scholarly journals Metabolic Syndrome in Hypothyroid Patients

2015 ◽  
Vol 7 (2) ◽  
pp. 57-61
Author(s):  
R Haque ◽  
S Ferdousi ◽  
SS Ferdousi ◽  
W Rahman ◽  
MN Uddin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Hdl Cholesterol ◽  
Overt Hypothyroidism ◽  
Serum Triglycerides ◽  
Fasting Plasma ◽  
Significant Difference ◽  
Hypothyroid Patients

Thyroid functions affect metabolic syndrome (MetS) parameters including blood pressure, fasting plasma glucose, serum triglycerides and HDL-Cholesterol. But the relationship between MetS and thyroid functions is yet to be identified clearly. Metabolic syndrome is a state in which most features of hypothyroidism can be seen. The aim of the present study was to investigate the frequency of MetS in hypothyroid patients. Thirty one patients with overt hypothyroidism, 32 patients with subclinical hypothyroidism (SCH) and 58 euthyroid controls were enrolled in this study. NCEP-ATP III criteria was used to diagnose metabolic syndrome. Majority of the participants were in the age group of 30-40 years. Body mass index and waist circumference, blood pressure, fasting plasma glucose and serum triglycerides were found to be higher in hypothyroid patients compared to that of euthyroid controls (p<0.001). On the other hand serum HDL-C was found to be significantly lower in hypothyroid patients compared to that of euthyroid controls (p<0.001). Prevalence of MetS was 82.5% in the hypothyroid group and 27.6% in eythyroid controls (p<0.001). No significant difference was found between SCH (81.3%) and overt hypothyroid (86.7%) groups in respect to prevalence of MetS (p<0.05). The findings of the study suggest a need to investigate the presence of hypothyroidism during the management of MetS patients. DOI: http://dx.doi.org/10.3329/bjmb.v7i2.22414 Bangladesh J Med Biochem 2014; 7(2): 57-61

scholarly journals Global 11 beta-hydroxysteroid dehydrogenase activity assessed by the circulating cortisol to cortisone ratio is associated with features of metabolic syndrome

2020 ◽  
Author(s):  
La-or Chailurkit ◽  
Wichai Aekplakorn ◽  
Nitchawat Paiyabhroma ◽  
Boonsong Ongphiphadhanakul
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
High Blood Pressure ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Serum Cortisol ◽  
Health Examination ◽  
Causative Role ◽  
Fasting Plasma ◽  
Liquid Chromatography Tandem Mass

Abstract Background 11 Beta-hydroxysteroid dehydrogenases (11HSD) are enzymes involved in the interconversion of cortisol and cortisone. There are two isoenzymes of 11HSD, 11HSD1 and 11HSD2. A causative role of 11HSD, particularly 11HSD1, in metabolic syndrome is well established in experimental animals. However, its role in human metabolic syndrome is less clear. We examined the influence of global 11HSD activity on metabolic syndrome in the general population, using the circulating cortisol:cortisone ratio as an index of global 11HSD activity.Methods A subsample of 269 sera randomly selected from the Thai National Health Examination Survey IV samples was analyzed for serum cortisol and cortisone levels by liquid chromatography-tandem mass spectrometry.Results There was no association between serum cortisol and age. However, circulating cortisone was negatively correlated with age (r = −0.12, p < 0.001), and the serum cortisol:cortisone ratio was positively associated with age (r = 0.03, P < 0.001). No association was found between serum cortisol:cortisone ratio and BMI or serum lipids. Multivariate analyses showed that the serum cortisol:cortisone ratio was associated with high blood pressure (P < 0.05) independent of age, BMI and sex. In subjects without hypertension, the serum cortisol to cortisone ratio was associated with mean systolic blood pressure after controlling for age, BMI and sex. The cortisol:cortisone ratio was not significantly different between subjects with and without diabetes. After excluding the 16 subjects with diabetes, it was found that the serum cortisol:cortisone ratio was positively associated with fasting plasma glucose independent of age, BMI and sex (P < 0.01).Conclusions The global index of 11HSD activity, assessed by the circulating cortisol:cortisone ratio, was related to high blood pressure and fasting plasma glucose. Modulation of 11HSD may help treat hypertension and diabetes but probably not other features of metabolic syndrome.

scholarly journals Serum Apolipoprotein H and its Relationship to Blood Pressure, Serum Lipids, Fasting Plasma Glucose and Insulin in Normal Individuals

2001 ◽  
Vol 38 (5) ◽  
pp. 494-498 ◽  
Author(s):  
M Crook ◽  
S I Ch'ng ◽  
P Lumb ◽  
F Reid
Keyword(s):  
Blood Pressure ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Serum Lipids ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Serum Cholesterol Concentration ◽  
Apolipoprotein H ◽  
Fasting Plasma ◽  
Normal Individuals

Apolipoprotein H (apo H), also known as β2-glycoprotein I, has recently become of interest in the field of haemostasis. As apo H is elevated in diabetes mellitus and dyslipidaemia, we wished to test the hypothesis that serum apo H concentration was related to fasting plasma glucose and insulin as well as blood pressure, body mass index, hip/waist ratio and serum lipids in normal individuals. Eighty-one healthy young individuals (46 females and 35 males) were studied. Their age was 20·7 ± 0·75 years. Serum apo H significantly correlated with fasting plasma glucose ( r=0·24, P=0·03) and serum LDL cholesterol ( r=0·30, P=0·006). In the females serum apo H significantly correlated with serum cholesterol concentration ( r=0·30, P=0·04) and in males with serum HDL cholesterol concentration ( r=0·35, P=0·04). In multifactorial regression analysis for serum apo H and the other variables for the 81 subjects, only gender and fasting plasma glucose remained statistically significant in the model. Serum apo H concentrations would be expected to increase by 21.7mg/L for each single mmol/L increase in fasting plasma glucose (95% CI 2·3–41·2), P=0·029, and to increase by 17·0mg/L if the gender is male (95% CI 0·7–33·2), P=0·041.

scholarly journals National Health Examination Metabolic Syndrome Item and Health Behavior Analysis

2020 ◽  
Vol 22 (4) ◽  
pp. 1-10
Author(s):  
Hyung-yeol Choi ◽  
Chang-hyun Jang ◽  
Soo-yeon Kim
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Density Lipoprotein ◽  
Fasting Plasma ◽  
Intensity Physical Activity ◽  
Physical Activity Group

OBJECTIVES The purpose of this study is to investigate the relationship between the habits of physical activities in several intensities, drinking, and smoking of the general public who live in the S city and diabetes, high blood pressure, high-density lipoprotein cholesterol, plasma triglyceride, and waist circumference of them.METHODS For research, residents of 2,438,370 in S city were selected by using the big data of health checkups sheets that were conducted by the National Health Insurance Corporation in 2017. Physical activities were classified into three groups by intensity. The part of drinking was divided into three groups of non-alcohol, low, and high-drinking people. There were four groups in smoking of non-smoking, the group that smoke lower than the half pack of cigarettes per day, the half to one pack, and more than one pack. Metabolic syndrome frequency analysis and logistic regression analysis were used for this research.RESULTS Compared to the low-intensity physical activity group, the high-intensity group had 0.992, 0.954, 0.871, 0.83, and 0.878 times of lower risk in fasting plasma glucose, blood pressure, high density lipoprotein (HDL-C), plasma triglycerides, and abnormal waist circumference. High drinking group had more risk of fasting plasma glucose, blood pressure, HDL-C, plasma triglyceride, and abnormal waist circumference by 1.326, 1.894, 1.334, 2.125 and 1.263 times than non-drinking group. The group who smoked more than one pack a day had more risk of fasting plasma glucose, blood pressure, HDL-C, plasma triglyceride, and abnormal waist circumference by 1.971, 1.225, 3.229, 2.871, and 1.522 times than the group of non-smoking.CONCLUSION The subjects who did not have risk factors for metabolic syndrome were 29.7%. The average of patients with metabolic syndrome was 25.2%, of which males were 30.3%, and females were 20.1% of them. Metabolic syndrome factors were proved statistically valid. In the physical activity group, the high-intensity physical activity group had a lower risk of metabolic syndrome factors than the low and medium-intensity physical activity groups. The high-drinking group had a higher risk of metabolic syndrome in triglycerides, and the smoking group who smoked more than one pack per day had a higher risk of metabolic syndrome in high-density lipoprotein cholesterol.

scholarly journals Prevalence of Metabolic Syndrom in Three Urban Communities of Dhaka City

1970 ◽  
Vol 2 (2) ◽  
pp. 44-48 ◽  
Author(s):  
Shurovi Sayeed ◽  
Akhter Banu ◽  
Parvin Akter Khanam ◽  
Sharmina Alauddin ◽  
Sabrina Makbul ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Urban Communities ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Urban Population ◽  
Population Characteristics ◽  
Dhaka City ◽  
Fasting Plasma ◽  
Prevalence Of Obesity ◽  
The Mean

Bangladeshis are prone to develop type 2 diabetes mellitus (T2DM), hypertension (sHTN and dHTN) and atherosclerotic heart diseases, observed more predominantly in the urban population. Though metabolic syndrome (MetS) is a related disorder, there are few studies in this regard. The prevalence of obesity, T2DM and MetS in three urban communities of Bangladesh were addressed in this study. Nine hundred non-slum urban households in three Dhaka City Wards were randomly selected. One member (age ≥ 25y) from each household was invited for investigation with an overnight fast. Socio-demographic information as well as height, weight, waist-girth, hip-girth and blood pressure were measured. Fasting plasma glucose (FPG), total cholesterol (chol), triglycerides (TG) and high-density lipoproteins-c (HDL) were estimated. A total of 705 (m / f = 239 / 466) subjects volunteered for the study. The mean value with 95% confidence interval (CI) of age was 42.4 (40.9 - 43.1) years for men and 37.8 (36.8 - 38.7) for women. The mean (CI) body mass index (BMI) was 21.0 (20.6 - 21.5) and 22.6 (22.2 - 22.9) and waist hip ratio (WHR) was 0.84 (0.83 - 0.84) and 0.82 (0.81 - 0.83), respectively for men and women. The mean (CI) FPG (fasting plasma glucose) was 5.5 (5.2 - 5.7) for men and 5.2 (5.0 - 5.4) for women. The prevalence of obesity (BMI ≥ 25.0) was 21%, T2DM (FPG ≥ 6.1 mmol/l) was 22.2%, triglyceridemia (TG ≥ 150mg/dl) was 45.1% and low HDL-c (HDL<40mg/ dl) was 43.8%. The crude prevalence of MetS varied based on different cluster combinations, being the lowest (0.3%) recommended by WHO cluster (FPG + BMI + SBP/DBP) and the highest (8.7%) by International Diabetes Federation (IDF) cluster (waist + FPG + HDL). The MetS was found higher in male than female by NCEP criteria and higher in female than male by IDF criteria. The study revealed an increased prevalence of obesity, T2DM and MetS in the urban communities. It also revealed that T2DM and MetS are moderately common and of growing healthcare burden in the rapidly growing urban population. Additionally, the study observed the wide ranging prevalence rates of MetS in the same study population indicating the need to establish a consistent and useful MetS-cluster depending on population characteristics. Ibrahim Med. Coll. J. 2008; 2(2): 44-48 Key Words: Metabolic syndrome, urban, diabetes, hypertension, dyslipidemia   doi: 10.3329/imcj.v2i2.2936

Association of Triglyceride-glucose Index and the Risk of Incident Diabetes: a Secondary Analysis Based on a Chinese Cohort Study

2020 ◽  
Author(s):  
Xiaoli Li ◽  
Guilong Li ◽  
Tiantian Cheng ◽  
Jing Liu ◽  
Guangyao Song ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Incident Diabetes ◽  
Family History Of Diabetes ◽  
Tyg Index ◽  
Fasting Plasma ◽  
Increased Risk ◽  
The Relationship

Abstract BackgroundTriglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance. However, study on the relationship between TyG index and incident diabetes remains limited. This study aimed to investigate the association between TyG index and incident diabetes in a large cohort of Chinese population.MethodsThe present study was a retrospective cohort study using healthy screening programme data in China. A total of 201,298 subjects free of baseline diabetes were included who received a health check with all medical records from 2010 to 2016. TyG index was calculated as Ln[fasting triglyceride level (mg/dl) x fasting plasma glucose (mg/dl)/2]. Diagnosis of diabetes was based on fasting plasma glucose ≥ 7.00 mmol/L and/or self-reported diabetes. Cox proportion-hazard model was used to assess the relationship between TyG index at baseline and the risk of incident diabetes. It should be noted that the data was uploaded to the DATADRYAD website, and we only used this data for secondary analysis.ResultsDuring a mean follow-up of 3.12 years of 201,298 individuals aged ≥ 20 years old, 3389 subjects developed diabetes. After adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, low density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, serum creatinine, smoking, drinking and family history of diabetes, multivariate cox hazards regression analysis indicated that TyG index was positive correlation with the risk of developing diabetes in Chinese population (HR, 3.34; 95% CI, 3.11 to 3.60). The risk of incident diabetes increased with increasing TyG index. Subjects with TyG index in the fourth quartile were 6.26 times more likely to develop diabetes than the lowest quartile (P trend < 0.001). Subgroup analysis showed the stronger association was observed in the population with age < 40, BMI (≥ 18.5, < 24 kg/m2), SBP < 140 mmHg or females (all P for interaction < 0.0001).Conclusions TyG index was independently correlated with the increased risk of diabetes in Chinese adults, suggesting that TyG index may be a useful marker for identifying individuals at high risk of developing diabetes.

scholarly journals Demographic Associations of Diabetes Status by Both Fasting Plasma Glucose Concentration and Glycated Hemoglobin in a Community Survey in Galle District, Sri Lanka

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Keddagoda Gamage Piyumi Wasana ◽  
Anoja Priyadarshani Attanayake ◽  
Thilak Priyantha Weerarathna ◽  
Kamani Ayoma Perera Wijewardana Jayatilaka
Keyword(s):  
Sri Lanka ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glycated Hemoglobin ◽  
Diagnostic Tools ◽  
Oral Glucose ◽  
Family History Of Diabetes ◽  
Fasting Plasma ◽  
Diabetes Status ◽  
Significant Difference

Diagnostic tools used in detecting individuals with diabetes mellitus (DM) include fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), and oral glucose tolerance test (OGTT). The present study was aimed to determine the demographic associations of diabetes status by both tests (FPG and HbA1C) in Galle district, Sri Lanka. 147 adults (30–60 years) who are having FPG ≥ 126 mg/dL underwent demographic evaluations and testing for HbA1C. Group 01 (diabetes status diagnosed by both tests) and group 2 (diabetes status diagnosed only by FPG) were compared using independant sample t-test and chi-square test. Logistic regression was used to study the association between the demographic factors and the diabetes status by both tests. Of the 147 study subjects, 38.1% were males, 61.9% were females, and 63.3% had a family history of diabetes among first-degree relatives (FDR). Mean age, body mass index (BMI), waist circumference (WC), FPG, and HbA1C of the participants were 48.4 ± 7.2 years, 25.1 ± 4.0 kg/m2, 88.8 ± 9.0 cm, 139.4 ± 30.1 mg/dL, and 6.4 ± 0.7%, respectively. The prevalence of diabetes based on both tests was 55.1%. There is a significant difference in mean BMI and WC while no significant differences in mean age between groups 01 and 02. No association was seen between gender and diabetes status (X2(1) = 0.086, p=0.770), while a significant difference was observed between DM among FDR and diabetes status (X2(1) = 33.215, p<0.001). Significance of odds of having diabetes by both tests with rising BMI (OR = 1.97, CI 1.15–3.36, p=0.013) and DM among FDR (OR = 7.95, CI 3.54–17.88, p=0.000) was seen. We conclude rising BMI and having DM among FDR are strongly associated with diabetes status diagnosed by both tests of FPG and HbA1C in community screening.

Fasting plasma glucose control among nigerians with metabolic syndrome.

2008 ◽  
Vol 5 (1) ◽  
Author(s):  
O S Adediran ◽  
O A Fasanmade ◽  
O A Ogbera ◽  
A E Ohwovoriole
Keyword(s):  
Metabolic Syndrome ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glucose Control ◽  
Fasting Plasma
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