiary care Hospital, between March 2018 to August 2019. A detailed history taking and clinical examination with nasal endoscopy and relevant preoperative investigations including CECT Nose and PNS and histopathological examination was done in all patients.Results: 50 Nasomaxillary swelling patients were selected for this study. 30 patients were male and 20 were females. Ages of patients were varied from 12 years to 72 years. 23 patients (46%) were malignant and 27 (54%) were benign. Histopathological examination results shows benign lesions like JNA (6 cases), fungal sinusitis (6 cases), dermoid cyst (1 case), inverted papilloma (3 cases), sebaceous cyst (1 case), jaw lesions (10 cases), (odontogenic like radicular/ infected cyst, dentigerous cyst, cystic ameloblastoma and non-odontogenic like fibrous dysplasia) and malignant lesions like SCC (squamous cell carcinoma) (12 cases), spindle cell sarcoma (2 cases), undifferentiated carcinoma (3 cases), adenocarcinoma (3 cases), adenoid cystic carcinoma (1 case), Invasive pleomorphic sarcoma (1 case) and malignant melanoma (1 case). SCC was most common lesion f/b JNA and fungal sinusitis. Well differentiated SCC was most common histological type (10 out of 12 cases of SCC). Most common symptom was nasal obstruction (66% cases) f/b epistaxis (52% cases) but epitasis was most common symptom among malignant and JNA cases. In 6 cases (3 JNA, 1 inverted papilloma, 1 malignancy and 1 radicular cyst) radiological diagnosis were not correlated with histological findings.Conclusions: Most our cases were malignant nasomaxillary lesions followed by fungal sinusitis and JNA. Most patients presented in advanced stage of disease so rapidly evaluation including nasal endoscopy should be done. CECT scan is essential to determine tumors extent and bony lesions. All patients should undergo hisotopatholigical examination. The final diagnosis should be made on the basis of clinical, radiological and histopathological findings.

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Histopathological study of endometrium in abnormal uterine bleeding

Journal of Pathology of Nepal ◽

10.3126/jpn.v2i4.6882 ◽

2012 ◽

Vol 2 (4) ◽

pp. 297-300 ◽

Cited By ~ 3

Author(s):

S Bhatta ◽

AK Sinha

Keyword(s):

Histopathological Examination ◽

Abnormal Uterine Bleeding ◽

Uterine Bleeding ◽

Common Finding ◽

Histopathological Study ◽

Endometrial Sampling ◽

Proliferative Endometrium ◽

Malignant Lesions ◽

Hematoxylin And Eosin ◽

Hematoxylin And Eosin Stain

Background: Histopathological evaluation of endometrial samples is essential in the workup of abnormal uterine bleeding. This study was carried out to evaluate patterns of endometrial histological findings in women with abnormal uterine bleeding and to correlate histopathological findings with clinical features.Materials and Methods: One hundred and twenty two patients with diagnosis of abnormal uterine bleeding underwent endometrial sampling. The slides stained with Hematoxylin and Eosin stain were studied.Results: The predominant endometrial histopathological finding was proliferative endometrium 32 cases (26.23%) followed by simple hyperplasia without atypia 22 cases (18.03%). Malignant lesions were more common in patients more than 40 years of age and comprised of 7 cases (5.74%) of all cases. Atrophic endometrium was most common finding in postmenopausal bleeding 8 cases (28.6%) followed by endometrial carcinoma 5 cases (17.9%).Conclusion: Histopathological examination of endometrium should be done generously in women presenting with abnormal uterine bleeding especially after the age of 40 years to rule out malignant pathology.Journal of Pathology of Nepal (2012) Vol. 2, 297-300DOI: http://dx.doi.org/10.3126/jpn.v2i4.6882

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Demographic And Histopathological Characteristics Of Colorectal Polyps: A Descriptive Study Based On Samples Obtained From Symptomatic Patients

Slovenian Journal of Public Health ◽

10.1515/sjph-2016-0016 ◽

2016 ◽

Vol 55 (2) ◽

pp. 118-123

Author(s):

Genta Cekodhima ◽

Altin Cekodhima ◽

Arben Beqiri ◽

Mehdi Alimehmeti ◽

Gerhard Sulo

Keyword(s):

Colorectal Cancer ◽

Histopathological Examination ◽

Colorectal Polyps ◽

Medium Size ◽

Polyp Size ◽

Patient Age ◽

Patient Âgé ◽

Potentially Malignant ◽

Study Population ◽

And Gender

Abstract Background Colorectal polyps (CP) are common among individuals older than 50 years. Some polyp types can precede colorectal cancer (CRC). This study aimed at describing histopathological characteristics of colorectal polyps in relation to age and gender among symptomatic patients referred for a colonoscopy examination during 2011-2014 in Tirana, Albania. Methods Study population included 267 individuals aged ≥ 20 years and diagnosed with ≥ 1 polyp during a colonoscopy examination. A total of 346 polyps were identified, excised and measured, and underwent histopathological examination. Results Adenomas accounted for 79.8% of all polyps and tubular type was the most frequent one (74.4%). The majority of polyps (42.5%) were small (<1 cm), 38.7% of a medium size (1-2 cm) and 18.8% large (>2 cm). Adenomas were larger than non-adenomatous polyps (p<0.01) There was no gender difference with regard to patient age (p=0.22) or polyp size (p=0.84) Adenomas were more frequent among men compared to women (p=0.02). Age was strongly related to polyp characteristics. The proportion of adenomas increased significantly with age (p<0.01). Within adenomas, the proportion of villous types - a precursor of colorectal cancer - increased remarkably with age (p=0.01). Older age was positively associated with potentially malignant adenomas (defined as adenomas > 1 cm and showing high-grade dysplasia) (p<0.01). Conclusion Adenomas accounted for the majority of polyps. Their morphology, size and malignant potential were related to patient age.

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Histopathological Scenario of Testicular Lesions with Few Uncommon Entities – 3 Years Study in a Tertiary Care Hospital

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/91 ◽

2021 ◽

Vol 8 (9) ◽

pp. 467-470

Author(s):

Padma Madana ◽

Vijayasree Mandava ◽

Neelima Govada ◽

Padmavathi Devi Chaganti ◽

Zafrul Haque Mohammed ◽

...

Keyword(s):

Histopathological Examination ◽

Tertiary Care ◽

Common Finding ◽

Care Hospital ◽

Malignant Tumours ◽

Cell Hyperplasia ◽

Equal Distribution ◽

Splenogonadal Fusion ◽

Inflammatory Conditions ◽

Neoplastic Lesions

BACKGROUND The incidence of testicular malignancy has been increasing in men, orchidectomy is necessary for the removal of neoplastic lesions or in patients with chronic inflammatory conditions resistant to treatment. We wanted to evaluate the various histopathological patterns of lesions in testis. METHODS A retrospective study of 86 orchidectomy specimens over a period of three years with age wise distribution from March 2017 to February 2020 was done in the Department of Pathology, Guntur Medical College, Guntur. Histopathological slides stained with haematoxylin and eosin were retrieved and reviewed. Immunohistochemistry was done in two cases. RESULTS Of the 86 cases, 78 (90.7 %) cases were non neoplastic and 8 (9.3 %) cases were neoplastic. Youngest age in non-neoplastic group was four days and in neoplastic group was 18 years. The oldest age was 82 years in the non-neoplastic lesions and 60 years in the neoplastic lesions. Non neoplastic lesions were common in the 3 rd decade. In malignant lesions, highest number of cases was seen in the 6 th decade and equal distribution was observed in 3rd and 5th decade. Unilateral involvement was common than bilateral involvement. Out of all non-neoplastic lesions, undescended testis 20 (25.64 %) cases was the common finding followed by non-specific epididymo orchitis 19 (24.36 %) cases, abscess 14 (17.95 %) cases, torsion infarction 13 (16.67 %) cases, Leydig cell hyperplasia 4 (5.13 %) cases, 3 (3.85 %) cases each of tuberculous epididymo orchitis and granulomatous epididymo orchitis. 1 (1.28 %) case each of rare entities like vanishing testis and splenogonadal fusion were also found. Among the neoplastic lesions, all 8 cases were malignant tumours. Out of these malignant tumours, mixed germ cell tumours were seen in 3 (37.5 %) cases followed by seminomas 2 (25 %) cases, post pubertal teratoma 1 (12.5 %) case, non-Hodgkin’s lymphoma (NHL) 1 (12.5 %) case and primitive neuroectodermal tumour (PNET) 1 (12.5 %) case. CONCLUSIONS Histopathological examination on routine haematoxylin and eosin (H&E) stained sections primarily differentiate non neoplastic lesions from neoplastic group and benign tumours from malignant tumours as the treatment modality varies. Immunohistochemistry (IHC) is useful in the diagnosis of poorly differentiated small round cell tumours. KEYWORDS Orchidectomy Specimens, Neoplastic and Non-Neoplastic Lesions

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Adenomyosis: correlating clinical suspicion with histopathological diagnosis in a retrospective study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20195206 ◽

2019 ◽

Vol 8 (12) ◽

pp. 4674

Author(s):

Preet Kamal ◽

Ripan Bala ◽

Madhu Nagpal ◽

Harleen Kaur

Keyword(s):

Retrospective Study ◽

Histopathological Examination ◽

Abnormal Uterine Bleeding ◽

Reproductive Organs ◽

Histopathological Diagnosis ◽

Medical Sciences ◽

Common Causes ◽

Chief Complaints ◽

The Common ◽

Chronic Cervicitis

Background: Adenomyosis and leiomyoma are the common causes of abnormal uterine bleeding (AUB). In this study it is aimed to evaluate the correlation of clinical and histopathological examination (HPE) of these entities leading to abnormal uterine bleeding.Methods: This retrospective study was carried out on hysterectomy specimens of subjects who presented themselves in the department of obstetrics and gynaecology of Sri Guru Ram Das Institute of medical sciences and research, Amritsar with chief complaints of AUB not responding to conservative treatment.Results: A total of 100 women with clinical diagnosis of AUB in which hysterectomies were performed, leiomyoma was found in 42% cases, adenomyosis in 22% cases. The most frequent combination of diagnosis was leiomyoma and adenomyosis i.e. 26%. In 9% cases chronic cervicitis and ovarian cyst were detected. In one case endometrial malignancy was found.Conclusions: Though adenomyosis and leiomyoma are clinically diagnosed along with other pathological conditions of the reproductive organs but their confirmation is still to be relied upon HPE; a most important investigation.

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Premalignant and malignant lesions in endometrial polyps in patients undergoing hysteroscopic polypectomy

Einstein (São Paulo) ◽

10.1590/s1679-45082014ao2764 ◽

2014 ◽

Vol 12 (1) ◽

pp. 16-21 ◽

Cited By ~ 6

Author(s):

Marco Antonio Lenci ◽

Vanessa Alessandra Lui do Nascimento ◽

Ana Beatriz Grandini ◽

Walid Makin Fahmy ◽

Daniella de Batista Depes ◽

...

Keyword(s):

Postmenopausal Women ◽

Histopathological Examination ◽

Transvaginal Ultrasound ◽

Abnormal Uterine Bleeding ◽

Uterine Bleeding ◽

Premalignant Lesions ◽

Endometrial Polyps ◽

Menstrual Status ◽

Cellular Atypia ◽

Malignant Lesions

Objective : To evaluate the incidence of premalignant lesions and cancer in endometrial polyps, in patients undergoing hysteroscopic polypectomy. Methods : The results of 1,020 pathological examinations of patients submitted to hysteroscopic polypectomy were analyzed, as well as their diagnostic and surgical hysteroscopy findings. As to their menstrual status, 295 (28.9%) patients were in menacme. Of the total, 193 (65.4%) presented abnormal uterine bleeding, and 102 (34.6%) were asymptomatic with altered endometrial echo on transvaginal ultrasound. Out of 725 (71.1%) postmenopausal patients, 171 (23.6%) were symptomatic (abnormal uterine bleeding), and 554 (76.4%) were asymptomatic with endometrial echo >5.0mm. Results : Twenty-one (2.0%) patients presented premalignant lesions in the polyps, 13 had simple glandular hyperplasia, of which 5 had no atypia, and eight presented atypia. Eight polyps presented focal area of complex hyperplasia: 4 with atypia and 4 without lesions. Cancer was diagnosed in 5 (0.5%) polyps. Of the 21 polyps that harbored premalignant lesions, 12 were interpreted as benign in diagnostic and surgical hysteroscopy. Of the polyps with cancer, 4 were also histeroscopically interpreted as normal. Conclusion : Symptomatic polyps in menacme and in all postmenopausal women should be resected and submitted to histopathological examination, since they may have a benign aspect, even when harboring areas of cellular atypia or cancer.

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Clinical and histopathological correlation of breast lesions

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20181295 ◽

2018 ◽

Vol 6 (4) ◽

pp. 1348

Author(s):

Kavita Sharma ◽

S. P. Vyas ◽

Subhash Dhayal

Keyword(s):

Invasive Carcinoma ◽

Histopathological Examination ◽

Breast Tumors ◽

Mucinous Carcinoma ◽

Malignant Tumour ◽

Benign Tumors ◽

Histopathological Study ◽

Breast Lesions ◽

Malignant Tumours ◽

Neoplastic Lesions

Background: To study the histopathological features of neoplastic and non neoplastic lesions of breast. To correlate the pathological findings with clinical parameters.Methods: We have studied total 170 cases of breast lesions over a period of two years in our institute. The specimens were received in histopathology section of our department. Detailed gross examination of specimens was done followed by fixation, thorough sampling, and tissue processing. The different lesions were studied by histopathological examination and analysed. Neoplastic lesions were classified according to the WHO classification.Results: Out of the 170 cases, 128 cases had neoplastic lesions and 41 cases had non-neoplastic lesions, and one case had coexistent neoplastic and nonneoplastic lesions. Out of the total 129 cases with neoplastic lesions, 76 cases had benign breast tumors, 51 cases had malignant breast tumors, and 2 cases had precursor lesions. Fibroadenoma was the most common benign tumour with 62 cases. Invasive carcinoma no special type was the most common malignant tumour with 43 cases. Special subtypes of invasive carcinoma found in our study were mucinous carcinoma (2 case). The most common nonneoplastic lesion was mastitis with 12 cases, followed by duct ectasia and fibrocystic change. There were 6 cases of gynaecomastia. All the tumors involved upper outer quadrant most frequently. The benign tumors were most frequent in second, third and fourth decades, malignant tumours were seen beyond 4th decade. The nonneoplastic lesions were common in 4th decade.Conclusions: Histopathological study is important in the management of breast lesions.

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HISTOPATHOLOGICAL SPECTRUM OF SALIVARY GLAND LESIONS WITH CLINICAL CORRELATION

10.36106/gjra/5201396 ◽

2020 ◽

pp. 1-3

Author(s):

Radhika Mucharla ◽

Ravikanth Kotagiri

Keyword(s):

Salivary Gland ◽

Clinical Laboratory ◽

Malignant Tumors ◽

Histopathological Examination ◽

Final Diagnosis ◽

Research Centre ◽

Benign Tumors ◽

Salivary Gland Tumours ◽

Chronic Sialadenitis ◽

Neoplastic Lesions

Salivary gland tumours account for 2-6.5% of all the neoplasms of the Head and Neck. Histopathology is most important in diagnosis of salivary gland tumors. AIMS and OBJECTIVES : To study age,sex and site distribution of various salivary gland lesions, to study the histomorphologic (gross &microscopic) aspect of these lesions to correlate clinical diagnosis with that of histopathologic features. MATERIALS AND METHODS: The study is conducted in the RAINBOW CLINICAL LABORATORY AND RESEARCH CENTRE, SIDDIPET during the period of September2018 to September 2020. Formalin fixed ,paraffin embedded sections and stained with hematoxylin and eosin slides were studied. RESULTS: Total number of specimens were 54. Out of these 39 were neoplastic (benign 70%,malignant 30%) and 15 were non neoplastic. Among the benign tumors majority are pleomorphic adenoma.Among the malignant tumors, mucoepidermoid carcinoma is the most common. Among the non neoplastic lesions chronic sialadenitis is most common. CONCLUSION: Histopathological examination of salivary gland lesions stands out to be the most important method in establishing the final diagnosis. It helps in differentiating non neoplastic and neoplastic lesions.

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A Case of Adenosarcoma of the Uterus

Case Reports in Obstetrics and Gynecology ◽

10.1155/2014/342187 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4

Author(s):

Shigeki Taga ◽

Mari Sawada ◽

Aya Nagai ◽

Dan Yamamoto ◽

Ryoji Hayase

Keyword(s):

Histopathological Examination ◽

Uterine Cavity ◽

Total Abdominal Hysterectomy ◽

Final Diagnosis ◽

Abdominal Hysterectomy ◽

Pelvic Lymphadenectomy ◽

Postoperative Treatment ◽

Case Presentation ◽

Magnetic Resonance Imaging Mri ◽

Gross Examination

Adenosarcoma is a rare tumor which consists of benign glandular epithelium and malignant mesenchymal component. Here we report a case of adenosarcoma of the uterine corpus.Case Presentation. A 59-year-old woman presented with vaginal bleeding and visited a local clinic. She had a uterine tumor pointed out and was referred to our hospital. Ultrasound scans revealed a large heterogeneous mass occupying the whole uterine cavity. Cytological test of endometrium was performed but the result was negative. A fractional endometrial curettage revealed no malignancy. Magnetic resonance imaging (MRI) revealed a heterogeneous solid tumor of 77 × 76 mm. Total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was performed. On gross examination, the tumor was arising from the uterine body and occupied the whole uterine cavity. Histopathological examination revealed phyllodes-like architecture on low magnification　and　periglandular cuffing of tumor cells. The lesion was confined to the uterus. Histopathological final diagnosis was adenosarcoma. Her postoperative course was uneventful and she was discharged without postoperative treatment and remains alive without disease 6 months after the surgery.

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