scholarly journals Anti ulcer activity of ethanol extract of the stem bark of Careya arborea Roxb.

2013 ◽  
Vol 2 (3) ◽  
pp. 78-82 ◽  
Author(s):  
Kamal Kumar ◽  
Kenganora Mruthunjaya ◽  
Satish Kumar ◽  
Rajendran Mythreyi
Keyword(s):  
Gastric Juice ◽  
Restraint Stress ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Phytochemical Analysis ◽  
Significant Activity ◽  
Dependent Manner ◽  
Pylorus Ligation ◽  
Cold Restraint Stress ◽  
Cold Restraint

The aim of the study was to determine anti ulcer activity of stem bark of Careya arbore Roxb. on the Wister strain albino rats. Dried stem bark of Careya arbore Roxb. was powdered and this coarse powder was extracted with 70% ethanol by soxhlet extraction method to yield a Ethanol extract of stem bark of Careya aborea Roxb. (EECA). The extract was subjected for preliminary phytochemical analysis and was evaluated for anti ulcer activity against various models such as Ethanol induced, cold restraint stress induced and Pylorus ligation induced models. In acute toxicity study, EECA was found to be safe till 3000mg/kg. So the doses of EECA at various concentration of 300 and 600mg/kg body weight was administered orally, twice daily for 5 days for prevention of ulcer from Pylorus ligation, Ethanol and cold restraint stress - induced ulcers. Analytical parameters like Percentage of Ulcer protection was calculated based on Ulcer index and Gastric juice volume, pH and acidity of gastric juice. Preliminary phytochemical analysis of EECA showed the presence of carbohydrates, glycosides, phytosterols, phenolic compounds, tannins and saponins. The EECA has shown significant activity at both 300mg/kg and 600mg/kg dose level in a dose dependent manner. Phytoconstituents like tannins and saponins may be responsible for anti ulcer activity of EECA.DOI: http://dx.doi.org/10.3329/icpj.v2i3.13633 International Current Pharmaceutical Journal, February 2013, 2(3): 78-82 

scholarly journals Evaluation of Antiulcer Activity of Ethanol Extract of Leaves of Lactuca sativa

2020 ◽  
Vol 10 (4) ◽  
pp. 196-199
Author(s):  
B. Maheswari ◽  
P Rajyalakshmi Devi ◽  
K. Ajith ◽  
P VedPrakash ◽  
K. SeshaSai Gayatri
Keyword(s):  
Peptic Ulcer ◽  
Restraint Stress ◽  
Ethanol Extract ◽  
Experimental Models ◽  
Control Group ◽  
Total Acidity ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Cold Restraint Stress ◽  
Cold Restraint

In this modern era, gastrointestinal disorders are the universal problem. Peptic ulcer is one of the major diseases affecting the human population. It develops due to the imbalance between aggressive factors like acid, pepsin, H. pylori and bile salts and defensive factors like mucous, bicarbonate, blood flow, epithelial cell restoration and prostaglandins. The anti-ulcer activity of Ethanol extract of leaves of Lactuca sativa (EELS) was estimated using the experimental models of acute gastric lesions induced by ethanol, pylorus ligation and cold restraint stress in Wistar albino rats. Animals pre-treated with doses of 250 mg/kg, 500 mg/kg of EELS were statistically analyzed and compared to the standard and control group with the parameters like volume of gastric secretion, total acidity and ulcer index. The results suggested that EELS significantly decreased volume of gastric acid secretion, total acidity and ulcer index in comparison with standard drug Omeprazole. EELS shown significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in Ethanol induced ulcer in experimental models. The gastric mucosal protective effect of EELS is brought by inhibiting the gastric secretion, which shows it may act like a proton pump inhibitor. Thus the present study indicates that EELS has anti-ulcerogenic potency in Ethanol induced, pylorus ligation and cold restraint stress induced ulcers in rats. Keywords: Antiulcer, ulcer index, cold stress, peptic ulcer, pylorus ligation

scholarly journals Evaluation of Antiulcerogenic Activity of Clerodendron Infortunatum Extract on Albino Rat Gastric Ulceration

2019 ◽  
Vol 9 (4-A) ◽  
pp. 57-62
Author(s):  
Arun Kumar ◽  
Rahul Shukla ◽  
Anurag Chaudhary
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Restraint Stress ◽  
Ethanolic Extract ◽  
North India ◽  
Gastric Ulcers ◽  
Albino Rat ◽  
Pylorus Ligation ◽  
Cold Restraint Stress ◽  
Cold Restraint

Clerodendron infortunatum Linn. (Verbenaceae) is an important and widely used medicinal plant, reported to contain active bitter substance like clerodin, has been widely used as tonic and anthelmintic agent in the country sides of North India. Though, variously used in Ayurveda, Unani system of medicine and Homeopathy in case of ailments like diarrhoea, skin disorders, venereal and scrofulous complaints, wounds, post-natal complications, as vermifuge, laxative and cholagogue, for the removal of ascarids in anus, as external applications on tumours, etc., Background: The present study reports the antiulcer properties of 50% ethanolic extract of Clerodendron infortunatum Linn. (Verbenaceae) leaves have assessed in different acute and chronic gastric ulcer models in rats. Methods: EECI (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 days for prevention from ethanol (EtOH), Cold-restraint stress (CRS), Pylorus-ligation (PL) and 10 days for prevention of acetic acid induced ulcers. Results: The EECI showed significant gastric ulcer protective effect in doses of 400 mg/kg, when given twice daily for 5 days against gastric ulcers induced by ethanol (EtOH), cold restraint stress (CRS) and pyloric ligation (PL). EECI showed dose dependent decrease in ulcer index (UI) against ulcers induced by: (i) Ethanol (control UI: 29.52±2.4 mm2/rat, EECI decrease 21.12±2.3 – 5.3±1.0 (ii) Cold restraint stress (CRS) (control UI: 32.13±2.1, EECI decrease 24.02±2.2 – 4.7±1.1 (iii) pylorus ligation (control UI: 29.25±2.4 mm2/rat, EECI decrease 22.32±2.7 – 5.3±1.0, EECI 400 mg/kg significantly healed ulcers induced by 50% acetic acid after 5 (control UI: 32.30 ± 2.9, EECI decrease 26.27±1.9 – 8.56±0.98 and after 10 days treatment (control UI: 29.02 ± 2.6, healing 21.28±2.1 – 5.78±1.2. EECI prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by significant decrease in superoxide dismutase, and increase in catalase activity. Conclusions: Our results show that Clerodendron infortunatum Linn. (Verbenaceae)  possess significant gastro-protective activity which might be due to gastric defence factors and clerodin might be the main constituents responsible for this activity.

scholarly journals Curative Effects of Aqueous and Ethanol Stem Bark Extracts of Vitex doniana on Doxorubicin-Induced Cardiotoxicity in Rats

2021 ◽  
pp. 8-17
Author(s):  
Mohammed A. Sulaiman ◽  
Daniel Dahiru ◽  
Mahmoud S. Jada ◽  
Ahmed I. Hayatu
Keyword(s):  
Oral Treatment ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Traditional Healers ◽  
Serum Marker ◽  
Serum Markers ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Dependent Manner ◽  
Vitex Doniana

Background: Cardiovascular diseases (CVDs) constitute the number one cause of mortality at the global level, representing 30% of all global deaths. Therefore, finding ways to reduce deaths due to CVDs remain an important public health goal. Traditional healers in northern Nigeria use the stem bark of Vitex doniana to treat hypertensive patients. This study was aimed to investigate the cardiocurative potential of Vitex doniana on doxorubicin-induced Cardiotoxicity in rats. Methods: Thirty five (35) adult Albino rats weighing 175 ± 25 g were used, of which 30 were induced with cardiotoxicity by intraperitoneal injection of doxorubicin (10 mg/kg) for three consecutive days. Rats were treated by oral administration of Silymarin (100 mg/kg) and Vitex doniana aqueous or ethanol extract (100 mg/kg and 200 mg/kg) for 14 consecutive days and thereafter were sacrificed on the 15th day. Blood, plasma and serum were analyzed for lipid profile and serum markers for cardiotoxicity. Results: Phytochemical analysis of the extracts showed the presence of alkaloids, tannins, flavonoids, steroids, phenols, saponins, terpenoids and glycosides. Oral treatment with Vitex doniana extracts significantly (p<0.05) lowered the elevated levels of total cholesterol, triglycerides and LDL but significantly (p<0.05) increased the level of HDL (18.61 ± 0.55 mg/dl to 57.98 ± 0.78 mg/dl). The extracts also significantly (p<0.05) decreased the levels of serum marker enzymes for cardiotoxicity ALT, AST, CK – mb and LDH. Conclusion: The prophylactic cardiocurative use of Vitex doniana stem bark has been confirmed in this study as the extracts exhibited hypolipidemic and cardiocurative effects in dose dependent manner in doxorubicin-induced cardiotoxicity rat model.

scholarly journals CAESALPINIA DECAPETALA

2013 ◽  
Vol 20 (03) ◽  
pp. 478-484
Author(s):  
MUHAMMAD KASHIF BAIG ◽  
IRAM IRSHAD ◽  
FAIZA NASEER
Keyword(s):  
Structural Changes ◽  
Ethanol Extract ◽  
Hepatoprotective Activity ◽  
Phytochemical Analysis ◽  
Dependent Manner ◽  
Medical College ◽  
Study Materials ◽  
Sinusoidal Dilatation ◽  
Histopathological Studies ◽  
Animal House

Members of genus Caesalpinia are found world widely in tropical and temperate areas. Caesalpinia species have variouspharmacological actions that include antidiabetic, antiulcer, anticancer, anti-inflammatory, antimicrobial and antirheumatic. Objectives:To assess the Hepatoprotective activity of ethanol extract of Caesalpinia decapetala. Duration of study: September 2012 to November2012. Setting: Pharmacology and Pathology departments of Independent medical college and animal House of university of agriculture,Faisalabad. Study design: Experimental study. Materials and Methods: Hepatoprotective activity was determined by measuring the livermarker enzymes like Bilirubin, AST, ALT and ALK levels and then hepatic biopsy to see any structural changes. Phytochemical analysis ofplant extract indicates that it contains polyphenols and flavonoids that possess antioxidant potential and hence possess Hepatoprotectiveactivity. Results: Liver enzyme levels were significantly raised in rabbits receiving paracetamol and the enzyme levels were significantlyreduced in rabbits who were receiving Caesalpinia Decapetala and paracetamol comparable to silymarin and Paracetamol. Resultsobservation was done in concentration and dose dependent manner. Histopathological studies indicated centrizonal and focal necrosisand ballooning in liver of rabbits treated with paracetamol. It showed only mild steatosis with sinusoidal dilatation and binucleate cells ingroups receiving Caesalpinia decapetala. Conclusions: It is concluded that Caesalpinia decapetala possesses significantHepatoprotective activity.

scholarly journals Gastroprotective effects of nebivolol and simvastatin against cold restraint stress-induced gastric ulcer in rats

2020 ◽  
Vol 53 (3) ◽  
pp. 301-312
Author(s):  
Samaa Samir Kamar ◽  
Noha Samir Abdel Latif ◽  
Mohamed Fathi Mohamed Elrefai ◽  
Shaimaa Nasr Amin
Keyword(s):  
Gastric Ulcer ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

Protective effect of hydrogen sulfide against cold restraint stress-induced gastric mucosal injury in rats

2013 ◽  
Vol 36 (12) ◽  
pp. 1507-1515 ◽  
Author(s):  
Esam M. Aboubakr ◽  
Ashraf Taye ◽  
Mohamed A. El-Moselhy ◽  
Magdy K. Hassan
Keyword(s):  
Hydrogen Sulfide ◽  
Protective Effect ◽  
Restraint Stress ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Cold Restraint Stress ◽  
Cold Restraint
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