scholarly journals Oxidant- Antioxidant Status in Suicide Behavior in Kurdish Ethnicity

2021 ◽  
Author(s):  
Mahin Oshnokhah ◽  
◽  
Maryam Bagheri ◽  
Hori Ghaneialvar ◽  
Karimeh Haghani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Antioxidant Status ◽  
Critical Role ◽  
Serum Levels ◽  
Current Experiment ◽  
Suicide Attempters ◽  
Suicide Behavior ◽  
Total Antioxidant

Introduction: Oxidative stress plays critical role in aging and pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior is not clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city. Methods: 50 suicide attempters and 40 control subjects (volunteers) aged 18-35 years were studied in the current experiment. In order to consider the oxidant-antioxidant status, serum levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and the total antioxidant capacity (TAC) were measured. Results: Serum levels of SOD enzyme and TAC were significantly lower in suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters in compare with the controls. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the controls. Conclusion: Presence of oxidative stress without MDA elevation, which has been detected in suicide attempters can be considered as a biochemical hallmark in suicide behavior.

Antioxidant Status, Oxidative Stress, and Damage in Elite Trained Kayakers and Canoeists and Sedentary Controls

2009 ◽  
Vol 19 (5) ◽  
pp. 443-456 ◽  
Author(s):  
Vitor Teixeira ◽  
Hugo Valente ◽  
Susana Casal ◽  
Franklim Marques ◽  
Pedro Moreira
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Uric Acid ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Antioxidant Defense System ◽  
Strenuous Exercise ◽  
Antioxidant Intake ◽  
Total Antioxidant ◽  
Β Carotene

Strenuous physical activity is known to generate reactive oxygen species to a point that can exceed the antioxidant defense system and lead to oxidative stress. Dietary intake of antioxidants, plasma enzymatic (superoxide dismutase, glutathione reductase [Gr], and glutathione peroxidase [GPx]) activities, nonenzymatic (total antioxidant status [TAS], uric acid, α-tocopherol, retinol, α-carotene, β-carotene, lycopene, and lutein + zeaxanthin) antioxidants, and markers of lipid peroxidation (thiobarbituricacid-reactive substances [TBARS]) and muscle damage (creatine kinase [CK]) were measured in 17 elite male kayakers and canoeists under resting conditions and in an equal number of age- and sex-matched sedentary individuals. Athletes showed increased plasma values of α-tocopherol (p = .037), α-carotene (p = .003), β-carotene (p = .007), and superoxide dismutase activity (p = .002) and a lower TAS level (p = .030). Antioxidant intake (α-tocopherol, vitamin C, and β-carotene) and plasmatic GPx, Gr, lycopene, lutein + zeaxanthin, retinol, and uric acid levels were similar in both groups. Nevertheless, TBARS (p < .001) and CK (p = .011) levels were found to be significantly higher in the kayakers and canoeists. This work suggests that despite the enhanced levels of antioxidants, athletes undergoing regular strenuous exercise exhibited more oxidative stress than sedentary controls.

scholarly journals Oxidant/Antioxidant Status Assessment of Blood in Selected Equine Diseases

2013 ◽  
Vol 57 (2) ◽  
pp. 225-230
Author(s):  
Wiesław Krumrych ◽  
Janusz Zbylut ◽  
Marcin Gołyński ◽  
Hanna Markiewicz
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Oxygen Metabolism ◽  
Upper Respiratory Tract ◽  
Total Antioxidant ◽  
Status Assessment ◽  
Upper Respiratory ◽  
Equine Diseases

Abstract The objective of the study was to assess ratio of oxidation to antioxidation in the blood of horses in selected equine diseases. The study was conducted on 47 Polish half-breed horses (36 mares, six stallions, and five geldings) aged 2 to 16 years. Nineteen mares were diagnosed with endometritis, seven horses with symptoms of colic, and six with upper respiratory tract infection. The remaining clinically healthy horses (n=15) served as control. The following parameters were measured: oxygen metabolism in neutrophils using a chemiluminescence (CL) method, total antioxidant status (TAS) of blood plasma, as well as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activity in whole blood. The results demonstrate increased CL of neutrophils in mares with endometritis, as well as in horses with symptoms of colic. This finding was associated with decreased values of SOD, GPx, and TAS (chiefly in mares with endometritis), which suggests oxidative stress. These results underscore the importance of a broader use of oxidant/antioxidant status assessment in studies of the pathogenesis and pathomechanisms of equine diseases.

scholarly journals Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats

2017 ◽  
Vol 22 (4) ◽  
pp. 562-566 ◽  
Author(s):  
Saeed Samarghandian ◽  
Abasalt Borji ◽  
Tahereh Farkhondeh
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Diabetic Rats ◽  
Portulaca Oleracea ◽  
Tnf Α ◽  
Total Antioxidant ◽  
Factor Α ◽  
Necrosis Factor

The present study was designed to investigate the protective effect of the aqueous extract of Portulaca oleracea against hyperglycemic, oxidative damage and inflammation in the serum of streptozotocin (STZ)-induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 Portulaca oleracea (100, 200, 400 mg/kg/d)–treated diabetic groups. At the end of the 4-week period, glucose, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), glutathione (GSH), and total antioxidant status (TAS) levels were measured. STZ caused an elevation in the serum levels of glucose, MDA, IL-6, and TNF-α with reduction in the levels of GSH and TAS ( P < .01). Portulaca oleracea ameliorated glucose, MDA, IL-6, TNF-α, GSH, and TAS levels in diabetic groups versus to the untreated groups ( P < .05). Taken together, Portulaca oleracea prevented hyperglycemia by preventing the oxidative stress and inflammation.

scholarly journals Impaired oxidative-antioxidative balance during migraine attack

2019 ◽  
Vol 6 (2) ◽  
pp. 2996-3002 ◽  
Author(s):  
Alireza Khosravi ◽  
Alireza Nakhaee ◽  
Abdoreza Ghoreishi ◽  
Zahra Arefpoor ◽  
Masoud Sadeghi
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Serum Levels ◽  
Protein Carbonyl ◽  
Stress Index ◽  
Healthy Controls ◽  
Antioxidative Status ◽  
Total Antioxidant ◽  
Migraine Group

Background: Recent evidence has suggested that oxidative stress may play a role in the pathophysiology of migraine. In this study, we aimed to evaluate the oxidative-antioxidative status in sera of migraine patients from an Iranian population during migraine attacks. Methods: This study recruited 46 migraine patients with or without aura and 45 sex- and age-matched healthy controls. The levels of protein carbonyl (PC), malondialdehyde (MDA) and total oxidants status (TOS) were measured as the indicators of oxidative stress. The levels of total thiols (T-SH), reduced glutathione (GSH) and total antioxidant capacity (TAC) were determined as markers of antioxidant status. Oxidative stress index (OSI) was calculated by dividing TOS to TAC. Results: The serum levels of MDA (4.10 +/- 0.70 vs. 3.20 +/- 0.62, P = 0.003), TOS (18.46 +/- 4.06 vs. 16.21 +/- 3.67, P = 0.007) and OSI (1.54 +/- 0.60 vs. 1.22 +/- 0.46, P = 0.006) were significantly higher in migraine group compared to controls, however, no statistically significant differences of PC levels were found between migraine patients and controls (0.615 +/- 0.161 vs. 0.517 +/- 0.126, P = 0.1). In contrast, the levels of T-SH (273 +/- 51.71 vs. 310.88 +/- 53.32, P = 0.001), GSH (28.08 +/- 6.20 vs. 32.13 +/- 5.8, P = 0.002) and TAC (1.27 +/- 0.226 vs. 1.41 +/- 0.26, P = 0.01) were significantly lower in migraine patients compared to healthy controls. Conclusion: Our study showed higher levels of oxidative stress and lower levels of antioxidant status in migraine group compared to controls, which indicates the possible role of oxidative stress in triggering migraine attacks.  

Antioxidant status of rabbits after treatment with epicatechin and patulin

Biologia ◽  
2016 ◽  
Vol 71 (7) ◽  
Author(s):  
Katarina Zbynovska ◽  
Peter Petruska ◽  
Anna Kalafova ◽  
Lubomir Ondruska ◽  
Rastislav Jurcik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Antioxidant Status ◽  
Total Antioxidant ◽  
Antioxidant Parameters

AbstractThe aim of this study was to assess antioxidant status by measuring of antioxidant parameters (SOD – superoxide dismutase, GPx – glutatione peroxidase, CAT – catalase, Trolox, TAC – total antioxidant capacity, bilirubin, albumin) and parameters associated with oxidative stress (MDA – malondialdehyde, MDA Adduct – malondialdehyde adduct, H

scholarly journals Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sylwia Dzięgielewska-Gęsiak ◽  
Ewa Wysocka ◽  
Sławomir Michalak ◽  
Ewa Nowakowska-Zajdel ◽  
Teresa Kokot ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Status ◽  
Plasma Lipids ◽  
Total Antioxidant Status ◽  
Oral Glucose ◽  
Elderly Persons ◽  
Arterial Blood ◽  
Total Antioxidant ◽  
Biomarkers Of Oxidative Stress

The relationship between hyperglycemia and oxidative stress in diabetes is well known, but the influence of metabolic disturbances recognized as prediabetes, in elderly patients especially, awaits for an explanation.Methods. 52 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed: waist circumference (WC), body mass index (BMI), percentage of body fat (FAT), and arterial blood pressure. During an oral glucose tolerance test (OGTT) fasting (0′) and 120-minute (120′) glycemia and insulinemia were determined, and type 2 diabetics (n=6) were excluded. Subjects were tested for glycated hemoglobin HbA1c, plasma lipids, total antioxidant status (TAS), thiobarbituric acid-reacting substances (TBARS), and activity of erythrocyte superoxide dismutase (SOD-1). According to OGTT results, patients were classified as normoglycemics, (NGT,n=18) and prediabetics, (PRE,n=28).Results. Both groups did not differ with their lipids, FAT, and TBARS. PRE group had higher WC (P<0.002) and BMI (P<0.002). Lower SOD-1 activity (P<0.04) and TAS status (P<0.04) were found in PRE versus NGT group.Significance. In elderly prediabetics, SOD-1 and TAS seem to reflect the first symptoms of oxidative stress, while TBARS are later biomarkers of oxidative stress.

Increased oxidative stress status in rat serum after five minutes treadmill exercise

Open Medicine ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. 722-728 ◽  
Author(s):  
Florin-Petrut Trofin ◽  
Alin Ciobica ◽  
Dumitru Cojocaru ◽  
Marin Chirazi ◽  
Cezar Honceriu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Antioxidant Status ◽  
Specific Activity ◽  
Total Antioxidant Status ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Oxidative Stress Status ◽  
Total Antioxidant

AbstractAlthough it is accepted that an important correlation exists between the physical exercise and the oxidative stress status, the data regarding the levels of the main oxidative stress markers after physical training have been difficult to interpret and a subject of many controversies. There are also very few studies regarding the effects of short-time exercise on the oxidative stress status modifications. Thus, in the present report we were interested in studying the modifications of some oxidative stress markers (two antioxidant enzymes-superoxide dismutase and glutathione peroxidase, a lipid peroxidation parameter — malondyaldehide, the total antioxidant status and protein carbonyl levels), from the serum of rats that were subject to one bout of five minutes exercise on a treadmill, when compared to a control sedentary group. In this way, we observed a decrease of superoxide dismutase specific activity in the rats which performed the exercises. Still, no modifications of glutathione peroxidase specific activity were found between groups. In addition, increased levels of malondyaldehide and protein carbonyls were observed in the rats subjected to exercises. In conclusion, our data provides new evidence regarding the increase of the oxidative stress status, as a result of a 5-minutes bout of treadmill exercising in rats, expressed through a decrease in the SOD specific activity and the total antioxidant status and also an increase of the lipid peroxidation and protein oxidation processes.

Antioxidative mechanism in the course of varicose veins

2017 ◽  
Vol 33 (7) ◽  
pp. 464-469 ◽  
Author(s):  
Anna Horecka ◽  
Jadwiga Biernacka ◽  
Anna Hordyjewska ◽  
Wojciech Dąbrowski ◽  
Piotr Terlecki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Varicose Vein ◽  
Antioxidant Status ◽  
Antioxidant Defense ◽  
Total Antioxidant Status ◽  
Superoxide Dismutase Activity ◽  
Clinical State ◽  
Vein Wall ◽  
Total Antioxidant

Objective Our objective was to evaluate the state of oxidative stress in the great saphenous varicose vein wall and blood of varicose vein patients taken from the antecubital vein. Methods The superoxide dismutase, reduced glutathione (GSH) and total antioxidant status were measured with commercially available colorimetric kits in erythrocytes, plasma and varicose vein wall of 65 patients (second degree of clinical state classification, etiology, anatomy and pathophysiology) aged 22–70 (49 women, 16 men) in comparison to normal great saphenous vein walls collected from 10 patients who underwent coronary artery bypass graft and blood collected from 20 healthy individuals. Results A statistically significant decrease (p < 0.001) in superoxide dismutase activity in erythrocytes and the increase (p < 0.05) in superoxide dismutase activity in varicose vein has been observed. There have been no significant changes in the concentration of GSH in plasma and in varicose vein. The decreased concentration of total antioxidant status in plasma (p < 0.001) and in varicose vein wall (p < 0.05) in comparison to the control has been noticed. Conclusion The varicose vein patients are affected by oxidative stress. Our results indicate impaired antioxidant defense mechanism in the blood of varicose vein patients. In contrast to the blood, an increased process of antioxidant defense in the varicose vein wall was noticed.

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