scholarly journals The Effects of Acute Stress on Memory, Attention and Cognition in Healthy Human Volunteers

2017 ◽  
Vol 20 (1) ◽  
pp. 14-19
Author(s):  
Md Monir Hossain ◽  
Shahnaz Naznin ◽  
Dolly Sen ◽  
Mahnaz Hossain Fariba
Keyword(s):  
Acute Stress ◽  
Digit Span ◽  
Pharmaceutical Journal ◽  
Stroop Test ◽  
Healthy Human ◽  
Logical Memory ◽  
Human Volunteers ◽  
Significant Difference ◽  
Test Digit ◽  
Trail Making

The study was designed to investigate the effects of an acute naturalistic stressor, namely, examination of stress on memory, attention and cognition in healthy human volunteers. Fifty-three students participated in this study. All the volunteers were assessed for their neuropsychological states, which are memory, attention and cognition, during non-examination and examination period. The neuropsychological tests used in this study were- logical memory test, digit span test, letter cancellation test, trail making test and Stroop test. It was revealed that there was significant difference (p<0.05) in the score of logical memory II, backward and total score of digit span, time taken to complete letter cancellation test and score in part C of Stroop test in the exam period. The present study thus demonstrated that acute naturalistic stress improves attention while impairs delayed memory retrieval and cognition.Bangladesh Pharmaceutical Journal 20(1): 14-19, 2017

scholarly journals A Comparative Study of Memory, Attention, Cognition and Oestradiol in Pre and Postmenopausal Women in Bangladesh

2021 ◽  
Vol 24 (1) ◽  
pp. 26-32
Author(s):  
Kaniz Rabeya ◽  
Mamtaz Mahal Neela ◽  
Ragib Ahsan ◽  
Bishyajit Kumar Biswas ◽  
Md Monir Hossain
Keyword(s):  
Postmenopausal Women ◽  
Cognitive Dysfunction ◽  
Estrogen Replacement Therapy ◽  
Digit Span ◽  
Premenopausal Women ◽  
Estrogen Replacement ◽  
Logical Memory ◽  
Significant Difference ◽  
Test Digit ◽  
Trail Making

Memory, attention, and cognitive dysfunction are psychopathological conditions which most commonly occur after menopause. Different clinical studies revealed a shred of substantial evidence that oxidative stress and estrogen are interlinked in various cognitive dysfunction, including memory impairment, age-related dementia, and Alzheimer's disease. There is a higher chance of developing cardiovascular disease after menopause. Sharp declines in concentrations of circulating estradiol and estrone are associated with menopause. Estrogen replacement therapy (ERT) enhances the blood circulation to the hippocampus and cortex, providing the optimum environment for the growth and survival of cholinergic neurons. Hence, it improves hippocampal neuron density and ultimately contributes to synaptic plasticity in the hippocampus enhances short and long-term memory. In this study, we assessed memory, attention, and cognition function between pre- and post-menopausal groups. After preliminary screening and applying exclusion criteria, fifteen premenopausal women and fifteen postmenopausal women were finally selected. Different neuropsychological tests such as logical memory test, digit span test, letter cancellation test, trail making test and Stroop test were performed to evaluate the memory, attention, and cognition status. Blood estradiol level was also assessed by using commercial kits. Significant difference (p<0.05) was found in LM-II in logical memory test, digit span test (backward), letter cancelation test, TMT-B in trail making test, the score of part C in stroop test between premenopausal and postmenopausal women. Serum oestradiol concentration (pg/ml) was significantly lower (p<0.001) in postmenopausal women (44.18±10.52) than premenopausal women (175.48 ± 43.20). The current study demonstrates the memory decline and cognitive dysfunction in postmenopausal women and there is a significant difference in estradiol level between pre and postmenopausal women. Estrogen has many neurotrophic actions in the brain and helps to improve memory and cognition. Therefore, estrogen replacement therapy, dietary supplements or a drug having an agonistic effect on estrogen receptors might improve the status of memory, attention, and cognitive function in postmenopausal women. Bangladesh Pharmaceutical Journal 24(1): 26-32, 2021

scholarly journals Effects of masticatory exercise on cognitive function in community-dwelling older adults

2021 ◽  
Vol 29 ◽  
pp. 125-131
Author(s):  
Tae-Hoon Kim
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Rehabilitation ◽  
Digit Span ◽  
Stroop Test ◽  
Community Dwelling ◽  
Healthy Older Adults ◽  
Digit Span Test ◽  
Span Test ◽  
Test Digit

BACKGROUND: Mastication improves cognitive function by activating cerebral cortical activity, and it is important to demonstrate the cognitive effects of masticatory training using a variety of different interventions. OBJECTIVE: This study aimed to evaluate the effects of masticatory exercise on cognitive function in healthy older adults living in the community. METHODS: For six weeks, twelve participants performed a masticatory exercise using a NOSICK exerciser device, and thirteen subjects performed daily life without masticatory exercises. Trail Making Test, Digit Span Test, and Stroop test were used to measure the cognitive function. RESULTS: The participants in the experimental group showed significant improvements in TMT-A/B (p= 0.001 and 0.004), DST-forward (p= 0.001), and ST-word (p= 0.001). The effect sizes after the intervention were calculated as (1.2 and 0.8) for TMT-A/B, (0.8 and 0.2) for Digit Span Test forward/backward, and (0.6 and 0.2) for Stroop test color/word. CONCLUSIONS: We suggest that the masticatory exercises improve cognitive function in healthy older adults. Therefore, masticatory exercises can be used as a therapeutic exercise during cognitive rehabilitation.

scholarly journals Free-Weight Resistance Exercise Is More Effective in Enhancing Inhibitory Control than Machine-Based Training: A Randomized, Controlled Trial

2020 ◽  
Vol 10 (10) ◽  
pp. 702 ◽  
Author(s):  
Jan Wilke ◽  
Vanessa Stricker ◽  
Susanne Usedly
Keyword(s):  
Digit Span ◽  
Controlled Trial ◽  
Stroop Test ◽  
Trail Making Test ◽  
Word Condition ◽  
Randomized Controlled ◽  
Digit Span Test ◽  
Span Test ◽  
Free Weight ◽  
Trail Making

Resistance exercise has been demonstrated to improve brain function. However, the optimal workout characteristics are a matter of debate. This randomized, controlled trial aimed to elucidate differences between free-weight (REfree) and machine-based (REmach) training with regard to their ability to acutely enhance cognitive performance (CP). A total of n = 46 healthy individuals (27 ± 4 years, 26 men) performed a 45-min bout of REfree (military press, barbell squat, bench press) or REmach (shoulder press, leg press, chest press). Pre- and post-intervention, CP was examined using the Stroop test, Trail Making Test and Digit Span test. Mann–Whitney U tests did not reveal between-group differences for performance in the Digit Span test, Trail Making test and the color and word conditions of the Stroop test (p > 0.05). However, REfree was superior to REmach in the Stroop color-word condition (+6.3%, p = 0.02, R = 0.35). Additionally, REfree elicited pre-post changes in all parameters except for the Digit Span test and the word condition of the Stroop test while REmach only improved cognitive performance in part A of the Trail Making test. Using free weights seems to be the more effective RE method to acutely improve cognitive function (i.e., inhibitory control). The mechanisms of this finding merit further investigation.

Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers

2014 ◽  
Vol 29 (4) ◽  
Author(s):  
Shravan Kumar Yamsani ◽  
Madhusudan Rao Yamsani
Keyword(s):  
Oral Bioavailability ◽  
Pharmacokinetic Parameters ◽  
Rat Intestine ◽  
Healthy Human ◽  
P Glycoprotein ◽  
Human Volunteers ◽  
Significant Difference

AbstractThe aim of this study was to investigate the effect of silymarin pretreatment on domperidone oral bioavailability in humans.The rats were pretreated with silymarin for 7 days. The transport of domperidone across the rat intestine (duodenum, jejunum, ileum, and colon) was studied by usingIn the everted sac and non-everted sac study with silymarin pretreatment, domperidone transport increased from the duodenum, jejunum, ileum, and colon. The silymarin pretreatment increased the bioavailability of domperidone. There was a statistically significant difference in the pharmacokinetic parameters CThe significant difference in absorption of domperidone on pretreatment with silymarin is due to the inhibition of P-glycoprotein and CYP3A. Silymarin, which inhibits CYP3A4, should be contraindicated for domperidone.

scholarly journals Allium sativumL. Improves Visual Memory and Attention in Healthy Human Volunteers

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Sara Tasnim ◽  
Parsa Sanjana Haque ◽  
Md. Sazzadul Bari ◽  
Md. Monir Hossain ◽  
Sardar Mohd. Ashraful Islam ◽  
...  
Keyword(s):  
Executive Function ◽  
Verbal Memory ◽  
Visual Memory ◽  
Neuropsychological Test ◽  
Healthy Human ◽  
Beneficial Effects ◽  
Memory And Attention ◽  
Human Volunteers ◽  
Short Period ◽  
Significant Difference

Studies have shown thatAllium sativumL. (AS) protects amyloid-beta peptide-induced apoptosis, prevents oxidative insults to neurons and synapses, and thus prevent Alzheimer’s disease progression in experimental animals. However, there is no experimental evidence in human regarding its putative role in memory and cognition. We have studied the effect of AS consumption by healthy human volunteers on visual memory, verbal memory, attention, and executive function in comparison to control subjects taking placebo. The study was conducted over five weeks and twenty volunteers of both genders were recruited and divided randomly into two groups: A (AS) and B (placebo). Both groups participated in the 6 computerized neuropsychological tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) twice: at the beginning and after five weeks of the study. We found statistically significant difference (p<0.05) in several parameters of visual memory and attention due to AS ingestion. We also found statistically nonsignificant (p>0.05) beneficial effects on verbal memory and executive function within a short period of time among the volunteers. Study for a longer period of time with patients suffering from neurodegenerative diseases might yield more relevant results regarding the potential therapeutic role of AS.

scholarly journals Test de Atención d2: Consistencia interna, estabilidad temporal y evidencias de validez/The d2 Test of Attention: Internal Consistency, Temporal Stability and Evidence of Validity

2020 ◽  
Vol 39 (2) ◽  
pp. 145-165
Author(s):  
Josiane Pawlowski
Keyword(s):  
Costa Rica ◽  
Internal Consistency ◽  
Digit Span ◽  
Temporal Stability ◽  
Validity Evidence ◽  
Test Digit ◽  
Trail Making ◽  
Effectiveness Index ◽  
Test Retest Reliability ◽  
Speed Accuracy

EspañolEl objetivo de esta investigación fue analizar la adecuación psicométrica del Test d2 para su uso en Costa Rica. Una muestra de 445 individuos con edades entre 18 y 47 años, 58% mujeres y 42% hombres, contestaron la prueba d2; 50 de ellos completaron la prueba una segunda vez y 40 respondieron también las pruebas Test del Trazo, Test de Colores y Palabras de Stroop, Span de Dígitos, Búsqueda de Símbolos, Claves y Cancelación. Fueron evaluadas la consistencia interna, la estabilidad temporal y las evidencias de validez basadas en relaciones con otras variables y en la estructura interna. Los puntajes más fiables fueron los siguientes: total de respuestas (TR), total de aciertos (TA), índice de efectividad en la prueba (TOT) e índice de concentración (CON), con resultados del alfa de Cronbach y de fiabilidad test-retest en el rango de .90 a .97. Las correlaciones con pruebas que evalúan atención sostenida y selectiva, velocidad de procesamiento, precisión y control inhibitorio sugieren evidencias de validez para los puntajes CON, TR, TA y O (errores de omisión). Además, el aumento de edad está relacionado a la disminución de los puntajes TA y CON, en especial. Se discuten los hallazgos respecto a la estructura factorial de la prueba. Los resultados corroboran estudios previos e indican puntajes válidos del d2 para evaluar individuos de nivel universitario de Costa Rica.EnglishIn this research, some psychometric properties of the d2 test were analyzed for its use in Costa Rica. A total of 445 participants aged between 18 and 47 years, 58% women and 42% men, completed the d2 test; a subset of 50 participants completed the test a second time, and 40 participants answered the additional tests: Trail Making Test, Stroop Test, Digit Span, Symbol Search, Coding and Cancellation. Internal consistency, temporal stability and validity evidences based on relations to other variables and based on the internal structure were evaluated. The most reliable scores were total number of responses (TR), total number of correct characters canceled (TA), effectiveness index (TOT) and concentration index (CON), with Cronbach’s Alpha results and test-retest reliability ranged from .90 to .97. Correlations with tests that evaluate sustained and selective attention, processing speed, accuracy, and inhibitory control suggest validity evidence for the CON, TR, TA, and O (omission errors) scores. In addition, aging is especially related to the decrease in TA and CON scores. The findings regarding the factorial structure of the test are discussed. The results corroborate previous studies and indicate validity evidence for d2 test scores for evaluating Costa Rican university students and graduates.

scholarly journals Effect of agomelatine on psychomotor function tests in healthy human volunteers

2017 ◽  
Vol 7 (1) ◽  
pp. 109
Author(s):  
G. Sirisha ◽  
Shovan P.
Keyword(s):  
Controlled Study ◽  
Psychomotor Function ◽  
Card Sorting ◽  
Healthy Human ◽  
Institutional Ethics ◽  
Function Tests ◽  
Human Volunteers ◽  
Significant Difference ◽  
Sorting Test ◽  
Flicker Fusion

Background: Agomelatine is a melatonergic agonist that acts specifically on MT1/MT2 melatonergic receptors and 5-HT2C antagonism. The present study was taken up to evaluate the effect of Agomelatine 25mg on psychomotor function in healthy human volunteers.Methods: The effect of Agomelatine was studied in 12 healthy volunteers of either gender. The study was a randomised, cross over, placebo controlled study, done after obtaining permission from NIMS Institutional Ethics Committee and informed consent taken from all the subjects, after briefly explaining the study procedure and training them adequately. Psychomotor function was assessed using Choice reaction time (CRT), Critical Flicker fusion test (CFFT), Digit letter substitution test (DLST), Six letter cancellation test (SLCT), Card sorting test (CST) and Visual analog scale (VAS). Psychomotor function tests were performed, 90 minutes after administering Agomelatine 25 mg or placebo. Washout period of seven days was allowed between the cross over. Statistical analysis was done by comparing groups using unpaired t test.Results: There was significant decrease in the mean percentage of time (p<0.01) in CRT in Agomelatine group (20.09±9.47%) when compared to placebo (10.48±3.68%). Improved mean percentage of performance was seen in CFFT with Agomelatine (6.2±2.1%) compared to placebo (9.11±2.99%). No significant difference was noted in the performance of DLST, SLCT and CST. Drug was subjectively rated as sedative on VAS.Conclusions: There is no significant effect of Agomelatine on psychomotor performance. CNS processing of information also improved. Agomelatine can thus be safely administered to depressed patients.

scholarly journals Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity

2007 ◽  
Vol 65 (2A) ◽  
pp. 262-267 ◽  
Author(s):  
Silvia Balsimelli ◽  
Maria Fernanda Mendes ◽  
Paulo H.F. Bertolucci ◽  
Charles Peter Tilbery
Keyword(s):  
Multiple Sclerosis ◽  
Digit Span ◽  
Stroop Test ◽  
Central Processing ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Attention Impairment

Neuropsychological studies have consistently reported cognitive dysfunctions associated with multiple sclerosis. One-hundred fifteen subjects with relapsing-remitting multiple sclerosis (RRMS) were compared with forty health controls according to a neuropsychological test battery, which included digit span, trail making, cancellation and stroop test. Both groups were matched for age, sex and educational level. Subjects with RRMS had a worse performance the speed of response. Subjects with RRMS spent more time to complete the test in either sections A (p=0.001) or B (p=0.001), although there was no significant difference in terms of number of errors. The total time required to finish the Stroop test was higher for subjects with RRMS (p<0.001), being the time difference between groups significant at trial 4 (p<0.001). Attention impairment in subjects with RRMS is related to slowed central processing, which may be affected in all stages, including impairment of automatic and controlled processing of information and in the motor program.

Pharmacokinetic Evaluation of Two Brands of Linezolid Tablets in Healthy Human Volunteers

2010 ◽  
Vol 3 (2) ◽  
pp. 933-939
Author(s):  
Parameshwar P ◽  
Y N Rao ◽  
Shobha J C ◽  
Y N Reddy ◽  
V M Reddy
Keyword(s):  
Lower Limit ◽  
Bioequivalence Study ◽  
Hplc Method ◽  
Pharmacokinetic Parameters ◽  
Healthy Human ◽  
Blood Samples ◽  
Upper Limit ◽  
Human Volunteers ◽  
Significant Difference ◽  
Healthy Adult Male

The aim of a  randomized, balanced, two treatment, two-period, two-sequence, single-dose, crossover pilot bioavailability and bioequivalence study conducted in 12 healthy adult male volunteers under fasting conditions was to compare steady state pharmacokinetics of Linezolid 600mg tablets of Dr.Reddy’s Laboratories Ltd, and Zyvox ® (Linezolid) 600mg tablets of Pharmacia & Upjohn Company, USA. The subjects were dosed once during the study and the pre-dose blood samples were collected within 1 hr prior to dosing. The concentrations of Linezolid from the blood samples were quantified by validated HPLC method and pharmacokinetic parameters were computed. 90% Confidence intervals of reference Vs test for Cmax  lower limit 87.23 and upper limit 109.24, AUC0-t lower limit 86.20 and upper limit 109.17, AUCO-α lower limit 85.48 and upper limit 111.54. Analysis of variance (ANOVA) did not show significant difference to these parameters. Based on the results obtained, both the formulations have exhibited the same rate and extent of absorption, indicating switch ability in clinical practice.

scholarly journals A study of effect of a single dose of second generation antihistaminics on cognitive and psychomotor function in healthy human volunteers

2020 ◽  
Vol 9 (12) ◽  
pp. 1836
Author(s):  
Kirti Saxena ◽  
Sachendra K. Shrivastva ◽  
Chaitali Mehta
Keyword(s):  
Single Dose ◽  
Second Generation ◽  
Psychomotor Function ◽  
Healthy Human ◽  
Speed Test ◽  
Human Volunteers ◽  
Significant Difference ◽  
Psychomotor Functions ◽  
Finger Tapping Test ◽  
Student’S T

Background: Objective of the study was to assess whether second generation antihistaminic alter psychomotor and cognitive function in comparison with promethazine (marked sedation; altered psychomotor and cognitive impairment).Methods: It was a single blind prospective study. Seventy five healthy human volunteers were registered, divided in five groups. These groups have received placebo, promethazine 25 mg, cetirizine 10 mg, fexofenadine 120 mg and loratadine 10 mg. Cognitive and psychomotor functions were assessed pretreatment and 60 minutes after single dose of drug(post treatment)by using a battery of standard tests (e.g. PST-Perceptual speed test, BVRT-Benton visual retention test,SSS- Stanford Sleepiness Scale, FTT-Finger tapping test etc.). The data were analyzed by student’s t-test and ANOVA test.Results: No significant effect was observed in any test parameter with placebo and fexofenadine. Significant difference with promethazine in PST, BVRT, SSS and cetirizine in DSST, FTT and loratadine in DSST were observed. Significant difference was observed in DSST between the placebo and promethazine, in SSS between promethazine and all other drugs. In FTT and BVRT significant difference between the groups were observed.Conclusions: Significant sedation and altered cognitive and psychomotor function were observed with promethazine. Cetirizine and loratadine do not cause sedation but both affect psychomotor functions. No significant effect was produced by fexofenadine. Thus, fexofenadine can safely be used in persons involved in activity where alertness is required while cetirizine and loratadine should be avoided.

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