scholarly journals Biological diagnostic markers and pancreatic cancer risk factors in patients with chronic pancreatitis (literature review)

2020 ◽  
Vol 46 (1) ◽  
pp. 6-11
Author(s):  
A. A. Litvin ◽  
S. V. Korenev ◽  
E. N. Kolokoltseva ◽  
V. S. Denisyuk ◽  
S. B. Rumovskaya
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Serum Markers ◽  
Cancer Risk Factors ◽  
Non Invasive ◽  
Hereditary Risk ◽  
B Virus ◽  
Mutant Genes

Pancreatic cancer (PC) prevalence has steadily increased in recent years. It is untimely diagnosed due to prolonged asymptomatic course, minor changes in routine laboratory indices, lack of informative value of standard visualizing techniques. In this regard, attention is paid to determination of PC risk factors and establishment of biomarkers (diagnostic, prognostic, predictive) for pancreatic neoplastic transformation on the background of chronic pancreatitis. Non-inherited PC risk factors include old age, smoking, chronic pancreatitis, Helicobacter pylori/hepatitis B virus infection, obesity, diabetes mellitus. PC family history, family adenomatous polyposis, carriage of mutant genes (PRSS1, SPINK1, BRCA2) dominate among hereditary risk factors. Biomarkers can be used not only for early non-invasive diagnosis of PC, but also for differential diagnosis between chronic pancreatitis and PC. Sensitivity and specificity of various PC serum markers, such as CA19-9, PAM4, MIC-1, are analyzed in the article. It is possible to distinguish PC from autoimmune pancreatitis by determining the serum concentration of IgG4. In addition to blood serum, fecal masses (K-RAS, BMP3) and saliva (KRAS, MBD3L2, ACRV1 and DPM1) can be used to determine the potential markers of PC. New data of determination the fecal miRNAs as PC cancer biomarkers are presented, namely miR-21, miR-155 and miR-216. Majority of PC biomarkers have not been introduced into a routine clinical practice yet, and research on their informative value is ongoing.

scholarly journals Chronic pancreatitis: pancreatic cancer risk factors

2020 ◽  
Vol 48 (3) ◽  
pp. 6-12
Author(s):  
N. B. Gubergrits ◽  
N. V. Byelyayeva ◽  
A. V. Tsys ◽  
T. L. Mozhyna ◽  
G. M. Lukashevich ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Meta Analysis ◽  
Pancreatic Tissue ◽  
Total Risk ◽  
Ras Gene ◽  
Cancer Risk Factors ◽  
Biological Tests ◽  
Time Required

The article discusses the known risk factors for pancreatic cancer (PC) in patients with chronic pancreatitis (CP), starting with the hypothesis expressed by the German pathologist Rudolph Virchow at the end of the 19th century, to modern worldviews. The difficulties of timely PC diagnosis and the short life expectancy of patients with CP who have PC are noted. According to modern concepts, the transformation of the inflammatory process in the pancreatic tissue into a neoplastic formation is caused not only by the features of the ordinary diet and well-known bad habits, but also by the effects of a number of chemical compounds, the presence of a concomitant pathology and genetic predisposition. The article shows the average period of time required for the neoplastic transformation of acinar or ductal epithelial cells in a state of chronic inflammation. The results of clinical studies and meta-analysis showing the correlation between different types of CP and the development of PC are presented. It is emphasized that the total risk of PC in patients with confirmed CP is less than 5%, which indirectly indicates a lack of sensitivity and specificity of non-invasive procedures in screening for neoplastic pancreatic lesions. The probability of developing PC in patients with hereditary pancreatitis, carriers of the mutant K-ras gene, as well as in patients suffering from cystic fibrosis is considered. Emphasis is placed on the need for further development of biological tests and biomarkers, which make it possible to differentiate CP and PC. The exclusion of known risk factors in patients with recurrent attacks of acute pancreatitis, CP will reduce the risk and prevent the occurrence of PC.

Fr336 RISK FACTORS FOR DEVELOPMENT OF PANCREATIC CANCER AMONG PATIENTS WITH CHRONIC PANCREATITIS: A CASE-CONTROL STUDY

2021 ◽  
Vol 160 (6) ◽  
pp. S-297-S-298
Author(s):  
Mark Kowalczyk ◽  
Sridevi K. Pokala ◽  
Joshua Demb ◽  
Fady Youssef ◽  
Lin Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Determination of Plasma Glycoprotein 2 Levels in Patients With Pancreatic Disease

2004 ◽  
Vol 128 (6) ◽  
pp. 668-674 ◽  
Author(s):  
Ying Hao ◽  
Jing Wang ◽  
Ningguo Feng ◽  
Anson W. Lowe
Keyword(s):  
Pancreatic Cancer ◽  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Tertiary Care ◽  
Pancreatic Disease ◽  
Pancreatic Acinar Cell ◽  
Enzyme Linked Immunosorbent Assay ◽  
Assay Sensitivity ◽  
Acute And Chronic Pancreatitis

Abstract Context.—Blood tests possessing higher diagnostic accuracy are needed for all the major pancreatic diseases. Glycoprotein 2 (GP2) is a protein that is specifically expressed by the pancreatic acinar cell and that has previously shown promise as a diagnostic marker in animal models of acute pancreatitis. Objective.—This study describes the development of an assay for GP2, followed by the determination of plasma GP2 levels in patients with acute pancreatitis, chronic pancreatitis, and pancreatic cancer. Design.—Rabbit polyclonal antisera and mouse monoclonal antibodies were generated against human GP2 and used to develop an enzyme-linked immunosorbent assay. The assay was tested in patients with an admitting diagnosis of pancreatic disease at 2 tertiary care facilities. The diagnosis of acute or chronic pancreatitis and pancreatic cancer was determined using previously established criteria that incorporated symptoms, radiology, pathology, and serology. Plasma GP2 levels were determined in 31 patients with acute pancreatitis, 16 patients with chronic pancreatitis, 36 patients with pancreatic cancer, and 143 control subjects without pancreatic disease. Amylase and lipase levels were also determined in patients with acute pancreatitis. Results.—The GP2 assay's sensitivity values were 0.94 for acute pancreatitis, 0.81 for chronic pancreatitis, and 0.58 for pancreatic cancer, which were greater than the 0.71 for acute pancreatitis and 0.43 for chronic pancreatitis (P = .02) observed for amylase. The lipase assay sensitivity for acute pancreatitis was 0.66. The accuracy of the GP2 assay was greater than that of the amylase or lipase assays for acute pancreatitis (GP2 vs lipase, P = .004; GP2 vs amylase, P = .003) when analyzed using receiver operator characteristic curves. When daily serial blood samples were obtained for 13 patients with acute pancreatitis, GP2 levels remained abnormally elevated for at least 1 day longer than the amylase or lipase levels. Conclusion.—The GP2 assay is a useful new marker for acute and chronic pancreatitis.

Chronische Pankreatitis und Pankreaskarzinom – Tumorrisiko und Screening

2018 ◽  
Vol 143 (12) ◽  
pp. 895-906 ◽  
Author(s):  
Georg Beyer ◽  
Jan D’Haese ◽  
Steffen Ormanns ◽  
Julia Mayerle
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Clinical Laboratory ◽  
Chronische Pankreatitis ◽  
Tumor Development ◽  
Life Time ◽  
High Morbidity ◽  
Patients At Risk ◽  
Nicotine Consumption

AbstractChronic pancreatitis is a fibroinflammatory syndrome of the exocrine pancreas, which is characterized by an increasing incidence, high morbidity and lethality. Common etiologies besides alcohol and nicotine consumption include genetic causes and risk factors. The life time risk for the development of pancreatic cancer is elevated 13- to 45-fold depending on the underlying etiology. In patients with chronic pancreatitis clinical, laboratory and imaging surveillance for early detection of complications, including pancreatic cancer, is recommended, although the available methods lack the desired sensitivity and specificity. In this article we review the epidemiology, etiologies and risk factors for chronic pancreatitis and pancreatic cancer and discuss current recommendations for screening and management of patients at risk for tumor development.

Upstaging in Early-Stage Pancreatic Cancer: Risk Factors and Effect on Survival

2020 ◽  
Vol 231 (4) ◽  
pp. S173-S174
Author(s):  
Elizabeth J. Olecki ◽  
Kelly Stahl ◽  
Madeline Torres ◽  
June Peng ◽  
Matthew Edmund Boyd Dixon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Early Stage ◽  
Cancer Risk Factors ◽  
Pancreatic Cancer Risk

Environmental Risk Factors for Chronic Pancreatitis and Pancreatic Cancer

2011 ◽  
Vol 29 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Claudia Nitsche ◽  
Peter Simon ◽  
F. Ulrich Weiss ◽  
Gabriele Fluhr ◽  
Eckhard Weber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Environmental Risk ◽  
Environmental Risk Factors

Clinical features and risk factors of pancreatic cancer in chronic pancreatitis

Pancreatology ◽  
2013 ◽  
Vol 13 (4) ◽  
pp. S38
Author(s):  
Joon Hyuk Choi ◽  
Myung-Hwan Kim ◽  
Dong Wan Seo ◽  
Sang Soo Lee ◽  
Do Hyun Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Clinical Features

scholarly journals The Risk Factors of Pancreatic Cancer Patients in Dr. Cipto Mangunkusumo National Hospital, Jakarta During 2014-2019

2020 ◽  
Vol 21 (2) ◽  
pp. 120-125
Author(s):  
Kaka Renaldi ◽  
Teddy Septianto ◽  
Dadang Makmun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Family History ◽  
Alcohol Consumption ◽  
Cancer Patients ◽  
Obesity And Diabetes ◽  
History Of ◽  
Age Adjusted Rates

Background: Pancreatic cancer is a very rare cancer with age-adjusted rates ranging from about 5 to 10 new cases per 100,000 persons per year. It has one of the worst prognoses of any type of cancer, with a 5-year survival rate of only 4.6%. Several risk factors have been identified, including older age, smoking, familial history of pancreatic cancer, obesity, chronic pancreatitis, diabetes mellitus, and alcohol consumption.Method: This was a descriptive study describing the risk factors of patients who were diagnosed with pancreatic cancer in the period between 1 January 2014 – 1 January 2019 at the Cipto Mangunkusumo National Referral Hospital (RSCM) Jakarta. Data were obtained from the medical records and Endoscopic Retrograde Cholangiopancreatography (ERCP) database from the RSCM Gastrointestinal Endoscopy Center.Results: From January 2014 to January 2019 there were 123 patients with newly diagnosed pancreatic cancer in RSCM. The mean age was 52 years old. The incidence of pancreatic cancer is more common in men (53%) than women (47%). The most common risk factor identified is smoking which was found in 29% of patients, followed by obesity at 27.9% and a history of diabetes mellitus at 19.5%. Risk factors with a fairly low prevalence include alcohol consumption at 9.7% and chronic pancreatitis at 2.4%. No family history of pancreatic cancer is identified in any subject.Conclusion: Smoking, obesity, and diabetes mellitus are common risk factors in pancreatic cancer patients. In contrast, chronic pancreatitis, alcohol consumption, and family history of pancreatic cancer are less commonly identified in patients.

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