Scaffold mediated delivery of drugs/genes for promoting nerve regeneration via gene silencing/pathway inhibition after traumatic nerve injuries

2020 ◽  
Author(s):  
◽  
Na Zhang
Keyword(s):  
Gene Silencing ◽  
Nerve Regeneration ◽  
Nerve Injuries ◽  
Pathway Inhibition

scholarly journals Recovery of Peripheral Nerve with Massive Loss Defect by Tissue Engineered Guiding Regenerative Gel

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Shimon Rochkind ◽  
Zvi Nevo
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Preclinical Study ◽  
Significant Loss ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Reconstructive Procedures ◽  
Nerve Conduits

Objective. Guiding Regeneration Gel (GRG) was developed in response to the clinical need of improving treatment for peripheral nerve injuries and helping patients regenerate massive regional losses in peripheral nerves. The efficacy of GRG based on tissue engineering technology for the treatment of complete peripheral nerve injury with significant loss defect was investigated.Background. Many severe peripheral nerve injuries can only be treated through surgical reconstructive procedures. Such procedures are challenging, since functional recovery is slow and can be unsatisfactory. One of the most promising solutions already in clinical practice is synthetic nerve conduits connecting the ends of damaged nerve supporting nerve regeneration. However, this solution still does not enable recovery of massive nerve loss defect.The proposed technologyis a biocompatible and biodegradable gel enhancing axonal growth and nerve regeneration. It is composed of a complex of substances comprising transparent, highly viscous gel resembling the extracellular matrix that is almost impermeable to liquids and gasses, flexible, elastic, malleable, and adaptable to various shapes and formats.Preclinical studyon rat model of peripheral nerve injury showed that GRG enhanced nerve regeneration when placed in nerve conduits, enabling recovery of massive nerve loss, previously unbridgeable, and enabled nerve regeneration at least as good as with autologous nerve graft “gold standard” treatment.

Advances in electrical and magnetic stimulation on nerve regeneration

2019 ◽  
Vol 14 (10) ◽  
pp. 969-979 ◽  
Author(s):  
Yun Qian ◽  
Yuan Cheng ◽  
Jiangyu Cai ◽  
Xiaotian Zhao ◽  
Yuanming Ouyang ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Magnetic Stimulation ◽  
Clinical Practices ◽  
Nerve Injuries ◽  
Physical Stimulation ◽  
Ion Channel Regulation ◽  
Biomaterial Scaffolds ◽  
Underlying Mechanisms ◽  
Factor Secretion ◽  
Growth Factor Secretion

Central and peripheral nerve injuries pose a great threat to people. Complications such as inflammation, muscle atrophy, traumatic neuromas and delayed reinnervation can bring huge challenges to clinical practices and barriers to complete nerve regrowth. Physical interventions such as electrical and magnetic stimulation show satisfactory results with varying parameters for acute and chronic nerve damages. The biological basis of electrical and magnetic stimulation mainly relies on protein synthesis, ion channel regulation and growth factor secretion. This review focuses on the various paradigms used in different models of electrical and magnetic stimulation and their regenerative potentials and underlying mechanisms in nerve injuries. The combination of physical stimulation and conductive biomaterial scaffolds displays an infinite potentiality in translational application in nerve regeneration.

scholarly journals Sciatic nerve regeneration induced by glycosaminoglycan and laminin mimetic peptide nanofiber gels

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 110535-110547 ◽  
Author(s):  
Busra Mammadov ◽  
Melike Sever ◽  
Mevhibe Gecer ◽  
Fatih Zor ◽  
Sinan Ozturk ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Bioactive Peptide ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Mimetic Peptide ◽  
The Usa ◽  
Sciatic Nerve Regeneration

Bioactive peptide gels enhance the regeneration of peripheral nerve injuries, which affect 20 million patients in the USA.

Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube

2003 ◽  
Vol 99 (3) ◽  
pp. 555-565 ◽  
Author(s):  
Rajiv Midha ◽  
Catherine A. Munro ◽  
Paul D. Dalton ◽  
Charles H. Tator ◽  
Molly S. Shoichet
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Collagen Gel ◽  
Nerve Injuries ◽  
Content Type ◽  
Synthetic Hydrogel ◽  
Fine Print

Object. The authors' long-term goal is repair of peripheral nerve injuries by using synthetic nerve guidance devices that improve both regeneration and functional outcome relative to an autograft. They report the in vitro processing and in vivo application of synthetic hydrogel tubes that are filled with collagen gel impregnated with growth factors. Methods. Poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (PHEMA-MMA) porous 12-mm-long tubes with an inner diameter of 1.3 mm and an outer diameter of 1.8 mm were used to repair surgically created 10-mm gaps in the rat sciatic nerve. The inner lumen of the tubes was filled with collagen matrix alone or matrix supplemented with either neurotropin-3 at 1 µg/ml, brain-derived neurotrophic factor at 1 µg/ml, or acidic fibroblast growth factor (FGF-1) at 1 or 10 µg/ml. Nerve regeneration through the growth factor—enhanced tubes was assessed at 8 weeks after repair by histomorphometric analysis at the midgraft level and in the nerve distal to the tube repair. The tubes were biostable and biocompatible, and supported nerve regeneration in more than 90% of cases. Nerve regeneration was improved in tubes in which growth factors were added, compared with empty tubes and those containing collagen gel alone (negative controls). Tubes filled with 10 µg/ml of FGF-1 dispersed in collagen demonstrated regeneration comparable to autografts (positive controls) and showed significantly better regeneration than the other groups. Conclusions. The PHEMA-MMA tubes augmented with FGF-1 in their lumens appear to be a promising alternative to autografts for repair of nerve injuries. Studies are in progress to assess the long-term biocompatibility of these implants and to enhance regeneration further.

Electroactive nanomaterials in the peripheral nerve regeneration

2021 ◽  
Author(s):  
Xiangyun Yao ◽  
Yun Qian ◽  
Cunyi Fan
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Life Quality ◽  
Peripheral Nerve Injuries ◽  
Human Beings ◽  
Nerve Injuries

Severe peripheral nerve injuries are threatening the life quality of human beings.

scholarly journals Protocol for a phase I trial of a novel synthetic polymer nerve conduit 'Polynerve' in participants with sensory digital nerve injury (UMANC)

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 959 ◽  
Author(s):  
Ralph Murphy ◽  
Alessandro Faroni ◽  
Jason Wong ◽  
Adam Reid
Keyword(s):  
Phase I ◽  
Nerve Regeneration ◽  
Treatment Options ◽  
Donor Site ◽  
Sensory Nerve ◽  
Sensory Nerves ◽  
Nerve Conduit ◽  
Nerve Injuries ◽  
Post Surgery ◽  
The Uk

Background: Peripheral nerve injuries are common, with approximately 9,000 cases in the UK annually. Young working individuals are predominantly affected, leading to significant health and social implications. Functional recovery is often poor with impaired hand sensation, reduced motor function and pain and cold intolerance. Where a nerve gap exists, nerve grafting remains the gold-standard treatment but creates a second surgical site, sensory deficit at the donor site, possible neuroma formation and has limited availability. Current commercially available synthetic and resorbable nerve conduit alternatives are reported to be rigid and inflexible. This study will set out to examine the first-in-man use of a new nerve conduit device ‘Polynerve’ to repair small nerve gaps in digital sensory nerves of the hand. Polynerve is a degradable co-polymer of poly-ε-caprolactone and poly-l-lactic acid, which is shaped as a cylinder that has greater tensile strength, flexibility and less acidic degradation compared with current commercially available synthetic nerve conduits. In addition, it has a novel micro-grooved internal lumen that aids Schwann cell ingress and alignment to improve nerve regeneration. Methods: In total, 17 eligible participants will be recruited to undergo repair of a transected sensory nerve of the hand using the Polynerve device. All participants that receive the nerve conduit device will be followed for a period of 12 months post-surgery. The primary endpoint is safety of the device and the secondary endpoint is degree of sensory nerve regeneration through the conduit assessed using standard sensory testing (2-PD, WEST monofilament testing and locognosia). Discussion: The ‘UMANC’ trial is a single-centre UK-based, prospective, unblinded, phase I clinical trial of a novel nerve conduit device. We aim to demonstrate the safety of Polynerve as a synthetic, biodegradable nerve conduit and improve the treatment options available to patients with significant nerve injuries. Registration: Clinicaltrials.gov: NCT02970864; EudraCT: 2016-001667-37.

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