Prevalence of cardiometabolic risk factors by weight status in a population-based sample of Quebec children and adolescents

Context: There has been an increasing interest in epidemiological and clinical studies concerning the role of uric acid in cardiometabolic diseases, especially in children and adolescents. However, these potential relationships remain undiscovered; accordingly, its pathophysiological mechanisms remain unrecognized. This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Objectives: This study aimed to assess the potential association between Serum Uric Acid (SUA) levels and cardiometabolic risk factors in a population-based sample of Iranian children and adolescents. Methods: The data of 595 individuals aged 7-18 years were assessed in this research. Anthropometric measurements and laboratory tests were performed according to standardized protocols. Results: The Mean±SD age of the 595 explored students was 12.39±3.07 years. The overall Mean±SD SUA level of the study participants was measured as 4.22±1.13 mg/dL, with significant gender-wise differences (4.04±0.97 mg/dL vs 4.38±1.24 mg/dL, respectively; P<0.05). The prevalence of hyperuricemia based on the 90th percentile of SUA levels was equal to 10.6%. There was a positive association between SUA levels and abdominal obesity (waist circumference: ≥90th percentile) [Odds Ratio (OR): 1.54; 95% Confidence Interval (CI): 1.26 to 1.86] and general obesity [gender-specific Body Mass Index (BMI) for >95th percentile] (OR: 2.32; 95% CI: 1.74 to 3.11). Conclusions: This study suggested BMI and waist circumference as cardiometabolic risk factors, i.e. significantly associated with SUA levels in children and adolescents.

Download Full-text

Association of Sleep Duration with Obesity and Cardiometabolic Risk Factors in Children and Adolescents: A Population-Based Study

Scientific Reports ◽

10.1038/s41598-019-45951-0 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 10

Author(s):

Sook Hyun Seo ◽

Young Suk Shim

Keyword(s):

Risk Factors ◽

Children And Adolescents ◽

Sleep Duration ◽

Cardiometabolic Risk ◽

Population Based ◽

Cardiometabolic Risk Factors ◽

Population Based Study

Download Full-text

Physical fitness as a moderator in the relationship between adiposity and cardiometabolic risk factors in children and adolescents

The Journal of Sports Medicine and Physical Fitness ◽

10.23736/s0022-4707.20.11130-7 ◽

2020 ◽

Vol 60 (12) ◽

Author(s):

Caroline Brand ◽

Ana P. Sehn ◽

Anelise R. Gaya ◽

Jorge Mota ◽

Javier Brazo-Sayavera ◽

...

Keyword(s):

Risk Factors ◽

Physical Fitness ◽

Children And Adolescents ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

The Relationship

Download Full-text

Assessment of the correlation between the atherogenic index of plasma and cardiometabolic risk factors in children and adolescents: might it be superior to the TG/HDL-C ratio?

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2016-0479 ◽

2017 ◽

Vol 30 (9) ◽

Cited By ~ 4

Author(s):

Nalan Hakime Nogay

Keyword(s):

Risk Factors ◽

Children And Adolescents ◽

Strong Correlation ◽

Cardiometabolic Risk ◽

Density Lipoprotein ◽

Cardiometabolic Risk Factors ◽

Atherogenic Index ◽

Fasting Period ◽

Atherogenic Index Of Plasma ◽

The Mean

AbstractBackground:Most of the studies investigating the correlation between the atherogenic index of plasma (AIP) and cardiometabolic risk factors have been conducted with adults, while only a limited number of related studies that involved children and adolescents has been conducted. The purpose of this study is to assess the correlation between the AIP and other cardiometabolic risk factors in adolescents.Methods:This study was conducted with 310 girls and 90 boys who were between the ages of 6 and 18 years. After a 10-h fasting period, the biochemical values of the participants were measured in the morning. The anthropometric measurements of the participants were also taken. The AIP was calculated as Log10 (triglycerides/high density lipoprotein-cholesterol; TG/HDL-C).Results:In adolescents between the ages of 12 and 18, the mean AIP of the group with TG ≥130 mg/dL was significantly higher than that of the groups with TG of 90–129 mg/dL and <90 mg/dL. There was a strong correlation between TG and AIP for both boys and girls among the children and adolescents, while there was a strong correlation between the TG/HDL-C ratio and TG only in the boys who were within the 6–11-year-old age group.Conclusions:An increase in AIP is associated with cardiovascular risk factors in children and adolescents other than those seen in adults. Based on the TG/HDL-C ratio, the AIP may be superior as a complementary index in the assessment of cardiometabolic risks in children and adolescents.

Download Full-text

Association of body mass index, sagittal abdominal diameter and waist-hip ratio with cardiometabolic risk factors and adipocytokines in Arab children and adolescents

BMC Pediatrics ◽

10.1186/1471-2431-12-119 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 10

Author(s):

Omar S Al-Attas ◽

Nasser M Al-Daghri ◽

Majed S Alokail ◽

Khalid M Alkharfy ◽

Hossam Draz ◽

...

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Children And Adolescents ◽

Body Mass ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Sagittal Abdominal Diameter ◽

Arab Children ◽

Waist Hip Ratio

Download Full-text

Cross-Sectional and Longitudinal Associations between Body Mass Index and Cardiometabolic Risk Factors in Adolescents in a Country of the African Region

International Journal of Endocrinology ◽

10.1155/2013/801832 ◽

2013 ◽

Vol 2013 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Tanica Lyngdoh ◽

Bharathi Viswanathan ◽

Edwin van Wijngaarden ◽

Gary J. Myers ◽

Pascal Bovet

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Young Adults ◽

Body Mass ◽

Weight Status ◽

Cardiometabolic Risk ◽

Linear Regression Analysis ◽

Cardiometabolic Risk Factors ◽

Cross Sectional

We assessed the association between several cardiometabolic risk factors (CRFs) (blood pressure, LDL-cholesterol, HDL-cholesterol, triglycerides, uric acid, and glucose) in 390 young adults aged 19-20 years in Seychelles (Indian Ocean, Africa) and body mass index (BMI) measured either at the same time (cross-sectional analysis) or at the age of 12–15 years (longitudinal analysis). BMI tracked markedly between age of 12–15 and age of 19-20. BMI was strongly associated with all considered CRFs in both cross-sectional and longitudinal analyses, with some exceptions. Comparing overweight participants with those having a BMI below the age-specific median, the odds ratios for high blood pressure were 5.4/4.7 (male/female) cross-sectionally and 2.5/3.9 longitudinally (P<0.05). Significant associations were also found for most other CRFs, with some exceptions. In linear regression analysis including both BMI at age of 12–15 and BMI at age of 19-20, only BMI at age of 19-20 remained significantly associated with most CRFs. We conclude that CRFs are predicted strongly by either current or past BMI levels in adolescents and young adults in this population. The observation that only current BMI remained associated with CRFs when including past and current levels together suggests that weight control at a later age may be effective in reducing CRFs in overweight children irrespective of past weight status.

Download Full-text

Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort

Nature Communications ◽

10.1038/s41467-020-19257-z ◽

2020 ◽

Vol 11 (1) ◽

Cited By ~ 1

Author(s):

Gunn-Helen Moen ◽

Ben Brumpton ◽

Cristen Willer ◽

Bjørn Olav Åsvold ◽

Kåre I. Birkeland ◽

...

Keyword(s):

Risk Factors ◽

Cardiometabolic Risk ◽

Genetic Risk Score ◽

Genetic Effect ◽

Later Life ◽

Population Based ◽

Cardiometabolic Risk Factors ◽

Cardiometabolic Disease ◽

Health And Disease ◽

Lower Birthweight

Abstract There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse environmental factors in utero increase future risk of cardiometabolic disease. Here, we explore if a genetic risk score (GRS) of maternal SNPs associated with offspring birthweight is also associated with offspring cardiometabolic risk factors, after controlling for offspring GRS, in up to 26,057 mother–offspring pairs (and 19,792 father–offspring pairs) from the Nord-Trøndelag Health (HUNT) Study. We find little evidence for a maternal (or paternal) genetic effect of birthweight associated variants on offspring cardiometabolic risk factors after adjusting for offspring GRS. In contrast, offspring GRS is strongly related to many cardiometabolic risk factors, even after conditioning on maternal GRS. Our results suggest that the maternal intrauterine environment, as proxied by maternal SNPs that influence offspring birthweight, is unlikely to be a major determinant of adverse cardiometabolic outcomes in population based samples of individuals.

Download Full-text