scholarly journals TO CORRELATE BETWEEN BIOCHEMICAL PARAMETERS AND DIFFERENT GRADES OF OBESITY

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Hemant Nargawe ◽  
Devidas Shankar Bantewad
Keyword(s):  
Diastolic Dysfunction ◽  
Lipid Profile ◽  
Serum Cholesterol ◽  
Lipid Level ◽  
Case Control ◽  
Sampling Procedure ◽  
Left Ventricular ◽  
Medical College ◽  
Significant Difference ◽  
Standard Sampling

Background & Method: In this case control (observational) study we include 114 participant (n=57 cases and n=57 controls) in this case and controls taken using standard sampling procedure participants are taken who attend Medicine OPD in Netaji Subhash Chandra Bose Medical college Jabalpur in period of March 2015 to August 2016. Result: We didn’t found significant difference in cases on the basis of BMI and FBS,PPBS and GTT.We found correlation in cases on the basis of BMI and in Lipid Profile and we found there is significant difference in low density lipid level in overweight and moderate obese (t>2.08) and Triglyceride level and Serum cholesterol/HDL ratio in overweight and sever obese (t>1.97, t>2.41) and moderate and severe Obese (t>2.14, t>2.10). Conclusion: In cases on the basis of Diastolic dysfunction and Lipid Profile we found significant difference between serum cholesterol/HDL levels in those who had Diastolic dysfunction compare to who don’t have Diastolic dysfunction. Diastolic dysfunction appears not to be influenced by sex. The association between diastolic dysfunction and obesity according to sex is not significant. In cases on the basis of BMI and FBS, PPBS and GTT we don’t found significant difference in cases. In grades of Diastolic Dysfunction and Lipid profile and we doesn’t found any significant difference in grade 1 and grade 2 diastolic dysfunction on the basis of lipid profile. Keywords: BMI, Left Ventricular, Transthoracic & Echocardiography.

scholarly journals Silhouette of cardiac impairment in diabetic patients at a medical college in Rewa district

2021 ◽  
Vol 9 (4) ◽  
pp. 1132
Author(s):  
Julie Abraham ◽  
Manoj Indurker ◽  
Seema Mahant ◽  
M. K. Jain ◽  
Kanniyan Binub
Keyword(s):  
Diastolic Dysfunction ◽  
Cholesterol Level ◽  
Serum Cholesterol ◽  
Diabetic Complications ◽  
Cardiac Dysfunction ◽  
Serum Cholesterol Level ◽  
Stress Test ◽  
Left Ventricular ◽  
Medical College ◽  
Positive Results

Background: The modern technology (TMT) had helped to detect cardiac impairment in diabetes patients relative to past. This study had attempted to use modern tools for detection of cardiac impairment in patients who attended OPD in a medical college of Rewa district. Objectives of the study was to evaluate cardiac dysfunction and factors associated with cardiac dysfunction (using values of TMT) in diabetic patients.Methods: A descriptive study was done with help of recording history of variables like smoking, alcohol, BMI, HBA1C value, cholesterol level and others. Chi square was done to assess test of significance.Results: Diastolic dysfunction was more in patients with diabetic complications than those without diabetic complications. Most patients having peripheral neuropathy, nephropathy and retinopathy had diastolic dysfunction. Patients had also shown high incidence of positivity to TMT. Half of the patients (50%) positive results for stress test were higher with cases who led a sedentary life style (13.64%). Most of patients (70%) had serum. cholesterol level less than 200 mg/dl but the positive results for stress test were higher in patients with Serum. cholesterol level 200 to 239 mg/dl.  Conclusions: The study could shower light on the conclusion that left ventricular diastolic dysfunction in type 2 diabetes mellitus patients is more relative to systolic dysfunction.

scholarly journals Left ventricular geometric patterns and cardiac function in patients with chronic renal failure undergoing hemodialysis

2005 ◽  
Vol 64 (1) ◽  
Author(s):  
Maria Teresa Manes ◽  
Manlio Gagliardi ◽  
Gianfranco Misuraca ◽  
Stefania Rossi ◽  
Mario Chiatto
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Diastolic Dysfunction ◽  
Cardiac Troponin ◽  
Ventricular Hypertrophy ◽  
Interventricular Septum ◽  
Myocardial Damage ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Posterior Wall Thickness ◽  
Significant Difference

The aim of this study was to estimate the impact and prevalence of left ventricular geometric alterations and systolic and diastolic dysfunction in hemodialysis patients, as well as the relationship with cardiac troponin as a marker of myocardial damage. Methods: 31 patients (pts), 19 males and 12 females, age 58.1±16.4 (26 on hemodialysis, 5 on peritoneal dialysis) and 31 healthy normal controls were enrolled. Echocardiography measurements were carried out according to the American Society of Echocardiography recommendations. Left ventricular mass was calculated, according to the Devereux formula and indexed to height and weight 2.7. Doppler echocardiography was performed to study diastolic function by measurements of isovolumetric relaxation period (IVRT), E wave deceleretion time (DTE) and E/A ratio. Cardiac troponin was measured by a third generation electrochemiluminescence immunoassay. Statistical analysis was performed using the t-test for between-group comparisons and the Pearson and Spearman’s tests to investigate correlations; p values of <0.05 were considered statistically significant. Results: Eccentric hypertrophy was the most frequent pattern (n=17; 55%), followed by normal cardiac geometry (n=7; 23%), and concentric hypertrophy (n=5; 16%). Only 6% of pts (n=2) showed concentric remodelling. Systolic dysfunction was present in terms of endocardial parameters in 3 pts (9%) (fractional shartening <25%, EF<50%), but in terms of midwall myocardial shortening in 51% (n=16). Diastolic dysfunction was present in 87% (n=27) with a pattern of impaired relaxation (in 5 without left ventricular hypertrophy). E/A was negatively correlated with age (r=-0.41, p=0.02); DTE was positively correlated with posterior wall thickness (r=0.36, p=0.05) and interventricular septum thickness (r=0.45, p=0.01); cardiac troponin was positively correlated with age (r=0.50, p=0.00), left ventricular mass (r=0.41, p=0.02), posterior wall thickness (r=0.41; p=0.02) and interventricular septum thickness (r=0.39, p=0.03) but not with diastolic dysfunction parameters. No significant difference was found in terms of duration of dialysis between patients with normal left ventricular geometry and those with left ventricular hypertrophy, but a significant difference in age was found (p=0.03). Pts with diastolic dysfunction had more frequent hypotensive episodes during dialysis (p <0.01). Conclusion: Impaired geometry and cardiac function is frequently observed in pts undergoing hemodialysis. Diastolic dysfuction is associated to a geometric pattern of left ventricular hypetrophy, although it can be an isolated initial manifestation of myocardial damage. Depressed midwall myocardial shortening can discriminate left ventricular dysfunction better than traditional endocardial systolic indexes.

scholarly journals Comparison of Clinical Features between Primary Aldosteronism and Essential Hypertension in Chinese Patients: A Case-Control Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xiaoyu Huang ◽  
Shuang Yu ◽  
Huangmeng Xiao ◽  
Ling Pei ◽  
Yan Chen ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Insulin Secretion ◽  
Clinical Features ◽  
Primary Aldosteronism ◽  
Structural Damage ◽  
Case Control ◽  
Secondary Hypertension ◽  
Left Ventricular ◽  
Chinese Patients ◽  
Significant Difference

Primary aldosteronism (PA) is one of the most common forms of secondary hypertension. Recent studies suggest that, compared with essential hypertension (EH), PA presents more severe disorders of glycolipid metabolism and organ damages. This case-control retrospective study aimed to ascertain clinical features and metabolic parameters between Chinese patients of PA and EH. 174 PA patients and 174 matched EH patients were recruited. Their clinical features, biochemistry parameters, the ventricular septal thickness, and left ventricular mass index (LVMI) were compared. HOMA-β% and HOMA-IR were calculated to evaluate glucose metabolism. The results showed that there was no significant difference regarding BMI, waist-to-hip ratio, and blood pressure between the two groups. The blood potassium level was significantly lower in PA patients than those in EH patients. The abnormal glucose tolerance and the incidence of diabetes in the PA group were not significantly different from those in EH group, but the insulin secretion levels at 0 min and 30 min were significantly weaker than those in the EH group, and the HOMA-β% was also lower in the PA group than those in the EH group. Left ventricular structural abnormalities in PA patients were more severe than those in EH patients. Subtype analysis indicated that patient with aldosterone-producing adenoma (APA) has more serious hypokalemia and lower levels of HOMA-β% and HOMA-IR comparing to those in the idiopathic adrenal hyperplasia (IHA) patient. These findings demonstrated that PA patients showed more impaired insulin secretion function and more severe left ventricular structural damage compared with EH patients.

scholarly journals EVALUATION OF LIPID PROFILE IN CASES SUFFERED FROM RHEUMATOID ARTHRITIS

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Vivek Kumar ◽  
Neeraj Kumar ◽  
Jaideo Prasad
Keyword(s):  
Rheumatoid Arthritis ◽  
Lipid Profile ◽  
Blood Sample ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Medical College ◽  
Systemic Inflammatory Disease ◽  
Significant Difference ◽  
Group B ◽  
Undetermined Etiology

Rheumatoid arthritis is a chronic systemic inflammatory disease of undetermined etiology involving primarily the synovial membranes and articular structures of multiple joints. The disease is often progressive and results in pain, stiffness, and swelling of joints. In late stages, deformity and ankylosis develop. Rheumatoid arthritis can also cause significant extra-articular manifestations most probably related to systemic inflammation. Hence based on above findings the present study was planned for Evaluation of Lipid Profile in Cases Suffered from Rheumatoid Arthritis. The present study was planned in Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India. In the present study 50 patients were evaluated. Out of that 25 cases of the arthritides were enrolled in Group A and remaining 25 control cases were evaluated in the Group B. For the biochemical parameters to be analyzed, blood sample were drawn from the anticubital vein avoiding venostasis. In all subjects a blood sample was collected after an overnight fast plain vials are used for the determination of lipid profile, Total cholesterol and HDL Cholesterol were measured by Henly‟s method. Serum triglyceride was estimated by Rosenberg and Gottfrieds. The data generated from the present study concludes that the lipid profile is altered in Rheumatoid arthritis characterized by low TC and LDL with lower RA factor titres. However, the mean triglycerides, HDL, LDL, VLDL, TC/HDL and mean LDL/HDL did not show a significant difference between subgroups of the patients having different titres of RA factor. Keywords: Lipid profile, Rheumatoid arthritis, Periarticular osteopenia, Hypercholesterolemia, Hypertriglyceridemia, RA factor, etc.

scholarly journals Utility of N-terminal pro-brain natriuretic peptide in detecting diastolic dysfunction in asymptomatic hypertensive patients: comparison with echocardiography

2019 ◽  
Vol 11 (1) ◽  
pp. 14-18
Author(s):  
Sahadeb Prasad Dhungana ◽  
Prahlad Karki ◽  
Madhab Lamsal
Keyword(s):  
Early Detection ◽  
Brain Natriuretic Peptide ◽  
Diastolic Dysfunction ◽  
Natriuretic Peptide ◽  
Systolic Function ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
Echocardiographic Parameters ◽  
Lv Diastolic Dysfunction

Introduction: Data suggest that brain natriuretic peptide (BNP) and NT pro-BNP partially reflect ventricular pressure and could have a role in the early detection of diastolic abnormalities in hypertensive patients with normal systolic function. This study aimed to assess the role of NT pro-BNP for early detection of diastolic dysfunction in patients with hypertension and to correlate its level with echocardiographic parameters of diastolic dysfunction. Methods: This is a comparative cross-sectional study. Hundred cases of asymptomatic hypertensive patients with normal left ventricular (LV) systolic function and 100 healthy subjects were subjected to echocardiography and measurement of serum NT-pro BNP who received care at outpatient department of internal medicine, B.P. Koirala Institute of health sciences, Nepal. Results: Both systolic and diastolic blood pressures were significantly higher (≥160 and/or 100 mm Hg) in cases compared to controls (<120/80 mm Hg). Echocardiographic parameters of diastolic dysfunction: E/A ratio, E/E’ratio, deceleration time and isovolumetric relaxation time showed a significant difference between cases and controls. Mean serum NT-proBNP was significantly higher in patients with hypertension (213.19 ±184.3 pg/mL) compared to controls (58.51 ± 11.01 pg/mL) (P=0.008). There was no significant difference in mean serum NT-pro BNP levels between cases with no LV diastolic dysfunction (n=14) and controls (n=100) but it showed a significant difference between cases with LV diastolic dysfunction of all grades (n=86) and controls (n=100) (P=0.00). NT-proBNP levels were higher in both group of patients with E/A ratios <0.9 and 0.9-1.5 (245.72 ± 166.73 pg/mL and 210.69 + 143.53 pg/mL respectively) as compared to controls. Mean serum NT-proBNP levels were significantly higher in patients with IVRT >90 ms (270.43 ± 180.81 pg/mL) as compared to controls (P=0.03) but the difference was not significant between cases with IVRT of 60-90 ms (152.02 ± 100.23 pg/mL) and controls (P=0.09). NT-proBNP levels were significantly higher in all groups of patients with E/E’ ratios <8, 8-12, >12 (197 ± 121.25 pg/mL, 263.12 ± 122.52 pg/mL and 180 ± 106.56 pg/mL respectively) compared to controls. Conclusion: Mean serum NT-proBNP was significantly higher in patients with hypertension as compared to controls. There is some correlation between echocardiographic parameters of diastolic dysfunction and serum NT-proBNP. Hence, NT-proBNP may be useful for early detection of LV diastolic dysfunction in patients with hypertension.

Role of Persistent Hyperlipidaemia in Relapse of Idiopathic Nephrotic Syndrome

2020 ◽  
Vol 33 (2) ◽  
pp. 69-75
Author(s):  
Bidhan K Pramanik ◽  
Md Shameem ◽  
Md Belal Uddin ◽  
MH Tarafder ◽  
Parimal K Paul ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Lipid Profile ◽  
Serum Cholesterol ◽  
Mental Health Problems ◽  
Lipid Level ◽  
P Value ◽  
Physical And Mental Health ◽  
College Hospital ◽  
Group 2 ◽  
Group 1

Background & objective: Impact of Nephrotic syndrome due to relapse on children and their families is so diverse and extreme that causes serious physical and mental health problems for a long time. Repeated Hyperlipidemia and frequent long term steroid treatment in relapsed cases add more burdens on already fragile health of these children. Materials & Methods: This descriptive, observational study was carried out in the Department of Pediatrics, Rajshahi Medical College Hospital over a period of 24 months from July 2015 to June 2017. If a child’s age at presentation was between 2 to 8 years of age group of either sex having typical features of nephrotic syndrome(first attack), such as- generalized swelling which started from the face, having abnormal urinary finding ( proteinuria 3+ or more and UTP >1gm/m2/24hrs hypoalbuminemia, hypercholesterolemia but responded to steroid was included in the study. When the child was in remission, serum Lipid profile was done following 10 hours of fasting once again. Then the child was followed up fortnightly for a period of six months from the initial attack for generalized edema and bedside urinary albumin 3+ or more. Results were tested with independent ‘t’ test and χ2 test to find out the association between high lipid profile during remission with the relapse . A two-tailed P value of 0.05 was considered statistically significant. Results: All 50 children were divided into two groups on the basis of lipid profile during remission. Group-1 consists of 20 children who had normal lipid profile during remission and group-2 consists of 30 children who had abnormal lipid profile during remission. Both group-1 & 2 had higher mean levels of serum cholesterol, LDL, and TG levels during initial diagnosis. During remission, group-2 patients showed higher mean serum cholesterol (364.60±64.00 mg/dl vs. 189.25±9.02 mg/dl), serum LDL (241.53±58.42 mg/dl vs. 146.65±3.60 mg/dl), and serum TG (225.10±43.79 mg/dl vs. 138.90±8.15 mg/dl). All these differences in lipid profile between these group were statistically highly significant (p=<0.001).Only 2(10%) cases underwent relapse from group-1 out of 20 cases, whereas 16(53.33%) cases underwent relapse out of 30 cases from group-2 within six (6) months follow-up. The difference between group-1 & group-2 was statistically significant (p=0.002).Among the relapsers, mean cholesterol (394.18±43.03 mg/dl vs. 329.50±67.81 mg/dl; p= 0.004) was significantly higher than that of non-relapsers of group-2 patients. Conclusion: Elevated lipid level, especially serum cholesterol during remission phase may be associated with subsequent relapse in idiopathic childhood nephrotic syndrome. TAJ 2020; 33(2): 69-75

scholarly journals Left ventricular dysfunction in hypertensive patients: an echocardiographic assessment

2018 ◽  
Vol 8 (3) ◽  
pp. 51-56
Author(s):  
Rishi Khatri ◽  
Devendra Khatri ◽  
Dhan Bahadur Shrestha ◽  
Parag Karki ◽  
Chiranjeevi Panta ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Diastolic Dysfunction ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Systolic Dysfunction ◽  
Systolic Dysfunction ◽  
Age Distribution ◽  
Left Ventricular ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Significant Difference

Introduction: Echocardiography is noninvasive procedure to assess heart. Ventricular mass increases due to left ventricular hypertrophy and performance of left ventricle decreases with increase in blood pressure. Left ven­tricular diastolic dysfunction (LVDD) is early sign of heart weakness which can be picked up early with Echo. This study was aimed to study cardiac anatomic and functional parametric alteration in echocardiography among hypertensive patients. Methods: This was a non-invasive, cross sectional hospital based retrospective review of the patient record from echo room among the hypertensive patient who undergone echocardiographic as­sessment from September 2017-February 2018 in Shree Birendra Hospital (SBH), Chhauni, Kathmandu. Results: Among 447 hypertensive cases, 232(51.9%) were having normal diastolic function while rest 215(48.1%) were having diastolic dysfunction of the heart. Among total cases evaluated, only 12(2.7%) patients were having ejec­tion fraction lower than 55%, while in rest it was normal. There were 53 (11.9%) cases having some form of as­sociated complication. Gender, Concentric Left Ventricular Hypertrophy and left atrial dilatation has significant difference (p<0.05) with LVDD. Statistically significant differences in age distribution of individuals with different categories of left ventricular systolic dysfunction (LVSD) and LVDD (p˂0.001) was observed. Conclusion: Signifi­cant number of hypertensive individuals were having LVDD though in most of the individual LV ejection fraction was maintained.

Subclinical Diastolic Dysfunction in Diabetic Population

2016 ◽  
Vol 70 (3) ◽  
pp. 140-144
Author(s):  
Slavica Mitrovska
Keyword(s):  
Diastolic Dysfunction ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Control Group ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Diabetic Population ◽  
And Control

Abstract Introduction. Left ventricular dysfunction is very frequent in asymptomatic diabetic population. Tissue Doppler Imaging (TDI) is a new echocardiographic technique, able to record early changes of left ventricular dysfunction and to identify asymptomatic diabetic patients at high risk of developing heart failure. Aim. To assess the role of TDI in early detection of diastolic dysfunction in asymptomatic diabetic patients. Methods. Cross-sectional study that involved a total number of 48 subjects. The target group consisted of 25 asymptomatic diabetic patients and control group was composed of 23 subjects without diabetes. All subjects underwent echocardiography (conventional 2D and Pulsed-Wave Doppler and contemporary-TDI) to analyze left ventricular function. We compared the results from both echo-techniques and analyzed the relation of echo-cardiographic parameters with risk factors. Results. We found statistically significant difference between TDI and PW Doppler (E/E'vs E/A) in target (Z=−3.17, p<0.001) and control group (Z=−2.4, p<0.003). There was no significant difference in E/A between the groups (Z=0.0, p<1.0). TDI identified significantly lower E' (Z= 2.03, p<0.04) and higher E/E' (Z= −2.12, p<0.03) in target vs control group. LVDD strongly correlated with duration of DM (p<0.00001), age (p<0.00001), female gender (p<0.0001) and obesity indices (BMI, BSA) (p<0.00001, p<0.00001) in both groups. Conclusion. TDI unmasks the presence of subclinical LV dysfunction in asymptomatic diabetic patients and has a valuable prognostic importance.

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