WLS-ILIAD: New Longitudinal Resource for Cognitive and Dementia Data

One of the distinctive strengths of WLS is the availability of Henmon-Nelson IQ scores on all participants while in high school, followed by prospective collection of data through cognitive batteries of varying size and sophistication. Launched in 1993, the initial longitudinal cognitive testing included 8 abstract reasoning items followed by the administration of larger cognitive batteries in 2004 and 2011 comprised of a 10-item word recall test, digit ordering task, phonemic and category fluency, as well as repeated and new items from the WAIS-R similarities task first administered in the 1993 survey. In 2018, with R01 funding from NIA, the scope of cognitive testing expanded significantly and includes administration of a phone-based cognitive screening measure, and a comprehensive in-person neuropsychological assessment for individuals identified at risk for dementia targeting a range of cognitive domains, including memory, language, attention, visuospatial abilities, and executive functioning.

Optimization of the Speech Test Material in a Group of Hearing Impaired Subjects: A Feasibility Study for Multilingual Digit Triplet Test Development

Background: The development of the global digit-in-noise test requires optimization of each language version on a group of normal-hearing native-speakers. An alternative solution may be an adaptive optimization during ongoing tests in a group of subjects with unknown hearing impairments. The objective of the research was to compare the optimization results between these groups. Methods: Digit triplets consisting of three pseudo-randomly selected digits were presented in speech-shaped noise at various signal-to-noise ratios (SNRs), according to the protocol of the final speech test. Digit-specific and position-specific speech reception thresholds (SRTs) were determined and compared between groups. Results: The study sample consisted of 82 subjects, 26 normal-hearing subjects and 56 patients with diverse hearing disorders. Statistically significant differences in digit-specific SRTs between the control and the investigated group were obtained for three digits in continuous noise (digits 0, 4, 6; p-value of 0.04, 0.03, 0.05) and two in modulated noise (digits 1 and 6; p-value of 0.05 and 0.01). An analysis including only ears with SRTs within the range of the normal hearing control group showed no statistically significant differences between digits. Conclusion: Optimization of speech material can be carried out in a group of subjects with unknown hearing impairments, provided the ears with scores outside normal range are rejected.

A multi-component, adaptive Working Memory Assessment Battery (WoMAB): validation and norms in an Italian population sample

Background Working memory (WM) abilities are frequently impaired in neurological disorders affecting fronto-parietal cortical/sub-cortical structures. WM deficits negatively influence interventional outcomes and everyday functioning. This study thus aimed at the following: (a) developing and standardizing an ecologically valid task for WM assessment ( Ice Cream Test, ICT); (b) validating and norming a novel WM test (Digit Ordering Test, DOT), as well as providing updated norms for digit span (DS) tasks, in an Italian population sample; (c) introducing a novel scoring procedure for measuring WM. Methods One-hundred and sixty-eight Italian healthy participants—73 male, 95 females; age: 48.4 ± 19.1 (18–86); education: 12.1 ± 4.8 (4–21)—underwent a thorough WM assessment—DOT, ICT, and both forward and backward DS tasks (FDS, BDS). The ICT requires participants to act as waiters who have to keep track of customers’ orders. For each task, WM and total (T) outcomes were computed, i.e., the number of elements in the longest sequence and that of recalled sequences, respectively. Norms were derived via the equivalent score (ES) method. Results DS ratios (DSRs) were computed for both WM/S and T outcomes on raw DS measures (BDS divided by FDS). Age and education significantly predicted all WM tasks; sex affected FDS and DSR-T scores (males > females). WM measures were highly internally related. Discussion The present work provides Italian practitioners with a normatively updated, multi-component, adaptive battery for WM assessment (WoMAB) as well as with novel outcomes which capture different WM facets—WM capacity and attentive monitoring abilities.

Neuropsychological Pattern in a Series of Post-Acute COVID-19 Patients in a Rehabilitation Unit: Retrospective Analysis and Correlation with Functional Outcomes

Intensive Care Unit delirium, insomnia, anxiety, and frontal/dysexecutive disorders have been described following COVID-19 infection. The aim of this case study was to re-evaluate the neuropsychological pattern in a series of patients with COVID-19 outcomes. We retrospectively evaluated 294 patients admitted to the Istituti Clinici Scientifici Maugeri of Lumezzane (Brescia) (May–September 2020). Neuropsychological assessment was available for 12 patients. We extracted clinical, functional data (FIM and Barthel Index score) and neuropsychological tests (MMSE, Trail making a-b, verbal fluency test, digit span, prose memory test, Frontal Assessment Battery, clock drawing test, Rey–Osterrieth complex figure, Tower of London test). The results were analyzed by Spearman (rho) correlation. Six patients presented dysexecutive alterations even in the presence of normal overall cognitive functioning. Forward digit span score was directly correlated to FIM value at admission (p = 0.015) and inversely correlated to delta FIM (p = 0.030) and delta Barthel Index (p = 0.025). In our experience, subclinical cognitive alterations were present in 4% of patients recovering from COVID-19 pneumonia. The possible correlation between verbal memory and frontal functions, and the degree of functional impairment at admission and its subsequent improvement, underscores the importance of an adequate cognitive evaluation and rehabilitation.

The Jena Voice Learning and Memory Test (JVLMT): A standardized tool for assessing the ability to learn and recognize voices

The ability to recognize someone’s voice exists on a broad spectrum with phonagnosia on the low end and super recognition at the high end. Yet there is no standardized test to measure an individual’s ability of learning and recognizing newly-learnt voices with samples of speech-like phonetic variability. We have developed the Jena Voice Learning and Memory Test (JVLMT), a 22min-test based on item response theory and applicable across languages. The JVLMT consists of three phases in which participants first become familiarized with eight speakers and then perform a three-alternative forced choice recognition task, using pseudo sentences devoid of semantics. Acoustic (dis)similarity analyses were used to create items with different levels of difficulty. Test scores are based on 22 Rasch-conform items. Items were selected based on 232 and validated based on 454 participants in an online study. Mean accuracy is 0.51 with an SD of .18. The JVLMT showed high and moderate correlations with the convergent validation tests (Bangor Voice Matching Test; Glasgow Voice Memory Test, respectively) and a weak correlation with the discriminant validation test (Digit Span). Empirical (marginal) reliability is 0.66. Four participants with super recognition abilities and 7 participants with phonagnosia were identified (at least 2 SDs above or below the mean, respectively).The JVLMT is a promising diagnostic tool to screen for voice recognition abilities in a scientific and neuropsychological context.

Effects of masticatory exercise on cognitive function in community-dwelling older adults

BACKGROUND: Mastication improves cognitive function by activating cerebral cortical activity, and it is important to demonstrate the cognitive effects of masticatory training using a variety of different interventions. OBJECTIVE: This study aimed to evaluate the effects of masticatory exercise on cognitive function in healthy older adults living in the community. METHODS: For six weeks, twelve participants performed a masticatory exercise using a NOSICK exerciser device, and thirteen subjects performed daily life without masticatory exercises. Trail Making Test, Digit Span Test, and Stroop test were used to measure the cognitive function. RESULTS: The participants in the experimental group showed significant improvements in TMT-A/B (p= 0.001 and 0.004), DST-forward (p= 0.001), and ST-word (p= 0.001). The effect sizes after the intervention were calculated as (1.2 and 0.8) for TMT-A/B, (0.8 and 0.2) for Digit Span Test forward/backward, and (0.6 and 0.2) for Stroop test color/word. CONCLUSIONS: We suggest that the masticatory exercises improve cognitive function in healthy older adults. Therefore, masticatory exercises can be used as a therapeutic exercise during cognitive rehabilitation.

Ongoing Oscillatory Electrophysiological Alterations in Frail Older Adults: A MEG Study

Objective: The role of the central nervous system in the pathophysiology of frailty is controversial. We used magnetoencephalography (MEG) to search for abnormalities in the ongoing oscillatory neural activity of frail individuals without global cognitive impairment.Methods: Fifty four older (≥70 years) and cognitively healthy (Mini-Mental State Examination ≥24) participants were classified as robust (0 criterion, n = 34) or frail (≥ 3 criteria, n = 20) following Fried's phenotype. Memory, language, attention, and executive function were assessed through well-validated neuropsychological tests. Every participant underwent a resting-state MEG and a T1-weighted magnetic resonance imaging scan. We performed MEG power spectral analyses to compare the electrophysiological profiles of frail and robust individuals. We used an ensemble learner to investigate the ability of MEG spectral power to discriminate frail from robust participants.Results: We identified increased relative power in the frail group in the mu (p < 0.05) and sensorimotor (p < 0.05) frequencies across right sensorimotor, posterior parietal, and frontal regions. The ensemble learner discriminated frail from robust participants [area under the curve = 0.73 (95% CI = 0.49–0.98)]. Frail individuals performed significantly worse in the Trail Making Test, Digit Span Test (forward), Rey-Osterrieth Complex Figure, and Semantic Fluency Test.Interpretation: Frail individuals without global cognitive impairment showed ongoing oscillatory alterations within brain regions associated with aspects of motor control, jointly to failures in executive function. Our results suggest that some physical manifestations of frailty might partly arise from failures in central structures relevant to sensorimotor and executive processing.

A Comparative Study of Memory, Attention, Cognition and Oestradiol in Pre and Postmenopausal Women in Bangladesh

Memory, attention, and cognitive dysfunction are psychopathological conditions which most commonly occur after menopause. Different clinical studies revealed a shred of substantial evidence that oxidative stress and estrogen are interlinked in various cognitive dysfunction, including memory impairment, age-related dementia, and Alzheimer's disease. There is a higher chance of developing cardiovascular disease after menopause. Sharp declines in concentrations of circulating estradiol and estrone are associated with menopause. Estrogen replacement therapy (ERT) enhances the blood circulation to the hippocampus and cortex, providing the optimum environment for the growth and survival of cholinergic neurons. Hence, it improves hippocampal neuron density and ultimately contributes to synaptic plasticity in the hippocampus enhances short and long-term memory. In this study, we assessed memory, attention, and cognition function between pre- and post-menopausal groups. After preliminary screening and applying exclusion criteria, fifteen premenopausal women and fifteen postmenopausal women were finally selected. Different neuropsychological tests such as logical memory test, digit span test, letter cancellation test, trail making test and Stroop test were performed to evaluate the memory, attention, and cognition status. Blood estradiol level was also assessed by using commercial kits. Significant difference (p<0.05) was found in LM-II in logical memory test, digit span test (backward), letter cancelation test, TMT-B in trail making test, the score of part C in stroop test between premenopausal and postmenopausal women. Serum oestradiol concentration (pg/ml) was significantly lower (p<0.001) in postmenopausal women (44.18±10.52) than premenopausal women (175.48 ± 43.20). The current study demonstrates the memory decline and cognitive dysfunction in postmenopausal women and there is a significant difference in estradiol level between pre and postmenopausal women. Estrogen has many neurotrophic actions in the brain and helps to improve memory and cognition. Therefore, estrogen replacement therapy, dietary supplements or a drug having an agonistic effect on estrogen receptors might improve the status of memory, attention, and cognitive function in postmenopausal women. Bangladesh Pharmaceutical Journal 24(1): 26-32, 2021

Test de Atención d2: Consistencia interna, estabilidad temporal y evidencias de validez/The d2 Test of Attention: Internal Consistency, Temporal Stability and Evidence of Validity

EspañolEl objetivo de esta investigación fue analizar la adecuación psicométrica del Test d2 para su uso en Costa Rica. Una muestra de 445 individuos con edades entre 18 y 47 años, 58% mujeres y 42% hombres, contestaron la prueba d2; 50 de ellos completaron la prueba una segunda vez y 40 respondieron también las pruebas Test del Trazo, Test de Colores y Palabras de Stroop, Span de Dígitos, Búsqueda de Símbolos, Claves y Cancelación. Fueron evaluadas la consistencia interna, la estabilidad temporal y las evidencias de validez basadas en relaciones con otras variables y en la estructura interna. Los puntajes más fiables fueron los siguientes: total de respuestas (TR), total de aciertos (TA), índice de efectividad en la prueba (TOT) e índice de concentración (CON), con resultados del alfa de Cronbach y de fiabilidad test-retest en el rango de .90 a .97. Las correlaciones con pruebas que evalúan atención sostenida y selectiva, velocidad de procesamiento, precisión y control inhibitorio sugieren evidencias de validez para los puntajes CON, TR, TA y O (errores de omisión). Además, el aumento de edad está relacionado a la disminución de los puntajes TA y CON, en especial. Se discuten los hallazgos respecto a la estructura factorial de la prueba. Los resultados corroboran estudios previos e indican puntajes válidos del d2 para evaluar individuos de nivel universitario de Costa Rica.EnglishIn this research, some psychometric properties of the d2 test were analyzed for its use in Costa Rica. A total of 445 participants aged between 18 and 47 years, 58% women and 42% men, completed the d2 test; a subset of 50 participants completed the test a second time, and 40 participants answered the additional tests: Trail Making Test, Stroop Test, Digit Span, Symbol Search, Coding and Cancellation. Internal consistency, temporal stability and validity evidences based on relations to other variables and based on the internal structure were evaluated. The most reliable scores were total number of responses (TR), total number of correct characters canceled (TA), effectiveness index (TOT) and concentration index (CON), with Cronbach’s Alpha results and test-retest reliability ranged from .90 to .97. Correlations with tests that evaluate sustained and selective attention, processing speed, accuracy, and inhibitory control suggest validity evidence for the CON, TR, TA, and O (omission errors) scores. In addition, aging is especially related to the decrease in TA and CON scores. The findings regarding the factorial structure of the test are discussed. The results corroborate previous studies and indicate validity evidence for d2 test scores for evaluating Costa Rican university students and graduates.