scholarly journals Approach to the Diagnosis of Bleeding Disorders in Children

2021 ◽  
Vol 9 (2) ◽  
pp. 45-53
Author(s):  
Muhammad Tawfique
Keyword(s):  
Physical Examination ◽  
Age Groups ◽  
Clot Formation ◽  
Bleeding Disorders ◽  
Pediatric Age ◽  
Related System ◽  
Vascular Walls ◽  
Methodical Approach ◽  
Laboratory Investigations ◽  
The Common

Hemostasis is the cessation of bleeding in the intravascular compartment. This occurs by the formation of clot formation at the site of injury. The intricately related system also regulates the size of the clots by the activation of fibrinolysis. The disorders that lead to the bleeding outside the intravascular space is bleeding disorder. Bleeding occurs as a result of defective quality or quantitative deficiencies of platelets, coagulation problems in the extrinsic or intrinsic or the common pathways and abnormalities in the vascular walls to contain hemorrhage. Although the values of different coagulation and fibrinlytic factors are pretty much like that of the adults yet, neonates have considerable differences in these values than their senior counterparts even in pediatric age groups. Considering all these facts the history, physical examination and laboratory investigations always provide the clinicians some important clues to reach the diagnosis. Because of the complicated relationship among the different pathways of coagulations and fibrinolytic systems the whole procedure might look complex yet methodical approach paves the way of an intelligent clinician to arrive at the diagnosis with precision and clinical perfection. CBMJ 2020 July: Vol. 09 No. 02 P: 45-53

scholarly journals Atypical presentation of testicular torsion: a case series

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Uzodimma Ejike Onwuasoanya
Keyword(s):  
Physical Examination ◽  
Testicular Torsion ◽  
Age Groups ◽  
Case Series ◽  
Atypical Presentation ◽  
Testicular Pain ◽  
Future Fertility ◽  
Urological Emergency ◽  
High Index Of Suspicion ◽  
Symptoms And Signs

Abstract Background Testicular torsion is a urological emergency and needs urgent intervention to prevent testicular loss and impaired future fertility. It is commonly seen in the neonatal and adolescent age groups. Testicular torsion can also present outside these common age groups with uncommon symptoms and signs. We report case series of patients managed at Lily Hospitals Limited, Warri, Delta State, Nigeria with atypical presentation of testicular torsion. Case Presentation The first patient was a 35-year-old male that presented with recurrent right testicular pain of 1-year duration, described as dull aching with no constitutional symptoms, physical examination findings were not pathognomonic of testicular torsion, he had scrotal exploration with right orchidectomy and left orchidopexy. The second patient was a 39-year-old male who presented with recurrent right testicular pain of 4-days duration, described as dull aching with no constitutional symptoms. Physical examination findings were not classical for testicular torsion, he had scrotal exploration with bilateral orchidopexy. Conclusion Testicular torsion although common in neonatal and adolescent age groups can also present outside these age groups with uncommon symptoms and signs, a high index of suspicion is thus invaluable in any patient presenting with testicular pain despite the age and severity to avoid missing the diagnosis as this can lead to testicular loss.

scholarly journals COVID-19 Shuts Doors to Flu but Keeps Them Open to Rhinoviruses

Biology ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 733
Author(s):  
Irina Kiseleva ◽  
Andrey Ksenafontov
Keyword(s):  
Influenza Pandemic ◽  
Age Groups ◽  
Influenza Viruses ◽  
Interferon Response ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Mild Disease ◽  
Viral Interference ◽  
The Common

It is well known that rhinoviruses are distributed across the globe and are the most common cause of the common cold in all age groups. Rhinoviruses are widely considered to be harmless because they are generally perceived as respiratory viruses only capable of causing mild disease. However, they may also infect the lower respiratory tract, inducing chronic obstructive pulmonary disease and exacerbations of asthma, bronchiolitis, etc. The role of rhinoviruses in pathogenesis and the epidemiological process is underestimated, and they need to be intensively studied. In the light of recent data, it is now known that rhinoviruses could be one of the key epidemiological barriers that may influence the spread of influenza and novel coronaviruses. It has been reported that endemic human rhinoviruses delayed the development of the H1N1pdm09 influenza pandemic through viral interference. Moreover, human rhinoviruses have been suggested to block SARS-CoV-2 replication in the airways by triggering an interferon response. In this review, we summarized the main biological characteristics of genetically distinct viruses such as rhinoviruses, influenza viruses, and SARS-CoV-2 in an attempt to illuminate their main discrepancies and similarities. We hope that this comparative analysis will help us to better understand in which direction research in this area should move.

Pattern of major injuries after motorcycle accidents in Egypt: The Mansoura Emergency Hospital experience

Trauma ◽  
2016 ◽  
Vol 19 (1) ◽  
pp. 39-45 ◽  
Author(s):  
El Yamani Fouda ◽  
Mohamed Youssef ◽  
Sameh H Emile ◽  
Hossam Elfeki ◽  
Waleed Thabet ◽  
...  
Keyword(s):  
Road Traffic ◽  
Head Injuries ◽  
Age Groups ◽  
Road Traffic Injuries ◽  
Emergency Hospital ◽  
Chest Injuries ◽  
The Common ◽  
Orthopedic Injuries ◽  
Motorcycle Accidents ◽  
Motorcycle Crashes

Background and aim Motorcycle accidents are one of the leading causes of road traffic injuries and mortality. The aim of this study was to determine the common patterns of major injuries associated with motorcycle accidents in patients attending Mansoura University Emergency Hospital in Egypt, and to measure the magnitude of the problem in our community. Patients and methods Patients involved in motorcycle crashes who were admitted to the hospital during August 2014 to April 2015 were retrospectively reviewed. All age groups and both genders were included. Results Two hundred patients (181 males) with a mean age of 30.7 ± 10.5 years were included with the majority of patients aged 20–40 years. Head injuries were the most frequent fatal injuries (9/61) patients; orthopedic injuries were the most common injuries, occurring in 78.5% of victims. Multisystem injuries occurred in 28% of patients. None of the motorcyclists involved in accidents wore helmets. Conclusion Motorcycle accidents are a common cause of road traffic injuries and mortalities in Egypt, occurring mainly in males aged 20–40 years. The majority of victims had an isolated trauma to single body system. Orthopedic injuries were the most common and least fatal type of injuries. The highest fatalities were among patients with chest injuries then patients with head injuries. None of the victims wore protective clothing or helmets at the time of accident.

Fulminant varicella hepatitis: a rare but lethal cause of abdominal pain

2021 ◽  
Vol 14 (9) ◽  
pp. e244081
Author(s):  
Christopher Fang ◽  
Junice Wong ◽  
Wei Wen Ang
Keyword(s):  
Abdominal Pain ◽  
Hepatitis A ◽  
Case Reports ◽  
Antibody Testing ◽  
Salient Points ◽  
Vesicular Rash ◽  
History Of ◽  
Laboratory Investigations ◽  
The Common ◽  
Upper Abdominal

An 81-year-old woman with no history of immunocompromise presented with 2 days of upper abdominal pain associated with nausea. On arrival, her physical examination was unremarkable apart from mild epigastric and right hypochondriac tenderness, and laboratory investigations were unremarkable apart from mild thrombocytopenia and transaminitis. A CT scan performed on the day of admission revealed a tiny 0.3 cm stone in the common bile duct, with no upstream dilatation. On day 2 of admission, she developed a vesicular rash and with acutely worsening transaminitis. She deteriorated rapidly and demised from complications of acute liver failure within the next 24 hours. The diagnosis of varicella was confirmed with antibody testing. Fulminant varicella hepatitis is an extremely rare and lethal condition with only a handful of reported cases in the current literature. We aim to share our clinical experience and summarise the salient points from existing case reports.

scholarly journals Time perception and age

2016 ◽  
Vol 74 (4) ◽  
pp. 299-302 ◽  
Author(s):  
Vanessa Fernanda Moreira Ferreira ◽  
Gabriel Pina Paiva ◽  
Natália Prando ◽  
Carla Renata Graça ◽  
João Aris Kouyoumdjian
Keyword(s):  
Time Perception ◽  
Healthy Subjects ◽  
Age Groups ◽  
Internal Clock ◽  
Time Interval ◽  
Comparison Test ◽  
Clock System ◽  
Multiple Comparison Test ◽  
The Common ◽  
Bonferroni Multiple Comparison Test

ABSTRACT Our internal clock system is predominantly dopaminergic, but memory is predominantly cholinergic. Here, we examined the common sensibility encapsulated in the statement: “time goes faster as we get older”. Objective To measure a 2 min time interval, counted mentally in subjects of different age groups. Method 233 healthy subjects (129 women) were divided into three age groups: G1, 15-29 years; G2, 30-49 years; and G3, 50-89 years. Subjects were asked to close their eyes and mentally count the passing of 120 s. Results The elapsed times were: G1, mean = 114.9 ± 35 s; G2, mean = 96.0 ± 34.3 s; G3, mean = 86.6 ± 34.9 s. The ANOVA-Bonferroni multiple comparison test showed that G3 and G1 results were significantly different (P < 0.001). Conclusion Mental calculations of 120 s were shortened by an average of 24.6% (28.3 s) in individuals over age 50 years compared to individuals under age 30 years.

scholarly journals Starvation in childhood and obesity in senior age

2017 ◽  
Vol 8 (6) ◽  
pp. 56-61
Author(s):  
Lidya P. Khoroshinina ◽  
Alexander V. Shabrov ◽  
Leonid G. Buynov
Keyword(s):  
Comparison Group ◽  
Age Groups ◽  
Older Age ◽  
Obesity Prevalence ◽  
Obese People ◽  
The World ◽  
Comparison Groups ◽  
Subcutaneous Layer ◽  
The Common ◽  
Severe Degree

The problem of children's starvation remains relevant and actual at the present time, as in the 21st century experts from the leading countries of the world coordinate their efforts to create programs aimed at eliminating extreme poverty and hunger of. At the same time, the analysis of obesity prevalence typical for the population of some countries of the world, indicates an increase in the number of obese people in both economically developed and developing countries. In this article we are talking about the common severe degree of abdominal obesity in people of older age groups, survivors in childhood, long periods of fasting. Studied 594 history and Protocol of autopsy of people in older age groups, born from 1927 to 1941 and the dead on the hospital for war veterans in St. Petersburg from 1989 to 2000. The whole array of documents was structured by sex, age, the fact of living in the blockaded Leningrad. Severe degree of obesity was considered to be exceeded more than 7 cm of thickness of deep abdominal subcutaneous layer of adipose tissue. It is well established that former young residents of the besieged Leningrad, regardless of gender, age, die sooner than men and women in the comparison groups; men who survived long periods of starvation in children, were dying earlier than men in the comparison group and earlier than women of the main group; women who have experienced a long period of starvation before the age of 11 years, often dying because of cardiovascular diseases than women in the corresponding subgroup comparisons; the emergence of pronounced obesity in older age-governmental groups from the former young residents of the blockaded Leningrad, determined by elk not only the fact of prolonged fasting, but child sex and age, which accounted for starvation.

scholarly journals Comparative study between throat swab and ear discharge swabs culture and sensitivity findings in pediatric patients with bilateral chronic otitis media

2019 ◽  
Vol 5 (4) ◽  
pp. 932
Author(s):  
Sudhakar Rao M. S. ◽  
Navneeth T. P.
Keyword(s):  
Otitis Media ◽  
Eustachian Tube ◽  
Middle Ear ◽  
Throat Swab ◽  
Chronic Otitis Media ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
The Common ◽  
Culture And Sensitivity

<p class="abstract"><strong>Background:</strong> Chronic otitis media is one of the common infections seen in pediatric age group. The most widely recognized route of infection is via the eustachian tube. The inflammation of the pharyngeal end of the eustachian tube may prevent gas exchange, leading to lowering of the middle ear pressure and predisposes to aspiration of nasopharyngeal microbes into the middle ear cleft.</p><p class="abstract"><strong>Methods:</strong> Eighty (80) cases of clinically diagnosed chronic otitis media among pediatric age group of both sexes selected on simple random basis were included in this study. Swabs from both ears and throat were taken and the samples were sent under strict aseptic conditions for culture and sensitivity testing.  </p><p class="abstract"><strong>Results:</strong> The mean age of patients was 6.1years and the frequency of chronic otitis media was maximum in 1-5 years age group. Male to female ratio was 1.6:1.The most frequent organism isolated was <em>S. Aureus</em> followed by <em>Psuedomonas</em>. The ear swab and throat swab findings showed positive relationship (p&lt;0.05) for the common organisms i.e., <em>S. Aureus</em>, <em>pseudomonas</em> and <em>Streptococcus pyogenes</em> respectively, thus suggesting a common etiological agent. Psuedomonal infection was found to be associated with large perforation in tympanic membrane.</p><p class="abstract"><strong>Conclusions:</strong> The pathology in bilateral ear disease is central i.e., throat. Treatment in these cases is focused on selected drug with optimum dose and calculated regimen of treatment completely, thus reducing the morbidity of loss of physiological function of the ear and the grave complications involved.</p><p> </p>

scholarly journals A cross preseptal and postseptal gonococcal orbital cellulitis in a 3-year-old male

2021 ◽  
Vol 8 (5) ◽  
pp. 920
Author(s):  
Trishell Simon ◽  
Chanique James
Keyword(s):  
Sexual Abuse ◽  
Physical Examination ◽  
Orbital Cellulitis ◽  
Age Group ◽  
Pediatric Age ◽  
Gonococcal Infection ◽  
Social Evaluation ◽  
Pediatric Age Group ◽  
Mode Of Transmission ◽  
Careful Physical Examination

Gonococcal orbital cellulitis is an infrequent presentation within the pediatric age group, with very few cases reported in literature. Even rarer, is the nonvenereal transmission via fomites. Careful physical examination with detailed social evaluation must always be obtained in any child with a gonococcal infection to look for signs or evidence of sexual abuse. This paper reports a 3-year-old male who developed a left preseptal and postseptal gonococcal orbital cellulitis via a nonsexual mode of transmission.

HuDA_COVID Human Disposition Analysis during COVID-19 using Machine Learning

2022 ◽  
Vol 13 (2) ◽  
pp. 0-0
Keyword(s):  
Machine Learning ◽  
Health Status ◽  
Human Life ◽  
Age Groups ◽  
Psychological Needs ◽  
Mass Survey ◽  
Negative Effects ◽  
Methodical Approach ◽  
The Social ◽  
The Impact

Coronavirus has greatly impacted various aspects of human life, including human psychology & human disposition. In this paper, we attempted to analyze the impact of the COVID-19 pandemic on human health. We propose Human Disposition Analysis during COVID-19 using machine learning (HuDA_COVID), where factors such as age, employment, addiction, stress level are studied for human disposition analysis. A mass survey is conducted on individuals of various age groups, regions & professions, and the methodology achieved varied accuracy ranges of 87.5% to 98%. The study shows people are worried about lockdown, work & relationships. Furthermore, 23% of the respondents have not had any effect. 45% and 32% have had positive and negative effects, respectively. It is a novel study in human disposition analysis in COVID-19 where a novel weighted assignment indicating the health status is also proposed. HuDA_COVID clearly indicates a need for a methodical approach towards the human psychological needs to help the social organizations formulating holistic interventions for affected individuals.

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