scholarly journals TO SEE THE HISTO-PATHOLOGICAL PATTERN OF ORAL MUCOSAL LESIONS

2021 ◽  
Vol 4 (11) ◽  
Author(s):  
Rahil Nidhan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Common Type ◽  
Premalignant Lesions ◽  
Malignant Cells ◽  
Verrucous Hyperplasia ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Background & Method: This prospective observational study was carried out with total number of patients 60 in the Department of Otorhinolaryngology and head and neck surgery, Amaltas Institute of Medical Sciences, Dewas, M.P., w.e.f. from August 2018 to September 2020. Patient was thoroughly investigated for complete haemogram, blood sugar, blood urea, serum creatinine, bleeding & Clotting time, coagulation profile, chest x-ray for any secondary focus. Result: Out of 35 cases of clinically premalignant lesions 30 cases were positive for malignant cells on histology. 5 were suspicious for malignant cells. Out of the 25 cases of clinically malignant lesions 25 cases were positive for malignant cells on histology and nil cases of suspicious for malignancy. In this present study, on histopathology premalignant lesions was found in 8.33%   and malignancy was seen   91.66% cases. On histopathological examination, squamous cell carcinoma was the most common type among all cases (78.33%). In squamous cell carcinoma, keratinizing type was found in 33.33% and non- keratinizing type was found in 45%. Verrucous carcinoma was seen in 6.66% cases and verrucous hyperplasia was seen in 3.33% cases. Conclusion: We Concluded in the study as diagnosed by histopathology were found premalignant in 8.33% and malignant 91.66% cases. The type of cancer was determined by histo-pathological examination after biopsy.  Squamous cell carcinoma was the most common type among all cases (78.33%). In squamous cell carcinoma, keratinizing type were found in 33.33% and non-keratinizing type were found in 45%, followed by verrucous carcinoma was seen in 6.66% cases, and verrucous hyperplasia was seen in 3.33% cases. Keywords: Histo-pathological, Oral Mucosal Lesions.

Prevalence and Risk Factors of Oral Mucosal Lesions: A Retrospective Study of Patients Attending Oral Diagnosis Department of Siohs Karachi, Pakistan

2021 ◽  
Vol 15 (11) ◽  
pp. 3273-3278
Author(s):  
Humera Akhlaq ◽  
Muhammad Sibghat Ullah Khan ◽  
Muhammad Nasir ◽  
Hifza Sheikh ◽  
Nosheen Mehmood ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Diagnosis ◽  
Age Related ◽  
Aphthous Ulcers ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

Background: The present study was conducted to evaluate the frequency of different types of Oral Mucosal Lesions (OMLs) and to identify the associated risk factors. Methodology: A retrospective study was conducted at the Department of oral diagnosis in collaboration with the department of oral pathology SIOHS, Karachi Pakistan between January 2017 to December 2020. All cases of lesions and ulcers of the oral cavity were included in the study. Missing data were excluded. Diagnosed cases of oral mucosal lesions were documented. The data was then stratified according to the age groups, gender, symptoms, comorbidities, marital status, etc. Results: A mean age of 38.3 ± 11.86 years was observed. The subjects manifested multiple lesions with OSF standing as the most prevalent one at 29%, followed by aphthous ulcers at 20.2%, candidiasis at 14%, and nicotinic stomatitis at 10.4%. The majority of the patients with aphthous ulcers were significantly associated with young age while frictional keratosis was significantly associated with elderly age (p=0.002), respectively. 15 (93.8%) patients who were married were diagnosed with squamous cell carcinoma (p<0.004) and stiffening of the mouth was significantly associated with squamous cell carcinoma (p<0.0001). Conclusion: In conclusion, the increased occurrence of oral mucosal lesions with age is most likely attributable to an age-related decline in health status and is highly correlated to substance abuse; its amount, duration, type, and regularity. Keywords: oral mucosal lesion, carcinoma, gingiva, buccal, maxillofacial, tumor

scholarly journals A Study to evaluate the Frequency and Association of Various Mucosal Conditions among Geriatric Patients

2013 ◽  
Vol 14 (5) ◽  
pp. 904-910 ◽  
Author(s):  
RGK Shet ◽  
Shobith R Shetty ◽  
M Kalavathi ◽  
M Naveen Kumar ◽  
Rishi Dev Yadav ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Geriatric Patients ◽  
Age Groups ◽  
Geriatric Dentistry ◽  
Group I ◽  
Oral Mucosal Lesions ◽  
Mucosal Lesions

ABSTRACT Geriatric dentistry or gerodontics is the delivery of dental care to older adults involving the diagnosis, prevention and treatment of problems associated with normal aging and age-related diseases as part of an interdisciplinary team with other health care professionals. Aim To evaluate the oral mucosal status in the elderly population of different age group and find out the association of age, gender and denture with oral mucosal disorders. Materials and methods The study sample consisted of 570 geriatric persons concentrating mainly on the oral mucosal changes or lesions occurring in the geriatric population. Individuals those are aged above 60 years were selected, and all the examined geriatric persons were categorized into 3 age groups to find out the association of oral mucosal lesions in each group. Group I—60 to 65 years, Group II—66 to 70 years, Group III—71 and above years. Results The sample of 570 elderly patients included 279 (48.95%) men and 291 (51.05%) women in three age groups: 61 to 65 years (40.35%), 66 to 70 years (31.05%), and 71 years and older (28.60%). The sample included 254 (44.56%) dentate patients, 205 (35.96%) denture wearers (partial and complete denture wearers) and 111 (19.47%) edentulous persons who lacked dentures in both the jaws. Almost half of the patients examined (48%) had one or more oral mucosal lesions. The 48% of the patients who presented with oral mucosal lesions, twenty five different oral mucosal conditions were identified and the three most common findings were lingual varices (13.68%), denture induced inflammatory fibrous hyperplasia (4.21%), squamous cell carcinoma (4.21%). There was some differences in the distribution of oral mucosal condition among the sexes. Leukoplakia and dysplasia were significantly associated with men (p < 0.001) whereas the association of fibroma and lichen planus with women were significant (p < 0.001). Conclusion In our study it was found that patients in groups II and III had more prevalence of oral mucosal disorders. Lingual varices, oral squamous cell carcinoma, fibroma and denture induced inflammatory fibrous hyperplasia were more commonly associated with the geriatric patients. The oral lesions (fibroma and lichen planus) were strongly associated with women while leukoplakia was strongly associated with men. Ageing is an important factor that can influence the occurrence of mucosal lesions and with age the oral mucosa becomes more permeable to noxious substances and more vulnerable to external carcinogens. How to cite this article Shet RGK, Shetty SR, M Kalavathi, Kumar MN, Yadav RD, S Soumya. A Study to evaluate the Frequency and Association of Various Mucosal Conditions among Geriatric Patients. J Contemp Dent Pract 2013;14(5):904-910.

scholarly journals Association of HPV and EBV in Oral Verrucous Squamous Cell Carcinoma and Oral Verrucous Hyperplasia

2021 ◽  
Author(s):  
Eakapong Tamboon ◽  
Phetmany Sihavong ◽  
Nakarin Kitkumthorn ◽  
Dusit Bumalee ◽  
Tawepong Arayapisit ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Oncogenic Viruses ◽  
Tissue Samples ◽  
Barr Virus ◽  
Verrucous Hyperplasia ◽  
Verrucous Squamous Cell Carcinoma ◽  
Epstein Barr

Abstract Objective Oral verrucous squamous cell carcinoma or oral verrucous carcinoma (OVC) is a rare verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2 to 12% of all oral carcinomas. Oral verrucous hyperplasia (OVH) is clinically similar to OVC and has been proposed to be a precursor lesion of OVC. Etiopathogenesis of both lesions is still inconspicuous. Oncogenic viruses such as human papillomavirus (HPV) and Epstein–Barr virus (EBV) have been reported to be associated with some cases of OSCC, and we hypothesized that it may act as a causative agent of these verrucous lesions. This study aimed to investigate frequency of HPV and EBV infections in OVC and OVH. Material and Methods Using polymerase chain reaction (PCR), a total of 35 formalin-fixed paraffin-embedded (FFPE) tissue samples, including 27 OVC samples and 8 OVH samples, were investigated for HPV and EBV infection. HeLa and B95-8 cell lines were used as positive controls of HPV and EBV PCR, respectively. Results All OVC and OVH samples show a positivity to GAPDH, whereas neither HPV nor EBV PCR products was detected in both OVC and OVH samples. Conclusions In summary, our study demonstrated that HPV and EBV are not involved in pathogenesis of OVC and OVH. Other etiologic factors contributing to OVC and OVH need to be further clarified.

Oral Cancer: Raising Awareness of the Importance of Suspicion in Early Detection

2021 ◽  
Vol 10 (1) ◽  
pp. 10-12
Author(s):  
Farooq Ahmed ◽  
Honieh Bolooki ◽  
Senathrajah Ariyaratnam ◽  
Michael N. Pemberton
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Mucosal Lesion ◽  
Morbidity And Mortality ◽  
Raising Awareness ◽  
Suspicious Lesions

Oral cancer is a significant cause of morbidity and mortality worldwide. In this article we present two cases of potentially innocuous looking lesions, initially thought to be traumatic in origin, but later diagnosed as cancer. The first patient presented with a persistent laceration thought to be caused by an accidental shaving injury, which was subsequently diagnosed as squamous cell carcinoma. The second patient presented with a hyperplastic mucosal lesion, suspected as forming due to denture-clasp irritation, which was subsequently diagnosed as proliferative verrucous carcinoma. The importance of early detection and palpation of suspicious lesions is emphasised in this article.

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