scholarly journals Chronic pancreatitis: pancreatic cancer risk factors

2020 ◽  
Vol 48 (3) ◽  
pp. 6-12
Author(s):  
N. B. Gubergrits ◽  
N. V. Byelyayeva ◽  
A. V. Tsys ◽  
T. L. Mozhyna ◽  
G. M. Lukashevich ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Meta Analysis ◽  
Pancreatic Tissue ◽  
Total Risk ◽  
Ras Gene ◽  
Cancer Risk Factors ◽  
Biological Tests ◽  
Time Required

The article discusses the known risk factors for pancreatic cancer (PC) in patients with chronic pancreatitis (CP), starting with the hypothesis expressed by the German pathologist Rudolph Virchow at the end of the 19th century, to modern worldviews. The difficulties of timely PC diagnosis and the short life expectancy of patients with CP who have PC are noted. According to modern concepts, the transformation of the inflammatory process in the pancreatic tissue into a neoplastic formation is caused not only by the features of the ordinary diet and well-known bad habits, but also by the effects of a number of chemical compounds, the presence of a concomitant pathology and genetic predisposition. The article shows the average period of time required for the neoplastic transformation of acinar or ductal epithelial cells in a state of chronic inflammation. The results of clinical studies and meta-analysis showing the correlation between different types of CP and the development of PC are presented. It is emphasized that the total risk of PC in patients with confirmed CP is less than 5%, which indirectly indicates a lack of sensitivity and specificity of non-invasive procedures in screening for neoplastic pancreatic lesions. The probability of developing PC in patients with hereditary pancreatitis, carriers of the mutant K-ras gene, as well as in patients suffering from cystic fibrosis is considered. Emphasis is placed on the need for further development of biological tests and biomarkers, which make it possible to differentiate CP and PC. The exclusion of known risk factors in patients with recurrent attacks of acute pancreatitis, CP will reduce the risk and prevent the occurrence of PC.

scholarly journals Biological diagnostic markers and pancreatic cancer risk factors in patients with chronic pancreatitis (literature review)

2020 ◽  
Vol 46 (1) ◽  
pp. 6-11
Author(s):  
A. A. Litvin ◽  
S. V. Korenev ◽  
E. N. Kolokoltseva ◽  
V. S. Denisyuk ◽  
S. B. Rumovskaya
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Serum Markers ◽  
Cancer Risk Factors ◽  
Non Invasive ◽  
Hereditary Risk ◽  
B Virus ◽  
Mutant Genes

Pancreatic cancer (PC) prevalence has steadily increased in recent years. It is untimely diagnosed due to prolonged asymptomatic course, minor changes in routine laboratory indices, lack of informative value of standard visualizing techniques. In this regard, attention is paid to determination of PC risk factors and establishment of biomarkers (diagnostic, prognostic, predictive) for pancreatic neoplastic transformation on the background of chronic pancreatitis. Non-inherited PC risk factors include old age, smoking, chronic pancreatitis, Helicobacter pylori/hepatitis B virus infection, obesity, diabetes mellitus. PC family history, family adenomatous polyposis, carriage of mutant genes (PRSS1, SPINK1, BRCA2) dominate among hereditary risk factors. Biomarkers can be used not only for early non-invasive diagnosis of PC, but also for differential diagnosis between chronic pancreatitis and PC. Sensitivity and specificity of various PC serum markers, such as CA19-9, PAM4, MIC-1, are analyzed in the article. It is possible to distinguish PC from autoimmune pancreatitis by determining the serum concentration of IgG4. In addition to blood serum, fecal masses (K-RAS, BMP3) and saliva (KRAS, MBD3L2, ACRV1 and DPM1) can be used to determine the potential markers of PC. New data of determination the fecal miRNAs as PC cancer biomarkers are presented, namely miR-21, miR-155 and miR-216. Majority of PC biomarkers have not been introduced into a routine clinical practice yet, and research on their informative value is ongoing.

PTU-079 K-ras gene mutations in pancreatic cancer and chronic pancreatitis patients in North Indian population

Gut ◽  
2010 ◽  
Vol 59 (Suppl 1) ◽  
pp. A81.1-A81
Author(s):  
S K Polipalli ◽  
P Kar ◽  
S A Husain ◽  
A Agarwal ◽  
R Gondal
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Indian Population ◽  
Gene Mutations ◽  
North Indian Population ◽  
Ras Gene

scholarly journals Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Michael Hocke ◽  
Christoph F. Dietrich
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Pancreatic Carcinoma ◽  
Endoscopic Ultrasound ◽  
Clinical Medicine ◽  
Pancreatic Tissue ◽  
Mechanical Index ◽  
Contrast Enhanced ◽  
Inflammatory Processes ◽  
Doppler Techniques

Discriminating between focal chronic pancreatitis and pancreatic cancer is always a challenge in clinical medicine. Contrast-enhanced endoscopic ultrasound using Doppler techniques can uniquely reveal different vascularisation patterns in pancreatic tissue alterated by chronic inflammatory processes and even allows a discrimination from pancreatic cancer. This paper will describe the basics of contrast-enhanced high mechanical index endoscopic ultrasound (CEHMI EUS) and contrast enhanced low mechanical index endoscopic ultrasound (CELMI EUS) and explain the pathophysiological differences of the vascularisation of chronic pancreatitis and pancreatic carcinoma. Furthermore it will discuss how to use these techniques in daily clinical practice.

Fr336 RISK FACTORS FOR DEVELOPMENT OF PANCREATIC CANCER AMONG PATIENTS WITH CHRONIC PANCREATITIS: A CASE-CONTROL STUDY

2021 ◽  
Vol 160 (6) ◽  
pp. S-297-S-298
Author(s):  
Mark Kowalczyk ◽  
Sridevi K. Pokala ◽  
Joshua Demb ◽  
Fady Youssef ◽  
Lin Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Breast Cancer Risk Factors in Iran: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Amir Shamshirian ◽  
Keyvan Heydari ◽  
Zahra Shams ◽  
Amir Reza Aref ◽  
Danial Shamshirian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Stress Condition ◽  
Vegetable Consumption ◽  
Meta Analysis ◽  
Cancer Risk Factors ◽  
Daily Exercise ◽  
Breast Cancer Risk Factors

To systematically investigate the epidemiology of breast cancer risk factors in Iran, we performed a systematic search via PubMed, Scopus, Web of Science and Persian databases for identifying studies published on breast cancer risk factors up to March 2019. Meta-analyses were done for risk factors reported in more than one study. We calculated odds ratios (ORs) with corresponding 95% confidence intervals (CIs) using a fixed/random-effects models.Thirty-nine studies entered into the meta-analysis. Pooling of ORs showed a significant harmful effect for risk factors including family history (OR: 1.80, 95%CI 1.47-2.12), HRT (OR: 5.48, 95%CI 0.84-1.74), ER positive (OR: 1.87, 95%CI 1.41-2.33), PR positive (OR: 1.84, 95%CI 1.38-2.29), stress condition (OR: 2.67, 95%CI 1.84-3.50), passive smokers (OR: 1.68, 95%CI 1.34-2.03), full-term pregnancy at age 30 (OR: 3.41, 95%CI 1.19-5.63), abortion (OR: 1.84, 95%CI 1.35-2.33), sweets consumption (OR: 1.71, 95%CI 1.32-2.11) and genotype Arg/Arg (crude OR: 1.59, 95%CI 1.07-2.10), whereas a significant protective effect for late menarche (OR: 0.58, 95%CI 0.32-0.83), nulliparity (OR: 0.68, 95%CI 0.39-0.96), 13 to 24 months of breastfeeding (OR: 0.68, 95%CI 0.46-0.90), daily exercise (OR: 0.59, 95%CI 0.44-0.73) and vegetable consumption (crude OR: 0.28, 95%CI 0.10-0.46).This study suggest that factors such as family history, HRT, ER and PR positive status, stress condition, passive smokers, late full-term pregnancy, abortion, sweets consumption and genotype Arg/Arg might increase risk of breast cancer development, whereas late menarche, nulliparity, 13-24 months breastfeeding, daily exercise and vegetable consumption had an inverse association with breast cancer development.

Chronische Pankreatitis und Pankreaskarzinom – Tumorrisiko und Screening

2018 ◽  
Vol 143 (12) ◽  
pp. 895-906 ◽  
Author(s):  
Georg Beyer ◽  
Jan D’Haese ◽  
Steffen Ormanns ◽  
Julia Mayerle
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Clinical Laboratory ◽  
Chronische Pankreatitis ◽  
Tumor Development ◽  
Life Time ◽  
High Morbidity ◽  
Patients At Risk ◽  
Nicotine Consumption

AbstractChronic pancreatitis is a fibroinflammatory syndrome of the exocrine pancreas, which is characterized by an increasing incidence, high morbidity and lethality. Common etiologies besides alcohol and nicotine consumption include genetic causes and risk factors. The life time risk for the development of pancreatic cancer is elevated 13- to 45-fold depending on the underlying etiology. In patients with chronic pancreatitis clinical, laboratory and imaging surveillance for early detection of complications, including pancreatic cancer, is recommended, although the available methods lack the desired sensitivity and specificity. In this article we review the epidemiology, etiologies and risk factors for chronic pancreatitis and pancreatic cancer and discuss current recommendations for screening and management of patients at risk for tumor development.

Upstaging in Early-Stage Pancreatic Cancer: Risk Factors and Effect on Survival

2020 ◽  
Vol 231 (4) ◽  
pp. S173-S174
Author(s):  
Elizabeth J. Olecki ◽  
Kelly Stahl ◽  
Madeline Torres ◽  
June Peng ◽  
Matthew Edmund Boyd Dixon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Early Stage ◽  
Cancer Risk Factors ◽  
Pancreatic Cancer Risk

scholarly journals K-rasMutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Jing Yang ◽  
Jingjing Li ◽  
Rong Zhu ◽  
Huawei Zhang ◽  
Yuanyuan Zheng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Diagnostic Accuracy ◽  
Test Performance ◽  
Meta Analysis ◽  
Diagnostic Odds Ratio ◽  
Pancreatic Tissue ◽  
Test Material ◽  
Original Research ◽  
Summary Receiver Operating Characteristic ◽  
Diagnostic Significance

Background. More clinically meaningful diagnostic tests are needed in pancreatic cancer (PC).K-rasmutations are the most frequently acquired genetic alteration.Methods. Original research articles involving the diagnostic accuracy ofK-rasmutation detection in PC were selected. Data were presented as forest plots and summary receiver operating characteristic (SROC) curve analysis was used to summarize the overall test performance.Results. We assessed 19 studies from 16 published articles. The reports were divided into three groups according to the process used to obtain the test material. The summary estimates for detectingK-rasstatus using an invasive method (fine needle aspiration (FNA), endoscopic retrograde cholangiopancreatography (ERCP), or surgery) were better than cytology: the pooled sensitivity was 77% (95% confidence interval (CI): 74–80%) versus 54% (95% CI: 47–61%); specificity was 88% (95% CI: 85–91%) versus 91% (95% CI: 83–96%); and diagnostic odds ratio (DOR) was 20.26 (11.40–36.03) versus 7.52 (95% CI: 2.80–20.18), respectively. When two procedures were combined, the diagnostic accuracy was markedly improved.Conclusions. The analysis ofK-rasmutations in pancreatic tissue has a promising diagnostic significance in PC. Further valuable studies are needed.

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