scholarly journals Emulsi Sereh Wangi untuk Konservasi Cagar Budaya Berbahan Batu dan Bata

2021 ◽  
Vol 15 (2) ◽  
pp. 18-33
Author(s):  
Sri Wahyuni
Keyword(s):  
Tween 80 ◽  
Disodium Salt ◽  
National Bureau

Cagar budaya berbahan batu terletak di dalam ruangan maupun di luar ruangan sangat rentan terhadap kerusakan dan pelapukan. Kerusakan dan pelapukan pada cagar budaya dapat disebabkan oleh faktor internal yaitu material penyusun benda itu sendiri maupun faktor eksternal yaitu lingkungan benda itu berada. Jenis kerusakan dan pelapukan terdiri dari fisis, kimia dan biologi. Pelapukan yang terjadi pada cagar budaya berbahan batu akibat faktor biologi disebabkan oleh pertumbuhan ganggang/algae, lumut/moss, lumut kerak/lichen. cara mengatasi lumut selama ini dilakukan dengan pembersihan secara mekanis kering, mekanis basah dan bahan kimia menggunakan hyvar XL. Sedangkan untuk mengatasi lumut kerak/lichen secara kimiawi dengan menggunakan AC 322 terdiri dari ammonium bikarbonat, sodium bikarbonat, disodium salt EDTA, CMC, Arkopal dan air. pembersihan dengan cara mekanis kering dan basah tidak mengatasi pertumbuhan lumut karena bersifat hanya memindahkan spora tidak membunuh lumut. Sedangkan penggunaan bahan kimia seperti Hyvar XL dan AC 322 dapat mencemari lingkungan. Bahan yang diuji sebagai bahan alternatif ramah lingkungan untuk membunuh koloni lumut dan lumut kerak/lichen adalah emulsi sereh wangi.  Emulsi sereh wangi terdiri dari minyak atsiri sereh wangi dan surfaktan tween 80. Variasi konsentrasi bahan yang diujikan yaitu 3%, 5%, 7% dan 10% dengan konsentrasi surfaktan tween 80 sebesar 5%. Pengujian bahan skala lapangan dengan cara penyemprotan bahan pada batu yang ditumbuhi koloni lumut dan lumut kerak/lichen.  Parameter yang diamati adalah pengamatan visual terhadap perubahan warna, nilai ΔE perubahan warna sebelum dan setelah dilakukan pengujian, dan dampak penggunaan emulsi sereh wangi 10%  pada batu segar. Hasil pengujian yang telah dilakukan menunjukkan bahwa penggunaan emulsi sereh wangi dapat menjadi bahan alternatif ramah lingkungan untuk membunuh koloni lumut pada cagar budaya berbahan batu. Bahan emulsi sereh wangi konsentrasi 3%, 5%, 7% dan 10% secara visual atau kualitatif dapat membunuh lumut dalam durasi kontak 24 jam dan  emulsi sereh wangi konsentrasi 5%, 7%, dan 10% dapat membunuh lumut kerak/lichen dalam durasi kontak 48 jam, dilihat dari perubahan warna lumut dari hijau menjadi kecoklatan dan layu mengering.  Sedangkan secara kuantitatif pengukuran perubahan warna dengan menggunakan alat kolori meter dilihat nilai LAB kemudian dihitung nilai ΔE dengan software colortool. Perubahan warna lumut setelah kontak 24 jam dengan emulsi sereh wangi konsentrasi 10%, dilihat dari nilai ΔE2000 sebesar 8,5721 sedangkan perubahan warna lumut kerak/lichen setelah kontak 48 jam denilai ΔE2000 sebesar 7,2063. Untuk mengetahui dampak penggunaan bahan terhadap batu bersih/segar, kontak dengan bahan selama 6 hari dilakukan pengukuran nilai ΔE2000 sebesar 3,4592, penggunaan bahan emulsi sereh wangi 10% tidak merubah warna batuan. Berdasarkan National Bureau of Standards GB7705-87 (National Institute of Standards and Technology), suatu benda dikatakan memiliki warna yang sama jika memiliki nilai ΔE ≤6.

Uji aktivitas antijamur ekstrak etanol Eleutherine americana Merr. terhadap Microsporum canis secara in vitro

2019 ◽  
Vol 5 (4A) ◽  
pp. 1497
Author(s):  
Buana Dewanti Wimpi ◽  
Diana Natalia ◽  
Effiana Effiana
Keyword(s):  
Tween 80 ◽  
Microsporum Canis ◽  
Eleutherine Americana

Latar Belakang: Dermatofitosis adalah suatu kondisi penyakit yang ditandai dengan infeksi pada jaringan berkeratin seperti epidermis, rambut dan kuku. Kondisi ini disebabkan oleh sekelompok jamur berfilamen terkait yang dikenal sebagai dermatofita. Bawang dayak (Eleutherine americana Merr.) merupakan tanaman berumbi merah yang mengandung senyawa bioaktif yang memiliki kemampuan menghambat pertumbuhan jamur golongan dermatofita. Metode: Umbi bawang dayak diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Uji aktivitas antijamur menggunakan metode difusi cakram Kirby-Bauer dengan 5 variasi konsentrasi yaitu 60%, 30%, 15%, 7,5% dan 3,75%. Kontrol positif yang digunakan adalah itrakonazol 8 µg/disk sedangkan kontrol negatif yang digunakan adalah pelarut Tween 80 sebesar 10%. Hasil: Ekstrak umbi bawang dayak mengandung senyawa metabolit sekunder berupa saponin, kuinon, flavonoid, fenol, tanin, alkaloid, steroid dan triterpenoid. Uji aktivitas antijamur ekstrak etanol umbi bawang dayak dengan metode difusi cakram tidak membentuk zona hambat terhadap pertumbuhan Microsporum canis. Kesimpulan: Ekstrak etanol umbi bawang dayak tidak memiliki aktivitas antijamur terhadap pertumbuhan Microsporum canis.

PERILAKU DISOLUSI KETOPROFEN DAN INDOMETASIN FARNESIL TERSALUT GEL KITOSAN-GOM GUAR

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Purwantiningsih Sugita ◽  
Bambang Srijanto ◽  
Budi Arifin ◽  
Fithri Amelia ◽  
Mahdi Mubarok
Keyword(s):  
Room Temperature ◽  
Guar Gum ◽  
Tween 80 ◽  
Chitosan Solution ◽  
In Vitro Dissolution ◽  
Dissolution Profile ◽  
Magnetic Stirrer ◽  
Dissolution Behaviour ◽  
Shrimp Shell Waste

Chitosan, a modification of shrimp-shell waste, has been utilized as microcapsule. However, it’s fragile gel property needs to be strengthened by adding glutaraldehyde (glu) and natural hydrocolloid guar gum (gg). This research’s purposes were to study dissolution behaviour of ketoprofen and infar through optimum chitosan-guar gum microcapsule. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid,38.1 mL of gg solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules and 0.05, 0.19, and 0.33% (w/v) for infar microcapsules, and stirred with magnetic stirrer until homogenous. Afterwards, 7.62mL of glu was added slowly under stirring, with concentrations varied: 3, 3.5, and 4% (v/v) for ketoprofen microcapsules, and 4, 4.5, and 5% (v/v) for infar microcapsules. All mixtures were shaked for 20 minutes for homogenization. All mixtures wereshaked for 20 minutes for homogenization. Into each  microcapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added, whereas solution of 100 mg of in 250 mL of 96% ethanol was added into each microcapsule mixture for infar. Every mixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Everymixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. The data of [gg], [glu], and medicine’s content from each microcapsule were treated with Minitab 14 software to obtain optimum [gg] and [glu] for microencapsulation. The dissolution behaviour of optimum ketoprofen and infar microcapsules were investigated. The result of optimization by using Minitab Release 14 software showed that among the microcapsule compositions of [gg] and [glu] were 0.35% (w/v) and 3.75% (v/v), respectively, optimum to coat ketoprofen, whereas [gg] and [glu] of 0.05% (w/v) and4.00% (v/v), respectively, optimum to coat infar, at constant chitosan concentration (1.75% [w/v]). In vitro dissolution profile showed that chitosan-guar gum gel microcapsule was more resistant in intestinal pH condition (rather basic) compared with that in gastric pH (very acidic).

Foreign Trade Regimes and Economic Development: India. By Jagdish N. Bhagwati and T.N. Sirinivasan. New York Columbia University Press (Published by the National Bureau of Economic Research 1975) 261 pages.

1977 ◽  
Vol 16 (1) ◽  
pp. 112-114
Author(s):  
Abdur Razzaq Shahid
Keyword(s):  
New York ◽  
Economic Development ◽  
Foreign Trade ◽  
Developed Countries ◽  
Exchange Rate Policy ◽  
Economic Research ◽  
National Bureau ◽  
Columbia University ◽  
The Government ◽  
Exchange Control

This volume on India is one of a series of research projects on exchange control, liberalization, and economic development, undertaken for many less developed countries. The study deals with three major topics: exchange control, liberalization, and growth. First, under 'The Anatomy of Exchange Control', the methods of allocation and intervention in the foreign trade and payments practised by the government during the restrictive period 1956-66 and their economic impact are discussed. Then, a detailed analysis of the 'Liberalization Episode' which covers the policies in the period 1966-68, including the June 1966 devaluation, and the episode's effect on price level, economic activity, and exports is given. Finally, the overall growth effects of the foreign trade regime (broadly defined as exchange rate policy plus the frame-work of relevant domestic policies such as industrial licensing), and their possible contribution to India's rather unsatisfactory economic performance are examined.

Foreign Trade Regimes and Economic Development: TURKEY. By Anne O. Kneger. New York : Columbia University Press 1975. (Published by the National Bureau of Economic Research, Inc., New York) xxiii + 339 pp. Price $ 17.50 for hard cover ; $ 5.00 for paperback.

1975 ◽  
Vol 14 (3) ◽  
pp. 377-380
Author(s):  
Javed Ashraf
Keyword(s):  
Economic Growth ◽  
New York ◽  
Economic Development ◽  
Foreign Trade ◽  
Economic Research ◽  
National Bureau ◽  
Columbia University ◽  
Individual Country ◽  
Depth Analysis ◽  
Exchange Control

The book is the first of a series of studies on Exchange Control, Liberalization and Economic Development sponsored by the National Bureau of Economic Research, New York. The ten-country study, of which the book under review is a part, provides an in-depth analysis of three major areas : The anatomy of exchange control along with its implications, the episode of the liberalization of the payments regime, and the relationship of growth with the exchange control regime. The findings of the individual country-studies have been consolidated in an overall synthesis. However, each study is complete in itself in accordance with the needs of scholars having an interest in only some of the studies. The book under review seeks to analyse Turkey's trade and payments regime and the effect that the latter has had on the country's economic growth. Whereas quite a few other factors are instrumental in development (e.g. agricultural productivity, levels of education, political and social stability, etc.), the focus on foreign trade alone is justified by the author on the grounds of the tremendous amount of government influence in foreign trade. Moreover, the author believes that an intensive study of the trade-growth relationship is more rewarding than: a general survey of all factors related to economic growth.

UJI DIFUSI MIKROEMULSI NITROGLISERIN MENGGUNAKAN TWEEN 80 SEBAGAI SURFAKTAN

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kori Yati ◽  
Almawati Situmorang ◽  
Ani Umoro
Keyword(s):  
Tween 80

Development and Oral Bioavailability of Self-Emulsifying Formulation of Ketoconazole

2013 ◽  
Vol 5 (4) ◽  
pp. 1858-1865
Author(s):  
Arundhati Bhattacharyya ◽  
M Bajpai
Keyword(s):  
Oral Bioavailability ◽  
Oral Delivery ◽  
Oral Absorption ◽  
Aqueous Suspension ◽  
Droplet Diameter ◽  
Tween 80 ◽  
Concurrent Administration ◽  
System Maintenance ◽  
Pure Drug ◽  
Ph Dependent

Ketoconazole is an imidazole antifungal drug belonging to the class II of Biopharmaceutic Classification System. Maintenance of gastric acidity is essential for adequate dissolution and absorption of ketoconazole. Concurrent administration of antacid and antiulcer preparations decreases the oral absorption of ketoconazole often causing therapeutic failure.  The aim of this study was to evaluate whether a self-emulsifying formulation of ketoconazole would be able to overcome the pH dependent dissolution and oral bioavailability. Self-emulsifying drug delivery system (SEDDS) was prepared after selecting the oil, surfactant and co-surfactant by solubility analysis. Optimum ratio of the components was finalized on the basis of drug content, self-emulsification and mean droplet diameter. The effect of pH on dissolution was studied in comparison to the pure drug. Oral bioavailability was determined in comparison to aqueous suspension in rats and the effect of co-administration of ranitidine hydrochloride solution and a commercially available liquid antacid preparation was studied. The optimized formulation containing 20% Capryol 90 and 40% each of Carbitol and Tween 80, exhibited 100% drug release regardless of the pH whereas the pure drug exhibited a highly pH dependent dissolution. The AUC0-24 resulted with oral administration of the SEDDS formulation was about 34%, 43% and 60% higher compared to the aqueous suspension when administered alone, administered with ranitidine and administered with antacid respectively. The results of the present study demonstrate that self-emulsifying formulations can be utilized for oral delivery of weakly basic drugs like ketoconazole which exhibit pH dependent dissolution.

Investigating Non-Therapeutic Pharmaceutical Substances for Improving In-Vitro Efficacy of Clindamycin Phosphate Against MRSA and Staphylococcus Epidermidis

2020 ◽  
Vol 18 (2) ◽  
pp. 63-72
Author(s):  
Mohd Aftab Alam ◽  
Fahad I. Al-Jenoobi ◽  
Khaled A. Alzahrani ◽  
Mohammad H. Al-Agamy ◽  
Abdullah M. Al-Mohizea
Keyword(s):  
Fusidic Acid ◽  
Staphylococcus Epidermidis ◽  
Sorbic Acid ◽  
Tween 80 ◽  
Lauryl Sulfate ◽  
Individual Substance ◽  
Dependent Effect ◽  
Pharmaceutical Excipients ◽  
Active Substances

The aim of present study was to investigate the effect of pharmaceutical excipients and other active substances on antimicrobial efficacy of standard antibiotic against resistant and susceptible microorganisms. Pharmaceutical excipients (sodium lauryl sulfate [SLS], Tween-80, citric acid, NaOH, NaCl) and active substances (fusidic acid, sorbic acid) were investigated to check in-vitro efficacy and their effect on the efficacy of standard antibiotic. Clindamycin was selected as standard antibiotic. Clindamycin was found to be ineffective against methicillin-resistant Staphylococcus aureus (MRSA). Fusidic acid and SLS showed concentration dependent effect against MRSA. Other tested substances were also ineffective against MRSA, and also failed to improve the susceptibility of MRSA towards clindamycin. The clindamycin + fusidic acid (0.05 µg, 0.1 µg), and clindamycin + SLS (0.5 mg, 1 mg) showed concentration dependent effect on Staphylococcus epidermidis (S. epidermidis). Clindamycin combinations with fusidic acid or SLS showed better inhibition of S. epidermidis, than individual substance. At lower concentration of clindamycin (2 µg), the sorbic acid (25 µg) improves its effectiveness. SLS (0.5 mg, 1 mg) and clindamycin (4 µg, 10 µg) showed almost equal zone of inhibition against S. epidermidis, respectively. Present findings showed that certain pharmaceutical excipients (e.g. SLS) are effective against resistant and susceptible microbes, and suggested that more excipients should be screened for their antimicrobial potential and their ability to improve the efficacy of standard antibiotics.

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