scholarly journals Study of Thyroid Hormone Status in Normal Newborn and Preterm, Low Birth Weight Baby

KYAMC Journal ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 787-790
Author(s):  
Tanvir Iqbal ◽  
M Obaidulla Ibne Ali ◽  
Nur E Atia ◽  
Tahorul Islam

Background: Screening for thyroid hormones in the newborn baby is extremely important to detect the newborns who are borned with hypofunctional state of thyroid gland. This screening program in first few weeks of life is essential to prevent serious complications of hypothyroidism in future such as mental retardation.Objective: To assess the thyroid hormone levels in normal newborn and preterm, low birth weight babies and comparison of thyroid dysfunction between these two groups.Method: This cross - sectional analytical type of study was conducted in the department of physiology and paediatrics of Rajshahi Medical College & Hospital (RMCH) from July 2015 to June 2016. A total of 70 newborn baby were enrolled by systematic sampling of which 40 were normal healthy newborn and 30 were preterm, low birth weight babies. Data was collected from the parents and they were filled out standard questionnaire. Then venous blood was collected from each and every neonate and blood was sent to laboratory for estimation of thyroid hormone levels. FT4 and TSH values were estimated as these two are the most important parameters for determination of thyroid function.Result: In this study, the mean (±SD) serum FT4 level in term and preterm neonates were 14.17±2.14 and 12.25±3.16 (pg/ml) respectively. This FT4 value is significantly higher in term neonates than preterm neonates (P<0.05). The mean (±SD) serum TSH level in term and preterm neonates were 3.37±2.12 and 4.23±3.23 (?IU/ml) respectively. Statistically there was no significant difference in TSH values between these two groups (P 0.05).Conclusion: From this study it was evident that preterm, low birth weight babies are more likely to develop hypofunctional state of thyroid gland than normal term babies. The newborns who were found hypothyroid, were informed to their parents for consultation with the concerned physicians. The physicians then took necessary steps to correct the hypofunctional state of thyroid gland.KYAMC Journal Vol. 7, No.-2, Jan 2017, Page 787-790

2018 ◽  
Vol 26 ◽  
pp. 20-23
Author(s):  
M Obaidulla Ibne Ali ◽  
Tanvir Iqbal ◽  
Nur E Atia ◽  
Tohorul Islam ◽  
K Khanam

Background : Screening for thyroid hormones in the newborn baby is extremely important to detect the newborns who are born with hypofunctional state of thyroid gland. This screening program in first few weeks of life is essential to prevent serious complications of hypothyroidism in future such as mental retardation. Objective : To assess the thyroid hormone levels in normal newborn and preterm, low birth weight babies and comparison of thyroid dysfunction between these two groups.Method : This cross - sectional analytical type of study was conducted in the department of physiology and paediatrics of Rajshahi Medical College & Hospital ( RMCH) from July 2015 to June 2016. A total of 70 newborn baby were enrolled by systematic sampling of which 40 were normal healthy newborn and 30 were preterm, low birth weight babies. Data was collected from the parents and they were filled out standard questionnaire. Then venous blood was collected from each and every neonate and blood was sent to laboratory for estimation of thyroid hormone levels. FT4 and TSH values were estimated as these two are the most important parameters for determination of thyroid function.Result : In this study, the mean (±SD) serum FT4 level in term and preterm neonates were 14.17±2.14 and 12.25±3.16 (pg/ml) respectively. This FT4 value is significantly higher in term neonates than preterm neonates (P< 0.05). The mean (±SD) serum TSH level in term and preterm neonates were 3.37±2.12 and 4.23±3.23 (μIU/ml) respectively. Statistically there was no significant difference in TSH values between these two groups (P≥0.05).Conclusion : From this study it was evident that preterm, low birth weight babies are more likely to develop hypofunctional state of thyroid gland than normal term babies. The newborns who were found hypothyroid, were informed to their parents for consultation with the concerned physicians. The physicians then took necessary steps to correct the hypofunctional state of thyroid gland.TAJ 2013; 26: 20-23


Author(s):  
J H Parr

Serum concentration of free T3 and, in female patients, FT4, were found to be lower in 20 asymptomatic, moderately-poor or well controlled, diabetics treated with insulin than in a group of non-diabetic subjects. Over a mean 3-month period of the study a significant fall occurred in HbA1 concentration in both groups of diabetics without change in free thyroid hormone levels. The mean capillary blood glucose, fasting free insulin and fasting lipid concentrations, other than high density lipoprotein (HDL) cholesterol, did not change. No correlations were found between the changes in HbA1 and free thyroid hormone concentrations. Improvement in long term metabolic control did not influence free thyroid hormone levels in well controlled and moderately-poor controlled diabetics, taking insulin.


2007 ◽  
Vol 92 (1) ◽  
pp. 208-211 ◽  
Author(s):  
Giorgos S. Metsios ◽  
Andreas D. Flouris ◽  
Athanasios Z. Jamurtas ◽  
Andres E. Carrillo ◽  
Demetrios Kouretas ◽  
...  

Abstract Context: Active smoking influences normal metabolic status and thyroid function. Objective: The objective was to assess experimentally the effects of 1 h of moderate passive smoking in a controlled simulated bar/restaurant environment on the metabolism and thyroid hormone levels in healthy nonsmokers. Participants: Eighteen (nine females, nine males) healthy individuals (mean ± sd: age, 25.3 ± 3.1 yr; height, 174.0 ± 10.1 cm; weight, 65.2 ± 13.7 kg) participated in the study. Design: In repeated-measures randomized blocks, participants visited the laboratory on 2 consecutive days. In the experimental condition, they were exposed to 1 h of moderate passive smoking at a carbon monoxide concentration of 23 ± 1 ppm in an environmental chamber, whereas in the control condition participants remained in the same chamber for 1 h breathing normal atmospheric air. Main Outcome Measures: In both conditions, cotinine serum and urine levels, resting energy expenditure (REE), as well as concentration of T3, free T4, and TSH were assessed before participants entered the chamber and immediately after their exit. Heart rate and blood pressure were tested in 10-min intervals during all REE assessments. Results: The mean ± sd difference of serum and urine cotinine levels (−0.27 ± 3.94 vs. 14.01 ± 6.54 and 0.05 ± 2.07 vs. 7.23 ± 3.75, respectively), REE (6.73 ± 98.06 vs. 80.58 ± 120.91) as well as T3 and free T4 (0.05 ± 0.11 vs. 0.13 ± 0.12 and 0.02 ± 0.15 vs. 0.22 ± 0.20) were increased in the experimental compared with the control condition at baseline and follow-up (P &lt; 0.05). No statistically significant variation was observed in the mean difference of the remaining parameters (P &gt; 0.05). Serum and urine cotinine values were linearly associated with REE (P &lt; 0.05). Conclusion: One hour of passive smoking at bar/restaurant levels is accompanied by significant increases in metabolism and thyroid hormone levels.


2019 ◽  
Vol 1 (2) ◽  
pp. 6-9
Author(s):  
Ika Nur Sapurtri ◽  
Dwi Handayani ◽  
Maharani Nazmi Nasution

Babies with low birth weight have a temperature that is unstable and prone to hypothermia (temperature <36,5ºC). Cold stress can increase mortality and hamper growth. The warmth of the mother's body or a known method of kangaroo care proved to be an effective heat source for infants born at term or low birth weight. This study aims to determine whether there is influence kangaroo care method to your body temperature low birth weight infants. This type of research is pre experiment with models (one group pre-post test design). The population of this research is all low birth weight babies. Sampling techniques in use purposive sampling, that the sampling technique was based on sample criteria specified by the researchers themselves. In this case the samples found as many as 22 people. Data analysis using paired sample t-test with a level of 95%. The results of this study gained an average prior to 34.7 kangaroo care method, after doing kangaroo care method 36.9. The mean before and after kangaroo care method 2.2273. Based on the analysis results showed pvalue (0.004) <α (0.05), It can be concluded no treatment effect kangaroo method to your body temperature low birth weight infants. Recommendations from this research is the kangaroo care method can be used as one LBW care that can be done by the mothers in raising and maintaining body temperature.


2007 ◽  
Vol 26 (4) ◽  
pp. 253-259 ◽  
Author(s):  
Robin Knobel

SCREENING THYROID HORMONE levels in the neonate during the first week of life is important because of their valuable link in identifying congenital hypothyroidism (CH), a condition that leads to mental retardation if left untreated. However, if CH is diagnosed early, it can be treated.


2017 ◽  
Vol 4 (3) ◽  
pp. 979
Author(s):  
Gowri S. ◽  
Kumar G. V.

Background: Gestational age and birth weight are the two most useful parameters for assessing maturity of the newborn. Major causes of neonatal mortality are diseases associated with low birth weight babies (LBW). It has been shown that foot length measurement is particularly valuable in premature babies who are so ill that conventional anthropometric measurements cannot be carried out due to the incubator and intensive care apparatus. Methods: The cross-sectional study was conducted in the department of pediatrics Sri Siddhartha Medical College Hospital, Tumkur, India. The birth weight in grams and length of the foot were documented in centimeters. Data was collected using standard proforma.Results: A total of 600 neonates were studied of which, males were 54.67 % (328) and females were 45.33 % (272). The neonates weighing less than 2.5 kg had a mean foot length of 6.94. The mean foot length for neonates weighing between 2.5 to 3.5 was 7.68. The mean foot length for neonates weighing more than 3.5 kg was 8.2cm. The correlation coefficient of birth weight with foot length was maximum in low birth weight babies (r= 0.94).Conclusions: The foot length is an efficient screening tool in identifying low birth weight babies. Foot length is a simple, quick and reliable anthropometric measurement which can be used as a proxy measurement to birth weight especially in sick and pre-term neonates receiving intensive care. 


2021 ◽  
Vol 4 (3) ◽  
pp. 121-138
Author(s):  
Adeosun L.T. ◽  
Amosu A.M.

Introduction: Globally, low birth weight remains a public health challenge and is a major risk factor for infant mortality. Therefore, this study investigated the factors associated with low birth weight babies delivered in health facilities within Abuja, Nigeria. Methodology: Secondary data from January 2017 to December 2020 was extracted from 330 delivery records in ten (10) Primary Health Care centres to assess the determinants of low birth weight babies born in Abuja. Findings: The results showed that the mean age of mothers was 27.8 ± 5.1. Majority of the mothers (93.6%) were between 16 and 35 years of age, 93.6% were married, 67% were Christians, 23.3% had no formal education, 31.5% were housewives and 75.8% lived in rural communities. The mean birth weight of babies was 3.05 ± 0.55 kg and 20.3% of the babies had low birth weight compared to 79.7% with normal weights at birth. Maternal age, p=0.02; marital status, p=0.02; religion, p=001; occupation, p=0.001; and weight, p=0.000 were found to be significantly associated with having LBW babies. Maternal obstetric characteristics such as birth spacing, p=0.00; haematocrit level, p=0.001; pregnancy termination, p=0.001; and medical conditions, p=0.00 were also significantly associated with birth weight. Conclusion: The study reported a high prevalence of low birth weight; it also revealed the protective effects of being married on LBW. However, being a housewife significantly increased the risk for having a low birth weight baby.


2019 ◽  
Vol 6 (6) ◽  
pp. 2242
Author(s):  
Balai Ch. Karmakar ◽  
Ramesh Ch. Kalder

Background: Advancement of skill, technology and perinatal medicine has led to improve survival of low birth weight babies during the last few decades but they have reported high incidence of growth failure during infancy and early childhood. The objective of the study was to find out the influence of perinatal risk factors on anthropometric outcome.Methods: A prospective cohort study conducted on 143 ELBW and VLBW babies admitted in Sick Newborn Care Unit (SNCU and PICU) of North Bengal Medical College and Hospital (NBMC), Darjeeling, West Bengal from 2016 to 2017 and discharged babies were followed up.Results: Total 143 neonates were studied at NBMC among male 82(57.3%) and female 61(42.7%), 95 were AGA and 48 were SGA babies. Significant positive correlations were found among birth weight, gestational age, perinatal infection (p<0.001). The mean weight for age (Mean±SD) was 7.615±1.1092 kg with median 7.8 kg. The mean length for age (Mean±SD) was 72.6±3.74 cm with median 73 cm. The mean head circumference for age (Mean±SD) was 42.5±2.12 cm median 43 cm. Adverse neonatal outcome associated with CRIB II score ≥10. Total CRIB II score with parameters of growth (<-2 Z score) like weight for age, length for age, weight for length and head circumference for age shows significant correlation (p<0.001).Conclusions: Perinatal risk factors are important determinant for future anthropometric outcome in very low and extremely low birth weight babies. They should be identified, and appropriate measures should be taken to achieve good outcome.


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