scholarly journals Comparison of Ocular Lens Thickness of Type-2 Diabetic Retinopathy Patients with Non-diabetic Control, Measured by High Resolution Ultrasonography

2021 ◽  
Vol 10 (1-2) ◽  
pp. 40-44
Author(s):  
Khalada Parvin Deepa ◽  
Nusrat Ghafoor ◽  
Nawshin Siraj ◽  
Md Ziaul Haque ◽  
Md Ubaidul Islam ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
High Resolution ◽  
Diabetic Patients ◽  
Ocular Lens ◽  
Lens Thickness ◽  
Background Retinopathy ◽  
High Resolution Ultrasonography ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Background & objective: The aim of this study was to verify whether the ocular lens of type-2 diabetic retinopathy patients was thicker (measured by high resolution Ultrasonography) than those of non-diabetic individuals.The study also evaluated the differences in lens thickness (LT) between right and left eyes of diabetic retinopathy patients, and the differences in LT between proliferative and background retinopathy cases. Methods: This case-control study was conducted on 68 subjects (34 cases and 34 controls) aged 20-60 years in the Department of Radiology and Imaging, BIRDEM Hospital from March 2015 to February 2016. Adult patients suffering from type-2 diabetic retinopathy confirmed by slit-lamp examination were selected as cases, while apparently healthy subjects were taken as control. Patients with history of heart failure, ocular surgery, acute eye conditions, such as, conjunctivitis, scleritis, cataract or any other co-morbidities were excluded. Ocular mean lens thickness was measured by high resolution ultrasonography and was compared between case and control groups by Un-paired t-Test. Results: The study showed that type 2 diabetic patients had significantly thicker lenses than their non-diabetic counterparts (in right eye:case 4.1 ± 0.3 mm versus control 3.7±0.1 mm, p<0.001 and in left eye:case 4.2 ± 0.3 mm vs. control 3.7±0.1 mm, p<0.001). The study also revealed that proliferative retinopathy cases had thicker lenses than any other diabetic retinopathy groups (p < 0.05) and there was also statistically significant difference of HbA1c level between proliferative and background type II diabetic retinopathy cases (p<0.05) Conclusion: The study concluded that lens thickness is increased in type-2 diabetic retinopathy patients than that in non-diabetic healthy controls.The proliferative diabetic retinopathy cases possess thicker lens than the background retinopathy cases. Ibrahim Card Med J 2020; 10 (1&2): 40-44

scholarly journals Leukocyte Lipid Peroxidation, Superoxide Dismutase and Catalase Activities of Type 2 Diabetic Patients with Retinopathy

2005 ◽  
Vol 48 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Naciye Kurtul ◽  
Ebubekir Bakan ◽  
Hülya Aksoy ◽  
Orhan Baykal
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Increased oxidative stress might play an important role in the initiation and progression of diabetic complications. The present study has been undertaken to investigate whether there is any relationship between retinopathy degree and leukocyte superoxide dismutase (SOD) and catalase (CAT) activities and lipid peroxidation (LPO) in diabetic individuals with type 2 diabetic retinopathy. Patients were groupped with respect to the degree of retinopathy. Leukocyte malondialdehyde (MDA) levels, and SOD and CAT activities were measured in patients with type 2 diabetes mellitus (n=41) and nondiabetic healthy controls (n=23). Leukocyte LPO of the type 2 diabetic patients with retinopathy was significantly increased (p< 0.001), whereas SOD and CAT activities were decreased (p<0.001 and p<0.001, respectively) compared to those of controls. MDA concentrations rose while SOD and CAT activities fell with increasing severity of diabetic retinopathy, altough there was no significant difference in comprasion of the parameters mentioned above between the diabetic patients with and without retinopathy. Our results show that leukocytes in patients with type 2 diabetic retinopathy are affected by oxidative stress which might be contribute to pathogenesis of diabetic retinopathy. Prospective studies are needed to evaulate the relationship between the leukocyte antioxidants status and DR.

scholarly journals THE PREVALENCE AND RISK FACTORS ASSOCIATED WITH TYPE 2 DIABETIC RETINOPATHY IN RWANDA

2021 ◽  
Vol 9 (10) ◽  
pp. 402-410
Author(s):  
A. Niyodusenga ◽  
◽  
T.N. Kiama ◽  
C. Muhizi ◽  
F. Bukachi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Ordinal Data ◽  
Ldl Cholesterol ◽  
Multivariate Logistic Regression Analysis ◽  
Diabetic Patients ◽  
Factors Associated ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Objective: To determine the prevalence and risk factors associated with type 2 diabetic retinopathy in Rwanda. Methods: A case-control study was conducted from January to September 2019 in four hospitals within the Republic of Rwanda. Type 2 diabetic patients were screened for retinopathy. Patients with retinopathy were considered as cases and those without retinopathy as controls. A study sample of 592 participants were enrolled, 66 cases and 526 controls. Diabetic retinopathy was assessed by indirect ophthalmoscopy performed for each eye with a slit-lamp +90D lens. Plasma glucose and Glycated hemoglobin (HbA1c) were measured by colorimetric enzymatic tests. Albuminuria was measured by quantitative spectrophotometric method. Triglycerides, Total, HDL and LDL cholesterol, Urea and Creatinine were assayed by colorimetric methods. A questionnaire was used to assess medical history and demographic status. Data were analyzed by use of SPSS version 20. Statistical analyses were performed by Chi square to show association between nominal and ordinal data. Multivariate logistic regression analysis to select independent variables was performed. Odds ratio was used as a measure of association. Results: The prevalence of diabetic retinopathy in this study population was 11.2%. Independent risk factors associated with diabetic retinopathy were long duration of diabetes, hyperglycemia, LDL cholesterol, triglycerides, and albuminuria. Conclusion: The prevalence of diabetic retinopathy is high and is associated with traditional modifiable risk factors. Early detection and management of diabetes mellitus and these risk factors, combined with good adherence to scheduled eye examination would greatly improve the quality of life of affected patients.

Male Type 2 Diabetic Patients Have Higher Diabetic Retinopathy Prevalence

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 599-P ◽  
Author(s):  
SARA CHERCHI ◽  
ALFONSO GIGANTE ◽  
PIERPAOLO CONTINI ◽  
DANILA PISTIS ◽  
ROSANGELA M. PILOSU ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Male Type ◽  
Type 2 Diabetic

Antihypertensive Drugs and Diabetic Retinopathy in Patients with Type 2 Diabetes

2015 ◽  
Vol 235 (2) ◽  
pp. 87-96
Author(s):  
Jen-Chieh Lin ◽  
Mei-Shu Lai
Keyword(s):  
Diabetic Retinopathy ◽  
Antihypertensive Drugs ◽  
Angiotensin Receptor Blockers ◽  
Incidence Rates ◽  
Diabetic Patients ◽  
Channel Blockers ◽  
Type 2 Diabetic Patients ◽  
Converting Enzyme Inhibitors ◽  
Type 2 Diabetic

Objective: To evaluate the association between the development of sight-threatening diabetic retinopathy (STDR) and antihypertensive drugs (AHDs) use among type 2 diabetic patients with concomitant hypertension. Methods: Type 2 diabetic patients aged 20-100 years who had at least one prescription for AHDs between 2000 and 2011 were identified from the Longitudinal Health Insurance Database (LHID) 2005. The incidence rates of STDR were followed and Cox proportional hazard models were used to analyze the risk associated with AHDs. Results: Users of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) were associated with a significantly higher risk than users of calcium channel blockers (CCBs), independent of baseline characteristics. After adjusting for time-varying use of concomitant medications for propensity score-matched or -unmatched cohorts, the results showed that patients receiving ACEIs/ARBs and CCBs were associated with a significantly greater risk compared with β-blocker users. Conclusions: Our study did not support a superiority of ACEIs/ARBs and CCBs over β-blockers for lowering the progression of diabetic retinopathy.

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