scholarly journals Antinociceptive and Anthelmintic Activities of Leaves of Leea aequata

2018 ◽  
Vol 17 (2) ◽  
pp. 251-255 ◽  
Author(s):  
Sushanta Halder ◽  
Nazmus Saqueeb ◽  
Nazmul Qais
Keyword(s):  
Crude Extract ◽  
Methanol Extract ◽  
Diclofenac Sodium ◽  
Anthelmintic Activity ◽  
Radiant Heat ◽  
Antinociceptive Activity ◽  
Dependent Manner ◽  
Standard Drug ◽  
Dose Dependent ◽  
Crude Methanol Extract

The objective of the study was to evaluate the antinociceptive and anthelmintic activities of the crude methanol extract of leaves of Leea aequata and its fractions. The crude extract and its fractions at 200- and 400-mg/kg bw were subjected to assay for their antinociceptive activity using acetic acid induced writhing and radiant heat tail flicking methods. The ethyl acetate soluble fraction at 400 mg/kg bw induced 40.97% inhibition of writhing in mice while the carbon tetrachloride and chloroform soluble fractions of crude extract at the same dose displayed activity with 40.28% inhibition of writhing as compared to standard diclofenac sodium. The crude extract elongated the reaction time by 57.04% after 30 minute of administration in radiant heat tail flicking method, which suggested the central antinociceptive activity as compared to morphine. The methanol extract of the leaves of L. aequata exhibited profound anthelmintic activity in a dose dependent manner with shortest time of paralysis and death at 100 mg/ml concentration. It caused paralysis of the earthworm Pheretima posthuma at 9.44 min and death at 12.9 min when compared to the standard drug albendazole, which at 10 mg/ml concentration revealed the same at 8.21 minutes and 11.18 minutes, respectively. Dhaka Univ. J. Pharm. Sci. 17(2): 251-255, 2018 (December)

scholarly journals Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root ofSchoenoplectus grossus

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Nirmal Kumar Subedi ◽  
S. M. Abdur Rahman ◽  
Mohammad Ahsanul Akbar
Keyword(s):  
Acetic Acid ◽  
Petroleum Ether ◽  
Methanol Extract ◽  
Diclofenac Sodium ◽  
Radiant Heat ◽  
Tail Flick ◽  
Dependent Manner ◽  
Tail Flick Test ◽  
Standard Drug ◽  
Pain Models

The study aims to evaluate analgesic and antipyretic activities of the methanol extract and its different fractions from root ofSchoenoplectus grossususing acetic acid induced writhing and radiant heat tail flick method of pain models in mice and yeast induced pyrexia in rats at the doses of 400 and 200 mg/kg. In acetic acid writhing test, the methanol extract, petroleum ether, and carbon tetrachloride fractions produced significant (P<0.001andP<0.05) inhibition of writhing responses in dose dependent manner. The methanol extract at 400 and 200 mg/kg being more protective with 54% and 45.45% of inhibition compared to diclofenac sodium of 56% followed by petroleum ether fractions of 49.69% and 39.39% at the same doses. The extracts did not produce any significant antinociceptive activity in tail flick test except standard morphine. When studied on yeast induced pyrexia, methanol and petroleum ether fractions significantly lowered the rectal temperature time dependently in a manner similar to standard drug paracetamol and distinctly more significant (P<0.001) after second hour. These findings suggest that the root extracts ofS. grossuspossess significant peripherally acting analgesic potential and antipyretic property. The phytochemical screening showed the presence of flavonoids, alkaloids, and tannins.

scholarly journals PRELIMINARY PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC AND MUSCLE RELAXANT ACTIVITY OF THE ETHANOLIC EXTRACT OF THE LEAVES OF MIRABILIS JALAPA

2017 ◽  
pp. 81-84
Author(s):  
Deepsikha Bharali ◽  
Dipankar Saha
Keyword(s):  
Muscle Relaxant ◽  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Dependent Manner ◽  
Phytochemical Screening ◽  
Standard Drug ◽  
Standard Procedures ◽  
Mirabilis Jalapa ◽  
Muscle Relaxant Activity ◽  
Dose Dependent

Objective: The aim and objectives of the present work is to determine pharmacological activity upon ethnopharmacological survey. The present study deals with phytochemical screening and analgesic as well as muscle relaxant activity of leaves of Mirabilis jalapa.Methods: The present study is aimed at phytochemical screening and evaluating the analgesic and muscle relaxant activities of ethanolic leaf extract of Mirabilis jalapa by using hot plate method and rota rod method respectively [1, 2]. The Phytochemical screening of the extract was done according to the standard procedures to reveal the presence of the active constituents like Alkaloids, flavonoids, phenols, glycosides, tannins, saponins, steroids, carbohydrates etc [3-5].Results: The analgesic and muscle relaxant activity study were dose dependent. The EEMJ extracts (100 mg/kg, 200 mg/kg, 500 mg/kg) and the standard drug Diclofenac sodium (25 mg/kg) shows significant increase in the reaction time when compared with control at 30 min, 60 min, 90 min and 120 min and the effect of standard was found to be highest during the study. Another study was designed to evaluate the skeletal muscle relaxant properties of ethanolic extract of leaves of Mirabilis jalapa. Linn by taking the EEMJ extracts (100 mg/kg, 200 mg/kg, 500 mg/kg) and standard drug Lorzepam (10 mg/kg). Both the extracts and standard drug show decrease in the fall of time in a dose dependent manner when compared with control at 15 min, 30 min, 45 min respectively. Conclusion: Therefore, from the above study it is revealed that Mirabilis jalapa showing better pharmacological activities (Analgesic and Muscle relaxant) in dose dependent manner.

scholarly journals INVESTIGATION ON PHARMACOGNOSY AS WELL AS THE ANTIOXIDANT, ANTI-INFLAMMATORY POTENTIAL OF THE KATHA POWDER

2021 ◽  
pp. 125-132
Author(s):  
PANKAJ SHARMA ◽  
RAJU L
Keyword(s):  
Diclofenac Sodium ◽  
In Vitro Study ◽  
Alcoholic Solution ◽  
Hot Water ◽  
Dependent Manner ◽  
Standard Drug ◽  
Anti Inflammatory ◽  
Acacia Catechu ◽  
Dose Dependent

Objective: The objective of the study was to investigate the pharmacognosy as well as the antioxidant, anti-inflammatory potential of the Katha powder. Methods: The Coarsely dried chips of Acacia catechu heartwood were treated with 10 % hydro-alcoholic solution to obtain Katha as the final product. The powdered Katha was standardized through pharmacognostic parameters. This Katha power is showing the good solubility in the hot water having astringent in the taste. The powder microscopy of the Katha powder is to be demonstrated fragments of acicular crystals, fibers, and bordered pitted vessels. Katha powder antioxidant potential is to be accessed by using the 2, 2-diphenyl-1-picryl hydrazyl assay and NO Scavenging assay using ascorbic acid as a standard drug. Further, the Katha powder is to be subjected for the assessment of its anti-inflammatory potential by the use of heat-induced hemolysis as well as hypotonicity-induced hemolysis approach by the use of the aspirin or diclofenac sodium as a standard drug. Results: Microscopical investigations were showed that Katha showing the presence of fragments of acicular crystals, fibers, and bordered pitted vessels. In vitro study shows that the Katha powder has excellent antioxidant as well as anti-inflammatory potential in a dose-dependent manner in comparison of the result of heartwood of A. catechu. Conclusion: So from this investigation, it is to be suggested that the Katha powder is rich in the phenolic compound and the experimentation study shows that the drug is to possess a good antioxidant as well as anti-inflammatory property.

scholarly journals Neuropharmacological Activities of Methanol Extract of Albizia lebbeck (L.) Benth.

2018 ◽  
Vol 21 (2) ◽  
pp. 80-86 ◽  
Author(s):  
Shanta Islam ◽  
Md Shafiullah Shajib ◽  
Bidyut Kanti Datta ◽  
Mohammad A Rashid
Keyword(s):  
Open Field ◽  
Plant Extract ◽  
Methanol Extract ◽  
Dependent Manner ◽  
Albizia Lebbeck ◽  
Sodium Thiopental ◽  
Sleeping Time ◽  
Time Test ◽  
Dose Dependent ◽  
Crude Methanol Extract

Albizia lebbeck (Linn.) Benth. is a deciduous tree which is planted as ornamental and avenue tree almost all over Bangladesh. Leaves of the plant are used in ethnomedicine for the treatment of convulsion and CNS related disorder. This study was aimed to evaluate the neuropharmacological effects of the methanol extract of A. lebbeck leaves in Swiss albino mice. The locomotor effect of crude methanol extract of the plant was investigated by open field and hole cross tests while the anxiolytic activity was determined using elevated plus-maze (EPM) and light/dark box (LDB) tests. Furthermore, the sedative activity of the plant extract was assessed by sodium thiopental-induced sleeping time test. The results demonstrated that the methanol extract significantly (p < 0.001) reduced locomotion of the animals in both hole cross and open field tests in dose-dependent manner at 200-400 mg/kg b.w. In both EPM and LDB tests, the plant extract produced significant anxiolytic effect (p < 0.05) at the doses of 100-400 mg/kg b.w. In addition, it showed significant (p < 0.001) dose-dependent decrease in the onset of sleep and an increase in duration of sleep in sodium thiopental-induced sleeping time test. Preliminary phytochemical analyses of the plant extract revealed the presence of alkaloid, flavonoid, glycoside, saponin, tannin and resin. In acute toxicity test, the leaf extract did not exhibit any adverse effect in mice during 7 days treatment. The results of the present studies suggest that the crude methanol extract of A. lebbeck leaves possesses significant CNS depressant, anxiolytic and sedative properties and rationalize the traditional uses of the plant.Bangladesh Pharmaceutical Journal 21(2): 80-86, 2018

Phytochemical, Quantitative Proximate and In vitro Anti-inflammatory Study of the Crude Methanol Extract of Stachytarpheta indica Leaves (Verbenaceae)

2019 ◽  
pp. 153-162
Author(s):  
Cyril Ogbiko ◽  
Dickson Achimugu Musa ◽  
Musa Usman Dabai ◽  
Ibeabuchi Jude Ali ◽  
Abubakar Sani Yelwa ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Proximate Analysis ◽  
Water Soluble ◽  
Inflammatory Activity ◽  
Dependent Manner ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Crude Methanol Extract

Herbal medicine despite its increase usage globally is being plagued by inadequate research on their effectiveness. Stachytarpheta indica commonly known as snakeweed is used locally in the management of asthma, headache, alopecia, bronchitis, bruise, chest cold, constipation, itch, diarrhea, skin sore, vermifuge, dysentery, dysmenorrhea among others. This study investigated the phytochemical composition, quantitative proximate parameters and in vitro anti-inflammatory activity of the leaves of S. indica using established methods. Results confirmed the presence of alkaloids, saponins, carbohydrate, cardiac glycosides, terpenoid, tannin, anthraquinones, phenolics and flavonoid. Moisture content (9.16 ± 0.04%), total ash (19.42 ± 0.15%), water insoluble ash (7.17 ± 0.22%), acid insoluble ash (3.63 ± 0.26%), alcohol soluble extractive (0.99 ± 0.06%) and water-soluble extractive (0.36 ± 0.02%) values were obtained from the quantitative proximate analysis. An infusion of the methanol leaf extract of Stachytarpheta indica demonstrated significant anti-inflammatory activity in a dose dependent manner comparable to that of indomethacin standard.

scholarly journals Antinociceptive Activity of Methanol Extract of Tamarix indica

1970 ◽  
pp. 1-3
Author(s):  
MAM Sarker ◽  
Md Abdul Matin Sarker
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Reducing Sugars ◽  
Diclofenac Sodium ◽  
Antinociceptive Activity ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Phytochemical Investigation ◽  
Albino Mice ◽  
Dose Dependent

The antinociceptive activity of the methanolic extract of the barks of Tamarix indica Roxb. was investigated using acetic acid-induced writhing model in swiss albino mice. The extract produced about 26.89%( P< 0.01) and 43.55% (P< 0.001) writhing inhibition at the dose of 250 and 500 mg/ kg of body weight respectively, which was comparable to the standard drug diclofenac sodium where the inhibition was about 63.64% (P< 0.001) at the dose of 25 mg/kg of body weight. At the above doses, the extract exhibited significant and dose dependent antinociceptive activity in acetic acid-induced writhing model in swiss albino mice. Phytochemical investigation of the extract indicate the presence of reducing sugars, tannins, gums, flavonoids and saponin. Key words: Tamarix indica; antinociceptive activity; acetic acid-induced writhing; phytochemical test. DOI: 10.3329/bjpp.v25i1.5736Bangladesh J Physiol Pharmacol 2009; 25(1&2) : 1-3

scholarly journals ANTI-ANALGESIC ACTIVITY OF METHANOLIC LEAF EXTRACT OF WATTAKAKA VOLUBILIS (LINN. F.) BENTH EX. HOOK F. (ASCLEPIADACEAE) - A RARE AND THREATENED MEDICINAL PLANT

2016 ◽  
Vol 3 (2) ◽  
pp. 70-71
Author(s):  
Udhayasankar M.R ◽  
Danya U ◽  
Arumugasamy K
Keyword(s):  
Acute Toxicity ◽  
Medicinal Plant ◽  
Analgesic Activity ◽  
Leaf Extract ◽  
Diclofenac Sodium ◽  
Dependent Manner ◽  
Standard Drug ◽  
Acute Toxicity Study ◽  
Threatened Medicinal Plant ◽  
Dose Dependent

The present study, investigates themethanolicleaves extract of Wattakaka volubilis (Family: Asclepiadaceae) designated as 'the extract' was evaluated for analgesic activity in mice. The analgesic activity was evaluated in mice models. In the acute toxicity study, it was found that the extract was non-toxic up to 1000mg/kg, p. o. The extract (150, 200 and 400 mg/kg, p. o.) was found to possessanalgesic activities in a dose-dependent manner and the effect was comparable with thatproduced by the standard drug, Diclofenac sodium.

scholarly journals Phytochemical screening, antinociceptive, anthelmintic and cytotoxicity studies of the leaves of Carissa carandas Linn. (Family: Apocynaceae)

2018 ◽  
Vol 4 (5) ◽  
pp. 119 ◽  
Author(s):  
Most. Nazma Parvin
Keyword(s):  
Cytotoxic Activity ◽  
Methanol Extract ◽  
Anthelmintic Activity ◽  
Antinociceptive Activity ◽  
Cytotoxic Activities ◽  
Phytochemical Screening ◽  
Standard Drug ◽  
Cytotoxicity Studies ◽  
Vincristine Sulphate ◽  
Carissa Carandas

<em><em></em></em><p class="abstract"><strong>Background:</strong> <em>Carissa carandas </em>Linn. (Bengali name- Karamya, Karancha, Karamcha, English name-Karaunda) commonly known as Karanda is a widly used medicinal plants belongs to apocynaceae family<em>. </em>The various plant parts of <em>C. carandas </em>have been used for ethnomedicine in the treatment of human diseases, such as diarrhea, stomachic, anorexia, intermittent fever, mouth ulcer and sore throat, syphilitic pain, burning sensation, scabies and epilepsy. The current studies were aimed to investigate the phytochemical constituents, antinociceptive, anthelmintic and cytotoxic activities of the methanol extract of leaves of <em>C. carandas</em>.</p><p class="abstract"><strong>Methods:</strong> The antinociceptive property of the methanol leaves extract of <em>C. carandas</em> was evaluated in swiss albino mice by using acetic acid-induced writhing test and anthelmintic activity of the fresh leaves juice was performed by observing the time of paralysis and the time of death of earth worms <em>Pheretima posthuma. </em>On the other hand, the methanol extract of leaves of <em>C. carandas</em> was screened for cytotoxic activity by brine shrimp lethality bioassay.  </p><p class="abstract"><strong>Results:</strong> Phytochemical screening showed that the methanol leaves extract contained alkaloids, steroids, flavanoids, tannins, saponins and reducing sugar. The antinociceptive activity test revealed that the extract showed significant antinociceptive activity and the fresh juice of the leaves of <em>C. carandas </em>showed potent anthelmintic activity. In cytotoxicity studies, the methanol leaves extract displayed moderate cytotoxic activity when compared with standard drug, vincristine sulphate.</p><p class="abstract"><strong>Conclusions:</strong> In the current studies, these observations also support the use of this plant for medicinal purposes and encourage further investigations for more fruitful results.</p>

scholarly journals Microwave Mediated Organic Reaction: A Convenient Approach for Rapid and Efficient Synthesis of Biologically Active Substituted 1,3-Dihydro-2H-indol-2-one Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Jnyanaranjan Panda ◽  
Biswa Mohan Sahoo ◽  
Nikunja Kishor Mishra ◽  
Sai Krushna Padhi ◽  
Jitendriya Mishra
Keyword(s):  
Anthelmintic Activity ◽  
Mannich Bases ◽  
Biologically Active ◽  
Secondary Amines ◽  
Dependent Manner ◽  
Substituted Anilines ◽  
Standard Drug ◽  
Compound Libraries ◽  
Work First ◽  
Dose Dependent

A simple and efficient method has been developed for the synthesis of 1,3-dihydro-2H-indol-2-one derivatives using microwave irradiation technique. By taking advantage of the efficient source of energy of microwave, compound libraries for lead generation and optimization can be assembled in a fraction of time. In the present work, first the Schiff’s bases are synthesized by reaction of isatin with substituted anilines in the presence of acetic acid under microwave heating. Then the condensation of Schiff bases with different secondary amines in the presence of formaldehyde produces Mannich bases. The newly synthesized Mannich bases were characterized by means of spectral data and then evaluated for anthelmintic activity againstPheretima posthuma(Indian earthworm) and compared with standard albendazole. The compounds were evaluated at the concentrations of 10, 20, and 50 mg/mL. The effect of the standard drug albendazole at 10 mg/mL was also evaluated. The results of the present study indicate that some of the test compounds significantly demonstrated paralysis and also caused death of worms in a dose-dependent manner.

IN VITRO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF PYRENACANTHA VOLUBILIS (EEPV)

2020 ◽  
pp. 156-158
Author(s):  
ANJALI P ◽  
VIMALAVATHINI R ◽  
KAVIMANI S
Keyword(s):  
Protein Denaturation ◽  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Dependent Manner ◽  
Membrane Stabilization ◽  
Standard Drug ◽  
Human Red Blood Cells ◽  
Anti Inflammatory ◽  
Dose Dependent

Objectives: The study was undertaken to evaluate the in vitro anti-inflammatory and anti-arthritic activity of the ethanolic extract of leaves of Pyrenacantha volubilis (EEPV) using human red blood cells (HRBCs) membrane stabilization and protein denaturation methods. Methods: In the present study, the in vitro anti-inflammatory and anti-arthritic activity of EEPV was carried out using HRBC membrane stabilization by hypotonicity-induced hemolysis and protein denaturation using egg albumin methods at various concentrations (100, 200, 400, 800, and 1000) of EEPV. Diclofenac sodium was used as reference standard. Results: P. volubilis was effective in inhibiting HRBC membrane stabilization and protein denaturation in a dose-dependent manner and was comparable to the standard drug diclofenac sodium. Conclusion: The study suggests that P. volubilis has potential anti-inflammatory and anti-arthritic activity.

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