scholarly journals Biochemical Factors associated with Breast Cancer in Bangladeshi Women

2014 ◽  
Vol 6 (2) ◽  
pp. 58-62
Author(s):  
DAS Hussain ◽  
S Ahmed ◽  
M Hoque ◽  
SMR Rabbi ◽  
S Masood ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Family History ◽  
Cancer Patients ◽  
Blood Levels ◽  
Breast Cancer Patients ◽  
Blood Samples ◽  
Factors Associated ◽  
Medical College ◽  
Biochemical Features

Breast Cancer is the commonest maligrancy in woment. A study was carried out in the Department of Biochemistry, Dhaka Medical College to investigate some of the biochemical features that are associated with breast cancer occurring in Bangladeshi women. Thirty diagnosed breast cancer patients and thirty healthy women were selected. A questionnaire was used for collecting information regarding age, family history, physical activity and exercise, BMI, diet, smoking, alcohol abuse, addiction, details of menstrual and obstetric history, breast-feeding, parity, use of contraceptives and HRT. Blood samples were collected and tested for fasting lipid profiles, serum estrogen and progesterone. The study has revealed that high levels of serum total cholesterol (P<0.05), TAG (P<0.05), LDL-C (P<0.05) and low level of serum and HDL-C (P<0.05) were found to be associated with breast cancer. The study further reveals that blood levels of estrogen (P<0.05) and progesterone (P<0.05) were found to be lower than that of the controls. DOI: http://dx.doi.org/10.3329/bjmb.v6i2.17644 Bangladesh J Med Biochem 2013; 6(2): 58-62

Factors associated with physical activity of breast cancer patients participating in exercise intervention

2018 ◽  
Vol 27 (5) ◽  
pp. 1747-1754 ◽  
Author(s):  
Si-Woon Park ◽  
Ilkyun Lee ◽  
Joong Il Kim ◽  
Hyuna Park ◽  
Jong Doo Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Breast Cancer Patients ◽  
Factors Associated

Factors associated with bilateral versus single mastectomy in a diverse, population-based sample of breast cancer patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6502-6502
Author(s):  
S. Hawley ◽  
R. Jagsi ◽  
A. S. Hamilton ◽  
J. Graff ◽  
J. J. Griggs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Family History ◽  
Los Angeles ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Tumor Stage ◽  
Bilateral Mastectomy ◽  
Breast Cancer Patients ◽  
Factors Associated

6502 Background: Rates of bilateral mastectomy are increasing in the U.S., even among women with cancer in only one breast. The goal of this analysis was to assess correlates of bilateral mastectomy in a large, racially/ethnically diverse sample of breast cancer patients. Methods: All women with ductal carcinoma-in-situ and a 20% random sample of women with invasive breast cancer aged < 79 years who were diagnosed in 2002 and reported to the Detroit and Los Angeles SEER registries were surveyed shortly after receipt of surgical treatment (response rate, 77.4%; n = 1,844). Patient survey data were merged with SEER data. The primary dependent variable, receipt of bilateral mastectomy, was obtained from patient report and validated by SEER. Independent variables included patient demographics, family history of breast cancer, tumor stage, and patient concerns about recurrence and body image. Logistic regression was used to evaluate factors associated with receipt of all mastectomy (including bilateral) vs. lumpectomy, and then to evaluate bilateral vs. single mastectomy. Results: The mean age was 60 years. 70% were white, 18% Black, and 12% Latina. Overall, 5% of women received bilateral mastectomy (13% of those getting mastectomy). The Table shows factors associated with receipt of any mastectomy vs. lumpectomy (model 1) and bilateral vs. single mastectomy (model 2). Advanced stage and concerns about recurrence were associated with increased odds of any mastectomy while body image concerns were associated with lumpectomy (P<0.05) (model 1). Model 2 shows family history (OR: 3.00; 95% CI 1.36–6.61) and concerns about recurrence (OR: 2.76, 95% CI 1.14–6.68) were associated with greater odds of receiving bilateral vs. single mastectomy. Conclusions: Decision making for any mastectomy vs. lumpectomy is quite different from that for bilateral vs. single mastectomy. The latter appears to be driven by genetic predisposition, but there continues to be a strong influence of women's concerns about recurrence. [Table: see text] No significant financial relationships to disclose.

scholarly journals Effects of a 1-Year Physical Activity Intervention on Markers of Hemostasis among Breast Cancer Survivors: A Randomized Controlled Trial

TH Open ◽  
2021 ◽  
Vol 05 (01) ◽  
pp. e14-e23
Author(s):  
Siv Kjølsrud Bøhn ◽  
Inger Thune ◽  
Vidar Gordon Flote ◽  
Hanne Frydenberg ◽  
Gro Falkenér Bertheussen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Postmenopausal Women ◽  
Cancer Patients ◽  
Physical Activity Intervention ◽  
Intervention Group ◽  
Factor Vii ◽  
Breast Cancer Patients ◽  
Hemostatic Factors

Abstract Introduction Physical activity may reduce the development of breast cancer. Whereas hypercoagulability has been linked to adverse outcomes in breast cancer patients, the effects of physical activity on their hemostatic factors are unknown. The study aimed to assess whether long-term (1 year) physical activity can affect hemostatic factors in breast cancer patients. Methods Fifty-five women (35–75 years) with invasive breast cancer stage I/II were randomized to a physical activity intervention (n = 29) lasting 1 year or to a control group (n = 26), and analyzed as intention to treat. Fibrinogen, factor VII antigen, tissue factor pathway inhibitor, and von Willebrand factor (VWF) antigen as well as prothrombin fragment 1 + 2, the endogenous thrombin potential and D-dimer, were measured in plasma before intervention (baseline), and then after 6 and 12 months. Results Maximal oxygen uptake (measure of cardiorespiratory fitness) decreased the first 6 months among the controls, but remained stable in the intervention group. We found no significant differences between the two study groups regarding any of the hemostatic factors, except a significantly higher increase in factor VII antigen in the intervention group. The effect of the intervention on VWF was, however, significantly affected by menopausal stage, and a significant effect of the intervention was found on VWF among postmenopausal women, even after adjustment for dietary intake. Conclusion Long-term physical activity had no effect on the majority of the hemostatic factors measured, but led to increased plasma concentrations of factor VII antigen and prevented an increase in VWF concentration after breast cancer treatment in postmenopausal women. The clinical impact of these findings for risk of vascular thrombosis warrants further studies.

scholarly journals An Exploration of Heart Failure Risk in Breast Cancer Patients Receiving Anthracyclines with or without Trastuzumab in Thailand: A Retrospective Study

2021 ◽  
Vol 11 (3) ◽  
pp. 484-493
Author(s):  
Jukapun Yoodee ◽  
Aumkhae Sookprasert ◽  
Phitjira Sanguanboonyaphong ◽  
Suthan Chanthawong ◽  
Manit Seateaw ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Breast Cancer Patients ◽  
Ventricular Ejection Fraction ◽  
Factors Associated ◽  
Palliative Intent ◽  
Increased Risk

Anthracycline-based regimens with or without anti-human epidermal growth factor receptor (HER) 2 agents such as trastuzumab are effective in breast cancer treatment. Nevertheless, heart failure (HF) has become a significant side effect of these regimens. This study aimed to investigate the incidence and factors associated with HF in breast cancer patients treated with anthracyclines with or without trastuzumab. A retrospective cohort study was performed in patients with breast cancer who were treated with anthracyclines with or without trastuzumab between 1 January 2014 and 31 December 2018. The primary outcome was the incidence of HF. The secondary outcome was the risk factors associated with HF by using the univariable and multivariable cox-proportional hazard model. A total of 475 breast cancer patients were enrolled with a median follow-up time of 2.88 years (interquartile range (IQR), 1.59–3.93). The incidence of HF was 3.2%, corresponding to an incidence rate of 11.1 per 1000 person-years. The increased risk of HF was seen in patients receiving a combination of anthracycline and trastuzumab therapy, patients treated with radiotherapy or palliative-intent chemotherapy, and baseline left ventricular ejection fraction <65%, respectively. There were no statistically significant differences in other risk factors for HF, such as age, cardiovascular comorbidities, and cumulative doxorubicin dose. In conclusion, the incidence of HF was consistently high in patients receiving combination anthracyclines trastuzumab regimens. A reduced baseline left ventricular ejection fraction, radiotherapy, and palliative-intent chemotherapy were associated with an increased risk of HF. Intensive cardiac monitoring in breast cancer patients with an increased risk of HF should be advised to prevent undesired cardiac outcomes.

Treatment Trends and Factors Associated with Survival in T1aN0 and T1bN0 Breast Cancer Patients

2007 ◽  
Vol 14 (10) ◽  
pp. 2918-2927 ◽  
Author(s):  
Timothy Kennedy ◽  
Andrew K. Stewart ◽  
Karl Y. Bilimoria ◽  
Lina Patel-Parekh ◽  
Stephen F. Sener ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Factors Associated ◽  
Treatment Trends

scholarly journals Changes in physical activity behavior and C-reactive protein in breast cancer patients

2018 ◽  
Vol 52 (7) ◽  
pp. 545-551 ◽  
Author(s):  
Catherine M Sabiston ◽  
Carsten Wrosch ◽  
Andrée L Castonguay ◽  
Benjamin D Sylvester
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Patients ◽  
Physical Activity Behavior ◽  
Breast Cancer Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Activity Behavior

scholarly journals Roles of Superoxide dismutase(SOD) , Malondialdehyde (MDA), 8-iso-prostaglandinF2α ( 8-iso-PGF2α)as oxidative stress in development and progression of Brest cancer in Iraqi females patients

2020 ◽  
Vol 25 (1) ◽  
pp. 1-4
Author(s):  
Ferdous Abbas Jabir ◽  
Ahmed Sabah Shaker
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Patients ◽  
Antioxidant Defenses ◽  
Blood Levels ◽  
P Value ◽  
Oxygen Species ◽  
Breast Cancer Patients ◽  
Markers Of Oxidative Stress ◽  
The Mean

               Oxidative stress occurs as a result of disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses. Markers of oxidative stress were measured the markers of oxidative stress in breast cancer patients after diagnosis of breast cancer and compared these plasma blood levels controls This study was conducted to three markers of oxidative stress ;these are (SOD) enzyme ,malondialdehyde (MDA)and8-iso-prostaglandinF2α plasma of patients with breast cancer and compare with controls .In this study ;  the mean MDA (ng/ml) levels for the breast cancer patients and the controls were55.91±3.31 and40.61±3.76  respectively, while the SOD (pg/ml) levels were1530.37±80.4 and1851.4 9±93.65  respectively and the 8-iso-PGF2α (ng/ml ) levels were 40.16±3.31 and 30.16±2.34  difference of the mean were statistically significant (p value <0.05).                                                                                                                       

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