scholarly journals Modern Dressing Wound Care Mempercepat Proses Penyembuhan Ulkus Kaki pada Pasien Diabetes: A Systematic Review

2021 ◽  
Vol 7 (1) ◽  
pp. 146-155
Author(s):  
Bangu Bangu ◽  
Heriviyatno Julika Siagian ◽  
Rosani Naim ◽  
Evodius Nasus
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Green Tea ◽  
Chronic Wound ◽  
Wound Care ◽  
Healing Process ◽  
Wound Dressings ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Cost Effective Treatment

Foot ulcers in diabetic patients should receive treatment to reduce the risk of infection and amputation and improve function and quality of life. Wound care techniques are developing very quickly, which can help nurses and patients to improve the healing of foot ulcers in diabetic patients. Several wound care methods that can accelerate the healing process of foot ulcers in DM patients include modern wound dressings, the process of healing diabetic ulcers. With modern dressing methods, chronic wound care with modern dressings, the potential of green tea in wound healing, honey as a debridement agent. Objective: This study reviews several dressing methods that accelerate the healing process of foot ulcers in diabetic patients. This study uses a Systematic Review based on Preferred Reporting Items for Systematic Reviews & Meta-Analyses (PRISMA) to identify all published literature using relevant databases and keywords. In the 5 articles that we analyzed, the use of modern wound dressings proved to be more effective in accelerating wound healing, especially foot ulcers in diabetic patients. Modern wound care (Modern wound dressing), chronic wound care with modern dressings, the potential of green tea in wound healing, Honey as a debridement agent: a systematic review. And the role of the family in helping patients take medication regularly is the right choice to accelerate the healing process of foot ulcers in diabetic patients with more cost-effective treatment.

scholarly journals Wound dressings: curbing inflammation in chronic wound healing

2021 ◽  
Author(s):  
Davide Vincenzo Verdolino ◽  
Helen A. Thomason ◽  
Andrea Fotticchia ◽  
Sarah Cartmell
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Wound Care ◽  
Healing Process ◽  
Standard Of Care ◽  
The Elderly ◽  
Wound Dressings ◽  
Wound Healing Process

Chronic wounds represent an economic burden to healthcare systems worldwide and a societal burden to patients, deeply impacting their quality of life. The incidence of recalcitrant wounds has been steadily increasing since the population more susceptible, the elderly and diabetic, are rapidly growing. Chronic wounds are characterised by a delayed wound healing process that takes longer to heal under standard of care than acute (i.e. healthy) wounds. Two of the most common problems associated with chronic wounds are inflammation and infection, with the latter usually exacerbating the former. With this in mind, researchers and wound care companies have developed and marketed a wide variety of wound dressings presenting different compositions but all aimed at promoting healing. This makes it harder for physicians to choose the correct therapy, especially given a lack of public quantitative data to support the manufacturers’ claims. This review aims at giving a brief introduction to the clinical need for chronic wound dressings, focusing on inflammation and evaluating how bio-derived and synthetic dressings may control excess inflammation and promote healing.

Identifying New Pathways and Targets for Wound Healing and Therapeutics from Natural Sources

2021 ◽  
Vol 18 ◽  
Author(s):  
Xinchi Feng ◽  
Jinsong Hao
Keyword(s):  
Wound Healing ◽  
Molecular Mechanisms ◽  
Chronic Wounds ◽  
Wound Care ◽  
Healing Process ◽  
Unmet Need ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Natural Sources ◽  
Viable Approach

: Chronic wounds remain a significant public problem and the development of wound treatments has been a research focus for the past few decades. Despite advances in the products derived from endogenous substances involved in a wound healing process (e.g. growth factors, stem cells, and extracellular matrix), effective and safe wound therapeutics are still limited. There is an unmet need to develop new therapeutics. Various new pathways and targets have been identified and could become a molecular target in designing novel wound agents. Importantly, many existing drugs that target these newly identified pathways could be repositioned for wound therapy, which will facilitate fast translation of research findings to clinical applications. This review discusses the newly identified pathways/targets and their potential uses in the development of wound therapeutics. Some herbs and amphibian skins have been traditionally used for wound repairs and their active ingredients have been found to act in these new pathways. Hence, screening these natural products for novel wound therapeutics remains a viable approach. The outcomes of wound care using natural wound therapeutics could be improved if we can better understand their cellular and molecular mechanisms and fabricate them in appropriate formulations, such as using novel wound dressings and nano-engineered materials. Therefore, we also provide an update on the advances in the wound therapeutics from natural sources. Overall, this review offers new insights into novel wound therapeutics.

Evidence for person-centred care in chronic wound care: A systematic review and recommendations for practice

2020 ◽  
Vol 29 (Sup9b) ◽  
pp. S1-S22 ◽  
Author(s):  
Georgina Gethin ◽  
Sebastian Probst ◽  
Jan Stryja ◽  
Natalia Christiansen ◽  
Patricia Price
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Wound Care ◽  
Patient Knowledge ◽  
Person Centered Care ◽  
Centered Care ◽  
Recommendations For Practice ◽  
The Impact

Background Chronic wounds affect an estimated 2.21 per 1000 population. They are a significant source of morbidity and affect individuals physically, psychologically, socially and financially. Person-centered care is one approach to improve patient outcomes in wound care as it values patients' perspectives, beliefs and autonomy and considers the person as a whole within the cultural context in which care is provided. Aim We aimed to review the evidence on the use of person-centered care (PCC) in chronic wound care management and provide recommendations for practice and future research. Method Using a systematic review methodology, we searched six databases for full-text papers from 2009–2019 published in peer-reviewed journals with no limits on language. Results Eighteen articles on studies involving 3149 patients from nine countries were identified. Studies were conducted under three broad intervention categories: healthcare professional education (n=1); patient education (n=14) and telemedicine (n=3). Studies were equally focused on prevention and treatment of chronic wounds. Significant improvements were reported in patient knowledge, pain and self-care behaviours. Only two studies evaluated the impact on wound healing and one study estimated the cost of implementing person-centered care. Conclusions The evidence base to support PCC in wound management is developing and based on our review has shown improved outcomes in areas of pressure ulcer prevention, patient satisfaction, patient knowledge and quality of life, but clinical outcomes such as wound healing were less well explored. Further research with more objective outcome measures are required.

Management of Diabetic Foot Ulcer with MA–ECM (Minimally Manipulated Autologous Extracellular Matrix) Using 3D Bioprinting Technology – An Innovative Approach

2021 ◽  
pp. 153473462110456
Author(s):  
Rajesh Kesavan ◽  
Changam Sheela Sasikumar ◽  
V.B. Narayanamurthy ◽  
Arvind Rajagopalan ◽  
Jeehee Kim
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Wound Care ◽  
Foot Ulcer ◽  
Test Group ◽  
Wound Dressings ◽  
Foot Ulcers ◽  
Control Group ◽  
3D Bioprinting

Chronic foot ulcers are the leading cause of prolonged hospitalization and loss of social participation in people with diabetes. Conventional management of diabetic foot ulcers (DFU) is associated with slow healing, high cost, and recurrent visits to the hospital. Currently, the application of autologous lipotransfer is more popular, as the regenerative and reparative effects of fat are well established. Herein we report the efficacy of minimally manipulated extracellular matrix (MA-ECM) prepared from autologous homologous adipose tissue by using 3D bioprinting in DFU (test group) in comparison to the standard wound care (control group). A total of 40 subjects were screened and randomly divided into test and control groups. In the test group, the customized MA-ECM was printed as a scaffold from the patient autologous fat using a 3D bioprinter device and applied to the wound directly. The control group received standard wound care and weekly follow-up was done for all the patients. We evaluated the efficacy of this novel technology by assessing the reduction in wound size and attainment of epithelialization. The patients in the test group (n = 17) showed complete wound closure with re-epithelialization approximately within a period of 4 weeks. On the other hand, most of the patients in the control group (n = 16) who received standard wound dressings care showed a delay in wound healing in comparison to the test group. This technique can be employed as a personalized therapeutic method to accelerate diabetic wound healing and may provide a promising potential alternative approach to protect against lower foot amputation a most common complication in diabetes.

scholarly journals Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 158 ◽  
Author(s):  
Jana Zarubova ◽  
Mohammad Mahdi Hasani-Sadrabadi ◽  
Lucie Bacakova ◽  
Song Li
Keyword(s):  
Wound Healing ◽  
Network Formation ◽  
Chronic Wound ◽  
Wound Care ◽  
Healing Process ◽  
Microfluidic System ◽  
Wound Healing Process ◽  
Delivery Platform ◽  
Endothelial Growth Factor

Here, we developed a combinatorial delivery platform for chronic wound healing applications. A microfluidic system was utilized to form a series of biopolymer-based microparticles with enhanced affinity to encapsulate and deliver vascular endothelial growth factor (VEGF). Presence of heparin into the structure can significantly increase the encapsulation efficiency up to 95% and lower the release rate of encapsulated VEGF. Our in vitro results demonstrated that sustained release of VEGF from microparticles can promote capillary network formation and sprouting of endothelial cells in 2D and 3D microenvironments. These engineered microparticles can also encapsulate antibiotic-loaded nanoparticles to offer a dual delivery system able to fight bacterial infection while promoting angiogenesis. We believe this highly tunable drug delivery platform can be used alone or in combination with other wound care products to improve the wound healing process and promote tissue regeneration.

scholarly journals The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

Jurnal NERS ◽  
2020 ◽  
Vol 14 (3) ◽  
pp. 177
Author(s):  
Mohammad Roni Alfaqih ◽  
Gabriel Wanda Sinawang ◽  
Rohmatul Faizah ◽  
Andrik Hermanto
Keyword(s):  
Systematic Review ◽  
Diabetic Foot ◽  
Wound Care ◽  
Healing Process ◽  
Relevant Literature ◽  
Foot Ulcers ◽  
Transformation Rate ◽  
Diabetic Foot Ulcers ◽  
Treatment Techniques ◽  
Cell Growth And Proliferation

Background: One of the complications caused by diabetes mellitus is the problem of diabetic foot ulcers (DFU). The management of the DFU problem can be carried out through the wound care focused on the foot using modern dressings. This research was to determine the effectiveness of modern dressings on the healing process of diabetic foot ulcers.Methods: The methods used in arranging this systematic review were (1) the identification of interventions in the literature, (2) the identification of relevant literature based on the topic and title, (3) obtaining the literature in full-text form and (4) the analysis of the results from the various interventions in the literature.Result: The literature search was carried out in several databases such as Scopus, Google Scholar and Pubmed. The samples in this article were research about the effect of modern dressings in the treatment of diabetic foot ulcers. A total of 22 evidence bases found 10 studies using the pre-experimental method, 3 RCTs, 2 quasi-experiments, 2 articles / systematic reviews, 2 perspective studies, 1 medical report, 1 case study and 1 vitro and vivo study.Conclusion: Based on the review, it explains that the research on modern dressings using nanocrystalline silver ion and curcumin can improves wound recovery by increasing the transformation rate of the ß1 growth factor, which is a protein involved in cell growth and proliferation.

scholarly journals Studi Kasus Uji Pra Klinik Perawatan Ulkus Kaki Diabetic Dengan Topikal Hidrokoloid Kunyit

2018 ◽  
Vol 13 (2) ◽  
pp. 111-119
Author(s):  
Doddy Yumam Prasetyo ◽  
Muhammad Mardiyono ◽  
Heni Kusuma
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Wound Care ◽  
Healing Process ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Ulcer ◽  
Warm Environment ◽  
The One

Diabetic foot ulcers is a chronic complications, which has many long term, can result amputation. Wound care is the one of nursinginterventions effective; principles in wound care are giving a moist and warm environment in order to improve wound healing process.Hydrocolloid turmeric is one of wound treatment moisture balance and can be used as an anti-inflammatory and anti-bacterial. This study aimed to analyze the effect of hydrocolloid turmeric against diabetic ulcer healing process. This research was conducted by case study on 7 respondents, wound care with hydrocolloid tumeric at 21 days. At 7 patient with diabetic foot ulcers were intervention wound care with hydrocolloid tumeric at 21 days, showed score decrease in degree of wound healing, based Betes Jensen Scale. 

Chronic Wounds: Innovations in Diagnostics and Therapeutics

2019 ◽  
Vol 25 (41) ◽  
pp. 5772-5781 ◽  
Author(s):  
Marieke Haalboom
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Current Knowledge ◽  
Wound Care ◽  
Healing Process ◽  
Diagnostic Tools ◽  
Bacterial Invasion ◽  
Wound Healing Process ◽  
Limited Effectiveness

Background: A major global health issue is the existence of chronic wounds. Appropriate diagnosis and treatment is essential to promote wound healing and prevent further complications. Traditional methods for treatment and diagnosis of chronic wounds have shown to be of limited effectiveness. Therefore, there is a need for the development of diagnostic and therapeutic innovations in chronic wound care. Objective: This mini-review aims to provide insight in the current knowledge of the wound healing process and the deficiencies encountered in chronic wounds, which provides a basis for the development of innovations in chronic wound care. Furthermore, promising diagnostic and therapeutic innovations will be highlighted. Methods: Literature was searched for recent articles (=<10 years) describing the current knowledge about the wound healing process and chronic wounds. The most promising diagnostic and therapeutic innovations were gathered from articles published in the past 5 years. Results/Conclusion: Wound healing is a well-organized process consisting of four phases: coagulation, inflammation, proliferation and wound remodelling. Chronic wounds often stagnate in the inflammatory phase and/or experience an impaired proliferative phase. This mini-review has demonstrated that increased knowledge about the processes involved in wound healing has paved the way for the development of new diagnostic tools and treatments for chronic wounds. Increased knowledge about bacterial invasion and infection in has encouraged researchers to develop diagnostic tools to help clinicians detect these phenomena appropriately and in time. Other researchers have shown that they are able to design/extract biochemical compounds that intervene in the disrupted healing processes in chronic wounds.

scholarly journals Therapeutic Effects of Medicinal Plants on Diabetic Foot Ulcers: A Systematic Review

2021 ◽  
Vol 7 (3) ◽  
pp. 167
Author(s):  
Efa Refiani ◽  
Rita Maliza ◽  
Husna Fitri ◽  
Putri Lestari
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Wound Healing ◽  
Medicinal Plants ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcers ◽  
Therapeutic Effects ◽  
Diabetic Foot Ulcers ◽  
Active Compounds

Diabetic Foot Pain and Ulcers is one of the complications diseases caused by Diabetes Mellitus (DM). Based on data from the Ministry of Health in 2014, diabetic foot ulcers in Indonesia 54%. Diabetic foot ulcer disease can cause infection and tissue death. Treatment of diabetic foot ulcers has been treated with ointments or gels containing antimicrobials, biomaterials, and active compounds, accelerating the wound healing process. The active compounds from medicinal plants that play a role in the treatment of diabetic foot ulcers have been widely reported. The purpose of writing this article is to look at the therapeutic effects of active compounds that play a role in wound healing. In this systematic review, we searched the PubMed, Science Direct, and Google Scholar databases to identify primer articles that were published from 2010 to 2020. Ten studies were selected and published between 2015-2020. Furthermore, the plant species used for the treatment of diabetic foot ulcers contain active phenolic, gallic acid, flavonoids, gallic acid, flavonoids, and tannins compounds that play a role in the acceleration of the healing process of diabetic foot ulcers. Keywords: Diabetes mellitus, diabetic foot ulcers, the active compound, medicinal plants

scholarly journals A review on wound management with special reference to nanotechnology

2020 ◽  
Vol 11 (3) ◽  
pp. 2815-2824
Author(s):  
Debosmita Datta ◽  
Raman Suresh kumar
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Wound Care ◽  
Skin Permeation ◽  
Healing Process ◽  
Water Soluble ◽  
Wound Dressings ◽  
Wound Management ◽  
Exciting Field ◽  
Molecular Events

Management of wound care mainly depends upon the advancement of innovative and effective wound care product to achieve speedy recovery and minimising scar formation. Wound healing management has been always an interesting field of research till date due to serious need for new wound treatment. Appropriate wound care is a significant challenge because of the complications associated with wounds as well as low permeability through the skin. The interconnected events of wound healing occur simultaneously to restore the tissue integrity and functions of the cells. Wound healing gets hampered by numerous factors. These physiological events occur easily in normal human being, but in some situations these molecular events are affected, resulting in hard to heal/ chronic wounds. In current years nanotechnology has emerged as an exciting field with several applications in skin regeneration. These nanoscale delivery systems have numerous benefits in the healing process such as decrease in drug’s cytotoxicity, administration of poorly water-soluble drugs, better skin permeation, controlled release behaviour, antimicrobial activity, as well as stimulation of fibroblast proliferation and reduced inflammation. Thus, emerged as an effective strategy and approach for the treatment of chronic wounds. This review briefly discusses about the wounds, characteristics of an ideal wound dressings along with a special mention regarding the several strategies of wound healing by nanotechnology with their functions and advantages.

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