scholarly journals Evaluation of Phytochemicals and Antioxidant potential of aqueous extract of Myristica fragrans

2020 ◽  
pp. 352-356
Author(s):  
Malarvizhi V ◽  
Jenni. P
Keyword(s):  
Chelating Agents ◽  
Vision Loss ◽  
Enzyme Inhibitor ◽  
Qualitative Evaluation ◽  
The Body ◽  
Radical Scavenger ◽  
Metal Chelating ◽  
Myristica Fragrans ◽  
Steroid Glycosides ◽  
Unstable Molecules

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable molecules that the body produces as a reaction to environmental and other pressures. Antioxidants act as radical scavenger, hydrogen donor, electron donor, peroxide decomposer, singlet oxygen quencher, enzyme inhibitor, synergist, and metal-chelating agents. The damage caused by antioxidants has been linked to cancer, atherosclerosis, and vision loss. Need of antioxidant with less side effects emerges nowadays. In this present qualitative evaluation shows this plant contains secondary metabolites like terpenoids, flavanoids, saponins, tannins, alkaloid, steroid, glycosides, proteins and coumarins. Myristica fragrans have been reported for its versatile antioxidant activity.

Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents

2012 ◽  
Vol 22 (13) ◽  
pp. 4462-4466 ◽  
Author(s):  
Fan-Chao Meng ◽  
Fei Mao ◽  
Wen-Jun Shan ◽  
Fangfei Qin ◽  
Ling Huang ◽  
...  
Keyword(s):  
Chelating Agents ◽  
Acetylcholinesterase Inhibitors ◽  
Design Synthesis ◽  
Metal Chelating

scholarly journals Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress

2021 ◽  
Vol 14 (8) ◽  
pp. 1260-1273
Author(s):  
Zi-Yan Cai ◽  
◽  
Ke Liu ◽  
Xuan-Chu Duan ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vision Loss ◽  
Eye Diseases ◽  
The Body ◽  
Age Related Macular Degeneration ◽  
Therapeutic Effects ◽  
Related Factor ◽  
Classical Pathway ◽  
Age Related ◽  
Important Relationship

Age-related eye diseases, including cataract, glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD), are the leading causes of vision loss in the world. Several studies have shown that the occurrence and development of these diseases have an important relationship with oxidative stress in the eye. The Keap1-Nrf2-ARE pathway is a classical pathway that resists oxidative stress and inflammation in the body. This pathway is also active in the development of age-related eye diseases. A variety of drugs have been shown to treat age-related eye diseases through the Keap1-Nrf2-ARE (Kelch-like ECH-Associating protein 1- nuclear factor erythroid 2 related factor 2-antioxidant response element) pathway. This review describes the role of oxidative stress in the development of age-related eye diseases, the function and regulation of the Keap1-Nrf2-ARE pathway, and the therapeutic effects of drugs associated with this pathway on age-related eye diseases.

Influence of Several Chelating Agents on the Distribution and Binding of Cadmium in Rats

1987 ◽  
Vol 6 (6) ◽  
pp. 451-458 ◽  
Author(s):  
W. Rau ◽  
F. Planas-Bohne ◽  
D.M. Taylor
Keyword(s):  
Molecular Weight ◽  
Binding Site ◽  
High Molecular Weight ◽  
Metal Concentration ◽  
Chelating Agents ◽  
Body Burden ◽  
The Body ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Human Use

1 Male Sprague-Dawley rats were injected with 109CdCl2 (3 μmol Cd/kg) and killed between 1 h and 200 d afterwards. Metal concentration in the critical organs, i.e. liver and kidneys decreased very slowly. Within the cells Cd is found mainly in the cytosol and — at very early times — in the nuclei. Within the cytosol of the liver most of the metal is initially bound to proteins with high molecular weight but as early as 3 h after incorporation more than 90% is bound to metallothionein which is always the main binding site in the kidneys. 2 Of the chelating agents tested only BAL and Puchel were able to reduce the body burden significantly. Both are lipophilic substances. Puchel cannot reduce the kidney Cd burden but removes Cd from the liver only while BAL is effective in both organs. Both chelating agents exert their effects at doses which are too near to the LDso to be considered as safe enough for human use.

scholarly journals Effect of metal chelating agents on pentylenetetrazole-induced seizure threshold in cholestatic mice

Seizure ◽  
2009 ◽  
Vol 18 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Hussein Rayatzadeh ◽  
Mohsen Nouri ◽  
Mehdi Ghasemi ◽  
Abbas Kebriaeezadeh ◽  
Shahram Ejtemaei Mehr ◽  
...  
Keyword(s):  
Chelating Agents ◽  
Seizure Threshold ◽  
Metal Chelating

Possibilities of using fosinopril in treatment of patients with chronic kidney disease in combination with cardiovascular diseases and diabetes mellitus

2021 ◽  
pp. 17-25
Author(s):  
E. Yu. Ebzeeva ◽  
O. D. Ostroumova ◽  
S. V. Batyukina ◽  
N. A. Shatalova ◽  
N. M. Doldo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Cardiovascular Diseases ◽  
Kidney Disease ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitor ◽  
The Body ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Secondary Damage

Chronic kidney disease is one of the most common diseases in general medical practice, due to their secondary damage to the kidneys in arterial hypertension, chronic heart failure, and diabetes mellitus. The coexistence of hypertension and diabetes increases the likelihood of developing chronic kidney failure tenfold. In turn, chronic kidney disease is an important independent risk factor for the development of cardiovascular complications, including fatal ones, due to the direct relationship of the pathogenetic mechanisms of cardiorenal relationships. Approaches to the treatment of chronic kidney disease should be aimed both at preventing the risks of developing renal dysfunction, and at treating existing pathology. The multifactorial nature of the disease and the complex etiopathogenetic relationships determine the need to optimize existing approaches to the treatment of chronic kidney disease in multimorbidity patients with concomitance cardiovascular diseases and diabetes mellitus. This is also due to the fact that, unlike other target organs, compensation for background disease does not always prevent further deterioration of kidney function. According to the recommendations of the main scientific communities, in such cases, it is advisable to start therapy with the most effective angiotensin-converting enzyme inhibitors that combine nephro-and cardioprotective effects and have a dual route of elimination from the body, which is especially important in multimorbidity, the aim to prevent polypharmacy, reduce the risk of drug interactions and, consequently, side effects. This article reviews the literature data indicating the high efficacy and safety of the angiotensin converting enzyme inhibitor fosinopril in patients with chronic kidney disease in combination with cardiovascular diseases and diabetes mellitus.

GLUTAMIC DEHYDROGENASE FROM UREDOSPORES OF PUCCINIA HELIANTHI SCHW.

1963 ◽  
Vol 9 (3) ◽  
pp. 345-351 ◽  
Author(s):  
J. E. Smith
Keyword(s):  
Nicotinamide Adenine Dinucleotide ◽  
Chelating Agents ◽  
Nicotinamide Adenine ◽  
Metal Chelating ◽  
Puccinia Helianthi ◽  
Glutamic Dehydrogenase ◽  
Sulphydryl Groups

Glutamic dehydrogenase was extracted from germinated uredospores of Puccinia helianthi and partially purified. The enzyme was specific for nicotinamide-adenine dinucleotide was inhibited by several metal-chelating agents and was shown to possess sulphydryl groups essential for activity.

scholarly journals The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 177 ◽  
Author(s):  
Guillermo Cásedas ◽  
Francisco Les ◽  
Carmen Choya-Foces ◽  
Martín Hugo ◽  
Víctor López
Keyword(s):  
Oxidative Stress ◽  
Enzyme Inhibitor ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Monoamine Oxidase A ◽  
Mitochondrial Activity ◽  
Radical Scavenger ◽  
Dependent Manner ◽  
Urolithin A ◽  
Ic50 Values

Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries. The objective of this study was to determine the cytoprotective capacity of this polyphenol in Neuro-2a cells subjected to oxidative stress, as well as its direct radical scavenging activity and properties as an inhibitor of oxidases. Cells treated with this compound and H2O2 showed a greater response to oxidative stress than cells only treated with H2O2, as mitochondrial activity (MTT assay), redox state (ROS formation, lipid peroxidation), and the activity of antioxidant enzymes (CAT: catalase, SOD: superoxide dismutase, GR: glutathione reductase, GPx: glutathione peroxidase) were significantly ameliorated; additionally, urolithin A enhanced the expression of cytoprotective peroxiredoxins 1 and 3. Urolithin A also acted as a direct radical scavenger, showing values of 13.2 μM Trolox Equivalents for Oxygen Radical Absorbance Capacity (ORAC) and 5.01 µM and 152.66 µM IC50 values for superoxide and 2,2-diphenyss1-picrylhydrazyl (DPPH) radicals, respectively. Finally, inhibition of oxidizing enzymes, such as monoamine oxidase A and tyrosinase, was also detected in a dose-dependent manner. The cytoprotective effects of urolithin A could be attributed to the improvement of the cellular antioxidant battery, but also to its role as a direct radical scavenger and enzyme inhibitor of oxidases.

A Preliminary Theoretical Study of Arterial Pressure Perturbations Under Shock Acceleration

1989 ◽  
Vol 111 (3) ◽  
pp. 233-240 ◽  
Author(s):  
E. Belardinelli ◽  
M. Ursino ◽  
E. Iemmi
Keyword(s):  
Young Modulus ◽  
Qualitative Evaluation ◽  
The Body ◽  
Shock Acceleration ◽  
Model Parameters ◽  
Suitable Model ◽  
Mathematical Inquiry ◽  
The Common ◽  
Pressure Changes ◽  
Pressure Perturbations

The artero-venous system is often stressed by accelerative perturbation, not only during exceptional performances, but also in normal life. For example, when the body is subject to fast pressure changes, accelerative perturbations combined with a change in hydrostatic pressure could have severe effects on the circulation. In such cases a preliminary mathematical inquiry, whose results allow qualitative evaluation of the perturbation produced is useful. Pressure variations are studied in this work when the body is subjected both to rectilinear and rotational movements as well as posture change. The dominant modes of the hemodynamic oscillations are emphasized and the numerical simulation results presented. The artery model used for simulation is obviously simplified with respect to the anatomical structure of an artery. Nevertheless, behavior of the main arteries (like the common carotid and aorta) can be approximately described, choosing suitable model parameters. The frequency of blood oscillations strictly depends on the Young modulus of the arterial wall. This connection could be employed for new clinical tests on the state of the arteries.

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