scholarly journals Hearing and Kidney: Effects of Chronic Kidney Disease on Various Auditory Parameters – Results from a Tertiary Care Hospital in India

2019 ◽  
Vol 21 (1) ◽  
pp. 31-35
Author(s):  
Deepak Jain ◽  
HK Aggarwal ◽  
Shailesh Bhatia ◽  
Jaikrit Bhutani
Keyword(s):  
Chronic Kidney Disease ◽  
Hearing Loss ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Care Hospital ◽  
Auditory Function ◽  
Auditory Evoked Response ◽  
Patient Groups

Background: An association between chronic kidney disease (CKD) and hearing loss was first described in patients with Alport syndrome. Patients with CKD develop sensorineural hearing loss with the progression of the disease. Studies using BAER as an index of auditory function among patients with CKD showed evidence of various degrees of auditory dysfunction. Materials and methods: 100 adult CKD patients (stage 3 – 5 and 5D) and 50 controls were included in the study. Clinical and biochemical parameters were assessed and all the patients and controls underwent Pure Tone Audiometry (PTA) and Brainstem Auditory Evoked Response (BAER) evaluation. Results: When hearing thresholds were compared between the patients and controls PTA showed an increase in hearing threshold in all patient groups. This increase was more noticeable at higher frequencies (4 and 8 kHz). Compared with healthy controls, a highly significant delay was observed in CKD patients in both absolute and interpeak latencies in BAER in the present study. Conclusion: The present study provides a concrete evidence to the otherwise disputed relation of auditory function in CKD proving that hearing is permanently affected by ESRD at all levels of the auditory neural pathway. J MEDICINE JAN 2020; 21 (1) : 31-35

To Study the Effect of Chronic Kidney Disease on Hearing Function of the Patients in a Tertiary Care Centre of North India

2021 ◽  
Vol 8 (36) ◽  
pp. 3288-3293
Author(s):  
Jasneet Kaur Sodhi ◽  
Vanita Sarin ◽  
Manish Chandey
Keyword(s):  
Chronic Kidney Disease ◽  
Hearing Loss ◽  
Kidney Disease ◽  
Sensorineural Hearing Loss ◽  
Tertiary Care ◽  
Pure Tone Audiometry ◽  
Sensorineural Hearing ◽  
Structural Level ◽  
Mild Degree ◽  
The Mean

BACKGROUND Chronic kidney disease (CKD) encloses a continuum of pathophysiological processes associated with deranged kidney function and a progressive decrease in glomerular filtration rate (GFR). There are many anatomic similitudes between cochlea and kidney at an ultra-structural level and antigenic level along with comparable physiological mechanisms, specifically, the active fluid and electrolytes transport in the cochlea and the kidney. The purpose of the present study was to determine the proportion, type and degree of hearing loss in patients with renal disease and its comparison according to the stage of CKD. METHODS The study was conducted on 60 patients of chronic kidney disease labelled as stage 3, 4 and 5 on the basis of GFR. An audiogram charted by pure tone audiometry was used to find the degree of hearing loss and its comparison in patients with moderate, severe and end stage CKD was done. The data was collected and analysed statistically. RESULTS The mean age of patients was 55.58 +/- 11.36 years and the mean duration of CKD was 15.61 months. 90 % patients of CKD had sensorineural hearing loss while 10 % had hearing sensitivity within normal limits. In the present study, mild degree hearing loss and high frequency hearing loss was found to be predominant constituting 68.3 % (n = 41) and 58.3 % (n = 35) respectively. Mild degree of hearing loss was a predominant finding irrespective of the stage and duration of CKD. CONCLUSIONS Sensorineural hearing loss was found predominantly amongst the CKD patients in our study population. Mild degree hearing loss was predominant but there was no correlation between stage of CKD and degree of hearing loss. While there was a significant correlation between degree of hearing loss with duration and haemodialysis amongst the non-diabetic CKD patients. KEYWORDS Chronic Kidney Disease, Sensorineural Hearing Loss

Correlation of Iron Profile with Different Stages of Chronic Kidney Disease in Children Presenting at a Tertiary Care Hospital

2021 ◽  
Vol 15 (8) ◽  
pp. 2013-2016
Author(s):  
Shahid Ishaq ◽  
Muhammad Imran ◽  
Hashim Raza ◽  
Khuram Rashid ◽  
Muhammad Imran Ashraf ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Tertiary Care ◽  
Transferrin Saturation ◽  
Maintenance Hemodialysis ◽  
Care Hospital ◽  
Iron Profile

Aim: To determine correlation of iron profile in children with different stages of chronic kidney disease (CKD) presenting to tertiary care hospital. Methodology: A total of 81 children with chronic kidney disease stage having glomerular filtration rate (GFR) less than 90 (ml/min/m2) aged 1 – 14 years of either sex were included. Three ml serum sample was taken in vial by hospital duty doctor for serum ferritin level, serum iron, transferrin saturation and total iron binding capacity. The sample was sent to hospital laboratory for reporting. Iron profiling was done evaluating hemoglobin (g/dl), serum iron (ug/dl), serum ferritin (ng/ml), transferrin saturation (%) and total iron binding capacity (ug/dl) while iron load was defined as serum ferritin levels above 300 ng/ml. Correlation of iron profile with different stages of CKD was determined applying one-way analysis of variance (ANOVA). Results: In a total 81 children, 46 (56.8%) were boys while overall mean age was 7.79±2.30 years. Mean duration on hemodialysis was 11.52 ± 9.97 months. Iron overload was observed in 26 (32.1%) children. Significant association of age above 7 years (p=0.031) and residential status as rural (p=0.017) was noted with iron overload whereas iron overload was increasing with increase in stages of CKD (p=0.002). Hemoglobin levels decreased significantly with increase in stages of CKD (p<0.001). Serum iron levels increased significantly with increase in the CKD stages (p=0.039). Serum ferritin levels were increasing significantly with the increase in CKD stages (p=0.031). Transferrin saturation also increased significant with increase in CKD stages (p=0.027). Conclusion: High frequency of iron overload was noted in children with CKD on maintenance hemodialysis and there was linear relationship with stages of CKD and iron overload. Significant correlation of hemoglobin, serum iron, serum ferritin and transferrin saturation was observed with different stages of CKD. Keywords: Iron overload, maintenance hemodialysis, ferritin level.

scholarly journals Cochlear function in patients with chronic kidney disease

2013 ◽  
Vol 60 (1) ◽  
Author(s):  
Samantha Marlanie Govender ◽  
Cyril Devdas Govender ◽  
Glenda Matthews
Keyword(s):  
Chronic Kidney Disease ◽  
Hearing Loss ◽  
Kidney Disease ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Drug Intake ◽  
Cochlear Function ◽  
Distortion Product ◽  
Cochlear Dysfunction

Objective: To evaluate cochlear functioning in patients (18 - 45 years old) with varying stages of chronic kidney disease (CKD). Using purposive sampling, 50 participants, 10 in each of the 5 stages of CKD, were selected and underwent pure tone audiometric testing and distortion product otoacoustic emissions (DPOAEs).Results: Significant differences (p<0.05) were found between pure tone audiometry and DPOAEs in detecting early cochlear dysfunction in the high-frequency range in stages 3 (6 000/5 000 Hz; p=0.00), 4 (6 000/5 000 Hz; p<0.03) and 5 (4 000/3 333 Hz; p<0.01, 8 000/6 667 Hz:p<0.05) with DPOAEs being more sensitive in identifying early cochlear dysfunction. Patients in stages 1 and 2 presented with normal puretone thresholds and DPOAEs, suggesting that cochlear functioning in these patients was normal. Early cochlear dysfunction, thereby indicating a subclinical hearing loss, was identified in stages 3, 4 and 5 by DPOAE testing. In addition, blood test results, drug intake and concomitant conditions were recorded and analysed which suggested a relationship between reduced cochlear functioning and increased electrolyte levels, treatment regimens and concomitant conditions.Conclusion: Participants in the later stages of CKD presented with early cochlear dysfunction, presenting with subclinical hearing loss. It was postulated that this subclinical hearing loss resulted from a combination of electrolytic, urea and creatinine imbalances, together with concomitant medical conditions and ototoxic drug intake. It was concluded that audiological monitoring be included in the management of patients with CKD and that DPOAEs be introduced as part of the test battery to monitor cochlear function in patients with varying degrees of CKD.

scholarly journals A study of secondary hyperparathyroidism in patients with chronic kidney disease in a tertiary care hospital

2019 ◽  
Vol 6 (2) ◽  
pp. 271
Author(s):  
Vishnu Shankar H. ◽  
Mahendra Kumar K. ◽  
Jagadeesan M. ◽  
Kannan R. ◽  
Chitrambalam P. ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Secondary Hyperparathyroidism ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Study Population ◽  
Chronic Morbidity ◽  
Spss Software

Background: Secondary hyperparathyroidism (SHPT) is one of the less recognized complications in patients with chronic kidney disease (CKD). The prevalence of SHPT in various stages of CKD was evaluated by measuring the levels of intact parathyroid hormone (iPTH).Methods: This cross-sectional study was carried out in 100 CKD patients. Serum creatinine, calcium, phosphorous and iPTH levels were measured and statistical analysis was carried out using the SPSS software (IBM, NY, USA).Results: Among the 100 participants, the mean age (SD) was 59.3 (7.8) years. In our study population, 52% were men and the rest were females. Hypertension (75%) was the most common chronic morbidity. Prevalence of hyperparathyroidism among chronic kidney disease patients was 22% (95% CI: 14.7-30.9%). The prevalence of secondary hyperparathyroidism among dialysis and non-dialysis patients were 30% and 14% respectively which was statistically significant.Conclusions: SHPT is an important complication which is often underdiagnosed. Secondary hyperparathyroidism starts to develop when eGFR falls below 60ml/min. PTH levels starts to rise as the disease progress. Hence it is important for the treating physicians to monitor the PTH levels early in the course of CKD to prevent and treat bone mineral disease.

scholarly journals HEMATOLOGICAL PROFILE IN PATIENTS OF CHRONIC KIDNEY DISEASE WITH ITS SEVERITY IN A TERTIARY CARE HOSPITAL, NORTH ODISHA

2020 ◽  
pp. 182-187
Author(s):  
BIBHU PRASAD BEHERA
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Microcytic Anemia ◽  
Treatment Modalities ◽  
Unknown Etiology ◽  
Care Hospital ◽  
College Hospital ◽  
Correct Treatment

Objective: Efforts can be made to normalize the hematological parameters and slow the progress of the disease so that the morbidity and mortality in these patients with chronic kidney disease could be effectively reduced. Methods: The observational study was carried out in the Department of General Medicine, Pandit Raghunath Murmu Medical College Hospital, Baripada, between May 2018 and January 2019. Two hundred seventy patients of chronic kidney disease (CKD) above 15 years of age, satisfying the inclusion and exclusion criteria, were included in the study. Results: In our study, 179 (66.30%) were male, and 91 (33.70%) were female with M:F of 1.97:1. The average age of the patients in the study was 55.72±12.77 years. About 42.59 % (115) of the patients were between 46 and 60 years of age. About 35.56% of CKD cases had determined etiology and, 64.44% of cases had unknown etiology. Hemoglobin, RBC, and packed cell volume were significantly lower in the patients with CKD compared to the controls (p=0.0001), and RDW was considerably higher in the patients with CKD compared to the controls (p=0.0001). Microcytic anemia was the most prevalent type of anemia. There was a hugely significant association between the prevalence of thrombocytopenia and the severity of CKD (p=0.006). Conclusion: This study concluded that patients with CKD show abnormal hematological parameters. Evaluation of hematological parameters in these patients helps in classifying the type of anemia, aids in choosing the correct treatment modalities, and decreases mortality.

scholarly journals A prospective study of peripheral arterial diseases in chronic kidney disease patient attending tertiary care hospital Andhra Pradesh

2021 ◽  
Vol 8 (7) ◽  
pp. 974
Author(s):  
Ramswarup K. Jawaharlal ◽  
Vamsi Krishna Mootha
Keyword(s):  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
Tertiary Care ◽  
Ankle Brachial Index ◽  
Disease Patient ◽  
Care Hospital ◽  
Male Predominance ◽  
Peripheral Arterial Diseases ◽  
History Of

Background: Around 10% populations worldwide develop chronic kidney disease and two million people require frequent dialysis due to it1. Cardiovascular diseases related complications are more common in chronic kidney patients and responsible for greater morbidity and mortality. This study is designed to determine the peripheral artery disease in patients with chronic kidney disease in our clinical setup and risk factor associated with them.Methods: In present study 140 patients with chronic kidney disease were enrolled for this study. Demographic profile of each patient was recorded. Detailed history of patients regarding claudication was taken. Ankle-brachial index was calculated in each patient with CKD for diagnosis of PAD based on American heart association guideline.Results: There was male predominance. History of smocking was present in 80 (57.14%) patients and absent in 60 (42.85%) patients. Symptom of PAD was present in 28 (20%) patients and absent in 114(80%) patients. Ankle-Brachial Index was positive in 38(27.14%) patients and absent in 102 (72.85%) patients. 80 (57.14%) patients were in stage 3 and 24 (17.14%) patients were in stage 4. Diabetes mellitus was present in 26 (18.57%) patients, Hypertension was present in 64 (45.71%), IHD was present in 22 (15.71%) remaining have no risk factor.Conclusions: From present study we can conclude that PAD was common in CKD patients more than 50 years of age and here is male predominance. It is more common in smoker and in most of the patients it was asymptomatic. Prevalence of PAD was 27.14% in CKD patients. In our study PAD was more common in stage 3 CKD and least common in stage 2, and cardiovascular risk factor was more common in PAD patients then CKD in general.

scholarly journals Demographic Profile of Hearing Deficiency in a peripheral referral hospital- A Five Year Study

2019 ◽  
Vol 27 (1) ◽  
pp. 29-35
Author(s):  
Amit Chakrabarti ◽  
Indranil Sen ◽  
Rupam Sinha ◽  
Manish Kumar ◽  
Rabi Hembrom ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Pure Tone Audiometry ◽  
Common Type ◽  
Sensorineural Hearing ◽  
Care Hospital ◽  
Bilateral Hearing Loss ◽  
Mild Degree ◽  
Study Population

Introduction: This present study is an attempt to study the demographic characteristics of individuals presenting with hearing loss in a peripheral tertiary care hospital using the available database of pure tone audiometry results. Materials and methods: A retrospective, observational, descriptive study was conducted over a period of 5 years in the Department of ENT of a peripheral tertiary care hospital wherein all subjects having a pure tone audiometry were included in the study. The records of PTA done were analyzed followed by systematic analysis. Results: A total of 9790 individuals inclusive of 5566 males and 4224 females were studied. Maximum no of individuals belonged to the age group of 21-30 years. Nearly 63% of total subjects suffered from Bilateral hearing loss. Sensorineural hearing loss was most prevalent type of loss. Mild degree of loss was most prevalent. Adolescents and young adults comprised the bulk of the study population. Sensorineural hearing is the most common type. Bilateral hearing loss is more frequent. Mild degree of loss is most frequent. Conclusion: This study emphasized the ‘Composite parameter distribution’ in addition to the classical single parameter demographic profile of deafness in a remote tertiary care hospital. Adolescents and young adults comprised the bulk of the study population. Sensorineural hearing is the most common type. Bilateral hearing loss is more frequent. Mild degree of loss is most frequent.

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