scholarly journals Role of MDCT Scan in the Evaluation of Pancreatic Mass with Histopathological Correlation

2017 ◽  
Vol 42 (3) ◽  
pp. 120-124
Author(s):  
Mohammad Sazzad Hossain ◽  
Partho Protim Saha ◽  
Mahmood Uz Jahan ◽  
Sadia Sharmin ◽  
Rawnak Afrin ◽  
...  
Keyword(s):  
Ct Scan ◽  
Critical Role ◽  
Pancreatic Disease ◽  
Pancreatic Mass ◽  
Pancreatic Tumors ◽  
Age Group ◽  
Pancreatic Lesion ◽  
Histopathological Correlation ◽  
Malignant Lesions

Diagonstic imaging plays a critical role in evaluation of the adenocarcinoma of the pancreas- the 4th leading cause of death for the cancer globally. The purpose of this study was to determine the role of multidetector computed tomography (MDCT) in evaluation of pancreatic tumors. The prospective and study was carried out in Dhaka, Bangladesh during the period of July, 2013 to December 2014. Amongst 47 publish with suspected pancreatic lesion (having positive CT scan findings). Patients underwent histopathology of their lesions, the report of which was used as gold standard for comparing the role of CT scan in evaluating such lesions. Pancreatic disease was found to be more prevalent in males. The commonest age group was 56-65 years. On the average malignant lesions were more common in elder age group than the benign ones. Head of the pancreas was the commonest site for malignant pancreatic mass.  Main pancreatic duct (MPD) dilatation was found to be a harbinger for malignant condition of pancreas. 72.3% patients showed MPD dilatation most of which proved to be malignant. Some 45% patients showed common bile duct (CBD) dilatation all of which presented clinically with jaundice. Out of 47 patients 33 (60.3%) were diagnosed to have malignant lesions while 14 (39.7%) had benign lesions. Finding of the study suggest that CT scan may be a useful tool for assessing and changing of Parcrease mass lesions. 

P103 Role of computerized tomography (CT) scan in the clinically accessible and inaccessible oral malignant lesions

2007 ◽  
Vol 2 (1) ◽  
pp. 161-162
Author(s):  
C.J. Devaraj ◽  
P.P. Bapsy ◽  
V.S.S. Attili ◽  
M.V. Kumar ◽  
K.S. Sabita ◽  
...  
Keyword(s):  
Ct Scan ◽  
Computerized Tomography ◽  
Malignant Lesions

scholarly journals Surgical resection of pancreatic tumors: review of 70 cases

2020 ◽  
Vol 10 (1) ◽  
pp. 15
Author(s):  
Ashraf Sobhy Zakaria ◽  
Mohammed Gamil ◽  
Hussein Okasha ◽  
Ali Hassan Mebed ◽  
Reda Hassan Tabashy
Keyword(s):  
Endoscopic Ultrasound ◽  
Local Treatment ◽  
Cost Effective ◽  
Pancreatic Tumors ◽  
Main Stream ◽  
Dark Urine ◽  
Malignant Lesions ◽  
Eus Elastography ◽  
Operative Staging

Background: Endoscopic ultrasound (EUS) has gradually become the main stream method of the diagnosis and local treatment of pancreatic tumors. Endoscopic ultrasound (EUS) is frequently used in making the cytological diagnosis of pancreatic cancer and its great role in the pre-operative staging of pancreatic tumors.Objective: To evaluate the role of EUS in diagnosis and treatment of pancreatic tumors prospectively for 2 years study 2014-2015.Patients and methods: Prospective study including 70 patients who presented with pancreatic tumors underwent EUS at the endoscopy unit at Faculty of Medicine Cairo University and National Cancer Institute, Cairo University.Results: Out of 70 patients; median age was 55 years (range 32_73 years). Males were 32 (46%) and females were 38 (54%). Jaundice was the main symptom 47 (67%), clay colored stool 46 (65.7%), dark urine 47 (67%) and abdominal pain 50 (71%). There were 20 patients with benign disease and 50 patients with malignant disease. The following results showing the accuracy of the EUS in detecting malignant pancreatic tumors; Sensitivity: 96.0%, specificity: 75%, PPV: 90.6%, NPV: 88.2%, accuracy: 90.0%.Conclusion: EUS can clarify locoregional spread when CT/MR are equivocal. EUS Elastography is a new application in the field of the endosonography and seems to be able to differentiate fibrous and benign tissue from malignant lesions. The combination of superior detection, good staging, tissue diagnosis and potential therapy makes EUS guided FNA a cost-effective modality.

scholarly journals FNAC and histopathological correlation of salivary gland lesions: an observational study

2017 ◽  
Vol 4 (7) ◽  
pp. 2148 ◽  
Author(s):  
Sneha Kakoty ◽  
Tridip Dutta Baruah ◽  
C. P. Ganesh Babu
Keyword(s):  
Salivary Gland ◽  
Observational Study ◽  
Needle Aspiration ◽  
Age Group ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Histopathological Correlation ◽  
Neoplastic Lesions ◽  
Malignant Lesions ◽  
Needle Aspiration Cytology

Background: Fine needle aspiration cytology (FNAC) is a sensitive and specific and yet an economically effective technique for diagnosis of salivary gland lesions. FNAC of salivary glands has achieved a pivotal role in the diagnosis and management of salivary gland lesions since its induction by Stewart et al in 1933. However, it has always been under scrutiny when compared to histopathology. Histopathology of salivary gland lesions is still the final method to establish diagnosis and predicting prognosis in these lesions.1Methods: A prospective observational study of 50 patients with salivary gland lesions was done at Gauhati Medical College and hospital from June 2011 to May 2012. 39 patients underwent histopathological confirmation. Cases with histopathological correlation were included in calculating diagnostic accuracy. The cytological findings were correlated with that of the histopathological diagnosis to obtain the accuracy of the cytological diagnosis. The parameters of diagnostic validity of the cytological technique in terms of sensitivity, specificity and predictive value were evaluated.Results: Study population included patients of age group ranging from 13-70 years with median age group being 31-40 years (30%). 54% of the affected patients were male with the parotid being the most commonly involved gland (62%). Neoplastic lesions constituted the major bulk of the lesions (39 cases, 78%) with benign tumours constituting 54%. The most commonly involved benign neoplastic lesion was pleomorphic adenoma (22cases, 44%). Among the non-neoplastic lesions (22%), the acute sialadenitis was frequently noted. Histopathological correlations were available in 39 cases with 11 cases being the malignant lesions. The acute sialadenitis lesions did not undergo histological examination. 28 cases of non-malignant lesions underwent the histological confirmation. In the present study, the specificity and the sensitivity were found to be 96.42% and 90.91% respectively. The predictive value of salivary gland cytology was 90.91% and diagnostic accuracy was 94.87%.Conclusions: Fine Needle Aspiration Cytology is thus a safe, reliable, quick, convenient and accurate method of diagnosis and should be considered as one of the first line of investigations in the evaluation of salivary gland lesions.

scholarly journals Endoscopic Ultrasound Guided Fine Needle Aspiration and Biopsy for Pancreatic Disease

2021 ◽  
Vol 26 (4) ◽  
pp. 241-247
Author(s):  
Kwang Hyuck Lee
Keyword(s):  
Endoscopic Ultrasound ◽  
Alimentary Tract ◽  
Needle Aspiration ◽  
Pancreatic Disease ◽  
Ultrasound Probe ◽  
Ultrasound Guided ◽  
Pancreatic Lesion ◽  
Histopathologic Diagnosis ◽  
Site Evaluation

The endoscopic ultrasound (EUS) is a device with an ultrasound probe on the tip of endoscope. We can observe the surrounding structures outside the alimentary tract by using EUS. It is also possible to get a tissue from the pancreatic lesion for histopathologic diagnosis by using EUS. The development of devices and techniques of EUS guided tissue acquisitions made it the choice of non-operative pathologic test for pancreatic diseases. This paper describes the clinical applications of this procedure in pancreatic lesions from the recent European and Korean guidelines, including how to choose the needle, role of rapid on site evaluation, usage of stylet, suction and fanning technique, how to process acquired specimen, procedure-related complications and educations of this method.

scholarly journals Role of FNAC in diagnosis of parotid lesions

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Ahmed Youssef ◽  
Daren Cope ◽  
Sundus Alsedra ◽  
Mohamed Zahran ◽  
Abdel Rahman El Tahan
Keyword(s):  
Salivary Gland ◽  
False Negative ◽  
Benign Lesions ◽  
True Negative ◽  
Histopathological Correlation ◽  
John Hunter ◽  
Malignant Group ◽  
Malignant Lesions ◽  
Sensitivity Specificity

Abstract Background Salivary gland masses are considered challenging for diagnosis regarding its origin and whether benign or malignant. Unique features of FNAC as a safe and easy diagnostic procedure with little discomfort to the patient made it a favorable primary diagnostic tool. Information regarding the nature of parotid lesions whether being benign or malignant is the main objective of FNAC. We have done a restrospective study for FNAC for parotid masses performed in John Hunter hospital (Newcastle, NSW, Australia) along the peroid from 2014-2018. Histopathological correlation was done in 74 cases to test the accuracy of FNAC in diagnosis of parotid lesions. Results Of the total 74 FNAC done for parotid lesions in which a histopathological correlation was done, we get 46 (62.2%) benign lesions (37 neoplastic and 9 non-neoplastic) while 28 (37.8%) were malignant tumor. Pleomorphic adenoma was the most common in benign tumor side (45.7%) while SCC is the most common in malignant group (53.6%). Compatibility between FNAC and histological diagnosis was found in 74% (55/74), of which 78.3% in benign lesions (36/46) and in 68% of malignant lesions (19/28). FNA cytology was true positive in 21/74 cases (28.4%) and true negative in 41/74 (55.4%) cases. We have 5 (6.8%) false-negative and 7 (9.5%) false-positive results. As a result, we get sensitivity of 81%, specificity of 85%, and accuracy of 84%. Conclusion The role of FNAC in diagnosis of primary salivary gland pathology is considered with some debate about sensitivity/specificity; however, sometimes it should be repeated or correlated with clinical/histopathological confirmation.

Matrix metalloproteinases-2, -3, and -9 secreted by explants of benign and malignant lesions of the uterine cervix

2004 ◽  
Vol 14 (2) ◽  
pp. 333-340 ◽  
Author(s):  
J. Argüello-Ramírez ◽  
E. PÉREZ-CÁRDENAS ◽  
R. Delgado-Chávez ◽  
G. Solorza-Luna ◽  
S. Villa-Treviño ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Poor Prognosis ◽  
Critical Role ◽  
Tumor Development ◽  
Cervical Lesions ◽  
Elevated Expression ◽  
Human Carcinomas ◽  
Malignant Lesions ◽  
Biological Development

Elevated expression of matrix metalloproteinases (MMPs) plays a critical role in extracellular matrix (EM) degradation in tumor development and prognosis of different human carcinomas. In cervical carcinoma (Ce Ca), the role of these proteinases in the biological development of this neoplasm is controversial. In the present study, we compared the secretion of MMP-2, MMP-3 and MMP-9 among 29 benign and premalignant cervical lesions (cervicitis and cervical intraepithelial neoplasias) and 46 tumoral explants of Ce Ca. The explants were cultured for 48 h. The gelatinases secreted into conditioned medium were revealed by zymography and quantified by densitometry. The results showed high levels of MMP-3 and MMP-9 in tumoral explants. In contrast, only the pro-MMP-2 was higher in benign cervical lesions, although both active and inactive MMP-2 species are associated with advanced clinical stages in tumoral samples, and only the secretion of MMP-3 was associated with unresponsiveness to radiotherapy. We can conclude that the expression of MMPs is related to the invasive process in Ce Ca and suggest that they may play a role in degradation of the EM during local invasion. In addition, MMP-3 secretion could be a marker of poor prognosis in Ce Ca.

scholarly journals The Six Questions that Do Not Go Away

1991 ◽  
Vol 30 (4II) ◽  
pp. 649-667
Author(s):  
Karol J. Krotki
Keyword(s):  
Critical Role ◽  
Women's Development ◽  
Age Group ◽  
Vital Registration ◽  
Federal Bureau ◽  
International Agencies ◽  
Women's Literacy ◽  
The Subject ◽  
Group 5

To any observer of Pakistani society and economy over the last 40 years four questions pose themselves with repeated persistence year after year, survey after survey, census after census, decade after decade. They are: the proportion aged less than 15 years of age, the reported age group 5-9, the masculinity ratio, female illiteracy and innumeracy. There are two other features of the Pakistani data situation that ought to be taken into account during any consideration of these data and their collection. They are: the innocence of vital registration systems, and the ineffectiveness of family planning programmes. The first four questions received little attention through the backstopping offered by international agencies, from the subject-matter units in the Federal Bureau of St.atistics (PBS), and from the analysts in such research institutions as the PIDE. There seems to be no awareness of the critical role of women's literacy and numeracy in the reorganization plans of the Ministry of Women's Development [MWD (1989, 1989a)]. The relevant concerns in WD publications are modest [e.g., WD (1980)]. The last two questions

COMPARISON OF ENDOSCOPIC ULTRASOUND AND COMPUTED TOMOGRAPHY FOR EVALUATION OF PANCREATIC MASS LESIONS ASSUMING HISTOPATHOLOGY AS GOLD STANDARD

2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Anil Kumar Paliwal ◽  
Kuldeep Mendiratta
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Correct Diagnosis ◽  
Pancreatic Mass ◽  
Vascular Involvement ◽  
Mass Detection ◽  
Pancreatic Lesion ◽  
Cross Sectional ◽  
Magnetic Resonance Imaging Mri ◽  
Mass Lesions

Background-Diagnostic imaging is an important tool to evaluate pancreatic neoplasms. Accurate detection and staging are essential for ensuring appropriate selection of patients who will benefit from surgery and for preventing unnecessary surgeries in patients with unresectable disease. Ultrasound (US), multidetector computed tomography (MDCT) with multiplanar reconstruction and magnetic resonance imaging (MRI) can help to do a correct diagnosis. Methods- Hospital based cross-sectional and quantitative study. Patients with suspected pancreatic mass lesions referred to Department of Radiodiagnosis and Modern Imaging and to Department of Gastroenterology for MDCT and EUS respectively. Results- EUS sensitivity was 98.00%, specificity was 75.00% and by CT scan sensitivity was 93.00%, specificity was 88.00% for mass detection. EUS sensitivity was 88.00%, specificity was 72.00% and of CT scan sensitivity was 76.00%, specificity was 100.00% in detection of vascular involvement. EUS sensitivity was 86.00%, specificity was 74.00% and by CT scan sensitivity was 92.00%, specificity was 100.00% for detection of lymphadenopathy. Conclusion- In conclusion, our results showed that CT with pancreas protocoland EUS correlate moderatelywell in terms of mass detection, masssize, vascular involvement and lymphadenopathy. Keywords: CT, EUS, Pancreatic lesion.

Diagnostic and therapeutic challenges of synchronous renal mass and pancreatic mass: a review

2020 ◽  
pp. 205141582097909
Author(s):  
Andrew S Knight ◽  
Freedom L Ha ◽  
Werner T de Riese
Keyword(s):  
Treatment Guidelines ◽  
Radiation Treatment ◽  
Pancreatic Mass ◽  
Pancreatic Tumors ◽  
Adjuvant Radiation ◽  
Synchronous Metastasis ◽  
Level Of Evidence ◽  
Pancreatic Lesion ◽  
Treatment Data ◽  
Synchronous Malignancies

Objective: Synchronous renal cell carcinoma (RCC) and pancreatic tumors are rare clinical events and have been described scarcely in the literature. Our institution has recently encountered one case. This review aims to summarize and present the diagnostic and therapeutic approaches that have been presented in the literature for these synchronous solid malignancies. Methods: After reviewing the literature using PubMed, 16 papers were collected that showed a total of 21 patients with a synchronous solid renal and pancreatic mass. The diagnostic and treatment data were then evaluated and analyzed. Results: Overall, 13 patients (59%) had two independent primary malignancies consisting of RCC and a pancreatic tumor, seven (31%) were diagnosed with primary RCC with synchronous metastasis to pancreas, one (5%) was found to have a primary pancreatic adenocarcinoma with synchronous metastasis to the kidney, and one (5%) was diagnosed with primary RCC with a benign solid pancreatic lesion. Of the 22 patients that were treated, 18 (81%) underwent surgery, one (5%) had no treatment, and three (14%) underwent chemotherapy without surgery. In the cohort of patients with surgical treatment 12 (66%) had no adjuvant therapy, one (6%) had adjuvant chemotherapy, four (22%) had adjuvant immunotherapy, and one (6%) had adjuvant radiation treatment. Conclusions: The occurrence of synchronous malignancies of the kidney and pancreas is rare. No clear guidelines have evolved in the literature in regard to diagnostics and treatment of these patients. This review presents recommended diagnostic and treatment guidelines for these rare clinical cases. Level of evidence: Not applicable for this multicenter review.

scholarly journals IMAGING OF LUNG CANCER STAGING USING ADVANCED CT SCAN TECHNIQUES

2020 ◽  
Vol 8 (3) ◽  
pp. 22-28
Author(s):  
Maha Esmeal Ahmed ◽  
Mwahib Sid Ahmed Aldosh
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Ct Scan ◽  
Cancer Patients ◽  
Critical Role ◽  
Cell Cancer ◽  
Small Cell ◽  
Management Approach ◽  
Age Group ◽  
Lung Cancer Patients

Background: Lung cancer is one of leading death worldwide, it begins when cells in the lung grow out of control and formed mass or nodules which classified in two known major forms, non-small cell and small cell cancer. The accurate assessment of the disease extent is important in management approach and Computed tomography imaging in nodal staging remains the important tool for lung cancer diagnosis, particularly when assessing intra and extra thoracic spread of lung cancer. Objective: This is a quantitative cross-sectional study conducted in Sudanese lung cancer patients in period from November 2019 to February 2020 in Khartoum state hospital. The main aim of the study was to evaluate staging of lung cancer using computed tomography technology. Method: A group of 100 participants patients were selected randomly in different gender and in age group between (30-80) years old. The inclusion limited to patients diagnosed with lung cancer by computed tomography techniques and the normal cases and other abnormalities was being excluded. The data were collected using a special collection sheet and the data statistical analyzed using SPSS program. Result: The outcomes of this study showed that patients in age group between (60-70) years old do not have lung cancer in the first stage, while lung cancer in the second stage occurred in 10 patients only with 10 % percentage. The third stage is the most common type with a high incidence rate which occurred in 90 patients with 90 %. Percent. Conclusion: Advance imaging with CT scan techniques play a critical role in the diagnosis and management of lung cancer patients adding to accurately describing the radiological extent of the disease. Moreover, the important to understand the principles of staging description and their impact on treatment decisions.

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