scholarly journals Effect of an Eight-week High-intensity Interval Training Program on Serum Cardiac Troponin I Level of Streptozotocin-induced Diabetic Rats

2020 ◽  
Vol 24 (5) ◽  
pp. 386-397
Author(s):  
Najmeh Miraghaee ◽  
◽  
Abbas Sadeghi ◽  
Navid Mohammadi ◽  
◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Interval Training ◽  
Diabetic Rats ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
Serum Cardiac Troponin ◽  
Ctni Level

Background: One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases. Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats. Methods: In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’s test were used to analyze the collected data, considering a significance level of P<0.05. Findings: The induction of diabetes caused a significant increase in blood glucose (P=0.01) and high-sensitive CtnI (P=0.01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0.001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0.591). Conclusion: he HIIT program can reduce the fasting blood glucose and increase the serum level of high-sensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.

scholarly journals High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin

2019 ◽  
Vol 106 (3) ◽  
pp. 213-224 ◽  
Author(s):  
J Amri ◽  
M Parastesh ◽  
M Sadegh ◽  
SA Latifi ◽  
M Alaee
Keyword(s):  
Blood Glucose ◽  
High Intensity ◽  
Fasting Blood Glucose ◽  
Interval Training ◽  
Diabetic Rats ◽  
Lipid Profiles ◽  
High Intensity Interval Training ◽  
Training Groups ◽  
High Intensity Interval

Background and aims In this study, we aimed to investigate the effects of 10 weeks of high-intensity interval training (HIIT) and endurance training (END) on irisin, betatrophin, insulin, fasting blood glucose (FBG) concentrations, and lipid profiles in diabetic rats. Methods Twenty-four Wistar rats (weight: 200–250 g) were randomly assigned into four groups as follows: (1) control (Cnt), (2) diabetic (Dibt), (3) diabetic HIIT (Dibt-HIIT), and (4) diabetic END (Dibt-END). For inducing diabetes, after 12 h of food starvation, nicotinamide (120 mg/kg) and streptozotocin (STZ; 65 mg/kg) were intraperitoneally injected. The diabetic training groups received 10 weeks of HIIT or END training following the induction of diabetes. Twenty-four hours following the last training session, blood serum samples were collected for evaluating the concentration of irisin, betatrophin, and insulin hormones through enzyme-linked immunosorbent assay. Results FBG and lipid profiles were measured by biochemical kits. A significant increase in the serum concentration of irisin (p < 0.05), betatrophin (p < 0.05), and insulin (p < 0.001) and significant decrease in the FBG (P < 0.01) and lipid profiles (p < 0.01) were observed in the Dibt-HIIT group compared to the Dibt-END group. In addition, irisin revealed a significant positive association with betatrophin and insulin values in diabetic training groups (p < 0.01). Conclusions It seems that HIIT leads to a more extensive improvement in diabetic conditions compared to the END training. Therefore, HIIT appears to be an important time-efficient approach for the treatment of type 2 diabetes.

scholarly journals Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zhaowei Kong ◽  
Shengyan Sun ◽  
Min Liu ◽  
Qingde Shi
Keyword(s):  
Body Composition ◽  
Blood Glucose ◽  
Cardiorespiratory Fitness ◽  
Young Women ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Short Term ◽  
High Intensity Interval

This study was to determine the effects of five-week high-intensity interval training (HIIT) on cardiorespiratory fitness, body composition, blood glucose, and relevant systemic hormones when compared to moderate-intensity continuous training (MICT) in overweight and obese young women.Methods. Eighteen subjects completed 20 sessions of HIIT or MICT for five weeks. HIIT involved 60 × 8 s cycling at ~90% of peak oxygen consumption (V˙O2peak) interspersed with 12 s recovery, whereas MICT involved 40-minute continuous cycling at 65% ofV˙O2peak.V˙O2peak, body composition, blood glucose, and fasting serum hormones, including leptin, growth hormone, testosterone, cortisol, and fibroblast growth factor 21, were measured before and after training.Results. Both exercise groups achieved significant improvements inV˙O2peak(+7.9% in HIIT versus +11.7% in MICT) and peak power output (+13.8% in HIIT versus +21.9% in MICT) despite no training effects on body composition or the relevant systemic hormones. Blood glucose tended to be decreased after the intervention (p=0.062). The rating of perceived exertion in MICT was higher than that in HIIT (p=0.042).Conclusion. Compared with MICT, short-term HIIT is more time-efficient and is perceived as being easier for improving cardiorespiratory fitness and fasting blood glucose for overweight and obese young women.

Effects of high-intensity interval training performed in the morning or evening on 24 h blood glucose profiles

2019 ◽  
Vol 13 (3) ◽  
pp. 291
Author(s):  
Samuel K. Pinto ◽  
Trine Moholdt ◽  
Evelyn B. Parr ◽  
Brooke L. Devlin ◽  
David W. Dunstan ◽  
...  
Keyword(s):  
Blood Glucose ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Glucose Profiles ◽  
High Intensity Interval

scholarly journals Effects of High Intensity Interval Training on the Gene Expression of PGC1-Α, CS and P-53 in the Cardiomyocyte of Male Obese Rats in Type 2 Diabetes

2021 ◽  
Author(s):  
Nadia Khayampour ◽  
Maghsoud Peeri ◽  
Mohammad Ali Azarbayjani ◽  
Maryam Delfan
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
High Intensity Interval Training ◽  
Healthy Control ◽  
High Intensity Interval ◽  
Obese Male ◽  
P 53

Introduction: Exercise training with different intensity regulates metabolism at the cellular level by regulating the expression of genes involved in mitochondrial biogenesis in diabetic patients. The aim of this study was to evaluate the effect of 4 weeks of high intensity interval training on the expression of PGC-1α, CS and p-53 genes in the cardiomyocytes of obese male rats with type 2 diabetes. Methods: The present study was an experimental one. Eighteen obese male diabetic rats were divided into three groups of six: high intensity interval training (HIIT), diabetic control (DC), healthy control (NC). Diabetes was induced in all groups except the healthy control group by streptozotocin (STZ) injection. After anesthesia, blood serum was obtained directly from their left ventricle and immediately extracted from their left ventricle. Plasma glucose was measured by glucose oxidase assay. To determine the expression of PGC-1α, CS and P-53 genes, PCR-Real time method and group comparison were used by one-way ANOVA test with application 8 version  graph pad prism at alpha level of 0.05. Results: The increase in PGC-1α gene expression in HIIT group compared to DC (P = 0.0001) and NC (P = 0.001) groups was significant. Increased expression of CS gene in HIIT group was significant compared to DC (P = 0.0001) and NC (P = 0.009) groups. Decreased expression of P-53 gene in HIIT group compared to DC (P = 0.0001) and NC (P = 0.001) groups were significantly different. Weight and glucose were significantly reduced in the HIIT group. Conclusion: The results showed that by increasing the PGC-1α, CS genes and decreasing the expression of P-53 gene in cardiomyocytes of obese diabetic rats, it improves the energy metabolism in diabetic patients due to mitochondrial deficiency and possibly it can improve diabetic cardiomyopathy.

scholarly journals Developing Sensitive Golden Plate Biosensor for Early Detection of Serum Cardiac Troponin I as Diagnostic Biomarkers

2018 ◽  
Author(s):  
Said Moselhy ◽  
Ehab Mostafa ◽  
Abdulrahman Almalki ◽  
Taha Kumosani ◽  
Youssri Soliman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Troponin ◽  
Healthy Subjects ◽  
Large Scale ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Diagnostic Biomarkers ◽  
Elisa Technique ◽  
Serum Cardiac Troponin ◽  
Ctni Level

Rapid diagnosis of acute myocardial infarction is critical for intervention and treatment to decrease morbidity and mortality. For this reasons, this study aimed to design a sensitive biosensor for cardiac troponin I (cTnI) for early prediction and intervention. The sensor was designed from golden plate immobilized with anti- cTnI antibody conjugated with horseradish peroxidase (HRP) enzyme. The rate of degradation of H2O2 is directly related to serum cTnI level. Serum cTnI level was quantified from 3 studied groups including; healthy subjects and patients with ischemic heart (IHD) diseases and myocardial infarction (MI) by ELISA and biosensor techniques to achieve the improved sensitivity of the biosensor. It was found that cTnI levels in healthy subjects ranged from 8-13 ng/dl and in patients with IHD ranged from 20 - 41 ng/dl and MI range from 57- 180 ng/dl. The sensitivity of biosensor was ranged from 85-95% compared with ELISA technique. The developed biosensor is promising in ICU hospitals for early diagnosis and prevent complications of the stroke. It is recommended to apply this biosensor in the large scale of patients with different stages of the cardiac disease.

scholarly journals The effect of Progressive Resistance Training and High Intensity Interval Training on TRAF6 gene expression of the heart muscle and serum TNF-α levels in male diabetic rats

2021 ◽  
Vol 43 (2) ◽  
pp. 209-219
Author(s):  
Seyedeh Fatemeh Tonkaboni ◽  
Neda Khaledi ◽  
Hossein Askari
Keyword(s):  
Gene Expression ◽  
Resistance Training ◽  
High Intensity ◽  
Interval Training ◽  
Diabetic Rats ◽  
Progressive Resistance Training ◽  
High Intensity Interval Training ◽  
Tnf Α ◽  
High Intensity Interval ◽  
Progressive Resistance

Background: The most common causes of mortality in diabetic patients are cardiovascular disorders, one of the reasons being inflammatory factors. Given that physical activity can reduce inflammation, the present study was to investigate the effects of two types of Progressive Resistance Training (RT) and High Intensity Interval (HIIT) on the expression of TRAF6 gene and serum levels of TNF-α in male diabetic rats. Methods: In this experimental study, 72 male rats were divided into 6 groups of 12 diabetic rats (n=12), control (n=12), diabetic High Intensity Interval Training (n=12), High Intensity Interval Training(n=12), diabetic Progressive Resistance Training(n=12) and Progressive Resistance Training(n=12). Progressive Resistance Training was performed in a 6-weekly 3-session, climbing the vertical ladder, with 50%, 75%, 90% and 100% the body weight of the animals. After successful completion, 30 gr were added to the weights, to the extent that the rats cannot carry the ladder. High Intensity Interval Training were also performed at 6-weekly 3-session, with an intensity of 50 to 110% of the VO2max. 24 hours after the completion of the training, the functional test was taken and the animals were autopsy 48 hours after the test. Finally, the expression of TRAF6 gene was evaluated using Real Time PCR and serum TNF-α level by ELISA method. Results: TRAF6 levels increased significantly after the two Training in the diabetic group, which was higher in the HIIT group and serum TNF-α levels decreased significantly after both types of training, which was more prominent in the HIIT group. Conclusion: HIIT and RT can play an important role in reducing the inflammatory factor of TNF-α in diabetic patient that HIIT is more effective in this regard. Increasing the gene expression of the mediating agent TRAF6 can be induced in inflammatory pathways, which may require a reduction in exercise intensity or in anti-inflammatory routes indicating a positive effect of training on diabetes.

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