Chronische Pankreatitis und Pankreaskarzinom – Tumorrisiko und Screening

2018 ◽  
Vol 143 (12) ◽  
pp. 895-906 ◽  
Author(s):  
Georg Beyer ◽  
Jan D’Haese ◽  
Steffen Ormanns ◽  
Julia Mayerle
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Clinical Laboratory ◽  
Chronische Pankreatitis ◽  
Tumor Development ◽  
Life Time ◽  
High Morbidity ◽  
Patients At Risk ◽  
Nicotine Consumption

AbstractChronic pancreatitis is a fibroinflammatory syndrome of the exocrine pancreas, which is characterized by an increasing incidence, high morbidity and lethality. Common etiologies besides alcohol and nicotine consumption include genetic causes and risk factors. The life time risk for the development of pancreatic cancer is elevated 13- to 45-fold depending on the underlying etiology. In patients with chronic pancreatitis clinical, laboratory and imaging surveillance for early detection of complications, including pancreatic cancer, is recommended, although the available methods lack the desired sensitivity and specificity. In this article we review the epidemiology, etiologies and risk factors for chronic pancreatitis and pancreatic cancer and discuss current recommendations for screening and management of patients at risk for tumor development.

Fr336 RISK FACTORS FOR DEVELOPMENT OF PANCREATIC CANCER AMONG PATIENTS WITH CHRONIC PANCREATITIS: A CASE-CONTROL STUDY

2021 ◽  
Vol 160 (6) ◽  
pp. S-297-S-298
Author(s):  
Mark Kowalczyk ◽  
Sridevi K. Pokala ◽  
Joshua Demb ◽  
Fady Youssef ◽  
Lin Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Environmental Risk Factors for Chronic Pancreatitis and Pancreatic Cancer

2011 ◽  
Vol 29 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Claudia Nitsche ◽  
Peter Simon ◽  
F. Ulrich Weiss ◽  
Gabriele Fluhr ◽  
Eckhard Weber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Environmental Risk ◽  
Environmental Risk Factors

Clinical features and risk factors of pancreatic cancer in chronic pancreatitis

Pancreatology ◽  
2013 ◽  
Vol 13 (4) ◽  
pp. S38
Author(s):  
Joon Hyuk Choi ◽  
Myung-Hwan Kim ◽  
Dong Wan Seo ◽  
Sang Soo Lee ◽  
Do Hyun Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Clinical Features

scholarly journals Role of Computed Tomography Scan in the Evaluation of Pancreatic Lesions

2021 ◽  
Vol 10 (11) ◽  
pp. 819-824
Author(s):  
Sharvari Shashikant Gulve ◽  
Pratapsingh Hanumantsingh Parihar ◽  
Rajasbala Pradeep Dhande
Keyword(s):  
Computed Tomography ◽  
Chronic Pancreatitis ◽  
Ct Scan ◽  
Clinical Laboratory ◽  
Imaging Modality ◽  
High Morbidity ◽  
Pancreatic Lesion ◽  
Diagnostic Modality ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced

BACKGROUND Pancreatic lesions range from inflammation to malignancy and are associated with high morbidity and mortality. Imaging pancreatic lesion is challenging as pancreas is located retroperitoneally and with close proximity to bowel and major blood vessels. Abdominal pain, vomiting, and nausea are commonly reported symptoms. They are associated with high morbidity. Multi detector computed tomography (MDCT) is the modality of choice for detecting pancreatic pathology. It is highly sensitive in detecting necrosis, pancreatitis, peripancreatic fluid collections, calcification, neoplasm, pancreatic enlargement, atrophy and cystic lesions of pancreas. Computed tomography (CT) scan has made it possible to identify and detect various benign and malignant pancreatic lesions. METHODS A prospective observational study of 180 patients with complaints suggestive of pancreatic disease was done based on clinical, laboratory and ultrasonography in the Department of Radiodiagnosis, Acharya Vinoba Bhave Rural Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe). Siemens Somatom 16 slice CT scan machine was used. All 180 patients underwent plain and contrast enhanced CT scan. RESULTS Out of 180 study participants 105 (58.33 %) were with acute pancreatitis followed by 43 (23.89 %) with chronic pancreatitis, 21 (11.67 %) with acute exacerbation of chronic pancreatitis, 10 (5.56 %) participants with carcinoma pancreas and 1 (0.56 %) participant with pancreatic injury participated in the study. CONCLUSIONS Contrast enhanced computed tomography (CECT) is an excellent diagnostic modality to stage severity of inflammatory process, staging of neoplastic lesions and traumatic injury. It is most accurate and affordable non-invasive imaging modality for the evaluation of pancreatic lesions. It is a standard investigation to identify and quantify distribution of various pancreatic lesions and also evaluates activeness and progression of disease. Thus, it helps in accurate diagnosis and characterization of lesion and in proper treatment of patients. KEY WORDS Pancreas, Imaging, Computed Tomography

scholarly journals The Risk Factors of Pancreatic Cancer Patients in Dr. Cipto Mangunkusumo National Hospital, Jakarta During 2014-2019

2020 ◽  
Vol 21 (2) ◽  
pp. 120-125
Author(s):  
Kaka Renaldi ◽  
Teddy Septianto ◽  
Dadang Makmun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Family History ◽  
Alcohol Consumption ◽  
Cancer Patients ◽  
Obesity And Diabetes ◽  
History Of ◽  
Age Adjusted Rates

Background: Pancreatic cancer is a very rare cancer with age-adjusted rates ranging from about 5 to 10 new cases per 100,000 persons per year. It has one of the worst prognoses of any type of cancer, with a 5-year survival rate of only 4.6%. Several risk factors have been identified, including older age, smoking, familial history of pancreatic cancer, obesity, chronic pancreatitis, diabetes mellitus, and alcohol consumption.Method: This was a descriptive study describing the risk factors of patients who were diagnosed with pancreatic cancer in the period between 1 January 2014 – 1 January 2019 at the Cipto Mangunkusumo National Referral Hospital (RSCM) Jakarta. Data were obtained from the medical records and Endoscopic Retrograde Cholangiopancreatography (ERCP) database from the RSCM Gastrointestinal Endoscopy Center.Results: From January 2014 to January 2019 there were 123 patients with newly diagnosed pancreatic cancer in RSCM. The mean age was 52 years old. The incidence of pancreatic cancer is more common in men (53%) than women (47%). The most common risk factor identified is smoking which was found in 29% of patients, followed by obesity at 27.9% and a history of diabetes mellitus at 19.5%. Risk factors with a fairly low prevalence include alcohol consumption at 9.7% and chronic pancreatitis at 2.4%. No family history of pancreatic cancer is identified in any subject.Conclusion: Smoking, obesity, and diabetes mellitus are common risk factors in pancreatic cancer patients. In contrast, chronic pancreatitis, alcohol consumption, and family history of pancreatic cancer are less commonly identified in patients.

scholarly journals Biological diagnostic markers and pancreatic cancer risk factors in patients with chronic pancreatitis (literature review)

2020 ◽  
Vol 46 (1) ◽  
pp. 6-11
Author(s):  
A. A. Litvin ◽  
S. V. Korenev ◽  
E. N. Kolokoltseva ◽  
V. S. Denisyuk ◽  
S. B. Rumovskaya
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Serum Markers ◽  
Cancer Risk Factors ◽  
Non Invasive ◽  
Hereditary Risk ◽  
B Virus ◽  
Mutant Genes

Pancreatic cancer (PC) prevalence has steadily increased in recent years. It is untimely diagnosed due to prolonged asymptomatic course, minor changes in routine laboratory indices, lack of informative value of standard visualizing techniques. In this regard, attention is paid to determination of PC risk factors and establishment of biomarkers (diagnostic, prognostic, predictive) for pancreatic neoplastic transformation on the background of chronic pancreatitis. Non-inherited PC risk factors include old age, smoking, chronic pancreatitis, Helicobacter pylori/hepatitis B virus infection, obesity, diabetes mellitus. PC family history, family adenomatous polyposis, carriage of mutant genes (PRSS1, SPINK1, BRCA2) dominate among hereditary risk factors. Biomarkers can be used not only for early non-invasive diagnosis of PC, but also for differential diagnosis between chronic pancreatitis and PC. Sensitivity and specificity of various PC serum markers, such as CA19-9, PAM4, MIC-1, are analyzed in the article. It is possible to distinguish PC from autoimmune pancreatitis by determining the serum concentration of IgG4. In addition to blood serum, fecal masses (K-RAS, BMP3) and saliva (KRAS, MBD3L2, ACRV1 and DPM1) can be used to determine the potential markers of PC. New data of determination the fecal miRNAs as PC cancer biomarkers are presented, namely miR-21, miR-155 and miR-216. Majority of PC biomarkers have not been introduced into a routine clinical practice yet, and research on their informative value is ongoing.

T1387 Idiopathic Chronic Pancreatitis, Diabetes, and Smoking are Significant Risk Factors for Pancreatic Cancer: Results of Case-Control and Cohort Studies

2010 ◽  
Vol 138 (5) ◽  
pp. S-551
Author(s):  
Shallu Midha ◽  
Vishnubhatla Sreenivas ◽  
Tushar K. Chatterjee ◽  
Madhulika Kabra ◽  
Yogendra K. Joshi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Cohort Studies ◽  
Significant Risk ◽  
Case Control ◽  
Idiopathic Chronic Pancreatitis

scholarly journals Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1765
Author(s):  
Niccolò Furbetta ◽  
Annalisa Comandatore ◽  
Desirée Gianardi ◽  
Matteo Palmeri ◽  
Gregorio Di Franco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Prognostic Factors ◽  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
Invasive Procedure ◽  
Review Of The Literature ◽  
Nutritional Factors ◽  
Comprehensive Review

Total pancreatectomy (TP) is a highly invasive procedure often performed in patients affected by anorexia, malabsorption, cachexia, and malnutrition, which are risk factors for bad surgical outcome and even may cause enhanced toxicity to chemo-radiotherapy. The role of nutritional therapies and the association between nutritional aspects and the outcome of patients who have undergone TP is described in some studies. The aim of this comprehensive review is to summarize the available recent evidence about the influence of nutritional factors in TP. Preoperative nutritional and metabolic assessment, but also intra-operative and post-operative nutritional therapies and their consequences, are analyzed in order to identify the aspects that can influence the outcome of patients undergoing TP. The results of this review show that preoperative nutritional status, sarcopenia, BMI and serum albumin are prognostic factors both in TP for pancreatic cancer to support chemotherapy, prevent recurrence and prolong survival, and in TP with islet auto-transplantation for chronic pancreatitis to improve postoperative glycemic control and obtain better outcomes. When it is possible, enteral nutrition is always preferable to parenteral nutrition, with the aim to prevent or reduce cachexia. Nowadays, the nutritional consequences of TP, including diabetes control, are improved and become more manageable.

scholarly journals Pancreatic Cancer in a Young Male in His Twenties

2020 ◽  
Vol 95 (1) ◽  
pp. 50-55
Author(s):  
Seung-Ho Baek ◽  
Seung Soo Lee ◽  
Ji Hoon Kim ◽  
So Hyun Kim ◽  
Jihye Lim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Literature Review ◽  
Elderly Patients ◽  
Early Onset ◽  
Young Male ◽  
The Elderly ◽  
Genetic Mutations

Pancreatic cancer is one of the most lethal malignancies worldwide. The risk of developing pancreatic cancer increases with age. Pancreatic cancer is seen mostly in the elderly; patients under the age of 30 years are rare. Known risk factors for pancreatic cancer include genetic mutations, smoking, chronic pancreatitis, and diabetes mellitus. We report a case of pancreatic cancer in a 27-year-old man without the PRSS1 mutation. Chronic pancreatitis and smoking may have contributed to the development of pancreatic cancer in this patient. We also conducted a literature review on early onset pancreatic cancer.

scholarly journals Prevalence of hypertension, levels of lipids and blood glucose in patients with acute pancreatitis, chronic pancreatitis and pancreatic cancer

2020 ◽  
Vol 25 (6) ◽  
pp. 3823
Author(s):  
I. N. Grigorieva ◽  
O. V. Efimova ◽  
T. S. Suvorova ◽  
N. L. Tov ◽  
T. I. Romanova
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Behavioral Risk ◽  
Russian Society ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Direct Association ◽  
Normal Body Weight

Aim. To determine the prevalence of hypertension (HTN) in patients with acute pancreatitis (AP), chronic pancreatitis (CP), pancreatic cancer (PC) and establish associations of HTN with other risk factors (obesity, dyslipidemia (DLP), plasma glucose ≥7,0 mmol/l, smoking, alcohol consumption).Material and methods. This observational multicenter clinical cross-sectional uncontrolled study included 44 patients with AP, 97 patients with CP and 45 patients with PC. The groups were comparable by sex and age. The HTN was diagnosed according to the criteria of Russian Society of Cardiology (2020).Results. HTN was much more common in patients with PC (55,6%) than in patients with AP (25,0%) (χ 2 =8,6, p=0,003). In patients with CP, the prevalence of HTN (39,2%) did not differ from those with AP or PC. Among patients with AP and HTN, higher levels of triglycerides (TG) (U=88,0, p=0,010) and glucose (U=89,5, p=0,011) than in non-HTN patients with AP were determined. In HTN patients with CP, glucose ≥7,0 mmol/l was recorded 3 times more often than in non-HTN patients with CP (χ 2 =16,2, p=0,000). In patients with PC and HTN, a higher mean body mass index (BMI) (F=7,8, p=0,008) and less common normal body weight than in non-HTN patients with PC (28,0 and 65,0%, χ 2 =6,2, p=0,013) was revealed. In patients with CP, increased glucose levels by 1 mmol/l (Exp (B)=1,933, 95% confidence interval (CI) 1,350-2,767, p=0,000) or BMI by 1 kg/m2 (Exp (B)=1,224, 95% CI 1,085-1,380, p=0,001) raised the probability of HTN; in patients with PC, increased BMI by 1 kg/ m2 (Exp (B)=1,394, 95% CI 1,057-1,840, p=0,019) or age by 1 year (Exp (B)=1,251, 95% CI 1,052-1,489, p=0,011) raised the probability of HTN.Conclusion. HTN was more often observed in patients with PC than in those with AP. In patients with CP, the prevalence of HTN did not differ from those with AP or PC. HTN was a cofactor to other metabolic risk factors (glucose ≥7,0 mmol/l, obesity) in patients with AP or CP; behavioral risk factors, on the contrary, were less common in HTN patients with AP or CP. In patients with CP, there was a direct association of HTN with glucose levels or BMI, and in patients with PC — HTN with BMI or age.

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