scholarly journals Relationship between rs3918242 Polymorphism of Matrix Methaloproteinase-9 Gene and Preeclampsia in Pregnant Women

2020 ◽  
Vol 24 (5) ◽  
pp. 434-443
Author(s):  
Mehdi Sahmani ◽  
◽  
Nilofar Ahmadi ◽  
Somayeh Asadian ◽  
Talaat Dabaghi Ghaleh ◽  
...  

Background: Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development of this disease, but there are no definitive results. Objective: This study aims to investigate the possible association between rs3918242 (−1562C>T) polymorphism in Matrix Metalloproteinase 9 (MMP9) gene with the risk of preeclampsia in pregnant women. Methods: In this cross-sectional study, participants were 90 pregnant women with preeclampsia and 199 healthy pregnant women (controls). The genotypes of rs3918242 polymorphism were investigated using Polymerase Chain Reaction technique and Limited Fragment Length Polymorphism method. Logistic regression analysis was used to investigate the relationship between rs3918242 polymorphism and preeclampsia. Findings: The frequency of CC, CT, TT genotypes of rs3918242 polymorphism was reported 47.8%, 47.8% and 4.2% in patients and 84.8, 13.1 and 2% in controls, respectively, and the difference between groups was significant (P<0.001). The frequency of TT genotype in patients was significantly higher than in controls (P<0.001). Moreover, the frequency of T allele in patients was 52.2%, while in controls it was 15.2% and the difference between the two groups was significant (P<0.001). Conclusion: The rs3918242 polymorphism of MMP9 gene plays an important role in the incidence of preeclampsia in pregnant women.

2020 ◽  
Vol 28 (4) ◽  
pp. 455-462
Author(s):  
Thanh Minh Nguyen ◽  
Thi Thuy Hang Bui ◽  
Xingxue Xiao ◽  
Vu Ha Le

Mindful parenting, a concept that has been coined and examined recently, refers to a parent’s ability to bring complete attention to their children in the present moment. The aims of this study are to examine the relationship between self-compassion and mindful parenting and the role of gratitude as a mediating variable in a cross-sectional study. Participants include 522 Vietnamese mothers ( M age = 35.17; SD = 5.56) randomly selected through an online investigation. A 26-item Self-Compassion Scale was used to measure self-compassion, gratitude was measured by the Gratitude Questionnaire Six-Item Form, and mindful parenting was measured by the Interpersonal Mindfulness in Parenting Scale. The results support two main findings: (a) self-compassion has a direct influence on mindful parenting (effect = 2.48, p < .001, 95% CI [1.75, 3.22]), and (b) the mediating role of gratitude in this model was significant (effect = 0.37, 95% CI [0.10, 0.70]). The study’s results also show that increasing self-compassion and gratitude can help to improve mindful parenting.


2021 ◽  
Vol 18 (3) ◽  
pp. 201-217
Author(s):  
Wiktor Razmus ◽  
Beata Zarzycka

Past research links a decrease in religiosity with the development of marketing and, in particular, with the growing role of brands in consumers’ lives. Building on James's (1920) theory of the self, we propose that focusing on brands as a strategy for self-expression (brand engagement in self-concept; BESC) does not exclude religious commitment and may even be related with higher levels of religious commitment. We also suggest that this relationship is moderated by grandiose narcissism. The hypotheses were tested on a sample of 306 individuals in a cross-sectional study. The findings provide evidence that BESC is positively related to religious commitment and the higher an individual’s narcissism is, the stronger the positive relationship between BESC and religious commitment. These findings suggest that using brands as a strategy for self-expression is not a substitute for religious commitment.


Author(s):  
L. Kannan ◽  
Praveena P.

Background: Stress is a mental, physical and emotional response to life demands. Long hours of work, client demands, changing laws- creates stress and eventually hypertension among advocates. Well-being of the advocates are being questioned. Hence the main objective of the study is to evaluate the relationship between stress and hypertension among practising advocates.Methods: A cross-sectional study was conducted in a sample of 300 practising advocates at Madurai district court for a period of 1 year by simple random sampling method.Results: Around 133 (44.33%) and 167 (55.66%) of study participants were in level of high stress and low stress respectively. Among high stressed participants, a majority of 113 (84.96%) were found to be hypertensives and among the low stressed participants only 10 (5.98%) were hypertensives. The difference of observation was found to be statistically significant (p=0.0000).Conclusions: In conclusion the study explains that practising advocates with high perceived stress 113 (84.96%) were found to be hypertensives. Stress has a significant association with hypertension. The right way to manage stress is to implement coping strategies.


2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Fifi Khoirul Fitriyah ◽  
Nur Hidayah ◽  
Muslihati Muslihati ◽  
Im Hambali ◽  
Mursyidul Ibad

Although many studies have examined the relationship between spirituality and empathy, very few studies have focused on demographic and spiritual dimensions in influencing empathy for pre-service teachers. This study analyzes the effect of gender, age, and years of formal education on spirituality and empathy and analyzes the influence of the spiritual dimensions on empathy. This research is a cross-sectional study, with 319 Muslim pre-service teachers as respondents. The data collection technique used an online questionnaire adapted from the Spirituality Assessment Scale (SAS) and the Interpersonal Reactivity Index (IRI). The results show that age affects spirituality, while empathy is influenced by age and gender. One unanticipated finding was that years of formal education had no effect on either spirituality or empathy. The most important finding of this study is the higher the level of innerness, the more likely it is to have high empathy. This study's findings are useful as an assessment material and creating counseling designs to increase empathy for pre-service teachers. This is a part of forming the ideal profile of counselors in schools later. Integrating Islamic values ​​is also an essential alternative in counseling for Muslims.


2018 ◽  
Vol 25 (6) ◽  
pp. 721-742 ◽  
Author(s):  
Sarah J. Ehlke ◽  
Michelle L. Kelley

This cross-sectional study examined whether depressive symptoms strengthened the relationship between different forms of sexual coercion victimization and drinking to cope motivations, which was hypothesized to influence alcohol use. Participants were 214 female undergraduates who completed an online survey. Participants who experienced any lifetime sexual coercion and reported higher depressive symptoms were the most likely to report drinking to cope motivations, which in turn were associated with alcohol use. Depressive symptoms did not strengthen the relationship between specific forms of sexual coercion, drinking to cope, and alcohol use. Increasing emotion regulation strategies among sexual coercion victims may reduce drinking.


Author(s):  
Alessandra Costanza ◽  
Marc Baertschi ◽  
Hélène Richard-Lepouriel ◽  
Kerstin Weber ◽  
Isabella Berardelli ◽  
...  

Emergency departments (EDs) play an increasingly crucial role in the management of patients with suicidal behavior (SB). Demoralization has been associated with SB in various populations and conditions, but little is known about the effect of this construct in SB patients who attend an ED. Therefore, a more inclusive SB assessment which considers the demoralization construct could be useful in clinical practice. The main aim of this study was to assess the presence and severity of demoralization in patients visiting EDs for SB. Secondly, the maintenance of the relationship between demoralization and SB after controlling for depression and the proportion of variance which accounted for hopelessness was investigated. A cross-sectional study of patients (N = 199) visiting an ED for SB was performed, which examined the role of demoralization, hopelessness, and depression on suicidal ideation (SI) and suicide attempts (SAs). Demoralization was strongly and positively correlated with SI. Demoralization was related to major depressive episodes, but it was confirmed to be a different and, probably, more sensitive construct for SB, validating its specificity in relation to depression. Hopelessness accounted for a small portion of the variance in SI, compared to demoralization. Formal support for the association of demoralization with SI was provided. Demoralization can improve SB assessment in EDs, particularly among patients whose suicide risk can be unnoticed. Furthermore, demoralization represents a clinically useful concept to increase comprehension of the suffering of the suicidal patient and a possible target for psychotherapeutic interventions.


2019 ◽  
Vol 22 (9) ◽  
pp. 1453-1459 ◽  
Author(s):  
Mirte A G Kuipers ◽  
Robert West ◽  
Emma V Beard ◽  
Jamie Brown

Abstract Introduction Since 2012, England has an annual “Stoptober” campaign for collective smoking cessation. Our aim was to assess (1) overall impact of the Stoptober campaign on quit attempts over its first 6 years, (2) consistency of impact over the campaign years, and (3) the role of the campaign budget. Methods We used data of 51 399 adult smokers and ex-smokers in 132 repeat cross-sectional monthly surveys in England, 2007–2017. In a quasiexperimental design, adjusted logistic regression analyses compared past-month quit attempt rate between (1) October and other months in the year, between 2007–2011 and 2012–2017; (2) October and other months, across years 2012–2017; and (3) October and other months, between high-budget (2012–2015) and low-budget Stoptober campaigns (2016–2017). Bayes factors (BF) differentiated insensitive data and absence of an effect. Results (1) In 2012–2017, quit attempts were more prevalent in October versus other months (odds ratio [OR]: 1.24, 95% confidence interval [CI]: 1.00 to 1.53), whereas similar in 2007–2011 (OR: 0.95, 95% CI: 0.76 to 1.18; BF = 0.2); data were somewhat insensitive but supported this difference (OR: 1.30, 95% CI: 0.97 to 1.75; BF = 2.1). (2) In 2012–2017, quit attempt prevalence ranged from 3.1% to 8.5% in October and 5.0% to 7.3% in other months. The difference between October and other months was large in 2012 (absolute unadjusted difference of 3.3%; OR: 1.92, 95% CI: 1.23 to 2.98) and 2015 (3.1%; OR: 1.84, 95% CI: 1.14 to 2.95), but small in 2013–2014 and 2016–2017 (0.36 &lt; BF &lt; 1.02). (3) Data were somewhat insensitive but supported interaction with campaign budget (OR: 1.50, 95% CI: 0.92 to 2.44; BF = 2.2). Discussion In 2012–2017, there appears to have been an increase in past-month quit attempts during October in England. The increase was inconsistent across Stoptober campaigns and appears to have been greater when the campaign budget was higher. Implications Over the first 6 years of Stoptober campaigns, there appears to have been an overall increase in past-month quit attempts during October in England, and the data imply that a sufficiently high budget contributes to greater impact of the Stoptober campaign. These findings encourage the further spread of the Stoptober campaign to other countries. Future research should clarify how increased quit attempts as a consequence of Stoptober translate into quit success and which of Stoptober’s ingredients were most important in increasing quit attempts, especially among vulnerable groups.


2017 ◽  
Vol 55 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Monavar Gilanifar ◽  
Moloud Aghajani Delavar

Abstract Introduction. Alexithymia is related to poor emotion regulation strategies as well as higher rates of somatic disorders. The aim of the present study was to assess the relationship between alexithymia and the general symptoms experienced by the pregnant women. Material and Methods. In a cross-sectional study, a total number of 350 pregnant women, attending the antenatal clinics, were randomly selected. A standardized Toronto Alexithymia Scale (TAS-20) was used to elicit responses from participants with alexithymia. The general symptoms scores were measured using the Iranian version of the Symptom Checklist-90-Revised, 90 items. The statistical associations between alexithymia and the general symptoms were then investigated through liner regression. Results. A total number of 186 of pregnant women with alexithymia were compared with the 164 cases without alexithymia. The high scores on Total Toronto Alexithymia Scale-20 and the difficulties to identify feelings emerged as major predictors for the current psychopathology on all SCL-90-R subscales. The difficulty in describing feelings features of alexithymia is positively associated with interpersonal sensitivity and paranoid ideation, but it is inversely associated with the phobic anxiety dimension. Conclusion. This study showed that the pregnant women with difficulty in describing feelings features of alexithymia are likely to show a broad range of psychopathology. Therefore, it is necessary to emphasize the benefits of specific psychotherapeutic techniques to improve self-differentiation so that we can reduce the likelihood of mental illnesses in pregnant women.


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