Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives
2021 ◽
Vol 11
(4)
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pp. 12178-12185
Keyword(s):
In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and 1H NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.
2019 ◽
Vol 41
(6)
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pp. 1090-1090
2018 ◽
Vol 10
(6)
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2015 ◽
Vol 10
(2)
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pp. 1934578X1501000
2011 ◽
Vol 6
(2)
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pp. 1934578X1100600
2014 ◽
Vol 9
(6)
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pp. 1934578X1400900
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2013 ◽
Vol 8
(9)
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pp. 1934578X1300800
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