scholarly journals Prognostic information of gastric carcinoma using Goseki system in relation to nuclear organizer region (AgNOR) and proliferating cell nuclear antigen (PCNA) expression

2010 ◽  
Vol 9 (2) ◽  
pp. 76-86 ◽  
Author(s):  
Sulekha Gosh ◽  
Tapan Kumar Ghosh ◽  
Nikhilesh Dewasi ◽  
Krishnendu Das
Keyword(s):  
Gastric Carcinoma ◽  
Rank Order ◽  
Organizer Region ◽  
Medical Science ◽  
Nuclear Antigen ◽  
Grading System ◽  
Prognostic Information ◽  
Agnor Count ◽  
Chi Squared

Objective: The present study was undertaken to find out the relationship of Goseki grading system (I-IV) with existing classification of WHO, Lauren and tumour differentiation of gastric carcinoma and its prognostic information in relation to AgNOR & PCNA expression. Materials and methods: To assess the reproducibility and usefulness of Goseki grading system thirty five gastric carcinoma were selected from January 2007 to July 2009 in the department of Pathology, Burdwan Medical College in West Bengal, India and analyzed in relation to existing grading system by chi-squared testing. Mean AgNOR count & mean PCNA leveling index quantities of different tissue sections were assessed according to different classification system of gastric carcinoma and interobserver variations of all data were evaluated from Spearman Rank-order Correlation Coefficient (rs ). Results: Highly significant predictable correlation of Goseki grading system for existing classification of gastric carcinoma was obtained statistically. Increasing values of mean AgNOR count and PCNA leveling index (2.35% & 15.14%, 2.91% & 21.32%, 3.08 %& 24.76% and 3.2% & 25.12 respectively) were observed from Grade I – IV of Goseki grade. Mucin rich (3.05% & 23.22%) and tubule poor (3.14% & 24.76%) tumours higher values than mucin poor (2.71% & 19.95%) and tubule rich (2.63% & 18.23%) tumors. No significant correlations were observed in other grading system. Conclusion: Following Goseki grading system increasing expression of proliferating marker in mucin rich than mucin poor tumours and tubules poor than tubules rich tumors indicate poor prognosis and tumour behavior. Simple system may help to select patients for adjuvant therapy. Key words: Goseki grade; gastric carcinoma; AgNOR; PCNA. DOI: 10.3329/bjms.v9i2.5655Bangladesh Journal of Medical Science Vol.09 No.2 Apr 2010 pp.76-86

scholarly journals Classification of gastric carcinoma using the Goseki system provides prognostic information additional to TNM staging

Cancer ◽  
1999 ◽  
Vol 85 (10) ◽  
pp. 2114-2118 ◽  
Author(s):  
Ilfet Songun ◽  
Cornelis J. H. van de Velde ◽  
Jan W. Arends ◽  
Paul Blok ◽  
A. Joris K. Grond ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Tnm Staging ◽  
Prognostic Information

Ethnopharmacological Survey of Medicinal Plants Used in Traditional Treatment of Kidney Diseases in Fez–Meknes Region, Morocco

2019 ◽  
Vol 18 (2) ◽  
pp. 99-114
Author(s):  
M. Chebaibi ◽  
D. Bousta ◽  
I. Iken ◽  
H. Hoummani ◽  
A. Ech-Choayeby ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Medicinal Plants ◽  
Kidney Diseases ◽  
Rank Order ◽  
Pearson Correlation ◽  
Use Value ◽  
Traditional Treatment ◽  
Toxic Plants ◽  
A Value ◽  
Chi Squared

The purpose of this study was to inventory and collect information on plants and mixtures commonly used by herbalists to treat kidney disease in the Fez–Meknes region. We also aimed to compare the results obtained with the results of the other studies and exploit the correlations between different factors. An ethnopharmacological survey was conducted from 289 local herbalists in eight different areas of Fez–Meknes region. Ethnomedicinal uses and ethnobotanical indices were analyzed using quantitative tools, i.e., the total number of citation (TNC), use value (UV), family use value (FUV), fidelity level (FL), and rank order priority (ROP). Statistical analyses such as Pearson correlation and chi-squared test were performed to delineate any correlation. Two hundred and eighty-nine herbalists were questioned. Sixty-nine plant species belonging to 38 families were cited by herbalists for traditional treatment of kidney disease. The highest value of UV was obtained for Herniaria glabra L. (UV = 0.79), and Caryophyllaceae was the family frequently cited (FUV = 0.795). Ammodaucus leucotrichus Coss. & Dur. had the highest value of FL with a value of 100%, and the highest value of ROP was recorded for Herniaria glabra L. (ROP = 91%). Sociodemographic characteristics had a significant impact on the knowledge of toxic plants. Our study has revealed a cultural heritage linked to herbalism and a great wealth of medicinal plants, whose valorization and protection are necessary. Several studies are needed to sensitize herbalists and population on the danger of toxic plants, to extract chemical compounds from the main plants used, and to evaluate their toxicity.

scholarly journals Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoei Miyabe ◽  
Kazunori Karasawa ◽  
Kenichi Akiyama ◽  
Shota Ogura ◽  
Tomo Takabe ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Clinical Findings ◽  
Grading System ◽  
Oxford Classification ◽  
Kaplan Meier ◽  
Hazard Ratios ◽  
The Oxford Classification ◽  
Renal Prognosis ◽  
Renal Survival Rate

AbstractThe Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification system (O-grade) that utilised the total MEST-C score (O-grade I: 0–1, II: 2–4, and III: 5–7 points), and the 10-year renal prognosis was analysed. The clinical findings became significantly severer with increasing O-grades, and the renal survival rate by the Kaplan–Meier method was 94.1%, 86.9%, and 74.1% for O-grades I, II, and III, respectively. The hazard ratios (HRs) for O-grades II and III with reference to O-grade I were 2.8 (95% confidence interval [CI] 1.3–6.0) and 6.3 (95% CI 2.7–14.5), respectively. In the multivariate analysis, mean arterial pressure and eGFR, proteinuria at the time of biopsy, treatment of corticosteroids/immunosuppressors, and O-grade (HR 1.63; 95% CI 1.11–2.38) were the independent factors predicting renal prognosis. Among the nine groups classified using the O-grade and Japanese clinical-grade, the renal prognosis had an HR of 15.2 (95% CI 3.5–67) in the severest group. The O-grade classified by the total score of the Oxford classification was associated with renal prognosis.

scholarly journals Factors Associated with Frailty According to Gender of Older Adults Living Alone

Healthcare ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 475
Author(s):  
Hye-Young Jang ◽  
Ji-Hye Kim
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Nutritional Status ◽  
Chronic Diseases ◽  
Multinomial Logistic Regression ◽  
Living Alone ◽  
Factors Associated ◽  
Chi Squared ◽  
Korean Elderly

This study was conducted to identify the factors associated with frailty according to gender of older adults living alone in Korea. Data from the National Survey of the Living Conditions of Korean Elderly in 2017 were used. Participants were 2340 older adults who live alone. Frailty was determined based on the frailty criteria developed by van Kan et al. that consist of fatigue, resistance, ambulation, and illness. The collected data were analyzed using descriptive statistics, chi-squared test, t-test, Jonckheere–Terpstra test and multinomial logistic regression. Among the older men living alone, 47.7% were in the pre-frail and 5.1% were in the frail. On the other hand, 51.8% were in the pre-frail and 12.2% were in the frail among the older women living alone. The factors associated with frailty according to gender are as follows. In males, depressive symptoms, limitation in IADL, and number of medications in pre-frail; BMI, limitation in IADL, and number of chronic diseases in frail. In females, depressive symptoms, number of chronic diseases, age, and nutritional status in pre-frail; limitation in IADL, depressive symptoms, age, number of chronic diseases, number of medications, nutritional status in frail. Based on the findings of this study, it is considered necessary to approach frailty management considering gender as well as the classification of frailty.

A simple classification of lymph node level in gastric carcinoma

1995 ◽  
Vol 169 (4) ◽  
pp. 382-385 ◽  
Author(s):  
Yosuke Adachi ◽  
Tatsuo Oshiro ◽  
Toshiro Okuyama ◽  
Tatsuro Kamakura ◽  
Masaki Mori ◽  
...  
Keyword(s):  
Lymph Node ◽  
Gastric Carcinoma ◽  
Simple Classification ◽  
Node Level

scholarly journals PATHYAPATHYA IN PRAMEHA

2021 ◽  
Vol 9 (8) ◽  
pp. 1806-1814
Author(s):  
Ripsa Raj K. P ◽  
P Sudhakar Reddy
Keyword(s):  
Diabetes Mellitus ◽  
Scientific Explanation ◽  
Medical Science ◽  
Great Influence ◽  
Clinical Entity ◽  
Causative Factors ◽  
The World ◽  
Growing Population

Diabetes mellitus is becoming the fastest considerable disease in the world. India has been estimated with the fast- est-growing population of Diabetics. According to International Diabetic Federation (IDF), the total number of Diabetic subjects will be around 151 million in India by 2045. The clinical entity of Prameha can be correlated with Diabetes Mellitus. It is considered a Lifestyle disorder, the food, drinks and sedentary habits are having a great influence on this disorder. In Ayurveda classics elaborately mentioned the Nidana (causative factors) and Pathya ahara (wholesome food & drinks) and Apathya ahara (unwholesome food & drinks), Pathya Vihara (Conducive lifestyle) and Apathya Vihara (Non-Conducive lifestyle) of Prameha. The classification of Prameha as per Susruta Samhita as Apathya nimittaja Prameha and Beeja doshaja Prameha indicates the importance of Ahara and Vihara in prevention as well as management of this disease. In this article, a sincere attempt has been made to incorporate the principles of Ayurveda and Modern medical science with a scientific explanation regarding Pathya (Diet) and Vihara (lifestyle) in Prameha (Diabetes Mellitus). Keywords: Pathya, Apathya, Prameha, Ahara, Vihara.

scholarly journals Molecular genetic changes in gastric carcinoma

2021 ◽  
Vol 6 ◽  
pp. 30-46
Author(s):  
Juhi Singh ◽  
Puneet Kumar ◽  
Khushi Verma ◽  
Satyender Kumar Tiwary ◽  
Gopeshwar Narayan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Wide Spectrum ◽  
Molecular Genetic ◽  
Survival Rates ◽  
High Throughput Analysis ◽  
Genetic Changes ◽  
Genetic Level ◽  
New Biomarkers

Gastric cancer remains highly prevalent and accounts for a notable proportion of global cancer mortality and this is associated with poor survival rates. Understanding the molecular genetic changes of gastric carcinoma may offer an insight into its pathogenesis helps in identifying new biomarkers, aid prognostication, and novel treatment targets. Over a past few decades, advances in technology and high throughput analysis have improved understanding of the molecular genetic aspects of gastric cancer. In this article, hierarchy of the changes at genetic and molecular level including several aspects which are heterogenous and represents a wide spectrum such as tumor suppressor genes, oncogenes, cellcycle regulators, apoptosis, cell-adhesion molecules, loss of heterozygosity, microsatellite instability, and epigenetic changes. The classification of gastric carcinoma at molecular and genetic level as well as hereditary gastric carcinoma is elaborated. The molecular genetic aspects regarding pathogenesis, changes and aberrations of all genes and pathways which are involved in gastric cancer are addressed in this review.

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