scholarly journals THE EFFECT OF GINKGO BILOBA AGAINST OTOTOXIC HEARING LOSS ON ADVANCED STAGE UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA RECEIVING CISPLATIN CHEMOTHERAPY

2020 ◽  
Vol 2 (02) ◽  
pp. 44-46
Author(s):  
Donny Hendriyanto ◽  
Made Setiamika ◽  
Novi Primadewi
Keyword(s):  
Hearing Loss ◽  
Nasopharyngeal Carcinoma ◽  
Ginkgo Biloba ◽  
Successful Outcome ◽  
Advanced Stage ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
The Third ◽  
Significant Difference ◽  
Undifferentiated Nasopharyngeal Carcinoma

Abstract Introduction: Undifferentiated nasopharyngeal carcinoma is the most common malignant tumor in nasopharynx, in which most patients come to a hospital in advanced stage. Cisplatin is one of the most effective widely used chemotherapy drugs for advanced stage undifferentiated nasopharyngeal carcinoma. Although it provides a successful outcome against cancer, there is serious side effect namely ototoxic hearing loss. Ginkgo biloba is a powerful antioxidant which may prevent ototoxic hearing loss. Objective: The study aims to determine the effect of ginkgo biloba against ototoxic hearing loss on advanced stage undifferentiated nasopharyngeal carcinoma receiving cisplatin chemotherapy. Methods: This study was double blind Randomized Control Trial with pre-post test design, was conducted in 22 patients with advanced stage undifferentiated nasopharyngeal carcinoma receiving cisplatin chemotherapy at the Department of Otorhinolaryngology Head and Neck Surgery dr. Moewardi Hospital Surakarta between June 1st and October 1st 2019. The subjects were allocated into control (plasebo) and treatment (80 mg Ginkgo biloba extract) groups. Hearing function was examined with pure tone audiometry, tympanometry and Distortion Product Otoacoustic Emission before and after the first, the second and the third cisplatin chemotherapy. The results of the examination of the two groups were tested using Friedman and Chi Square test. P value of <0.05 was considered significant. Results: The study subjects were mostly male (63.6%), with the age range of 40-59 years (90.9%). The baseline characteristics of the study subjects were homogeneous (p>0.05). There was a significant difference in the incidence of ototoxic hearing loss between control and treatment group after getting the second and the third chemotherapy (p=0.043 and p=0.033, respectively). Conclusion: There is a significant effect of ginkgo biloba in term of preventing ototoxic hearing loss on advanced stage undifferentiated nasopharyngeal carcinoma patients receiving cisplatin chemotherapy.

scholarly journals Peran Ginkgo biloba terhadap pencegahan gangguan dengar sensorineural pada terapi sisplatin penderita tumor ganas

2015 ◽  
Vol 44 (2) ◽  
pp. 96 ◽  
Author(s):  
Raden Mohamad Krisna Barata ◽  
Muhammad Thaufiq Siddiq Boesoirie ◽  
Ratna Anggraeni Soepardi Poerwana
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Ginkgo Biloba ◽  
Malignant Tumors ◽  
Otoacoustic Emission ◽  
Ginkgo Biloba Extract ◽  
Sensorineural Hearing ◽  
Egb 761 ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

Latar belakang: Kemoterapi sisplatin adalah terapi yang sering diberikan untuk penderita tumor ganas yang mempunyai efek samping ototoksik dengan terbentuknya radikal bebas yang enyebabkan kematian sel rambut luar koklea sehingga terjadi gangguan dengar. Ginkgo biloba adalah antioksidan yang terbukti memiliki efek otoprotektif terhadap ototoksisitas akibat sisplatin dengan menghambat pembentukan radikal bebas. Tujuan: Mengetahui peran Ginkgo biloba terhadap pencegahan gangguan dengar sensorineural pada penderita tumor ganas dengan sisplatin. Metode: Penelitian ini merupakan penelitian uji klinis acak dengan sampel adalah semua penderita tumor ganas yang mendapat kemoterapi sisplatin di Rumah Sakit Hasan Sadikin pada bulan Oktober 2013 sampai Januari 2014. Sampel dibagi dua, kelompok perlakuan menjalani pengobatan kemoterapi sisplatin dengan tambahan ekstrak Ginkgo biloba (Egb 761) peroral 80 mg perhari sejak 1 hari sebelum kemoterapi selama 30 hari. Kelompok kontrol menjalani pengobatan kemoterapi sisplatin saja. Pemeriksaan fungsi pendengaran dilakukan dengan timpanometri, audiometri, dan Distortion Product Otoacoustic Emission (DPOAE) sebelum dan setelah kemoterapi sisplatin siklus pertama dan kedua. Hasil: Didapatkan total 40 data dari 20 pasien yang dibagi dalam dua kelompok. Kejadian gangguan dengar sensorineural setelah siklus pertama dengan pemeriksaan DPOAE didapatkan perbedaan yang bermakna (p=0,027). Kesimpulan: Pemberian terapi ekstrak Ginkgo biloba 80 mg peroral dapat mencegah gangguan dengar sensorineural akibat kemoterapi sisplatin pada penderita tumor ganas. Kata kunci: Sisplatin, Ginkgo biloba, ototoksik, gangguan dengar sensorineural, tumor ganas.ABSTRACTBackground: Chemotherapy with cisplatin is a treatment which often given to patients with malignant tumors with side effects of ototoxicity due to the formation of free radicals that caused cochlea outer hair cells death, causing hearing impairment. Ginkgo biloba is an antioxidant with otoprotective effect to cisplatin induced ototoxicity by inhibiting the formation of free radicals. Purpose:To find out the role of Ginkgo biloba against sensorineural hearing loss in patients with malignant tumors treated with cisplatin. Methods: This is a quasiexperimental clinical trial. The subject were all patients with malignant tumors who received cisplatin chemotherapy in Hasan Sadikin Hospital from October 2013 until January 2014. Sample was divided into 2 groups, the first group (treatment) are those who undergoing cisplatin chemotherapy treatment with additional Ginkgo biloba extract (EGb 761) 80 mg per day orally, started from 1 day prior chemotherapy for 30 days. The second group (control) is those who underwnet only cisplatin chemotherapy. Auditory function were assesed by tympanometry, audiometry and Distortion Product Otoacoustic Emission (DPOAE) examination before and after the first and second cycles cisplatin chemotherapy. Result: The data from right and left ear were analyzed separately, giving total 40 data from 20 patients divided in 2 groups. The incidence of sensorineural hearing loss after first cycle of chemotherapy with the DPOAE results showed significant differencess (p=0,027). Conclusion: Ginkgo biloba extract 80 mg perday orally could prevent cisplatin-induced ototoxicity in patients with malignancy. Keywords: Cisplatin, Ginkgo biloba, ototoxic, sensorineural hearing loss, malignant tumors.

scholarly journals The Effects of Round Window Membrane Injury and the Use of a Model Electrode Application on Hearing in Rats

2021 ◽  
pp. 014556132199018
Author(s):  
Murat Koc ◽  
Abdullah Dalgic ◽  
Mehmet Ziya Ozuer
Keyword(s):  
Hearing Loss ◽  
Cochlear Implant ◽  
Round Window ◽  
Mechanical Trauma ◽  
Round Window Membrane ◽  
Albino Rats ◽  
Topical Steroids ◽  
Distortion Product ◽  
Significant Difference ◽  
Group 3

Objective: To investigate the effects of the mechanical trauma to the round window, a model electrode inserted into the scala tympani on the cochlear reserve, and the efficacy of topical steroids in preventing hearing loss. Materials and Methods: 21 male Wistar Albino rats were equally categorized into three groups. In all groups an initial mechanical injury to round window was created. Only subsequent dexamethasone injection was administrated into the cochlea in the subjects of group 2 while a multichannel cochlear implant guide inserted into the cochlea prior to dexamethasone administration for group 3. Distortion product otoacoustic emissions (DPOAEs) were obtained prior to and immediately after the surgical injury, eventually on postoperative seventh day (d 7). Mean signal/noise ratios (S/Ns) obtained at 2000, 3000, and 4000 Hz were calculated. Data sets were compared with non-parametric statistical tests. Results: The early intraoperative mean S/Ns were significantly less than preoperative measurements for group 1 and 2; however, preoperative and postoperative d 7 average S/Ns did not differ. There was statistically significant difference between preoperative, intraoperative and postoperative d 7 average S/Ns for group 3. Conclusion: We observed that hearing was restored approximately to the preoperative levels following early postoperative repair. However, an electrode insertion into the cochlea via round window subsequent to mechanical trauma seems to cause a progressive hearing loss. Therefore, a special care must be taken to avoid the injury to the round window membrane in the course of the placement of a cochlear implant electrode and surgery for the chronic otitis media.

Effect of mastoid drilling on hearing of the contralateral ear

2013 ◽  
Vol 127 (10) ◽  
pp. 952-956 ◽  
Author(s):  
A Goyal ◽  
P P Singh ◽  
A Vashishth
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Prospective Clinical Study ◽  
Distortion Product Otoacoustic Emission ◽  
High Frequencies ◽  
Distortion Product ◽  
Contralateral Ear

AbstractObjectives:This study aimed to: understand the effect that high intensity noise associated with drilling (during otological surgery) has on hearing in the contralateral ear; determine the nature of hearing loss, if any, by establishing whether it is temporary or persistent; and examine the association between hearing loss and various drill parameters.Methods:A prospective clinical study was carried out at a tertiary centre. Thirty patients with unilateral cholesteatoma and normal contralateral hearing were included. Patients were evaluated pre-operatively and for five days following surgery using high frequency pure tone audiometry, and low and high frequency transient evoked and distortion product otoacoustic emission testing.Results:The findings revealed statistically significant changes in distortion product otoacoustic emissions at high frequencies (p = 0.016), and in transient evoked otoacoustic emissions at both low and high frequencies (p = 0.035 and 0.021, respectively). There was a higher statistical association between otoacoustic emission changes and cutting burrs compared with diamond burrs.Conclusion:Drilling during mastoid surgery poses a threat to hearing in the contralateral ear due to noise and vibration conducted transcranially.

scholarly journals The Effect of Endoscopic Endonasal Transsphenoidal Skull Base Surgery on Cochlear Function

2019 ◽  
Vol 80 (06) ◽  
pp. 604-607
Author(s):  
Murat Samet Ates ◽  
Murat Benzer ◽  
Isa Kaya ◽  
Huseyin Biceroglu ◽  
Erkin Ozgiray ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Skull Base ◽  
Skull Base Surgery ◽  
Sella Turcica ◽  
Early Period ◽  
Distortion Product Otoacoustic Emission ◽  
Bone Drilling ◽  
Cochlear Function ◽  
Distortion Product ◽  
Significant Difference

AbstractEndoscopic transsphenoidal skull base surgery (ETSS) has become a standard approach in the treatment of sellar and clival lesions, such as pituitary adenoma and chordoma. Due to the close proximity of the clivus and the sella turcica to the inner ear, it is thought that bone drilling in the surgery may have effects on hearing. The aim of this study was to assess the effect of bone drilling in ETSS procedure on cochlear function. This study was performed on 18 patients who underwent ETSS procedure between December 2016 and May 2017. The study was designed as a prospective study. All of the data were prospectively collected. These included demographic data, date of surgery, type of surgery, preoperative pure-tone audiometry, and preoperative and postoperative distortion product otoacoustic emission (DPOAE) measurements. Of the DPOAE measurements of the patients who were operated for pituitary adenoma, there was a statistically significant difference between the signal-to-noise ratio (SNR) measurements at 0.5, 1, 2 and 4 kHz (p < 0.05). Additionally, there were no significant differences in preoperative and postoperative SNR measurements of six patients who were selected for clivus chordoma. When the preoperative and postoperative tonal audiometric tests of the patients were compared, no statistically significant difference was found (p > 0.05). In conclusion, it is found that bone drilling in ETSS procedure has a negative effect on cochlear function in the early period. This is the first study to evaluate the degree of noise-induced cochlear damage in patients who were gone under ETSS procedure.

The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions

2017 ◽  
Vol 131 (11) ◽  
pp. 1017-1025 ◽  
Author(s):  
H Keppler ◽  
S Degeest ◽  
I Dhooge
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Homeostatic Plasticity ◽  
Distortion Product Otoacoustic Emissions ◽  
Chronic Tinnitus ◽  
Distortion Product Otoacoustic Emission ◽  
Frequency Range ◽  
Distortion Product ◽  
The Relationship

AbstractObjectives:Chronic tinnitus is associated with reduced auditory input, which results in changes in the central auditory system. This study aimed to examine the relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. For audiometry, the parameters represented the edge frequency of hearing loss, the frequency of maximum hearing loss and the frequency range of hearing loss. For distortion product otoacoustic emissions, the parameters were the frequency of lowest distortion product otoacoustic emission amplitudes and the frequency range of reduced distortion product otoacoustic emissions.Method:Sixty-seven patients (45 males, 22 females) with subjective chronic tinnitus, aged 18 to 73 years, were included.Results:No correlation was found between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. However, tinnitus pitch fell mostly within the frequency range of hearing loss.Conclusion:The current study seems to confirm the relationship between tinnitus pitch and the frequency range of hearing loss, thus supporting the homeostatic plasticity model.

scholarly journals Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice

2021 ◽  
Vol 13 ◽  
Author(s):  
Leslie K. Climer ◽  
Aubrey J. Hornak ◽  
Kaitlin Murtha ◽  
Yang Yang ◽  
Andrew M. Cox ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cell Function ◽  
Otoacoustic Emission ◽  
Cell Types ◽  
Auditory Brainstem ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Age Related ◽  
Brainstem Response

Ca2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca2+ binding protein (CaBP) preferentially expressed in outer hair cells (OHCs) of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM delays hearing loss in mice of two different genetic backgrounds: CBA/CaJ and C57Bl/6J. In both backgrounds, genetic disruption of Ocm leads to early progressive hearing loss as measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). In both strains, loss of Ocm reduced hearing across lifetime (hearing span) by more than 50% relative to wild type (WT). Even though the two WT strains have very different hearing spans, OCM plays a considerable and similar role within their genetic environment to regulate hearing function. The accelerated age-related hearing loss (ARHL) of the Ocm KO illustrates the importance of Ca2+ signaling in maintaining hearing health. Manipulation of OCM and Ca2+ signaling may reveal important clues to the systems of function/dysfunction that lead to ARHL.

scholarly journals Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258158
Author(s):  
Neil J. Ingham ◽  
Navid Banafshe ◽  
Clarisse Panganiban ◽  
Julia L. Crunden ◽  
Jing Chen ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Cell Function ◽  
Low Frequency ◽  
Mutant Mice ◽  
Auditory Brainstem Responses ◽  
Distortion Product Otoacoustic Emission ◽  
Inner Hair Cell ◽  
Distortion Product ◽  
Age Related

Age-related hearing loss in humans (presbycusis) typically involves impairment of high frequency sensitivity before becoming progressively more severe at lower frequencies. Pathologies initially affecting lower frequency regions of hearing are less common. Here we describe a progressive, predominantly low-frequency recessive hearing impairment in two mutant mouse lines carrying different mutant alleles of the Klhl18 gene: a spontaneous missense mutation (Klhl18lowf) and a targeted mutation (Klhl18tm1a(KOMP)Wtsi). Both males and females were studied, and the two mutant lines showed similar phenotypes. Threshold for auditory brainstem responses (ABR; a measure of auditory nerve and brainstem neural activity) were normal at 3 weeks old but showed progressive increases from 4 weeks onwards. In contrast, distortion product otoacoustic emission (DPOAE) sensitivity and amplitudes (a reflection of cochlear outer hair cell function) remained normal in mutants. Electrophysiological recordings from the round window of Klhl18lowf mutants at 6 weeks old revealed 1) raised compound action potential thresholds that were similar to ABR thresholds, 2) cochlear microphonic potentials that were normal compared with wildtype and heterozygous control mice and 3) summating potentials that were reduced in amplitude compared to control mice. Scanning electron microscopy showed that Klhl18lowf mutant mice had abnormally tapering of the tips of inner hair cell stereocilia in the apical half of the cochlea while their synapses appeared normal. These results suggest that Klhl18 is necessary to maintain inner hair cell stereocilia and normal inner hair cell function at low frequencies.

Sign in / Sign up

Export Citation Format

Share Document