scholarly journals Research Paper: Effects of Different Doses and Time-Dependency of Busulfan on Testes Parameters and Spermatogenesis in a Rat Model: A Quantitative Stereological Study

2019 ◽  
pp. 155-162 ◽  
Author(s):  
Soghra Bahmanpour ◽  
Bahia Namavar Jahromi ◽  
Farhad Koohpeyma ◽  
Mojtaba Keshavarz ◽  
Azizollah Bakhtari
Keyword(s):  
Rat Model ◽  
Research Paper ◽  
Time Dependency ◽  
Different Doses

scholarly journals Effect of Solanum macrocarpon Linn leaf aqueous extract on the brain of an alloxan-induced rat model of diabetes

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092264
Author(s):  
Mary A. Okesola ◽  
Basiru O. Ajiboye ◽  
Babatunji E. Oyinloye ◽  
Olukemi A. Osukoya ◽  
Ofogho S. Owero-ozeze ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Rat Model ◽  
Fasting Blood Glucose ◽  
Diabetes Control ◽  
Antioxidant Enzyme Activities ◽  
Diabetes Group ◽  
Leaf Aqueous Extract ◽  
The Brain ◽  
Different Doses ◽  
Control Diabetes

Objective This study was designed to evaluate the protective effect of aqueous extract of Solanum macrocarpon Linn leaf in the brain of an alloxan-induced rat model of diabetes. Methods The experimental model of diabetes was induced by a single intraperitoneal injection of freshly prepared alloxan. Rats were then divided into six groups: normal control, diabetes control, diabetes group treated with metformin, and three diabetes groups treated with different concentrations of S. macrocarpon. Rats were sacrificed on day 14 of the experiment and different brain biochemical parameters were assessed and compared between groups. Results Administration of different doses of S. macrocarpon leaf aqueous extract was associated with significantly reduced levels of fasting blood glucose, lipid peroxidation, neurotransmitters, cholinesterases, cyclooxygenase-2 and nitric oxide compared with diabetes control rats. In addition, antioxidant enzyme activities were significantly increased in diabetes rats administered 12.45, 24.9 and 49.8 mg/kg body weight of S. macrocarpon versus diabetes control rats. Conclusion Aqueous extract of S. macrocarpon Linn leaf may be useful in the management of diabetic neuropathy.

Pharmacokinetics of different doses of methotrexate at steady state by in situ microdialysis in a rat model

1995 ◽  
Vol 36 (4) ◽  
pp. 283-289 ◽  
Author(s):  
Per O. Ekstr�m ◽  
Anders Andersen ◽  
David J. Warren ◽  
Karl E. Giercksky ◽  
Lars Sl�rdal
Keyword(s):  
Steady State ◽  
Rat Model ◽  
Different Doses

Evaluation of colistin nephrotoxicity administered at different doses in the rat model

Renal Failure ◽  
2013 ◽  
Vol 35 (8) ◽  
pp. 1130-1135 ◽  
Author(s):  
Zohra Ghlissi ◽  
Ahmed Hakim ◽  
Hela Mnif ◽  
Fatma Makni Ayadi ◽  
Khaled Zeghal ◽  
...  
Keyword(s):  
Rat Model ◽  
Different Doses

Effects of three different doses of a fruit extract ofTerminalia chebulaon metabolic components of metabolic syndrome, in a rat model

2010 ◽  
Vol 24 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Inderjeet Singh ◽  
Pawan Kumar Singh ◽  
Shobhit Bhansali ◽  
Nusrat Shafiq ◽  
Samir Malhotra ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Rat Model ◽  
Fruit Extract ◽  
Different Doses

Pharmacokinetics of different doses of methotrexate at steady state by in situ microdialysis in a rat model

1995 ◽  
Vol 36 (4) ◽  
pp. 283-289 ◽  
Author(s):  
Per O. Ekstr�m ◽  
Anders Andersen ◽  
David J. Warren ◽  
Karl E. Giercksky ◽  
L. Sl�rdal
Keyword(s):  
Steady State ◽  
Rat Model ◽  
Different Doses

scholarly journals Acute protective effects of different doses of simvastatin in the rat model of renal ischemia-reperfusion injury

2008 ◽  
Vol 58 (5-6) ◽  
pp. 413-427
Author(s):  
Nesic Zorica ◽  
Todorovic Z. ◽  
Stojanovic R. ◽  
Basta-Jovanovic Gordana ◽  
Radojevic-Skodric Sanja ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Model ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Protective Effects ◽  
Renal Ischemia Reperfusion Injury ◽  
Different Doses

scholarly journals Effect of different doses of dexmedetomidine on lung function and tissue cell apoptosis in a rat model of hyperoxic acute lung injury

2020 ◽  
Vol 19 (5) ◽  
pp. 1093-1098
Author(s):  
Yan Yang ◽  
Xian Qin ◽  
Chuangang Han ◽  
Yan Huang ◽  
Lei Jin ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Function ◽  
Lung Injury ◽  
Rat Model ◽  
Cell Apoptosis ◽  
Tissue Cell ◽  
High Dose ◽  
Apoptosis Index ◽  
Tnf Α ◽  
Different Doses

Purpose: To study the effect of different doses of dexmedetomidine on lung function and lung tissue cell apoptosis in a rat model of hyperoxic acute lung injury. Methods: Five groups of healthy male Sprague-Dawley rats were used: normal rats, untreated hyperoxic rats, and hyperoxic rats given 3 different doses of dexmedetomidine, with 20 rats in each group. The levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined usingenzyme-linked immunosorbent assay (ELISA). Parietal paraffin cuts were taken from the right upper lobe for measurement of apoptosis using in situ terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and the apoptosis index was calculated. Results: At 24 and 48 h, the levels of IL-6 and TNF-α in the hyperoxia model group were significantly higher than those in the normal control group, and their levels in the middle- and high-dose groups were markedly lowered, relative to untreated hyperoxia rats (p < 0.05). Apoptosis index in the hyperoxia model rats significantly increased, relative to normal rats (p < 0.05). The apoptosis index in the mediumand high-dose groups decreased significantly (p < 0.05). Conclusion: Dexmedetomidine inhibits inflammatory responses caused by high concentration of oxygen inhalation, minimizes lung injury, improves lung function and inhibits lung apoptosis. Keywords: Dexmedetomidine, Hyperoxia, Acute lung injury, Lung function, Apoptosis

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