scholarly journals Estrogen Receptor Alpha (Esr) Gene Polymorphism As Risk Factor For Type 2 Diabetes Mellitus (T2dm) In Javenese Menopause Women of Indonesia

2013 ◽  
Vol 12 (2) ◽  
pp. 172-179
Author(s):  
Syaefudin Ali Akhmad ◽  
Maliyah Madiyan ◽  
Pramudji Hastuti ◽  
Hemi Sinorita
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Estrogen Receptor ◽  
Risk Factor ◽  
Allele Frequency ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Menopausal Women

Background: The number of menopausal women who suffer from low level estrogen-associated type-2 diabetes has been increasing recently. The role of estrogen in metabolism of glucose depends on estrogen receptor alpha expression that is regulated by estrogen receptor alpha gene (ESR ?). PvuII and XbaI polymorphisms in the ESR ? receptor may decrease the expression of ESR ? protein and receptor activity, thereby increasing the risk of developing type 2 diabetes mellitus in menopausal women. Purpose: to determine the ESR ? polymorphism as a risk factor for type 2 diabetes mellitus (DM) in menopause women of Javanese in Indonesia. Methods: Sixty five menopausal women were recruited for the study consisted of 40 women with T2DM and 25 women as control. PvuII and XbaI polymorphisms were determined by polymerase chain reacton-restriction fragment length polymorphism (PCR-RFLP). The absence of PvuII and XbaI restriction sites were indicated by “P1” and “X1” and presence by “P2” and “X2”, respectively. Chai Square test were used in statistical analyisis to measure Hardy Weinberg Equilibrium (HWE) and the risk of P1/P2 and X1/X2 allele for suffering T2DM. Results: PvuII genotype was distributed as; 22.5% (P1P1), 45% (P1P2), 32.5% (P2P2) while XbaI genotype was distributed as 10 % (X1X1), 62.5% (X1X2) and 27.5% (X2X2) in diabetics respectively. There was no difference in distribution of P1 and P2 between diabetics and non diabetics but difference for X1 and X2 existed between groups. The frequency of P2 allele was 55 % while P1 allele frequency is 45% in diabetics. X2 allele frequency was 58.8% while X1 allele is 41.2%. X2 allele had an impact on the 3.6 times higher risk of getting type 2 diabetes in Javanese menopausal women (OR = 3.662, CI = 1.711 to 7.840). Conclusions: PvuII and XbaI polymorphism was found in Javanese menopause women of Indonesia in patients with type 2 diabetes mellitus. The allele frequency of P2 and X2 are 55% and 58.8% respectively. X2 allele was found as a risk factor for type 2 diabetes mellitus in Javanese menopause women of Indonesia. Bangladesh Journal of Medical Science Vol. 12 No. 02 April’13 Page 171-179 DOI: http://dx.doi.org/10.3329/bjms.v12i2.14946

scholarly journals Quercetin promotes long noncoding RNA lncSHGL expression via estrogen receptor α to suppress type 2 diabetes mellitus in mice

2020 ◽  
Author(s):  
Hanlu Fan ◽  
Haiwen Li ◽  
Huijiao Liu ◽  
Peng Li ◽  
Xiaomeng Jia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Estrogen Receptor ◽  
Noncoding Rna ◽  
Estrogen Receptor Alpha ◽  
Grape Pomace ◽  
Active Compounds ◽  
Organ Systems

Abstract Background Type 2 diabetes mellitus (T2DM) is the most common type of metabolic disorder involving multiple organ systems. Grape has been reported to improve the symptoms of T2DM, the precise mechanism of its action is unclear. Our study was aimed to determine the effect and mechanism of grape pomace extract in T2DM mice induced by high fat diet (HFD). Materials and methods Ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry were used to identify the main active compounds in grape pomace extract to improve T2DM. C57BLK/6J mice induced by HFD supplemented with or without quercetin were used to show the effects of quercetin improving T2DM. By online database research, bioinformatics analysis and molecular biology experiments, Estrogen receptor alpha (ERα)-lncSHGL (lncRNA suppressor of hepatic gluconeogenesis and lipogenesis) pathway was identify as the target for quercetin. Results Quercetin was identified as one of the most active compounds in grape pomace extract to improve T2DM. Quercetin could inhibit HFD-induced T2DM in mice by activing ERα. LncSHGL was identified as the downstream of ERα and inhibited HFD-induced T2DM. Conclusions Quercetin could be beneficial for T2DM by promoting lncSHGL transcription and activating the lncSHGL pathway, and may be used as a drug component to treat T2DM.

Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type 2 Diabetes Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 50 (06) ◽  
pp. 469-477 ◽  
Author(s):  
Jiajia Yang ◽  
Renfang Han ◽  
Mengya Chen ◽  
Yaping Yuan ◽  
Xingxing Hu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Meta Analysis ◽  
Pvuii Polymorphism ◽  
Xbai Polymorphism

AbstractThe associations between PvuII (T>C) and XbaI (A>G) polymorphisms of estrogen receptor alpha (ESR1) gene with type 2 diabetes mellitus (T2DM) or metabolic syndrome (MetS) are reported in many studies, but the results are inconsistent. This present work aims to assess the associations by performing a comprehensive meta-analysis. Relevant studies were searched through several databases. The pooled odd ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations of PvuII and XbaI polymorphisms with the risk of T2DM and MetS by using the STATA 14.0 software. Eight studies for T2DM and three articles about MetS were included in this meta-analysis. The overall results indicated that PvuII, rather than XbaI polymorphism, was associated with T2DM (regressive model: OR=0.673, 95% CI=0.550 to 0.823, praw<0.001, pFDR<0.003). The subgroup analysis based on race revealed an association of PvuII polymorphism with the decreased T2DM risk in Chinese population and a relationship between XbaI polymorphism and the reduced T2DM susceptibility in Caucasians. The difference of country may be one source of the heterogeneity for PvuII polymorphism and T2DM. However, neither PvuII nor XbaI polymorphism was related to the risk of MetS. The C allele of PvuII polymorphism presents a protective role in T2DM risk, especially in Chinese people. The G allele of XbaI polymorphism is related to a reduced risk for T2DM in Caucasian population. Nevertheless, neither of PvuII nor XbaI polymorphism is associated with MetS risk.

scholarly journals Home Blood Pressure Measurement in the Morning Related to Cancer in Patients with Type 2 Diabetes Mellitus: 10 Years-Term Results of a Longitudinal Study and Cancer

2015 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Kyuzi Kamoi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Cause Of Death ◽  
Japanese Patients ◽  
Pressure Measurements ◽  
Significant Difference

Previous longitudinal studies have demonstrated that blood pressure measurements at home (HBP) in the wakening- up display stronger predictive power for death, and vascular complications in patients with type 2 diabetes mellitus (T2DM) than clinic blood pressure measurements (CBP). The leading cause of death was cancer. Patients with T2DM have associated with cancer, and high CBP is a risk factor for cancer. Therefore, this study investigated whether HBP or CBP is related to cancer event in patients with T2DM for 10 years. At baseline, 400 Japanese patients with T2DM were classified as hypertensive (HT) or normotensive (NT) based on HBP and CBP. Mean (± SD) duration was 95 ± 35 months. Primary and secondary endpoints were death and cancer, respectively. Differences in outcome between HT and NT were analyzed using survival curves from Kaplan-Meier analysis and log-rank testing. Associated risk factors were assessed using Cox proportional hazards. On basis of HBP, death and event of cancer were significantly higher in HT than in NT. The leading cause of death was cancer. On basis of CBP, there was no significant difference in the incidence of death and event of cancer between patients with HT and NT at baseline. Associated risk factor for cancer was T2DM. Home morning HT may be reflected more keenly state of cancer than clinic HT, which may be superior to clinic NT. When we meet with such patients, it is important that cancer may be one of many causes for morning HT in Japanese patients with T2DM.

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose

2008 ◽  
Vol 18 (11) ◽  
pp. 967-975 ◽  
Author(s):  
Ingrid Dahlman ◽  
Martine Vaxillaire ◽  
Maria Nilsson ◽  
Cecile Lecoeur ◽  
Harvest F. Gu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Estrogen Receptor ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Estrogen Receptor Alpha ◽  
Gene Variants ◽  
Receptor Alpha ◽  
Estrogen Receptor Alpha Gene ◽  
Alpha Gene

The Correlation Between Heavy Metal Cadmium and the Prevalence of Type 2 Diabetes Mellitus

2021 ◽  
Vol 11 (2) ◽  
pp. 339-343
Author(s):  
Ling Hu ◽  
Xiao-Ling Yin ◽  
Ting Li
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Jiangxi Province ◽  
Cluster Sampling ◽  
Cadmium Content ◽  
Blood Cadmium ◽  
Blood Cadmium Levels

Objective: This study aims to analyze the blood cadmium level and prevalence of type 2 diabetes mellitus in the general population and explore the correlation between blood cadmium levels and the prevalence of type 2 diabetes mellitus. Methods: From February to December 2017, a multistage, random cluster sampling method was adopted to conduct this cross-sectional epidemiological survey of permanent residents aged >18 years in Nanchang, Jiangxi province (including one urban area, Changdong district and one county, Jinxing county). Blood cadmium levels and the prevalence of type 2 diabetes in the population were analyzed, and the correlation between blood cadmium levels and the incidence of type 2 diabetes was analyzed. Results: The average blood cadmium content of the population in Nanchang (Changdong town, Jinxian county) was 2.91 ± 0.08 ug/L, and the prevalence of type 2 diabetes was 9.2%. The average blood cadmium content of the population in Jinxian county was higher than that of the population of the Changdong district. The results of multivariate regression analysis indicate that high blood cadmium levels are a risk factor for type 2 diabetes. Conclusions: Elevated levels of cadmium in human blood may be a risk factor for type 2 diabetes.

scholarly journals Aging Is a Powerful Risk Factor for Type 2 Diabetes Mellitus Independent of Body Mass Index

Gerontology ◽  
2019 ◽  
Vol 66 (2) ◽  
pp. 209-210
Author(s):  
Pouneh K. Fazeli ◽  
Hang Lee ◽  
Matthew L. Steinhauser
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Body Mass
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