scholarly journals The Relationship Between Serum Uric Acid and Cardiometabolic Risk Factors in Iranian Children and Adolescents

2021 ◽  
Vol 9 (2) ◽  
pp. 167-174
Author(s):  
Motahar Heidari-Beni ◽  
◽  
Roya Riahi ◽  
Fatemeh Mohebpour ◽  
Majid Khademian ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Waist Circumference ◽  
Children And Adolescents ◽  
Serum Uric Acid ◽  
Cardiometabolic Risk ◽  
Population Based ◽  
Cardiometabolic Risk Factors ◽  
Potential Association ◽  
Iranian Children

Context: There has been an increasing interest in epidemiological and clinical studies concerning the role of uric acid in cardiometabolic diseases, especially in children and adolescents. However, these potential relationships remain undiscovered; accordingly, its pathophysiological mechanisms remain unrecognized. This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Objectives: This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Methods: The data of 595 individuals aged 7-18 years were assessed in this research. Anthropometric measurements and laboratory tests were performed according to standardized protocols. Results: The Mean±SD age of the 595 explored students was 12.39±3.07 years. The overall Mean±SD SUA level of the study participants was measured as 4.22±1.13 mg/dL, with significant gender-wise differences (4.04±0.97 mg/dL vs 4.38±1.24 mg/dL, respectively; P<0.05). The prevalence of hyperuricemia based on the 90th percentile of SUA levels was equal to 10.6%. There was a positive association between SUA levels and abdominal obesity (waist circumference: ≥90th percentile) [Odds Ratio (OR): 1.54; 95% Confidence Interval (CI): 1.26 to 1.86] and general obesity [gender-specific Body Mass Index (BMI) for >95th percentile] (OR: 2.32; 95% CI: 1.74 to 3.11). Conclusions: This study suggested BMI and waist circumference as cardiometabolic risk factors, i.e. significantly associated with SUA levels in children and adolescents.

scholarly journals Passive smoking and cardiometabolic risk factors in Iranian children and adolescents: CASPIAN-V study

2019 ◽  
Vol 18 (2) ◽  
pp. 401-408 ◽  
Author(s):  
Mehdi Ebrahimi ◽  
Mohammadreza Hashemi Aghdam ◽  
Mostafa Qorbani ◽  
Faeze Abbaspour Kaboodan ◽  
Gita Shafiee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Passive Smoking ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Iranian Children

scholarly journals Serum Uric Acid Levels are Associated with Cardiometabolic Risk Factors in Healthy Young and Middle-Aged Adults

2018 ◽  
Author(s):  
Thaís da Silva Ferreira ◽  
Julia Freitas Rodrigues Fernandes ◽  
Luciene da Silva Araújo ◽  
Lívia de Paula Nogueira ◽  
Priscila Mansur Leal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Middle Aged ◽  
Middle Aged Adults

URIC ACID IS ASSOCIATED WITH CARDIOMETABOLIC RISK FACTORS IN OVERWEIGHT AND OBESE CHILDREN AND ADOLESCENTS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e18
Author(s):  
J. Alvarez ◽  
P. Redon ◽  
M. Torro ◽  
F. Aguilar ◽  
J. Redon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

scholarly journals C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

2014 ◽  
Vol 27 (3) ◽  
pp. 279-288 ◽  
Author(s):  
Anajás da Silva Cardoso ◽  
Renata Oliveira Cardoso ◽  
Danielle Franklin de Carvalho ◽  
Neusa Collet ◽  
Carla Campos Muniz Medeiros
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Waist Circumference ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Severe Obesity ◽  
Cardiometabolic Risk Factors ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

scholarly journals Association Between Serum Uric Acid Levels and Cardiometabolic Risk Factors Among Japanese Junior High School Students

2010 ◽  
Vol 74 (8) ◽  
pp. 1570-1577 ◽  
Author(s):  
Minoru Hongo ◽  
Hiroya Hidaka ◽  
Shigeko Sakaguchi ◽  
Keisuke Nakanishi ◽  
Motoki Ichikawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
High School ◽  
Uric Acid ◽  
High School Students ◽  
Serum Uric Acid ◽  
Junior High School ◽  
Cardiometabolic Risk ◽  
Junior High School Students ◽  
Cardiometabolic Risk Factors ◽  
School Students

scholarly journals Prevalence of cardiometabolic risk factors by weight status in a population-based sample of Quebec children and adolescents

2008 ◽  
Vol 24 (7) ◽  
pp. 575-583 ◽  
Author(s):  
Marie Lambert ◽  
Edgard E. Delvin ◽  
Emile Levy ◽  
Jennifer O’Loughlin ◽  
Gilles Paradis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Weight Status ◽  
Cardiometabolic Risk ◽  
Population Based ◽  
Cardiometabolic Risk Factors

scholarly journals Uric Acid Associates With Executive Function in Children and Adolescents With Hypertension

Hypertension ◽  
2021 ◽  
Author(s):  
Stella Stabouli ◽  
Katerina Chrysaidou ◽  
Athanasia Chainoglou ◽  
Dimos Gidaris ◽  
Vasilios Kotsis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Uric Acid ◽  
Systolic Blood Pressure ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Behavior Regulation ◽  
Executive Performance ◽  
High Uric Acid

Observational studies show that serum uric acid levels associate with cardiometabolic risk factors and subclinical target organ damage. The aim of the present study is to investigate the association of traditional cardiometabolic risk factors and uric acid with the executive performance in children and adolescents. Ninety-nine children and adolescents aged 5 to 18 years referred for assessment of primary hypertension were included. Traditional cardiometabolic risk factors, uric acid, and ambulatory blood pressure parameters were assessed. Executive performance was assessed by the validated Behavior Rating Inventory of Executive Function parent questionnaire. Serum uric acid correlated with cardiometabolic parameters, daytime and nighttime systolic blood pressure. High uric acid levels and ambulatory hypertension were associated with behavior regulation independently of other cardiometabolic risk factors or presence of metabolic syndrome. Participants with combined hypertension and high uric acid levels presented the lowest behavior regulation performance. Children with high uric acid had worse behavior regulation indices T scores with estimated marginal means 56.47 (95% CI, 51.68–61.27) compared with 49.22 (95% CI, 45.91–52.53) in those with low uric acid levels ( P =0.023, adjusted for age, sex, nighttime systolic blood pressure, daytime and nighttime heart rate). Mediation analysis showed that part of the effect of high uric acid levels on behavior regulation was mediated by nighttime systolic blood pressure. In conclusion, we found a positive association of serum uric acid with worse executive performance in children at risk for primary hypertension. Extending these cross-sectional findings with longitudinal studies may determine whether high uric acid levels increases the risk of cognitive decline in youth.

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